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prochlorperazine and Dizzyness

prochlorperazine has been researched along with Dizzyness in 8 studies

Prochlorperazine: A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
prochlorperazine : A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.

Research Excerpts

ExcerptRelevanceReference
"Considering the prevailing concerns about extrapyramidal symptoms (EPS) associated with oral prochlorperazine, this study was conducted to assess the safety of oral prochlorperazine (in recommended dose/duration) in the management of acute dizziness."7.96The Real-World Safety and Effectiveness of Prochlorperazine in Indian Patients with Dizziness. ( A, B; Haldipur, D; Krishnamurthy, N, 2020)
" While prochlorperazine is effective in relieving nausea and vomiting, its low bioavailability following first pass metabolism in the liver and metabolism in the intestinal wall, compounded by the likelihood of regurgitation in the nauseous patient, may limit the therapeutic value of the oral preparation."6.69Comparison of buccal and oral prochlorperazine in the treatment of dizziness associated with nausea and/or vomiting. ( Bond, CM, 1998)
"Considering the prevailing concerns about extrapyramidal symptoms (EPS) associated with oral prochlorperazine, this study was conducted to assess the safety of oral prochlorperazine (in recommended dose/duration) in the management of acute dizziness."3.96The Real-World Safety and Effectiveness of Prochlorperazine in Indian Patients with Dizziness. ( A, B; Haldipur, D; Krishnamurthy, N, 2020)
"Prescribers should consider the possible contributing role of newly initiated medicines with the potential to cause of dizziness, and where possible address this through dose reduction or cessation of the medicine, rather than prescribing prochlorperazine."3.76Increased risk of hip fracture in the elderly associated with prochlorperazine: is a prescribing cascade contributing? ( Caughey, GE; Gilbert, AL; Pratt, N; Roughead, EE; Shakib, S; Vitry, AI, 2010)
" While prochlorperazine is effective in relieving nausea and vomiting, its low bioavailability following first pass metabolism in the liver and metabolism in the intestinal wall, compounded by the likelihood of regurgitation in the nauseous patient, may limit the therapeutic value of the oral preparation."2.69Comparison of buccal and oral prochlorperazine in the treatment of dizziness associated with nausea and/or vomiting. ( Bond, CM, 1998)
"Nabilone is an effective oral anti-emetic drug for moderately toxic chemotherapy, but the range and unpredictability of its side-effects warrant caution in its use."2.65Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy. ( Ahmedzai, S; Calder, IT; Carlyle, DL; Moran, F, 1983)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Haldipur, D1
Krishnamurthy, N1
A, B1
Smith, LA1
Azariah, F1
Lavender, VT1
Stoner, NS1
Bettiol, S1
Caughey, GE1
Roughead, EE1
Pratt, N1
Shakib, S1
Vitry, AI1
Gilbert, AL1
Ahmedzai, S1
Carlyle, DL1
Calder, IT1
Moran, F1
Baloh, RW1
Bond, CM1
Besson, JA1
Palin, AN1
Ward, AE1

Reviews

2 reviews available for prochlorperazine and Dizzyness

ArticleYear
Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy.
    The Cochrane database of systematic reviews, 2015, Nov-12, Issue:11

    Topics: Adult; Antiemetics; Antineoplastic Agents; Cannabinoids; Chlorpromazine; Dizziness; Domperidone; Eup

2015
Approach to the dizzy patient.
    Bailliere's clinical neurology, 1994, Volume: 3, Issue:3

    Topics: Anxiety Disorders; Brain Diseases; Diazepam; Dizziness; Heart Diseases; Humans; Meclizine; Meniere D

1994

Trials

3 trials available for prochlorperazine and Dizzyness

ArticleYear
Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.
    British journal of cancer, 1983, Volume: 48, Issue:5

    Topics: Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cli

1983
Comparison of buccal and oral prochlorperazine in the treatment of dizziness associated with nausea and/or vomiting.
    Current medical research and opinion, 1998, Volume: 14, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antiemetics; Cheek; Dizziness; Double-Blind Method; F

1998
Studies of prochlorperazine as a buccal tablet (Buccastem) and an oral tablet (Stemetil) for the treatment of dizziness, nausea or vomiting in a general practice setting.
    The British journal of clinical practice, 1988, Volume: 42, Issue:6

    Topics: Administration, Buccal; Administration, Oral; Adult; Aged; Clinical Trials as Topic; Dizziness; Doub

1988

Other Studies

3 other studies available for prochlorperazine and Dizzyness

ArticleYear
The Real-World Safety and Effectiveness of Prochlorperazine in Indian Patients with Dizziness.
    The Journal of the Association of Physicians of India, 2020, Volume: 68, Issue:2

    Topics: Antiemetics; Dizziness; Female; Humans; India; Male; Prochlorperazine; Prospective Studies; Vomiting

2020
Increased risk of hip fracture in the elderly associated with prochlorperazine: is a prescribing cascade contributing?
    Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:9

    Topics: Aged; Aged, 80 and over; Antiemetics; Australia; Databases, Factual; Dizziness; Drug-Related Side Ef

2010
Tardive dyskinesia, depression and ECT.
    The British journal of psychiatry : the journal of mental science, 1991, Volume: 159

    Topics: Aged; Aged, 80 and over; Depressive Disorder; Dizziness; Dyskinesia, Drug-Induced; Electroconvulsive

1991