prochlorperazine has been researched along with Acathisia, Drug-Induced in 23 studies
Prochlorperazine: A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
prochlorperazine : A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The utility of intravenous prochlorperazine as an antiemetic agent and abortive therapy for headache may be limited by the frequent occurrence of akathisia, the distressing effects of which have been shown to disrupt patient care." | 5.09 | Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial. ( Drotts, DL; Vinson, DR, 2001) |
| " Patients aged 18 years or older treated with prochlorperazine for headache, nausea, or vomiting were eligible for inclusion." | 5.09 | Intravenous administration of prochlorperazine by 15-minute infusion versus 2-minute bolus does not affect the incidence of akathisia: a prospective, randomized, controlled trial. ( Brizendine, EJ; Chisholm, CD; Collins, RW; Cordell, WH; Giles, BK; Jones, JB; Walthall, JD, 2001) |
| "We report on a case of a cancer patient taking prochlorperazine as an antiemetic drug who experienced dyspnea accompanied by severe restlessness associated with respiration." | 3.74 | A case of respiratory akathisia in a cancer patient: a case report. ( Araki, K; Endo, H; Ichikawa, W; Miya, T; Nagashima, F; Narabayashi, M; Nishida, T; Onishi, H; Sasaki, Y; Sunakawa, Y; Wada, M, 2008) |
| " These studies had used a conventional Long instrument in the prospective assessment of 360 adult ED patients aged 17-65 years who received intravenous prochlorperazine (10 mg) in the treatment of headache or nausea and vomiting." | 3.73 | Development of a simplified instrument for the diagnosis and grading of akathisia in a cohort of patients receiving prochlorperazine. ( Vinson, DR, 2006) |
| "Pediatric migraine is a common, chronic, and disabling neurological disorder in children and adolescents." | 2.66 | Intravenous Migraine Treatment in Children and Adolescents. ( Hershey, AD; Kabbouche, M; Maconochie, I; Murphy, B; Qaiser, S; Werner, K, 2020) |
| " The outcomes were the number of patients without headache or with reduced headache severity, the number of adverse events, and the need for rescue analgesia." | 2.61 | The Efficacy and Safety of Prochlorperazine in Patients With Acute Migraine: A Systematic Review and Meta-Analysis. ( Bozorgi, F; Cheraghmakani, H; Golikhatir, I; Jahanian, F; Montazer, SH; Sazgar, M, 2019) |
| "Akathisia and dystonia are known adverse reactions to the use of this medication, but their incidence in the ED has not been well studied." | 1.31 | Frequency of adverse reactions to prochlorperazine in the ED. ( Clark, JA; Keng, JA; Olsen, JC, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 13 (56.52) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Werner, K | 1 |
| Qaiser, S | 1 |
| Kabbouche, M | 1 |
| Murphy, B | 1 |
| Maconochie, I | 1 |
| Hershey, AD | 1 |
| Golikhatir, I | 1 |
| Cheraghmakani, H | 1 |
| Bozorgi, F | 1 |
| Jahanian, F | 1 |
| Sazgar, M | 1 |
| Montazer, SH | 1 |
| Kostic, MA | 1 |
| Gutierrez, FJ | 1 |
| Rieg, TS | 1 |
| Moore, TS | 1 |
| Gendron, RT | 1 |
| Trottier, ED | 1 |
| Bailey, B | 1 |
| Lucas, N | 1 |
| Lortie, A | 1 |
| Gupta, R | 1 |
| Weaver, CS | 1 |
| Jones, JB | 2 |
| Chisholm, CD | 2 |
| Foley, MJ | 1 |
| Giles, BK | 2 |
| Somerville, GG | 1 |
| Brizendine, EJ | 2 |
| Cordell, WH | 2 |
| Vinson, DR | 7 |
| Baden, EY | 1 |
| Prodany, K | 1 |
| Wiener, SW | 1 |
| Hoffman, RS | 1 |
| Kawanishi, C | 1 |
| Onishi, H | 2 |
| Kato, D | 1 |
| Kishida, I | 1 |
| Furuno, T | 1 |
| Wada, M | 3 |
| Hirayasu, Y | 1 |
| Sunakawa, Y | 1 |
| Nishida, T | 1 |
| Araki, K | 1 |
| Endo, H | 1 |
| Nagashima, F | 1 |
| Ichikawa, W | 1 |
| Miya, T | 1 |
| Narabayashi, M | 1 |
| Sasaki, Y | 1 |
| Fleishman, SB | 1 |
| Lavin, MR | 1 |
| Sattler, M | 1 |
| Szarka, H | 1 |
| Dukoff, R | 1 |
| Horak, ID | 1 |
| Hassan, R | 1 |
| Rosenstein, DL | 1 |
| Drotts, DL | 2 |
| Olsen, JC | 1 |
| Keng, JA | 1 |
| Clark, JA | 1 |
| Migala, AF | 1 |
| Quesenberry, CP | 1 |
| Collins, RW | 1 |
| Walthall, JD | 1 |
| Rodgers, C | 1 |
| Bateman, DN | 1 |
| Darling, WM | 1 |
| Boys, R | 1 |
| Rawlins, MD | 1 |
| Weiden, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130] | Phase 4 | 58 participants (Actual) | Interventional | 2017-05-16 | Completed | ||
| A Randomized Double Blinded Study Comparing Use of Prochlorperazine Versus Prochlorperazine and Ketorolac in the Treatment of Pediatric Migraine in the Emergency Department[NCT01534806] | Phase 4 | 0 participants (Actual) | Interventional | 2012-01-31 | Withdrawn (stopped due to Drug is backordered;) | ||
| A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache[NCT03472872] | Phase 4 | 500 participants (Actual) | Interventional | 2017-09-05 | Terminated (stopped due to no longer recruiting or studying) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
2 reviews available for prochlorperazine and Acathisia, Drug-Induced
| Article | Year |
|---|---|
Intravenous Migraine Treatment in Children and Adolescents.
Topics: Administration, Intravenous; Adolescent; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Inflammat | 2020 |
The Efficacy and Safety of Prochlorperazine in Patients With Acute Migraine: A Systematic Review and Meta-Analysis.
Topics: Acute Disease; Akathisia, Drug-Induced; Dopamine Antagonists; Drug Therapy, Combination; Emergency S | 2019 |
8 trials available for prochlorperazine and Acathisia, Drug-Induced
| Article | Year |
|---|---|
A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
Topics: Adult; Akathisia, Drug-Induced; Analgesics; Conscious Sedation; Diphenhydramine; Double-Blind Method | 2010 |
A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
Topics: Adult; Akathisia, Drug-Induced; Analgesics; Conscious Sedation; Diphenhydramine; Double-Blind Method | 2010 |
A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
Topics: Adult; Akathisia, Drug-Induced; Analgesics; Conscious Sedation; Diphenhydramine; Double-Blind Method | 2010 |
A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
Topics: Adult; Akathisia, Drug-Induced; Analgesics; Conscious Sedation; Diphenhydramine; Double-Blind Method | 2010 |
Prochlorperazine in children with migraine: a look at its effectiveness and rate of akathisia.
Topics: Adolescent; Akathisia, Drug-Induced; Child; Diphenhydramine; Dopamine Antagonists; Drug Therapy, Com | 2012 |
Droperidol vs prochlorperazine for the treatment of acute headache.
Topics: Acute Disease; Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Dopamine Antagonists; | 2004 |
Diphenhydramine in the treatment of akathisia induced by prochlorperazine.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antiparkinson Agents; Cohort Studies; Diphenhydramine; D | 2004 |
Prochlorperazine induces akathisia in emergency patients.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Emergency Treatment; Female; Humans; | 1999 |
Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antiemetics; Conscious Sedation; Diphenhydramine; Double | 2001 |
Slow infusion for the prevention of akathisia induced by prochlorperazine: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Double-Blind Method; Female; Humans; | 2001 |
Intravenous administration of prochlorperazine by 15-minute infusion versus 2-minute bolus does not affect the incidence of akathisia: a prospective, randomized, controlled trial.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Dose-Response Relationship, Drug; Double-Blind Met | 2001 |
13 other studies available for prochlorperazine and Acathisia, Drug-Induced
| Article | Year |
|---|---|
Akathisia can be reduced by lowering the dose of D2 receptor antagonists.
Topics: Akathisia, Drug-Induced; Dopamine Antagonists; Droperidol; Humans; Prochlorperazine | 2003 |
Diphenhydramine in the treatment of akathesia induced by prochlorperazine.
Topics: Akathisia, Drug-Induced; Antiparkinson Agents; Antipsychotic Agents; Diphenhydramine; Emergency Serv | 2005 |
Development of a simplified instrument for the diagnosis and grading of akathisia in a cohort of patients receiving prochlorperazine.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Dopamine Antagonists; Female; Headach | 2006 |
Unexpectedly high prevalence of akathisia in cancer patients.
Topics: Akathisia, Drug-Induced; Antiemetics; Female; Humans; Male; Middle Aged; Neoplasms; Palliative Care; | 2007 |
A case of respiratory akathisia in a cancer patient: a case report.
Topics: Aged; Akathisia, Drug-Induced; Antiemetics; Biperiden; Carcinoma, Squamous Cell; Dyspnea; Esophageal | 2008 |
Antiemetic-induced akathisia in cancer patients receiving chemotherapy.
Topics: Akathisia, Drug-Induced; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans; Male; Met | 1994 |
Akathisia associated with prochlorperazine as an antiemetic: a case report.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Female; Humans; Prochlorperazine | 1996 |
Frequency of adverse reactions to prochlorperazine in the ED.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Dose-Response Relationship, Drug; Dru | 2000 |
Frequency of adverse reactions to prochlorperazine in the ED: a response.
Topics: Akathisia, Drug-Induced; Dopamine Antagonists; Emergency Service, Hospital; Humans; Prochlorperazine | 2001 |
Akathisia: problematic but preventable.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Confidence Intervals; Diphenhydramine; Dopamine Antagon | 2002 |
Extrapyramidal side effects of antiemetics presenting as psychiatric illness.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Anxiety Disor | 1992 |
Extrapyramidal reactions to metoclopramide and prochlorperazine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Basal Ganglia Diseases; Child; | 1989 |
Akathisia from prochlorperazine.
Topics: Adult; Akathisia, Drug-Induced; Humans; Male; Prochlorperazine | 1985 |