procyclidine has been researched along with Parkinson Disease in 27 studies
Procyclidine: A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
procyclidine : A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, cross-over trial of the effectiveness of piribedil, procyclidine and placebo in the control of parkinsonism induced by fluphenazine decanoate was conducted in sixteen cases of chronic schizophrenia." | 5.04 | A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism. ( Bradley, R; Lamb, P; Mindham, RH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SIGWALD, J | 1 |
| ZIER, A | 1 |
| DOSHAY, LJ | 1 |
| KONCHEGUL, L | 1 |
| GROSS, H | 1 |
| LANGNER, E | 1 |
| SCHWAB, RS | 1 |
| CHAFETZ, ME | 1 |
| NAKAZAWA, T | 1 |
| KASAHARA, T | 1 |
| KOMIYA, H | 1 |
| MONTUSCHI, E | 1 |
| PHILLIPS, J | 1 |
| PRESCOTT, F | 1 |
| GREEN, AF | 1 |
| Pavoncello, S | 1 |
| Di Bianco, V | 1 |
| Di Castro, A | 1 |
| Caviglia, A | 1 |
| Cellitti, M | 1 |
| Gabriel, E | 1 |
| Karobath, M | 1 |
| Lenz, G | 1 |
| Taylor, J | 1 |
| Mindham, RH | 1 |
| Lamb, P | 1 |
| Bradley, R | 1 |
| Butzer, JF | 1 |
| Silver, DE | 1 |
| Sahs, AL | 1 |
| Parkenberg, H | 1 |
| Mano, T | 1 |
| Birket-Smith, E | 1 |
| Nakano, KK | 3 |
| Bass, H | 1 |
| Tyler, HR | 3 |
| Benesová, O | 1 |
| Itil, TM | 1 |
| Patterson, CD | 1 |
| Keskiner, A | 1 |
| Holden, JM | 1 |
| Zubick, H | 1 |
| Denber, HC | 1 |
| Mohr, CP | 1 |
| Timberlake, WH | 2 |
| Muscettola, GB | 1 |
| Giovannucci, M | 1 |
| Montanini, R | 1 |
| Morselli, PL | 1 |
| Garattini, S | 1 |
| Pecknold, JC | 1 |
| Ananth, JV | 1 |
| Ban, TA | 1 |
| Lehmann, HE | 1 |
| Boman, K | 1 |
| Meurman, T | 1 |
| Korn, M | 1 |
| Pinchard, A | 1 |
| Breulet, M | 1 |
| Goffioul, F | 1 |
| Bobon, J | 1 |
1 review available for procyclidine and Parkinson Disease
| Article | Year |
|---|---|
[Review of current pharmacotherapy of Parkinsonism. Comprehensive review].
Topics: 5-Hydroxytryptophan; Amantadine; Anticonvulsants; Apomorphine; Benztropine; Carboxy-Lyases; Chemical | 1973 |
9 trials available for procyclidine and Parkinson Disease
| Article | Year |
|---|---|
A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism.
Topics: Chronic Disease; Clinical Trials as Topic; Fluphenazine; Humans; Parkinson Disease; Parkinson Diseas | 1977 |
Amantadine in Parkinson's disease. A double-blind, placebo-controlled, crossover study with long-term follow-up.
Topics: Activities of Daily Living; Aged; Amantadine; Benztropine; Clinical Trials as Topic; Diphenhydramine | 1975 |
Levodopa in Parkinson's disease: effect on pulmonary function.
Topics: Age Factors; Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Evaluation Studies as Topic; Fe | 1972 |
Comparison of phenothiazine and nonphenothiazine neuroleptics according to psychopathology, side effects and computerized EEG.
Topics: Alpha Rhythm; Chronic Disease; Clinical Trials as Topic; Computers; Electroencephalography; Female; | 1974 |
Speech defects of parkinsonian patients. Effects of levodopa therapy on speech intelligibility.
Topics: 1-Propanol; Adult; Aged; Antiparkinson Agents; Dihydroxyphenylalanine; Evaluation Studies as Topic; | 1973 |
Mefexamide as an antiparkinson drug. (A double-blind study).
Topics: Amides; Clinical Trials as Topic; Extrapyramidal Tracts; Female; Glycolates; Humans; Parasympatholyt | 1969 |
Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders.
Topics: 1-Propanol; Adult; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Male; Middle Ag | 1970 |
Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders.
Topics: 1-Propanol; Adult; Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Male; Mid | 1970 |
A double-blind study of the effects of levodopa in Parkinson's disease.
Topics: Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Motor Ski | 1971 |
17 other studies available for procyclidine and Parkinson Disease
| Article | Year |
|---|---|
[Activity of kemadrin on the symptoms of Parkinson's disease; comparison with other therapeutics].
Topics: Cardiovascular Agents; Coal Tar; Muscle Relaxants, Central; Parkinson Disease; Procyclidine | 1953 |
Procyclidine hydrochloride (kemadrin) treatment of parkinsonism; result in 108 patients.
Topics: Parkinson Disease; Parkinsonian Disorders; Procyclidine; Trihexyphenidyl | 1957 |
The use of kemadrin in the treatment of drug-induced parkinsonism; preliminary report.
Topics: Parkinson Disease; Parkinsonian Disorders; Procyclidine; Trihexyphenidyl | 1958 |
[Prophylaxis and therapy of a drug-related Parkinson syndrome with procyclidine hydrochloride (Kemadrin)].
Topics: Humans; Paralysis; Parasympatholytics; Parkinson Disease; Procyclidine | 1962 |
Kemadrin in the treatment of parkinsonism.
Topics: Muscle Relaxants, Central; Parkinson Disease; Parkinsonian Disorders; Procyclidine | 1955 |
[A study on antiparkinson drugs with special reference to Kemadrin (procyclidine)].
Topics: Antiparkinson Agents; Parasympatholytics; Parkinson Disease; Procyclidine | 1962 |
Kemadrin in postencephalitic parkinsonism.
Topics: Cardiovascular Agents; Muscle Relaxants, Central; Parkinson Disease; Parkinson Disease, Postencephal | 1952 |
[Neurological aspects and modern trends in therapy of Parkinson's disease].
Topics: Atropine; Biperiden; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Procyclidine; Trihexyp | 1980 |
[The extrapyramidal symptoms in the combination of lithium long-term lithium therapy with nortriptyline. A case report on the formation of a pathogenesis hypothesis].
Topics: Adult; Basal Ganglia Diseases; Bipolar Disorder; Chlorprothixene; Clopenthixol; Dibenzazepines; Drug | 1976 |
Parkinson's disease.
Topics: Amantadine; Benztropine; Humans; Levodopa; Parkinson Disease; Procyclidine; Trihexyphenidyl | 1977 |
[Treatment of parkinsonism].
Topics: Amantadine; Benztropine; Biperiden; Humans; Levodopa; Orphenadrine; Parkinson Disease; Procyclidine; | 1976 |
[Dyskinesia induced by anticholinergic drugs--electrophysiological analysis].
Topics: Aged; Benztropine; Biperiden; Electromyography; Female; Humans; Male; Middle Aged; Movement Disorder | 1974 |
Abnormal involuntary movements induced by anticholinergic therapy.
Topics: Aged; Biperiden; Dibenzazepines; Female; Humans; Mastication; Middle Aged; Movement Disorders; Orphe | 1974 |
Relationship between desipramine plasma levels and the effect in Parkinson's syndrome.
Topics: Adult; Aged; Contracture; Desipramine; Drug Synergism; Female; Humans; Male; Middle Aged; Paralysis; | 1972 |
Lack of indication for use of antiparkinson medication. A follow-up study.
Topics: Adolescent; Adult; Female; Follow-Up Studies; Humans; Intellectual Disability; Male; Mental Disorder | 1971 |
Investigations on the effect of some drugs on the Parkinsonian rigidity.
Topics: Adult; Atropine; Biperiden; Female; Humans; Injections, Intravenous; Male; Middle Aged; Muscle Contr | 1970 |
[Long-acting antiparkinson agents. I. Pilot study on benzetimide (342 cases)].
Topics: Adolescent; Adult; Aged; Benzyl Compounds; Extrapyramidal Tracts; Humans; Middle Aged; Movement Diso | 1971 |