procarbazine has been researched along with Postpartum Amenorrhea in 13 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Breast cancer survivors, those treated with procarbazine or other alkylating agents and those with a higher age at diagnosis are at highest risk of diminished ovarian function." | 4.95 | Chemotherapy-related late adverse effects on ovarian function in female survivors of childhood and young adult cancer: A systematic review. ( Kaspers, GJ; Lambalk, CB; Overbeek, A; van den Berg, MH; van Dulmen-den Broeder, E; van Leeuwen, FE, 2017) |
| "4% of the women receiving eight cycles of dose-escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) had continuous amenorrhea." | 3.73 | Secondary amenorrhea after Hodgkin's lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: a report from the German Hodgkin's Lymphoma Study Group. ( Behringer, K; Breuer, K; Diehl, V; Engert, A; Klimm, B; May, M; Nogova, L; Reineke, T; Schmitz, T; Wildt, L, 2005) |
| " Buserelin (d-Ser-[TBU]6 LHRH ethylamide) was prescribed in two different dosage schedules to twenty men, and in a single dosage schedule to eight women." | 2.66 | Failure to preserve fertility in patients with Hodgkin's disease. ( Ahmed, R; Besser, GM; Crowther, D; Gregory, W; Malpas, JS; Rees, LH; Shalet, S; Smith, D; Waxman, JH; Wrigley, PF, 1987) |
| "A questionnaire was sent to 180 Hodgkin lymphoma (HL) patients." | 1.43 | Fertility in young patients following treatment for Hodgkin's lymphoma: a single center survey. ( Boltežar, L; Jezeršek Novaković, B; Pintarić, K, 2016) |
| "Persistent amenorrhea has occurred in 11 of 24 patients (46 percent) treated with MOPP alone or MOPP plus radiation excluding the pelvis." | 1.26 | Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin's disease. ( DeVita, VT; Hubbard, SM; Schilsky, RL; Sherins, RJ; Wesley, MN; Young, RC, 1981) |
| "Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kreissl, S | 1 |
| Borchmann, P | 1 |
| Boltežar, L | 1 |
| Pintarić, K | 1 |
| Jezeršek Novaković, B | 1 |
| Overbeek, A | 1 |
| van den Berg, MH | 1 |
| van Leeuwen, FE | 1 |
| Kaspers, GJ | 1 |
| Lambalk, CB | 1 |
| van Dulmen-den Broeder, E | 1 |
| Behringer, K | 1 |
| Breuer, K | 1 |
| Reineke, T | 1 |
| May, M | 1 |
| Nogova, L | 1 |
| Klimm, B | 1 |
| Schmitz, T | 1 |
| Wildt, L | 1 |
| Diehl, V | 1 |
| Engert, A | 1 |
| Giuseppe, L | 1 |
| Attilio, G | 1 |
| Edoardo, DN | 1 |
| Loredana, G | 1 |
| Cristina, L | 1 |
| Vincenzo, L | 1 |
| Dein, RA | 1 |
| Mennuti, MT | 1 |
| Kovach, P | 1 |
| Gabbe, SG | 1 |
| Waxman, JH | 2 |
| Terry, YA | 1 |
| Wrigley, PF | 2 |
| Malpas, JS | 2 |
| Rees, LH | 2 |
| Besser, GM | 2 |
| Lister, TA | 1 |
| Schilsky, RL | 1 |
| Sherins, RJ | 1 |
| Hubbard, SM | 1 |
| Wesley, MN | 1 |
| Young, RC | 1 |
| DeVita, VT | 1 |
| Clark, ST | 1 |
| Radford, JA | 1 |
| Crowther, D | 2 |
| Swindell, R | 1 |
| Shalet, SM | 1 |
| Lange, B | 1 |
| Littman, P | 1 |
| Schnaufer, L | 1 |
| Evans, A | 1 |
| Thumb, N | 1 |
| Lacher, MJ | 1 |
| Toner, K | 1 |
| Ahmed, R | 1 |
| Smith, D | 1 |
| Gregory, W | 1 |
| Shalet, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ovarian Tissue Freezing For Fertility Preservation In Women Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen: A Study By The National Physicians Cooperative of the Oncofertility Consortium At Northwestern University[NCT00902720] | Phase 4 | 25 participants (Anticipated) | Interventional | 2009-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for procarbazine and Postpartum Amenorrhea
| Article | Year |
|---|---|
Chemotherapy-related late adverse effects on ovarian function in female survivors of childhood and young adult cancer: A systematic review.
Topics: Age Factors; Amenorrhea; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Breast Neoplasms; | 2017 |
The reproductive potential of young men and women with Hodgkin's disease.
Topics: Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Congenital Abnormalities; Female; | 1984 |
3 trials available for procarbazine and Postpartum Amenorrhea
| Article | Year |
|---|---|
Ovarian function after cancer treatment in young women affected by Hodgkin disease (HD).
Topics: Adolescent; Adult; Amenorrhea; Anti-Mullerian Hormone; Antineoplastic Combined Chemotherapy Protocol | 2007 |
Gonadal function following chemotherapy for Hodgkin's disease: a comparative study of MVPP and a seven-drug hybrid regimen.
Topics: Adolescent; Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Doxorub | 1995 |
Failure to preserve fertility in patients with Hodgkin's disease.
Topics: Amenorrhea; Animals; Antineoplastic Combined Chemotherapy Protocols; Buserelin; Dogs; Female; Follic | 1987 |
8 other studies available for procarbazine and Postpartum Amenorrhea
| Article | Year |
|---|---|
[Treatment of advanced Hodgkin lymphoma].
Topics: Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brentuximab Vedotin; Cause of | 2013 |
Fertility in young patients following treatment for Hodgkin's lymphoma: a single center survey.
Topics: Adolescent; Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazin | 2016 |
Secondary amenorrhea after Hodgkin's lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: a report from the German Hodgkin's Lymphoma Study Group.
Topics: Adolescent; Adult; Age Factors; Aged; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Bl | 2005 |
Gonadal function in Hodgkin's disease: long-term follow-up of chemotherapy.
Topics: Adolescent; Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Child; Drug Therapy, | 1982 |
Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin's disease.
Topics: Adolescent; Adult; Amenorrhea; Antineoplastic Agents; Female; Follow-Up Studies; Hodgkin Disease; Ho | 1981 |
Treatment of advanced Hodgkin's disease in pediatric patients.
Topics: Adolescent; Amenorrhea; Antineoplastic Agents; Bone Marrow; Child; Cyclophosphamide; Female; Hodgkin | 1978 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
Pregnancies and menstrual function before and after combined radiation (RT) and chemotherapy (TVPP) for Hodgkin's disease.
Topics: Adolescent; Adult; Age Factors; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Combined | 1986 |