procyclidine has been researched along with Disease Models, Animal in 5 studies
Procyclidine: A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
procyclidine : A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1)." | 7.76 | Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| " The treatment was given 1 and 5 min after exposure to a supralethal dose of nerve agents, and the results showed that the triple regimen successfully prevented or terminated seizures and preserved the lives of rats exposed to 5×LD50 of soman, sarin, cyclosarin, or VX, but solely 3×LD50 of tabun was managed by this regimen." | 3.81 | Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats. ( Aas, P; Enger, S; Mariussen, E; Myhrer, T, 2015) |
| "Results from studies based on microinfusions into seizure controlling brain sites (area tempestas, medial septum, perirhinal cortex, posterior piriform cortex) have shown that procyclidine, muscimol, caramiphen, and NBQX, but not ketamine, exert anticonvulsant effects against soman-induced seizures." | 3.77 | Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats. ( Aas, P; Enger, S; Jonassen, M; Myhrer, T, 2011) |
| " The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1)." | 3.76 | Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Myhrer, T | 4 |
| Mariussen, E | 1 |
| Enger, S | 4 |
| Aas, P | 4 |
| Jonassen, M | 1 |
| Joosen, MJ | 1 |
| van der Schans, MJ | 1 |
| Kuijpers, WC | 1 |
| van Helden, HP | 1 |
| Noort, D | 1 |
1 review available for procyclidine and Disease Models, Animal
| Article | Year |
|---|---|
Timing of decontamination and treatment in case of percutaneous VX poisoning: a mini review.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibi | 2013 |
4 other studies available for procyclidine and Disease Models, Animal
| Article | Year |
|---|---|
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats.
Topics: Animals; Anticonvulsants; Antidotes; Body Weight; Brain; Disease Models, Animal; Dose-Response Relat | 2015 |
Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electroencephalography; GABA Agon | 2010 |
Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats.
Topics: Animals; Anticonvulsants; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinester | 2011 |
The perirhinal cortex of rats: an intricate area for microinfusion of anticonvulsants against soman-induced seizures.
Topics: Animals; Anticonvulsants; Brain Waves; Catheters, Indwelling; Cerebral Cortex; Cyclopentanes; Cyclop | 2013 |