procarbazine has been researched along with Testicular Diseases in 7 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Testicular Diseases: Pathological processes of the TESTIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Procarbazine (P) is an effective chemotherapeutic drug especially used in lymphoma treatment; however testicular toxicity is a limiting factor." | 1.40 | The effect of melatonin on procarbazine induced testicular toxicity on rats. ( Akgül, EÖ; Alp, BF; Babacan, O; Erdem, O; Gulgun, M; Kesik, V; Korkmazer, N; Malkoç, E; Poyrazoglu, Y; Saldır, M; Yiğit, N, 2014) |
| "The progeny of patients treated for Hodgkin's disease appear normal and no excess fetal wastage has been noted." | 1.28 | Gonadal status and reproductive function following treatment for Hodgkin's disease in childhood: the Stanford experience. ( Donaldson, SS; Ortin, TT; Shostak, CA, 1990) |
| "Gynecomastia was not associated with an increase in either serum estradiol or prolactin concentrations." | 1.26 | Gynecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin's disease. ( Olweny, CL; Sherins, RJ; Ziegler, JL, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alp, BF | 1 |
| Kesik, V | 1 |
| Malkoç, E | 1 |
| Yiğit, N | 1 |
| Saldır, M | 1 |
| Babacan, O | 1 |
| Akgül, EÖ | 1 |
| Poyrazoglu, Y | 1 |
| Korkmazer, N | 1 |
| Gulgun, M | 1 |
| Erdem, O | 1 |
| Whitehead, E | 1 |
| Shalet, SM | 1 |
| Jones, PH | 1 |
| Beardwell, CG | 1 |
| Deakin, DP | 1 |
| Bokemeyer, C | 1 |
| Schmoll, HJ | 1 |
| van Rhee, J | 1 |
| Kuczyk, M | 1 |
| Schuppert, F | 1 |
| Poliwoda, H | 1 |
| Papadakis, V | 1 |
| Vlachopapadopoulou, E | 1 |
| Van Syckle, K | 1 |
| Ganshaw, L | 1 |
| Kalmanti, M | 1 |
| Tan, C | 1 |
| Sklar, C | 1 |
| Sherins, RJ | 1 |
| Olweny, CL | 1 |
| Ziegler, JL | 1 |
| Ortin, TT | 1 |
| Shostak, CA | 1 |
| Donaldson, SS | 1 |
| Ward, JA | 1 |
| Robinson, J | 1 |
| Morris, ID | 1 |
7 other studies available for procarbazine and Testicular Diseases
| Article | Year |
|---|---|
The effect of melatonin on procarbazine induced testicular toxicity on rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cytoprotection; Disease Models, Animal; Follicle Stimu | 2014 |
Gonadal function after combination chemotherapy for Hodgkin's disease in childhood.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Drug Therapy, Combination; Female; Hodgk | 1982 |
Long-term gonadal toxicity after therapy for Hodgkin's and non-Hodgkin's lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclop | 1994 |
Gonadal function in young patients successfully treated for Hodgkin disease.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclopho | 1999 |
Gynecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin's disease.
Topics: Adolescent; Age Factors; Antineoplastic Agents; Child; Child, Preschool; Drug Therapy, Combination; | 1978 |
Gonadal status and reproductive function following treatment for Hodgkin's disease in childhood: the Stanford experience.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modali | 1990 |
Strain-dependency of procarbazine-induced testicular toxicity.
Topics: Animals; Body Weight; Chorionic Gonadotropin; Genitalia, Male; Iodine Radioisotopes; Male; Organ Siz | 1989 |