procarbazine has been researched along with Spinal Cord Neoplasms in 8 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Spinal Cord Neoplasms: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Between May 1992 and January 1998, eight children with unresectable or recurrent intramedullary glioma were treated with the BB SFOP protocol (a 16-month chemotherapy regimen with carboplatin, procarbazine, vincristine, cyclophosphamide, etoposide and cisplatin)." | 5.09 | Chemotherapy for unresectable and recurrent intramedullary glial tumours in children. Brain Tumours Subcommittee of the French Society of Paediatric Oncology (SFOP). ( Chastagner, P; Chouffai, Z; Couanet, D; Doireau, V; Grignon, Y; Grill, J; Kalifa, C; Lellouch-Tubiana, A; Marchal, JC; Zerah, M, 1999) |
| "Procarbazine was not given as a specified protocol, but for patients who were ineligible or refused other protocols." | 2.38 | Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors. ( Levin, VA; Prados, M; Rodriguez, LA; Silver, P, 1989) |
| "Two cases of malignant schwannoma are reported 13 and 15 years following combined modality treatment for Hodgkin's disease." | 1.29 | Malignant schwannoma following treatment for Hodgkin's disease. ( Bridges, LR; Cartwright, SC; Dodwell, DJ; Fisher, PM; Stone, J, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ater, JL | 1 |
| Zhou, T | 1 |
| Holmes, E | 1 |
| Mazewski, CM | 1 |
| Booth, TN | 1 |
| Freyer, DR | 1 |
| Lazarus, KH | 1 |
| Packer, RJ | 1 |
| Prados, M | 2 |
| Sposto, R | 1 |
| Vezina, G | 1 |
| Wisoff, JH | 1 |
| Pollack, IF | 1 |
| Fisher, PM | 1 |
| Dodwell, DJ | 1 |
| Bridges, LR | 1 |
| Cartwright, SC | 1 |
| Stone, J | 1 |
| Doireau, V | 1 |
| Grill, J | 1 |
| Zerah, M | 1 |
| Lellouch-Tubiana, A | 1 |
| Couanet, D | 1 |
| Chastagner, P | 1 |
| Marchal, JC | 1 |
| Grignon, Y | 1 |
| Chouffai, Z | 1 |
| Kalifa, C | 1 |
| Henson, JW | 1 |
| Thornton, AF | 1 |
| Louis, DN | 1 |
| Rodriguez, LA | 1 |
| Silver, P | 1 |
| Levin, VA | 1 |
| Gershanovich, ML | 1 |
| Arkhipov, AI | 1 |
| Vilenskiĭ, BS | 1 |
| Lyding, JM | 1 |
| Tseng, A | 1 |
| Newman, A | 1 |
| Collins, S | 1 |
| Shea, W | 1 |
| Gurney, HP | 1 |
| Phadke, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than Ten Years Old[NCT00002944] | Phase 3 | 428 participants (Actual) | Interventional | 1997-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for procarbazine and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Female; Glioblastoma; Glioma; Hum | 1989 |
2 trials available for procarbazine and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Central Nervous System | 2012 |
Chemotherapy for unresectable and recurrent intramedullary glial tumours in children. Brain Tumours Subcommittee of the French Society of Paediatric Oncology (SFOP).
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carboplatin; Chemotherapy, Adjuvant; Ch | 1999 |
5 other studies available for procarbazine and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Malignant schwannoma following treatment for Hodgkin's disease.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Female | 1994 |
Spinal cord astrocytoma: response to PCV chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biopsy; Fatal Outcome; Humans; L | 2000 |
[Use of nitrosourea derivatives in the treatment of patients with Hodgkin's disease with lesions of the central nervous system].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Evaluation; | 1988 |
Intramedullary spinal cord metastasis in Hodgkin's disease. Rapid diagnosis and treatment resulting in neurologic recovery.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hodgkin Di | 1987 |
Hodgkin's disease presenting with central nervous system involvement.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Hodgkin Disease; Humans; Mal | 1987 |