procyclidine has been researched along with Seizures in 17 studies
Procyclidine: A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
procyclidine : A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results showed that MPEP or DCG-IV combined with HI-6 and procyclidine resulted in substantial antidotal efficacy when administered 20 min after onset of seizures elicited by soman." | 7.79 | Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats. ( Aas, P; Enger, S; Mariussen, E; Myhrer, T, 2013) |
| " The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1)." | 7.76 | Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| " after exposure to a soman dose of 4 x LD(50) completely terminated seizures with a moderate mortality rate (25%)." | 7.73 | Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| "Procyclidine and propofol were considered as the most relevant double regimen to replace a previous triple regimen (procyclidine, diazepam, pentobarbital) against soman-induced seizures." | 5.33 | Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| "The sustained seizures were subsequently treated with diazepam (10 mg/kg) and pentobarbital (30 mg/kg) and finally terminated 25 min after onset." | 5.32 | Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts. ( Aas, P; Andersen, JM; Myhrer, T; Nguyen, NH, 2004) |
| " The treatment was given 1 and 5 min after exposure to a supralethal dose of nerve agents, and the results showed that the triple regimen successfully prevented or terminated seizures and preserved the lives of rats exposed to 5×LD50 of soman, sarin, cyclosarin, or VX, but solely 3×LD50 of tabun was managed by this regimen." | 3.81 | Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats. ( Aas, P; Enger, S; Mariussen, E; Myhrer, T, 2015) |
| " The results showed that MPEP or DCG-IV combined with HI-6 and procyclidine resulted in substantial antidotal efficacy when administered 20 min after onset of seizures elicited by soman." | 3.79 | Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats. ( Aas, P; Enger, S; Mariussen, E; Myhrer, T, 2013) |
| "Results from studies based on microinfusions into seizure controlling brain sites (area tempestas, medial septum, perirhinal cortex, posterior piriform cortex) have shown that procyclidine, muscimol, caramiphen, and NBQX, but not ketamine, exert anticonvulsant effects against soman-induced seizures." | 3.77 | Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats. ( Aas, P; Enger, S; Jonassen, M; Myhrer, T, 2011) |
| " The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1)." | 3.76 | Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| " after exposure to a soman dose of 4 x LD(50) completely terminated seizures with a moderate mortality rate (25%)." | 3.73 | Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| "The procyclidine regimen has apparently capacities to serve as a universal therapy against soman intoxication in rats." | 1.39 | Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility. ( Aas, P; Enger, S; Mariussen, E; Myhrer, T, 2013) |
| "Procyclidine and propofol were considered as the most relevant double regimen to replace a previous triple regimen (procyclidine, diazepam, pentobarbital) against soman-induced seizures." | 1.33 | Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| "The sustained seizures were subsequently treated with diazepam (10 mg/kg) and pentobarbital (30 mg/kg) and finally terminated 25 min after onset." | 1.32 | Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts. ( Aas, P; Andersen, JM; Myhrer, T; Nguyen, NH, 2004) |
| "Soman induced profound limbic convulsions and 30% mortality, leading to increased blood-brain barrier permeability, neural injuries, learning and memory impairments, and physical incapacitation of survived rats pretreated with HI-6." | 1.32 | Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats. ( Che, JH; Choi, EK; Ha, YC; Hur, GH; Hwang, SY; Jang, JY; Kim, DJ; Kim, J; Kim, JC; Kim, YB; Park, D; Seong, YH; Shin, S; Yon, JM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Myhrer, T | 11 |
| Enger, S | 8 |
| Mariussen, E | 3 |
| Aas, P | 10 |
| Jonassen, M | 1 |
| Nguyen, NH | 1 |
| Andersen, JM | 1 |
| Choi, EK | 1 |
| Park, D | 1 |
| Yon, JM | 1 |
| Hur, GH | 1 |
| Ha, YC | 1 |
| Che, JH | 1 |
| Kim, J | 1 |
| Shin, S | 1 |
| Jang, JY | 1 |
| Hwang, SY | 1 |
| Seong, YH | 1 |
| Kim, DJ | 1 |
| Kim, JC | 1 |
| Kim, YB | 1 |
| Haug, KH | 1 |
| Fonnum, F | 1 |
| Zarnowski, T | 1 |
| Kleinrok, Z | 1 |
| Turski, WA | 1 |
| Czuczwar, SJ | 1 |
| Boissier, JR | 1 |
| Simon, P | 1 |
| Villeneuve, A | 1 |
| Larousse, C | 1 |
| Fink, M | 1 |
| Ursillo, RC | 1 |
| McCulloch, JA | 1 |
| Millichap, JG | 1 |
| Pitchford, GL | 1 |
| Millichap, MG | 1 |
2 reviews available for procyclidine and Seizures
| Article | Year |
|---|---|
Choice of approaches in developing novel medical countermeasures for nerve agent poisoning.
Topics: Animals; Anticonvulsants; Antidotes; Brain; Cholinergic Agents; Humans; Levetiracetam; Organophospha | 2014 |
CNS effects of convulsive therapy: significance for a theory of depressive psychosis.
Topics: Alpha Rhythm; Amobarbital; Antidepressive Agents; Bipolar Disorder; Brain; Depression; Electroconvul | 1972 |
15 other studies available for procyclidine and Seizures
| Article | Year |
|---|---|
Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility.
Topics: Animals; Anticonvulsants; Male; Neuroprotective Agents; Physostigmine; Procyclidine; Rats; Rats, Wis | 2013 |
Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cyclopropanes; Drug Interacti | 2013 |
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relat | 2015 |
Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electroencephalography; GABA Agon | 2010 |
Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats.
Topics: Animals; Anticonvulsants; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinester | 2011 |
The perirhinal cortex of rats: an intricate area for microinfusion of anticonvulsants against soman-induced seizures.
Topics: Animals; Anticonvulsants; Brain Waves; Catheters, Indwelling; Cerebral Cortex; Cyclopentanes; Cyclop | 2013 |
Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts.
Topics: Animals; Cholinesterase Inhibitors; Convulsants; Dizocilpine Maleate; Dose-Response Relationship, Dr | 2004 |
Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats.
Topics: Animals; Avoidance Learning; Blood-Brain Barrier; Brain; Capillary Permeability; Cholinesterase Inhi | 2004 |
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Dipeptides; Drug Combinations; Lethal Dose 50; | 2006 |
Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact.
Topics: Animals; Anticonvulsants; Antidotes; Ethanol; GABA Modulators; Hippocampus; Male; Muscarinic Antagon | 2006 |
The combination of donepezil and procyclidine protects against soman-induced seizures in rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Body Temperature; Brain; Convulsants; Donepezil; Elect | 2007 |
The NMDA antagonist procyclidine, but not ifenprodil, enhances the protective efficacy of common antiepileptics against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Drug Synergism; Electroshock; Male; Memory; Mice; Move | 1994 |
Flurothyl in mice: seizure, post-convulsive behavior, and interactions with psychotropic drugs.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Biperiden; Caffeine; Catalepsy; Central Nervous Sy | 1968 |
The effect of elantrine, a new anti-Parkinsonism agent, on drug-induced tremor in mice.
Topics: Alkaloids; Animals; Antiparkinson Agents; Atropine; Benztropine; Body Temperature; Central Nervous S | 1972 |
Anticonvulsant activity of antiparkinsonism agents.
Topics: Animals; Anticonvulsants; Child; Child, Preschool; Electroshock; Female; Glaucoma; Humans; Infant; M | 1968 |