Page last updated: 2024-09-02

procyanidin and Hypertension

procyanidin has been researched along with Hypertension in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (10.00)29.6817
2010's19 (63.33)24.3611
2020's8 (26.67)2.80

Authors

AuthorsStudies
Defernez, M; Hollands, WJ; Kiely, ME; Kroon, PA; Lucey, AJ; Perez Moral, N; Philo, M; Tapp, H; Winterbone, MS1
de Graaf, Y; de Groot, E; Draijer, R; Slettenaar, M; Wright, CI1
Asher, GN; Caughey, M; Dominik, R; Hinderliter, AL; Viera, AJ; Weaver, MA1
Campos, H; Chevaux, K; Coletti, C; Hollenberg, NK; Jackson, L; Martinez, G; McCullough, ML; Preston, M; Schmitz, HH1
Enríquez, RG; Fernández, G; Lobato, C; Magos, GA; Márquez, C; Mateos, JC; Páez, E1
Chu, Y; Gu, W; Liu, L; Wang, R; Xu, R1
Chamasemani, A; Firouzabadi, N; Mousaei, M; Shirazi-Tehrani, E1
Kim, HC; Kim, MK; Kim, YM; Koh, SB; Kong, JS; Shin, JH; Shin, MH; Woo, HW1
Bastos, JK; Boeing, T; Bolda Mariano, LN; Cechinel-Filho, V; Cechinel-Zanchett, CC; da Costa, JC; Da Silva, LM; de Souza, P1
Arola-Arnal, A; Bravo, FI; Iglesias-Carres, L; Mas-Capdevila, A; Muguerza, B; Suárez, M1
An, J; Chen, M; Ma, Y; Ren, J; Yang, H1
Ma, Y; Ren, J1
Nurizadeh, F; Rajabi, B; Saneei, P1
Gao, H; Liang, Y; Qiu, J; Wang, J; Wang, Q; Zhang, J; Zhao, S1
Bai, S; Bi, K; Cui, C; Li, Q; Shi, A; Yan, P1
Cheng, P; Gao, S; Hu, J; Lv, FH; Zhu, FQ1
Dong, M; Feng, YM; Hao, JP; Ji, X; Qie, LY; Shi, H; Zhang, CM; Zhang, J1
Ballesteros, S; de las Heras, N; Fuller, PJ; Lahera, V; Martín-Fernández, B; Stanton, PG; Valero-Muñoz, M; Yao, YZ1
Ding, L; Gao, S; Guo, K; Huang, LL; Pan, C; Wang, HZ; Wang, L; Xu, AM1
Ding, L; Gao, S; Guo, K; Kan, HW; Lan, CZ; Ou, YR; Su, YL; Wang, L1
Gao, HQ; Liang, Y; Qiu, J; Wang, J; Wang, QZ; Zhang, J1
Hügel, HM; Jackson, N; May, B; Xue, CC; Zhang, AL1
Gao, H; Liang, Y; Qiu, J; Wang, J; Wang, Q; Zhang, J1
Arola, L; Fernández-Castillejo, S; Llauradó, E; Pedret, A; Puiggrós, F; Solà, R; Valls, RM1
Aleixandre, A; Cienfuegos-Jovellanos, E; Miguel, M; Moulay, L; Muguerza, B; Quiñones, Mdel M1
Dietrich, H; Drossard, C; Fröhling, B; Kersting, M1
Kiso, Y; Matsumura, Y; Ohkita, M1
Aketa, S; Hirayama, M; Kawakami, K; Nishida, H; Sakai, H; Watanabe, Y1
Furuuchi, R; Hirayama, M; Hirokawa, N; Sakai, H; Watanabe, Y; Yokoyama, T1
Cui, X; Feng, H; Gao, H; Liu, X; Zhao, S1

Reviews

3 review(s) available for procyanidin and Hypertension

ArticleYear
Effect of proanthocyanidins on blood pressure: A systematic review and meta-analysis of randomized controlled trials.
    Pharmacological research, 2021, Volume: 165

    Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Proanthocyanidins; Randomized Controlled Trials as Topic

2021
Polyphenol protection and treatment of hypertension.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Feb-15, Volume: 23, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Anthocyanins; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Diet; Endothelium, Vascular; Flavones; Flavonoids; Flavonols; Humans; Hypertension; Oxidative Stress; Phytotherapy; Polyphenols; Proanthocyanidins; Randomized Controlled Trials as Topic; Vasodilation

2016
Pharmacology in health foods: improvement of vascular endothelial function by French maritime pine bark extract (Flavangenol).
    Journal of pharmacological sciences, 2011, Volume: 115, Issue:4

    Topics: Acute Kidney Injury; Animals; Antioxidants; Biflavonoids; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Food, Organic; Humans; Hypertension; Nitric Oxide Synthase Type III; Plant Extracts; Proanthocyanidins; Reperfusion Injury

2011

Trials

4 trial(s) available for procyanidin and Hypertension

ArticleYear
Lack of acute or chronic effects of epicatechin-rich and procyanidin-rich apple extracts on blood pressure and cardiometabolic biomarkers in adults with moderately elevated blood pressure: a randomized, placebo-controlled crossover trial.
    The American journal of clinical nutrition, 2018, 11-01, Volume: 108, Issue:5

    Topics: Aged; Biflavonoids; Biomarkers; Blood Pressure; Cardiovascular Diseases; Catechin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Male; Malus; Middle Aged; Plant Extracts; Proanthocyanidins

2018
Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects.
    Nutrients, 2015, Apr-30, Volume: 7, Issue:5

    Topics: Adult; Aged; Anthocyanins; Biflavonoids; Blood Pressure; Catechin; Cross-Over Studies; Double-Blind Method; Endothelin-1; Female; Flavonols; Humans; Hypertension; Lipoproteins; Male; Middle Aged; Plant Extracts; Platelet Function Tests; Polyphenols; Proanthocyanidins; Vascular Stiffness; Vasodilation; Vitis; Wine

2015
Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial.
    BMC complementary and alternative medicine, 2012, Mar-29, Volume: 12

    Topics: Adult; Aged; Biflavonoids; Blood Circulation; Blood Pressure; Brachial Artery; Catechin; Crataegus; Cross-Over Studies; Humans; Hypertension; Middle Aged; Nitric Oxide; Patient Acceptance of Health Care; Phytotherapy; Plant Extracts; Proanthocyanidins; Vasodilation

2012
Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Nov-15, Volume: 23, Issue:12

    Topics: Aged; Apolipoprotein A-I; Blood Pressure; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Humans; Hypertension; Lipids; Lipoproteins, LDL; Male; Middle Aged; Molecular Weight; Phytotherapy; Pinus; Plant Bark; Plant Extracts; Polyphenols; Proanthocyanidins; Risk Factors

2016

Other Studies

23 other study(ies) available for procyanidin and Hypertension

ArticleYear
Hypertension, the Kuna, and the epidemiology of flavanols.
    Journal of cardiovascular pharmacology, 2006, Volume: 47 Suppl 2

    Topics: Acculturation; Adult; Animals; Beverages; Biflavonoids; Cacao; Catechin; Diet; Diet Surveys; Female; Fishes; Flavonoids; Fruit; Humans; Hypertension; Indians, Central American; Male; Middle Aged; Panama; Proanthocyanidins; Sodium, Dietary; Vegetables

2006
Hypotensive and vasorelaxant effects of the procyanidin fraction from Guazuma ulmifolia bark in normotensive and hypertensive rats.
    Journal of ethnopharmacology, 2008, Apr-17, Volume: 117, Issue:1

    Topics: Animals; Aorta, Thoracic; Biflavonoids; Blood Pressure; Catechin; Heart Rate; Hypertension; Male; Malvaceae; Nitric Oxide; Plant Extracts; Plants, Medicinal; Proanthocyanidins; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Vasodilation

2008
Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARγ/sFlt-1 axis in preeclampsia.
    Pharmacological research, 2022, Volume: 177

    Topics: Animals; Biflavonoids; Catechin; Endoglin; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; NF-E2-Related Factor 2; Placenta; PPAR gamma; Pre-Eclampsia; Pregnancy; Proanthocyanidins; Rats; Receptor Protein-Tyrosine Kinases; Vascular Endothelial Growth Factor Receptor-1

2022
ncRNAs and polyphenols: new therapeutic strategies for hypertension.
    RNA biology, 2022, Volume: 19, Issue:1

    Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelial Cells; Genome-Wide Association Study; Hypertension; Hypoxia; MicroRNAs; NF-kappa B; Nitric Oxide; Phosphatidylinositol 3-Kinases; Polyphenols; Proanthocyanidins; Rats; Rats, Inbred SHR; RNA, Long Noncoding

2022
Prospective Associations between Cumulative Average Intake of Flavonoids and Hypertension Risk in the CArdioVascular Disease Association Study (CAVAS).
    Nutrients, 2023, Feb-27, Volume: 15, Issue:5

    Topics: Adult; Anthocyanins; Cardiovascular Diseases; Diet; Flavonoids; Humans; Hypertension; Male; Middle Aged; Obesity; Overweight; Proanthocyanidins; Prospective Studies; Risk Factors

2023
Diuretic and Renal Protective Effect of Kaempferol 3-
    Journal of natural products, 2020, 06-26, Volume: 83, Issue:6

    Topics: Animals; Antioxidants; Bauhinia; Calcium; Chlorides; Cyclooxygenase Inhibitors; Diuretics; Hypertension; Kaempferols; Kidney Diseases; Mannosides; Molecular Structure; Muscarinic Antagonists; Plant Leaves; Proanthocyanidins; Protective Agents; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species

2020
Changes in arterial blood pressure caused by long-term administration of grape seed proanthocyanidins in rats with established hypertension.
    Food & function, 2020, Oct-21, Volume: 11, Issue:10

    Topics: Animals; Antihypertensive Agents; Antioxidants; Arterial Pressure; Blood Pressure; Diet; Disease Models, Animal; Drug Administration Schedule; Grape Seed Extract; Hypertension; Proanthocyanidins; Rats; Rats, Wistar; Time Factors

2020
Response to comment by Bahar Rajabi: "Effect of proanthocyanidins on blood pressure: A systematic review and meta-analysis of randomized controlled trials".
    Pharmacological research, 2021, Volume: 168

    Topics: Blood Pressure; Humans; Hypertension; Proanthocyanidins; Randomized Controlled Trials as Topic

2021
Comment on "Effect of proanthocyanidins on blood pressure: A systematic review and meta-analysis of randomized controlled trials".
    Pharmacological research, 2021, Volume: 168

    Topics: Blood Pressure; Humans; Hypertension; Proanthocyanidins; Randomized Controlled Trials as Topic

2021
Alleviative effect of grape seed proanthocyanidin extract on small artery vascular remodeling in spontaneous hypertensive rats via inhibition of collagen hyperplasia.
    Molecular medicine reports, 2017, Volume: 15, Issue:5

    Topics: Animals; Collagen; Hyperplasia; Hypertension; Proanthocyanidins; Rats; Rats, Inbred SHR; Seeds; Vascular Remodeling; Vitis

2017
Novel Antihypertensive Prodrug from Grape Seed Proanthocyanidin Extract via Acid-Mediated Depolymerization in the Presence of Captopril: Synthesis, Process Optimization, and Metabolism in Rats.
    Journal of agricultural and food chemistry, 2018, Apr-11, Volume: 66, Issue:14

    Topics: Animals; Antihypertensive Agents; Captopril; Grape Seed Extract; Humans; Hypertension; Male; Polymerization; Proanthocyanidins; Prodrugs; Rats; Rats, Sprague-Dawley; Seeds; Urine; Vitis

2018
Effects of oligomeric grape seed proanthocyanidins on L-NAME-induced hypertension in pregnant mice: Role of oxidative stress and endothelial dysfunction.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:9

    Topics: Animals; Aorta; Blood Pressure; Female; Grape Seed Extract; Heart; Hypertension; Kidney; Mice; NG-Nitroarginine Methyl Ester; Oxidative Stress; Pregnancy; Proanthocyanidins

2018
Role of GSPE in improving early cerebral vascular damage by inhibition of Profilin-1 expression in a ouabain-induced hypertension model.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:20

    Topics: Animals; Blood Pressure; Grape Seed Extract; Hypertension; Male; Nitric Oxide Synthase Type III; Ouabain; Proanthocyanidins; Profilins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Remodeling

2018
Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in rat heart through mineralocorticoid receptor blockade.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Aldosterone; Animals; Cell Line; Chlorocebus aethiops; Heart; Hypertension; Immediate-Early Proteins; Male; Mineralocorticoid Receptor Antagonists; Plant Extracts; Proanthocyanidins; Protein Serine-Threonine Kinases; Prunus; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spironolactone

2014
Protective effects of grape seed proanthocyanidins on cardiovascular remodeling in DOCA-salt hypertension rats.
    The Journal of nutritional biochemistry, 2015, Volume: 26, Issue:8

    Topics: Animals; Blood Pressure; Cardiovascular System; Desoxycorticosterone Acetate; Endothelin-1; Grape Seed Extract; Hydroxyproline; Hypertension; Male; Malondialdehyde; Natriuretic Peptide, Brain; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proanthocyanidins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase

2015
Grape seed proanthocyanidins prevent DOCA-salt hypertension-induced renal injury and its mechanisms in rats.
    Food & function, 2015, Volume: 6, Issue:7

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone Acetate; Grape Seed Extract; Humans; Hypertension; Kidney; Kidney Diseases; Male; Malondialdehyde; Oxidative Stress; Proanthocyanidins; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2015
Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells.
    Journal of translational medicine, 2015, Oct-08, Volume: 13

    Topics: Angiotensin II; Animals; Antioxidants; Chemokine CCL2; Cofilin 1; Creatinine; Cytoskeleton; Epithelial Cells; Gene Expression Regulation; Grape Seed Extract; Humans; Hypertension; Inflammation; Interleukin-1beta; Kidney Tubules; Male; NF-kappa B p50 Subunit; Nitrogen; Proanthocyanidins; Rats; Rats, Inbred SHR; Renal Insufficiency; RNA, Small Interfering; Urea

2015
Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress.
    Molecular medicine reports, 2016, Volume: 14, Issue:4

    Topics: Animals; Antioxidants; Aorta; Aortic Diseases; Endothelin-1; Grape Seed Extract; Hypertension; Male; Nitric Oxide; Oxidative Stress; Proanthocyanidins; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Remodeling; Vitis

2016
Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans.
    Journal of agricultural and food chemistry, 2009, Jul-22, Volume: 57, Issue:14

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cacao; Flavonoids; Food Handling; Hypertension; Male; Phenols; Polyphenols; Proanthocyanidins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Theobromine

2009
Anthocyanin analysis in banana fruit--a mistake.
    The American journal of clinical nutrition, 2011, Volume: 93, Issue:4

    Topics: Anthocyanins; Fruit; Humans; Hypertension; Multivariate Analysis; Musa; Phytotherapy; Plant Extracts; Proanthocyanidins

2011
Antihypertensive and vasorelaxant effects of water-soluble proanthocyanidins from persimmon leaf tea in spontaneously hypertensive rats.
    Bioscience, biotechnology, and biochemistry, 2011, Volume: 75, Issue:8

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cyclic GMP; Diospyros; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Phytotherapy; Plant Extracts; Plant Leaves; Proanthocyanidins; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Solubility; Tea; Vasodilator Agents

2011
Antihypertensive effect of boysenberry seed polyphenols on spontaneously hypertensive rats and identification of orally absorbable proanthocyanidins with vasorelaxant activity.
    Bioscience, biotechnology, and biochemistry, 2012, Volume: 76, Issue:9

    Topics: Absorption; Administration, Oral; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Plant Extracts; Proanthocyanidins; Rats; Rats, Inbred SHR; Rosaceae; Seeds; Tissue Culture Techniques; Vasodilator Agents

2012
Grape seed proanthocyanidin extracts enhance endothelial nitric oxide synthase expression through 5'-AMP activated protein kinase/Surtuin 1-Krüpple like factor 2 pathway and modulate blood pressure in ouabain induced hypertensive rats.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:12

    Topics: AMP-Activated Protein Kinases; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Grape Seed Extract; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Kruppel-Like Transcription Factors; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Ouabain; Phytotherapy; Proanthocyanidins; Rats; Rats, Sprague-Dawley; Seeds; Sirtuin 1; Vitis

2012