prochlorperazine has been researched along with Melanoma in 3 studies
Prochlorperazine: A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
prochlorperazine : A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cutaneous melanoma is least common (only about 1% of skin cancers) but is the deadliest malignant tumor." | 5.51 | Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines. ( Otręba, M; Pajor, M; Warncke, JD, 2019) |
| "Two drugs known to inhibit the action of calmodulin, prochlorperazine offP) and N-(6-aminohexyl)-5-chloro-1-napthalene sulfonamide (W7), were investigated for their ability to control cell proliferation in murine B16 melanoma cells in culture." | 3.67 | Effects of extracellular calmodulin and calmodulin antagonists on B16 melanoma cell growth. ( Bleehen, SS; Mac Neil, S; Senior, HJ; Tomlinson, S; Walker, SW, 1984) |
| "Cutaneous melanoma is least common (only about 1% of skin cancers) but is the deadliest malignant tumor." | 1.51 | Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines. ( Otręba, M; Pajor, M; Warncke, JD, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Otręba, M | 1 |
| Pajor, M | 1 |
| Warncke, JD | 1 |
| POTTS, AM | 1 |
| Mac Neil, S | 1 |
| Walker, SW | 1 |
| Senior, HJ | 1 |
| Bleehen, SS | 1 |
| Tomlinson, S | 1 |
3 other studies available for prochlorperazine and Melanoma
| Article | Year |
|---|---|
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines.
Topics: Antineoplastic Agents; Antipsychotic Agents; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Re | 2019 |
TRACER STUDIES ON A TRANSPLANTABLE HAMSTER MELANOMA.
Topics: Animals; Chlorpromazine; Cricetinae; Eye Neoplasms; Fluoresceins; Idoxuridine; Iodine Isotopes; Mela | 1964 |
Effects of extracellular calmodulin and calmodulin antagonists on B16 melanoma cell growth.
Topics: Animals; Calmodulin; Cell Line; Cells, Cultured; Culture Media; DNA, Neoplasm; Dose-Response Relatio | 1984 |