procyclidine has been researched along with Neuroleptic Malignant Syndrome in 6 studies
Procyclidine: A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
procyclidine : A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "High dose intravenous therapy with the anticholinergic drug, procyclidine hydrochloride, temporarily diminished the muscle rigidity and reversed most of the autonomic features in a patient with NMS occurring after a single intramuscular dose of the dopamine antagonist metoclopramide." | 7.69 | Paradoxical autonomic response to procyclidine in the neuroleptic malignant syndrome. ( Balzan, MV, 1995) |
| "High dose intravenous therapy with the anticholinergic drug, procyclidine hydrochloride, temporarily diminished the muscle rigidity and reversed most of the autonomic features in a patient with NMS occurring after a single intramuscular dose of the dopamine antagonist metoclopramide." | 3.69 | Paradoxical autonomic response to procyclidine in the neuroleptic malignant syndrome. ( Balzan, MV, 1995) |
| "In a fatal case of neuroleptic malignant syndrome, a muscle sample taken within 1 h of death showed acute myopathic features with absence of muscle glycogen and neutral lipid." | 1.27 | Muscle pathology in the neuroleptic malignant syndrome. ( Martin, DT; Swash, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Waqas, S | 1 |
| Talty, M | 1 |
| O'Keeffe, S | 1 |
| Flood, J | 1 |
| Doherty, AM | 1 |
| Balzan, MV | 1 |
| Spivak, B | 1 |
| Gonen, N | 1 |
| Mester, R | 1 |
| Averbuch, E | 1 |
| Adlersberg, S | 1 |
| Weizman, A | 1 |
| Burrell, MF | 1 |
| Fewster, C | 1 |
| Szabadi, E | 1 |
| Cashman, M | 1 |
| Bamrah, JS | 1 |
| Martin, DT | 1 |
| Swash, M | 1 |
6 other studies available for procyclidine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
There is more to this fever than meets the eye: A case of neuroleptic malignant-like syndrome (NMLS) secondary to withdrawal of procyclidine and L-dopa on a background of long-standing flupenthixol depot use.
Topics: Antipsychotic Agents; Flupenthixol; Humans; Levodopa; Neuroleptic Malignant Syndrome; Procyclidine | 2023 |
Paradoxical autonomic response to procyclidine in the neuroleptic malignant syndrome.
Topics: Autonomic Nervous System; Hernia; Humans; Injections, Intravenous; Male; Middle Aged; Muscle Rigidit | 1995 |
Neuroleptic malignant syndrome associated with abrupt withdrawal of anticholinergic agents.
Topics: Adult; Antipsychotic Agents; Delayed-Action Preparations; Fluphenazine; Humans; Male; Muscarinic Ant | 1996 |
Clozapine-treated NMS.
Topics: Adult; Chlorpromazine; Clopenthixol; Clozapine; Drug Therapy, Combination; Humans; Male; Neuroleptic | 1991 |
Neuroleptic-induced pyrexia. A benign variant.
Topics: Adult; Droperidol; Female; Humans; Lithium; Neuroleptic Malignant Syndrome; Procyclidine | 1988 |
Muscle pathology in the neuroleptic malignant syndrome.
Topics: Adult; Fluphenazine; Humans; Male; Muscles; Neuroleptic Malignant Syndrome; Procyclidine; Psychotic | 1987 |