procarbazine has been researched along with Polycythemia Vera in 3 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Polycythemia Vera: A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients showed secondary tumors after 9 or 11 years respectively." | 1.26 | [A contribution to the cytostatic long-term chemotherapy of polycythemia vera (author's transl)]. ( Fereberger, W; Robier, FP; Sailer, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fereberger, W | 1 |
| Robier, FP | 1 |
| Sailer, S | 1 |
| Brodskaia, NA | 1 |
| Spivack, SD | 1 |
2 reviews available for procarbazine and Polycythemia Vera
| Article | Year |
|---|---|
[Natulan (experimental and clinical data on its antitumor effect)].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzoates; Bronchial Neoplasms; Hodgkin Diseas | 1972 |
Drugs 5 years later: procarbazine.
Topics: Animals; Bone Neoplasms; Carcinogens; Carcinoma; Drug Evaluation; Hodgkin Disease; Humans; Lung Neop | 1974 |
1 other study available for procarbazine and Polycythemia Vera
| Article | Year |
|---|---|
[A contribution to the cytostatic long-term chemotherapy of polycythemia vera (author's transl)].
Topics: Female; Humans; Male; Middle Aged; Neoplasms; Polycythemia Vera; Procarbazine; Time Factors | 1979 |