procarbazine has been researched along with Pregnancy in 77 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sex-related differences in the frequency of cleft palates and microgenia in rat fetuses prenatally treated with procarbazine (200 mg/kg on day 14 of gestation (GD14), group 1), and the anti-teratogenic effect of prenatal folic acid supplementation (4 mg/kg on GD14 through GD17, group 2) were studied in LEW." | 7.72 | Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2003) |
| "We investigated the effects of prenatal folic acid supplementation on procarbazine (PCZ)-induced intra-uterine growth retardation (IUGR), cleft palates, and microgenia." | 7.72 | Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2004) |
| "In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals." | 7.71 | Is it possible to prevent cleft palate by prenatal administration of folic acid? An experimental study. ( Bienengräber, V; Fanghänel, J; Gundlach, KK; Malek, FA; Möritz, KU; Weingärtner, J, 2001) |
| "A 26-year-old woman with Hodgkin's disease was treated with multiple-agent chemotherapy at 26 weeks' gestation." | 5.26 | MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) given during pregnancy. ( Jones, RT; Weinerman, BH, 1979) |
| "The study aimed at to induce cleft-lip-alveolus-palate (CLAP) applying procarbazine in rat fetuses at the 14(th) day of pregnancy, to supply thiocyanate and/or folic acid sufficient for preventive treatment and subsequently to investigate cleft extent in the palatal area as well as bone maturity." | 3.74 | Different bone sesitivity to malformations induced by procarbazine in fetal rats. ( Fanghanel, J; Gedrange, T; Gredes, T; Kubein-Meesenburg, D; Kundt, G; Proff, P; Weingartner, J, 2008) |
| "Sex-related differences in the frequency of cleft palates and microgenia in rat fetuses prenatally treated with procarbazine (200 mg/kg on day 14 of gestation (GD14), group 1), and the anti-teratogenic effect of prenatal folic acid supplementation (4 mg/kg on GD14 through GD17, group 2) were studied in LEW." | 3.72 | Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2003) |
| "We investigated the effects of prenatal folic acid supplementation on procarbazine (PCZ)-induced intra-uterine growth retardation (IUGR), cleft palates, and microgenia." | 3.72 | Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2004) |
| "In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals." | 3.71 | Is it possible to prevent cleft palate by prenatal administration of folic acid? An experimental study. ( Bienengräber, V; Fanghänel, J; Gundlach, KK; Malek, FA; Möritz, KU; Weingärtner, J, 2001) |
| "A case of human fetal renal maldevelopment following the administration of nitrogen mustard, vincristine, procarbazine, and prednisone in early pregnancy for therapy of Hodgkin's disease is reported." | 3.65 | Fetal renal malformation following treatment of Hodgkin's disease during pregnancy. ( Mellman, WJ; Mennuti, MT; Shepard, TH, 1975) |
| "Erythema nodosum is the most frequent clinicopathological variant of the panniculitides." | 2.42 | [Erythema nodosum association with malignant lymphoma]. ( Griniūte, R; Pileckyte, M, 2003) |
| "The association between Hodgkin's disease and pregnancy is rare." | 2.38 | [Hodgkin's disease and pregnancy. 3 case reports and a review of the literature]. ( Abboud, J; Chahine, G; Nasnas, R; Nasrallah, T, 1993) |
| "A questionnaire was sent to 180 Hodgkin lymphoma (HL) patients." | 1.43 | Fertility in young patients following treatment for Hodgkin's lymphoma: a single center survey. ( Boltežar, L; Jezeršek Novaković, B; Pintarić, K, 2016) |
| "National Cancer Institute, National Institutes of Health, and the American Lebanese-Syrian Associated Charities." | 1.43 | Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort. ( Armstrong, GT; Chow, EJ; Donaldson, SS; Ginsberg, JP; Green, DM; Kenney, LB; Leisenring, WM; Levine, JM; Oeffinger, KC; Robison, LL; Shnorhavorian, M; Sklar, CA; Stovall, M; Stratton, KL, 2016) |
| "Twelve women (12%) experienced 13 miscarriages after a median of 50 months (range, 13-120) from the end of therapy." | 1.38 | Impact of different treatment approaches on pregnancy outcomes in 99 women treated for Hodgkin lymphoma. ( Alfò, M; Annechini, G; Cavalieri, E; De Sanctis, V; Enrici, RM; Filippone, FR; Minniti, G; Muni, R; Osti, MF; Pulsoni, A; Valeriani, M, 2012) |
| "A woman with Hodgkin's disease and her gestational carrier." | 1.34 | Live birth after the transfer of human embryos developed from cryopreserved oocytes harvested before cancer treatment. ( Brown, SE; Brubaker, C; Nguyen, K; Reddy, V; Winslow, KL; Yang, D, 2007) |
| "Because several previous authors have repeatedly described treatment with thiamine as one of the sufficient prophylactic measures in slowing the development of viscerocranial malformations, especially cleft alveolus and palate, it is of utmost importance that the timing of treatment and dosage of thiamine be taken into consideration not only in animal experiments but also when applying results to humans." | 1.30 | Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats. ( Bienengräber, V; Fanghänel, J; Kundt, G; Malek, FA, 1997) |
| "Procarbazine (PCZ) is an antineoplastic agent useful in the treatment of Hodgkin's disease, brain tumors, and chronic leukemia." | 1.29 | Profile of procarbazine-induced embryotoxicity in an embryo hepatocyte co-culture system and after in utero glutathione depletion. ( Andrews, JE; Ebron-McCoy, MT; Kavlock, RJ; Nichols, HP, 1995) |
| "The peak incidence of Hodgkin's disease occurs during the reproductive age, and its association with pregnancy is at a rate of between 1:1,000-1:6,000." | 1.28 | Maternal and foetal outcome following Hodgkin's disease in pregnancy. ( Degendorfer, P; Koren, G; Lishner, M; Panzarella, T; Sutcliffe, SB; Zemlickis, D, 1992) |
| " Time-response and dose-response were studied for chromosomal aberrations induced by transplacental treatment of mouse embryos." | 1.27 | New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. II. Clastogenic effects determined in transplacentally treated mouse embryos. ( Adler, ID, 1983) |
| "Procarbazine and BCNU were given for 5 months before conception and throughout the first and second trimesters, and streptozotocin was given throughout the third trimester." | 1.27 | Successful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancy. ( Chudley, AE; Schapira, DV, 1984) |
| "Mitomycin C was slightly less effective in foetal liver than in maternal bone marrow." | 1.27 | Sister-chromatid exchange and micronucleus induction as indicators of genetic damage in maternal and foetal cells. ( Aghamohammadi, Z; Cole, H; Cole, J; Cole, R; Henderson, L; Regan, T, 1984) |
| "Br." | 1.27 | [Pregnancy and fetal development after therapy of Hodgkin's disease]. ( Slanina, J; Spratler, J; Wannenmacher, M, 1985) |
| " The time of expression and dose-response relationships obtained with gamma-radiation, methyl methanesulphonate, procarbazine, mitomycin C and benzo[a]pyrene are analysed in terms of this model." | 1.26 | Short-term tests for transplacentally active carcinogens. I. Micronucleus formation in fetal and maternal mouse erythroblasts. ( Arlett, CF; Cole, J; Cole, RJ; Taylor, N, 1981) |
| "Persistent amenorrhea has occurred in 11 of 24 patients (46 percent) treated with MOPP alone or MOPP plus radiation excluding the pelvis." | 1.26 | Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin's disease. ( DeVita, VT; Hubbard, SM; Schilsky, RL; Sherins, RJ; Wesley, MN; Young, RC, 1981) |
| " Male mice were dosed once and mated with fresh virgin females each week." | 1.26 | Action of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine hydrochloride) in the germ tissue of mice: dominant lethal effects. ( Johnson, FM; Malling, HV; Roberts, GT; Sharma, RK, 1979) |
| "A 26-year-old woman with Hodgkin's disease was treated with multiple-agent chemotherapy at 26 weeks' gestation." | 1.26 | MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) given during pregnancy. ( Jones, RT; Weinerman, BH, 1979) |
| "The management of Hodgkin's disease during pregnancy is reviewed in the light of experience from 15 patients." | 1.26 | The investigation and management of Hodgkin's disease in the pregnant patient. ( Biochem, D; Peckham, MJ; Thomas, PR, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (66.23) | 18.7374 |
| 1990's | 10 (12.99) | 18.2507 |
| 2000's | 10 (12.99) | 29.6817 |
| 2010's | 5 (6.49) | 24.3611 |
| 2020's | 1 (1.30) | 2.80 |
| Authors | Studies |
|---|---|
| Russell, J | 1 |
| Collins, A | 1 |
| Fowler, A | 1 |
| Karanth, M | 1 |
| Saha, C | 1 |
| Docherty, S | 1 |
| Padayatty, J | 1 |
| Maw, K | 1 |
| Lentell, I | 1 |
| Cooke, L | 1 |
| Hodson, A | 1 |
| Shah, N | 1 |
| Sadullah, S | 1 |
| Grigoropoulos, N | 1 |
| Qian, W | 1 |
| Kirkwood, AA | 1 |
| Uttenthal, BJ | 1 |
| Johnson, P | 1 |
| Follows, GA | 1 |
| Boltežar, L | 1 |
| Pintarić, K | 1 |
| Jezeršek Novaković, B | 1 |
| Chow, EJ | 1 |
| Stratton, KL | 1 |
| Leisenring, WM | 1 |
| Oeffinger, KC | 1 |
| Sklar, CA | 1 |
| Donaldson, SS | 1 |
| Ginsberg, JP | 1 |
| Kenney, LB | 1 |
| Levine, JM | 1 |
| Robison, LL | 1 |
| Shnorhavorian, M | 1 |
| Stovall, M | 1 |
| Armstrong, GT | 1 |
| Green, DM | 1 |
| Weingartner, J | 2 |
| Proff, P | 1 |
| Fanghanel, J | 7 |
| Kundt, G | 3 |
| Gedrange, T | 1 |
| Kubein-Meesenburg, D | 1 |
| Gredes, T | 1 |
| Behringer, K | 2 |
| Thielen, I | 2 |
| Mueller, H | 2 |
| Goergen, H | 2 |
| Eibl, AD | 2 |
| Rosenbrock, J | 2 |
| Halbsguth, T | 2 |
| Eichenauer, DA | 1 |
| Fuchs, M | 2 |
| Reiners, KS | 2 |
| Renno, JH | 2 |
| van der Ven, K | 2 |
| Kuehr, M | 2 |
| von Wolff, M | 2 |
| Diehl, V | 2 |
| Engert, A | 2 |
| Borchmann, P | 2 |
| De Sanctis, V | 1 |
| Filippone, FR | 1 |
| Alfò, M | 1 |
| Muni, R | 1 |
| Cavalieri, E | 1 |
| Pulsoni, A | 1 |
| Annechini, G | 1 |
| Valeriani, M | 1 |
| Osti, MF | 1 |
| Minniti, G | 1 |
| Enrici, RM | 1 |
| Stumpf, V | 1 |
| Wessels, C | 1 |
| Wiehlpütz, M | 1 |
| Schober, T | 1 |
| Malek, FA | 5 |
| Möritz, KU | 4 |
| Pileckyte, M | 1 |
| Griniūte, R | 1 |
| Bienengräber, V | 5 |
| Yang, D | 1 |
| Brown, SE | 1 |
| Nguyen, K | 1 |
| Reddy, V | 1 |
| Brubaker, C | 1 |
| Winslow, KL | 1 |
| van Beek, RD | 1 |
| van den Heuvel-Eibrink, MM | 1 |
| Laven, JS | 1 |
| de Jong, FH | 1 |
| Themmen, AP | 1 |
| Hakvoort-Cammel, FG | 1 |
| van den Bos, C | 1 |
| van den Berg, H | 1 |
| Pieters, R | 1 |
| de Muinck Keizer-Schrama, SM | 1 |
| Adler, ID | 1 |
| Schapira, DV | 1 |
| Chudley, AE | 1 |
| Cole, RJ | 3 |
| Cole, J | 3 |
| Henderson, L | 3 |
| Taylor, NA | 1 |
| Arlett, CF | 2 |
| Regan, T | 3 |
| Dein, RA | 1 |
| Mennuti, MT | 2 |
| Kovach, P | 1 |
| Gabbe, SG | 1 |
| Cole, R | 1 |
| Cole, H | 2 |
| Aghamohammadi, Z | 1 |
| Specht, L | 1 |
| Hansen, MM | 1 |
| Geisler, C | 1 |
| Johnson, JM | 2 |
| Thompson, DJ | 2 |
| Burek, JD | 1 |
| Haggerty, GC | 2 |
| Dyke, IL | 2 |
| Lower, CE | 2 |
| Solomon, JL | 1 |
| Whittaker, J | 1 |
| Andrieu, JM | 2 |
| Ochoa-Molina, ME | 2 |
| Wiestler, OD | 1 |
| Kleihues, P | 1 |
| Rice, JM | 1 |
| Ivankovic, S | 2 |
| Daly, H | 1 |
| McCann, SR | 1 |
| Hanratty, TD | 1 |
| Temperley, IJ | 1 |
| Neuhäuser-Klaus, A | 1 |
| Chryssanthou, CP | 1 |
| Wallach, RC | 1 |
| Atchison, M | 1 |
| Warzok, R | 1 |
| Mendel, J | 1 |
| Thust, R | 1 |
| Blaufuss, EM | 1 |
| Batka, H | 1 |
| Schwarz, H | 1 |
| Card, RT | 1 |
| Holmes, IH | 1 |
| Sugarman, RG | 1 |
| Storb, R | 1 |
| Thomas, ED | 1 |
| Cunningham, J | 1 |
| Mauch, P | 1 |
| Rosenthal, DS | 1 |
| Canellos, GP | 1 |
| Schmid, BP | 1 |
| Trippmacher, A | 1 |
| Bianchi, A | 1 |
| Taylor, N | 1 |
| Schilsky, RL | 1 |
| Sherins, RJ | 1 |
| Hubbard, SM | 1 |
| Wesley, MN | 1 |
| Young, RC | 1 |
| DeVita, VT | 1 |
| Abboud, J | 1 |
| Nasrallah, T | 1 |
| Chahine, G | 1 |
| Nasnas, R | 1 |
| Ebron-McCoy, MT | 1 |
| Nichols, HP | 1 |
| Andrews, JE | 1 |
| Kavlock, RJ | 1 |
| Brice, P | 1 |
| Pautier, P | 1 |
| Marolleau, JP | 1 |
| Castaigne, S | 1 |
| Gisselbrecht, C | 1 |
| Gundlach, KK | 2 |
| Malek, F | 1 |
| Maslovsky, I | 1 |
| Volchek, L | 1 |
| Blumental, R | 1 |
| Ducach, A | 1 |
| Lugassy, G | 1 |
| Avilés, A | 3 |
| Neri, N | 1 |
| Llombart, A | 1 |
| Schein, PS | 1 |
| Winokur, SH | 1 |
| Garrett, MJ | 2 |
| Das, S | 1 |
| Smith, JD | 1 |
| Freedman, LS | 1 |
| Johnson, SA | 1 |
| Goldman, JM | 1 |
| Hawkins, DF | 1 |
| Lee, IP | 2 |
| Dixon, RL | 2 |
| Einhorn, LH | 1 |
| Sieber, SM | 1 |
| Roberts, GT | 1 |
| Johnson, FM | 1 |
| Malling, HV | 1 |
| Sharma, RK | 1 |
| Jones, RT | 1 |
| Weinerman, BH | 1 |
| King, MT | 1 |
| Wild, D | 1 |
| Thomas, PR | 1 |
| Biochem, D | 1 |
| Peckham, MJ | 1 |
| Baumgartner, G | 1 |
| Stutzman, L | 1 |
| Shepard, TH | 1 |
| Mellman, WJ | 1 |
| Habiger, VW | 1 |
| Díaz-Maqueo, JC | 1 |
| Talavera, A | 1 |
| Guzmán, R | 1 |
| García, EL | 1 |
| Zepeda, G | 1 |
| Cruz, J | 1 |
| Lishner, M | 1 |
| Zemlickis, D | 1 |
| Degendorfer, P | 1 |
| Panzarella, T | 1 |
| Sutcliffe, SB | 1 |
| Koren, G | 1 |
| Tournaye, H | 1 |
| Camus, M | 1 |
| Bollen, N | 1 |
| Wisanto, A | 1 |
| Van Steirteghem, AC | 1 |
| Devroey, P | 1 |
| Wright, JA | 1 |
| Brickell, L | 1 |
| Foster, J | 1 |
| Lacher, MJ | 1 |
| Toner, K | 1 |
| Sauer, MV | 1 |
| Macaso, TM | 1 |
| Ishida, EH | 1 |
| Giudice, L | 1 |
| Marshall, JR | 1 |
| Buster, JE | 1 |
| Baĭsogolov, GD | 1 |
| Le Pors, P | 1 |
| Tschupp, MJ | 1 |
| de Queiroz, D | 1 |
| Grosbois, B | 1 |
| Lemoine, H | 1 |
| Grall, JY | 1 |
| Asada, E | 1 |
| Koide, M | 1 |
| Kato, H | 1 |
| Kobayashi, I | 1 |
| Hasegawa, G | 1 |
| Slanina, J | 1 |
| Wannenmacher, M | 1 |
| Spratler, J | 1 |
| Shalet, SM | 1 |
| Vaughan Williams, CA | 1 |
| Whitehead, E | 1 |
| Zwaveling, A | 1 |
| Wakem, CJ | 1 |
| Bennett, JM | 1 |
| Viola, MV | 1 |
| Kovi, J | 1 |
| Nukhopadhyay, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Maternal Cancer Diagnosis and Treatment During Pregnancy:a Registry for Maternal, Fetal, and Neonatal Outcomes With Longitudinal Follow up of Child Development and Maternal Psychological Well Being[NCT02749474] | 400 participants (Anticipated) | Observational [Patient Registry] | 2003-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for procarbazine and Pregnancy
| Article | Year |
|---|---|
[Erythema nodosum association with malignant lymphoma].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Diagnosis, Dif | 2003 |
The reproductive potential of young men and women with Hodgkin's disease.
Topics: Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Congenital Abnormalities; Female; | 1984 |
[Hodgkin's disease and pregnancy. 3 case reports and a review of the literature].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bleomycin; Bone Marrow Examination; C | 1993 |
Immunosuppressive and cytotoxic chemotherapy: long-term complications.
Topics: Alkylating Agents; Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Carcinogens; Chemical a | 1975 |
Mutagenicity, carcinogenicity and teratogenicity of procarbazine.
Topics: Animals; Carcinogens; Carcinoma, Ehrlich Tumor; Cell Line; Chromosomes, Human; Drosophila melanogast | 1978 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; | 1977 |
Current status of treatment of lymphomas.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combin | 1975 |
[Chemotherapy of solid tumors].
Topics: Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Antineoplastic Agents; Bone Marrow; Diges | 1973 |
69 other studies available for procarbazine and Pregnancy
| Article | Year |
|---|---|
Advanced Hodgkin lymphoma in the East of England: a 10-year comparative analysis of outcomes for real-world patients treated with ABVD or escalated-BEACOPP, aged less than 60 years, compared with 5-year extended follow-up from the RATHL trial.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Top | 2021 |
Fertility in young patients following treatment for Hodgkin's lymphoma: a single center survey.
Topics: Adolescent; Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazin | 2016 |
Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort.
Topics: Adolescent; Adult; Canada; Child; Cyclophosphamide; Female; Fertility Preservation; Humans; Live Bir | 2016 |
Different bone sesitivity to malformations induced by procarbazine in fetal rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Cleft Palate; Drug Therapy, Combination; Femal | 2008 |
Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial.
Topics: Adult; Anti-Mullerian Hormone; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosp | 2012 |
Impact of different treatment approaches on pregnancy outcomes in 99 women treated for Hodgkin lymphoma.
Topics: Abortion, Spontaneous; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Congenital | 2012 |
Gonadal function and fertility in survivors after Hodgkin lymphoma treatment within the German Hodgkin Study Group HD13 to HD15 trials.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dacarbazine; Dox | 2013 |
Effects of prenatal procarbazine administration on intrauterine development in rats.
Topics: Animals; Cesarean Section; Embryonic and Fetal Development; Female; Fetal Death; Fetus; Pregnancy; P | 2003 |
Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats.
Topics: Animals; Cleft Palate; Congenital Abnormalities; Dietary Supplements; Female; Folic Acid; Male; Mand | 2003 |
Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats.
Topics: Animals; Antineoplastic Agents; Cleft Palate; Dietary Supplements; Disease Models, Animal; Dose-Resp | 2004 |
Live birth after the transfer of human embryos developed from cryopreserved oocytes harvested before cancer treatment.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fertilization in Vi | 2007 |
Anti-Mullerian hormone is a sensitive serum marker for gonadal function in women treated for Hodgkin's lymphoma during childhood.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Anti-Mullerian Hormone; Antineoplastic Combined Chemot | 2007 |
New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. II. Clastogenic effects determined in transplacentally treated mouse embryos.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Bleomycin; Chromosome Aberrations; Embryo, Mammalian; Female; | 1983 |
Successful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Fema | 1984 |
Short-term tests for transplacentally active carcinogens. A comparison of sister-chromatid exchange and the micronucleus test in mouse foetal liver erythroblasts.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Crossing Over, Genetic; Cyclophosphamide; Diethylnitrosamine; | 1983 |
Sister-chromatid exchange and micronucleus induction as indicators of genetic damage in maternal and foetal cells.
Topics: Animals; Bone Marrow Cells; Cell Nucleus; Crossing Over, Genetic; Cyclophosphamide; Female; Liver; M | 1984 |
Ovarian function in young women in long-term remission after treatment for Hodgkin's disease stage I or II.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Estrad | 1984 |
The neuroteratogenicity of procarbazine in the rat: behavioral, morphological, and neurochemical aspects.
Topics: Abnormalities, Drug-Induced; Animals; Avoidance Learning; Behavior, Animal; Brain; Choline; Choline | 1984 |
Short-term tests for transplacentally active carcinogens. Induction of sister-chromatid exchanges in foetal brain, lung and blood-forming cells by procarbazine and cyclophosphamide.
Topics: Animals; Brain; Carcinogens; Cells, Cultured; Crossing Over, Genetic; Cyclophosphamide; Female; Hema | 1983 |
Menstrual cycle, pregnancies and offspring before and after MOPP therapy for Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Thera | 1983 |
DNA methylation in maternal, fetal and neonatal rat tissues following perinatal administration of procarbazine.
Topics: Animals; Animals, Newborn; Biotransformation; DNA; Female; Fetus; Guanine; Liver; Methylation; Pregn | 1984 |
Successful pregnancy during combination chemotherapy for Hodgkin's disease.
Topics: Adult; Cyclophosphamide; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Prednisone; Pre | 1980 |
Procarbazine hydrochloride.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Female; Haplorhini; Humans; Male; Maternal-Feta | 1981 |
An approach towards to standardization of the mammalian spot test.
Topics: Animals; Embryo, Mammalian; Female; Genotype; Methyl Methanesulfonate; Mice; Mitomycin; Mitomycins; | 1981 |
Meiotic chromosomal changes and sterility produced by nitrogen mustard and procarbazine in mice.
Topics: Animals; Animals, Newborn; Chromosome Aberrations; Female; Infertility; Litter Size; Male; Meiosis; | 1983 |
[Pregnancies and offspring after MOPP therapy].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Fertility; Fetus; Hodgkin | 1982 |
Differences in carcinogenicity after transplacental and postnatal administration of drugs and pesticides.
Topics: Animals; Carcinogens; Female; Maternal-Fetal Exchange; Pesticides; Pregnancy; Procarbazine; Rats; To | 1980 |
Successful pregnancy after high dose chemotherapy and marrow transplantation for treatment of aplastic anemia.
Topics: Adult; Anemia, Aplastic; Antilymphocyte Serum; Antineoplastic Agents; Bone Marrow Transplantation; C | 1980 |
Long-term complications of MOPP chemotherapy in patients with Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Drug Therapy, Combination; Female | 1982 |
Teratogenicity induced in cultured rat embryos by the serum of procarbazine treated rats.
Topics: Animals; Cell Differentiation; Culture Media; Embryo, Mammalian; Female; Male; Organ Culture Techniq | 1982 |
Short-term tests for transplacentally active carcinogens. I. Micronucleus formation in fetal and maternal mouse erythroblasts.
Topics: Animals; Carcinogens; Cell Nucleus; Dose-Response Relationship, Drug; Dose-Response Relationship, Ra | 1981 |
Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin's disease.
Topics: Adolescent; Adult; Amenorrhea; Antineoplastic Agents; Female; Follow-Up Studies; Hodgkin Disease; Ho | 1981 |
Profile of procarbazine-induced embryotoxicity in an embryo hepatocyte co-culture system and after in utero glutathione depletion.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Biotransformation; Buthionine Sulfoximine; Ce | 1995 |
Pregnancy after autologous bone marrow transplantation for malignant lymphomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cyt | 1994 |
Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats.
Topics: Abnormalities, Drug-Induced; Alveolar Process; Animals; Body Weight; Bone and Bones; Cleft Palate; C | 1997 |
Malformations of the temporo-mandibular joint in laboratory animals and in man.
Topics: Abnormalities, Drug-Induced; Animals; Cyclophosphamide; Female; Glycine; Humans; Hydroxamic Acids; I | 1999 |
Disturbances of palatogenesis and their prophylaxis in animal experiments.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Embryonic and Fetal Development; Female; Humans; | 1999 |
Persistent paraneoplastic neurologic syndrome after successful therapy of Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Ataxia; Bleomycin; Combined Modality Therapy; | 2001 |
Is it possible to prevent cleft palate by prenatal administration of folic acid? An experimental study.
Topics: Animals; Chin; Cleft Palate; Female; Fetal Diseases; Folic Acid; Pilot Projects; Pregnancy; Procarba | 2001 |
Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Bleomyci | 2001 |
Tumoral drugs as possible blastogenic agents the problem of anti-blastic medication.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinogens; Cyclophosphamide; Dactinomycin; Daunorubicin | 1976 |
Long term experience with combination chemotherapy in advanced Hodgkin's disease.
Topics: Adult; Antineoplastic Agents; Bleomycin; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; | 1977 |
Pregnancy after chemotherapy for Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Drug Administration Schedule; Drug Therapy, Combina | 1979 |
Cancer chemotherapy.
Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Leuk | 1977 |
Action of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine hydrochloride) in the germ tissue of mice: dominant lethal effects.
Topics: Animals; Embryo, Mammalian; Female; Fertility; Genes, Dominant; Genes, Lethal; Germ Cells; Male; Mic | 1979 |
MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) given during pregnancy.
Topics: Adult; Antineoplastic Agents; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Infant, Ne | 1979 |
Transplacental mutagenesis: the micronucleus test on fetal mouse blood.
Topics: Animals; Bone Marrow; Cell Nucleus; Cyclophosphamide; DNA; Erythrocytes; Female; Fetal Blood; Gestat | 1979 |
The investigation and management of Hodgkin's disease in the pregnant patient.
Topics: Adult; Female; Hodgkin Disease; Humans; Pregnancy; Pregnancy Complications; Procarbazine; Radiothera | 1976 |
[Cytostatic therapy of inoperable carcinomas].
Topics: Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin | 1976 |
Fetal renal malformation following treatment of Hodgkin's disease during pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Adult; Autopsy; Female; Fetus; Hodgkin Disease; Huma | 1975 |
[Serotonin effect on the fetus and the feto-maternal relationship in the rat].
Topics: Animals; Brain; Drug Synergism; Female; Fetal Death; Fetus; Gestational Age; Iproniazid; Liver; Mate | 1975 |
Growth and development of children of mothers treated with chemotherapy during pregnancy: current status of 43 children.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Bleomyci | 1991 |
[Hodgkin's disease during pregnancy. Study of late effects in the newborn infants].
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chrom | 1991 |
Maternal and foetal outcome following Hodgkin's disease in pregnancy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Birth Weight; Case-Control Studies; Cesarean | 1992 |
In vitro fertilization techniques with frozen-thawed sperm: a method for preserving the progenitive potential of Hodgkin patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cryopreservation; Embryo Transfer; Female; Fe | 1991 |
The neuroteratogenicity of procarbazine hydrochloride in the rat: histopathological and immunocytochemical aspects.
Topics: Abnormalities, Drug-Induced; Animals; Astrocytes; Cerebral Cortex; Female; Neurons; Oligodendroglia; | 1989 |
Pregnancies and menstrual function before and after combined radiation (RT) and chemotherapy (TVPP) for Hodgkin's disease.
Topics: Adolescent; Adult; Age Factors; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Combined | 1986 |
Pregnancy following nonsurgical donor ovum transfer to a functionally agonadal woman.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Embryo Transfer; Estradiol; Female; Hodgkin D | 1987 |
[Clinical studies of the diagnosis and treatment of Hodgkin's disease (1967-1986)].
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Female; | 1987 |
[Twin pregnancy after iatrogenic menopause].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Estrogens; Female; Hodgkin Disease; Humans; I | 1987 |
[Pregnancy following chemotherapy of non-Hodgkin lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; | 1986 |
[Pregnancy and fetal development after therapy of Hodgkin's disease].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Embryonic and Fetal Develop | 1985 |
Pregnancy after chemotherapy induced ovarian failure.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Hodgkin Disease; Humans; Mechloretham | 1985 |
The effect of prenatal procarbazine treatment on brain development in the rat.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Dose-Response Relationship, Drug; Female; Mate | 1985 |
[Induction of malignomas in rats after transplacental exposure to N-isopropyl-alpha-2-(methyl-hydrazino)-p-toluamide-HCl].
Topics: Animals; Antineoplastic Agents; Benzoates; Brain Neoplasms; Female; Fetus; Gestational Age; Maternal | 1972 |
Hodgkin's disease terminating as acute leukaemia: case report and review of the literature.
Topics: Acute Disease; Adolescent; Adult; Bone Marrow; Female; Granuloma; Hodgkin Disease; Humans; Leukemia, | 1972 |
Reversal of myelofibrosis in Hodgkin disease.
Topics: Adult; Anemia, Aplastic; Biopsy, Needle; Cyclophosphamide; Female; Hodgkin Disease; Humans; Predniso | 1973 |
Letter: Teratogenic effects of combination chemotherapy.
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Agents; Drug Therapy, Combination; Female; Foot D | 1974 |
Effects of procarbazine on spermatogenesis determined by velocity sedimentation cell separation technique and serial mating.
Topics: Animals; Antineoplastic Agents; Benzoates; Cell Fractionation; Centrifugation, Density Gradient; Dep | 1972 |