procarbazine has been researched along with Peripheral Nerve Diseases in 12 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-five previously untreated patients with metastatic malignant melanoma were treated with lomustine, vincristine, and procarbazine." | 7.67 | Lomustine, vincristine, and procarbazine in the treatment of metastatic malignant melanoma. ( Bodurtha, A; Iscoe, N; Paterson, A; Quirt, I; Russell, J; Shelley, W; Young, V, 1985) |
| "Sixty-five previously untreated patients with metastatic malignant melanoma were treated with lomustine, vincristine, and procarbazine." | 3.67 | Lomustine, vincristine, and procarbazine in the treatment of metastatic malignant melanoma. ( Bodurtha, A; Iscoe, N; Paterson, A; Quirt, I; Russell, J; Shelley, W; Young, V, 1985) |
| "Peripheral neurotoxicity is a crucial side effect of chemotherapeutic agents." | 2.41 | [Peripheral nervous system neurotoxicity secondary to chemotherapy treatment] . ( Iñiguez, C; Larrodé, P; Mauri, JA; Mayordomo, JI; Morales, F; Trés, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bakemeier, RF | 1 |
| Anderson, JR | 1 |
| Costello, W | 1 |
| Rosner, G | 1 |
| Horton, J | 1 |
| Glick, JH | 1 |
| Hines, JD | 1 |
| Berard, CW | 1 |
| DeVita, VT | 1 |
| Sagar, HJ | 1 |
| Read, DJ | 1 |
| Kaplan, RS | 1 |
| Wiernik, PH | 2 |
| Nomura, K | 1 |
| Ohno, R | 1 |
| Iñiguez, C | 1 |
| Larrodé, P | 1 |
| Mayordomo, JI | 1 |
| Mauri, JA | 1 |
| Trés, A | 1 |
| Morales, F | 1 |
| Maslovsky, I | 1 |
| Volchek, L | 1 |
| Blumental, R | 1 |
| Ducach, A | 1 |
| Lugassy, G | 1 |
| Wilson, CB | 1 |
| Gutin, P | 1 |
| Boldrey, EB | 1 |
| Drafts, D | 1 |
| Levin, VA | 1 |
| Enot, KJ | 1 |
| Klimek, A | 1 |
| Krykowski, E | 1 |
| Poźiak-Patewicz, E | 1 |
| Heiss, WD | 1 |
| Turnheim, M | 1 |
| Mamoli, B | 1 |
| Shelley, W | 1 |
| Quirt, I | 1 |
| Bodurtha, A | 1 |
| Iscoe, N | 1 |
| Russell, J | 1 |
| Paterson, A | 1 |
| Young, V | 1 |
| Sacks, P | 1 |
| Jacobs, P | 1 |
| Gale, D | 1 |
| Lynch, SR | 1 |
| Bothwell, TH | 1 |
| Stevens, K | 1 |
| Weiss, HD | 1 |
| Walker, MD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Varenicline Influence Alcohol Consumption in Alcohol Dependent Individuals?[NCT00846859] | Phase 2 | 162 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for procarbazine and Peripheral Nerve Diseases
| Article | Year |
|---|---|
[Neurologic complications of chemotherapy (vincristine etc.)].
Topics: Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Cisplatin; Humans; Peripheral | 1999 |
[Peripheral nervous system neurotoxicity secondary to chemotherapy treatment] .
Topics: Anti-HIV Agents; Antineoplastic Agents; Cyclosporine; Depsipeptides; Docetaxel; Doxorubicin; Humans; | 2000 |
Neurotoxicity of commonly used antineoplastic agents (second of two parts).
Topics: Achilles Tendon; Animals; Antineoplastic Agents; Autonomic Nervous System; Central Nervous System Di | 1974 |
1 trial available for procarbazine and Peripheral Nerve Diseases
| Article | Year |
|---|---|
BCVPP chemotherapy for advanced Hodgkin's disease: evidence for greater duration of complete remission, greater survival, and less toxicity than with a MOPP regimen. Results of the Eastern Cooperative Oncology Group study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Carmustine; Clinical Trials | 1984 |
8 other studies available for procarbazine and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Subacute sensory neuropathy with remission: an association with lymphoma.
Topics: Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Hypesthesia; Mechlorethamine; Middle Age | 1982 |
Neurotoxicity of antineoplastic drugs.
Topics: Altretamine; Antineoplastic Agents; Asparaginase; Brain; Central Nervous System Diseases; Cisplatin; | 1982 |
Persistent paraneoplastic neurologic syndrome after successful therapy of Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Ataxia; Bleomycin; Combined Modality Therapy; | 2001 |
Single-agent chemotherapy of brain tumors. A five-year review.
Topics: Astrocytoma; Bone Marrow Diseases; Brain Neoplasms; Carmustine; Glioma; Humans; Imidazoles; Lomustin | 1976 |
[Polyneuropathy in patients with Hodgkin's disease and acute leukemia treated by the combined cyclic method according to the MOPP and POMP schedules].
Topics: Adult; Aged; Antineoplastic Agents; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Leuk | 1976 |
Combination chemotherapy of malignant glioma. Effect of postoperative treatment with CCNU, vincristine, amethopterine and procarbazine.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Drug Therapy, Combination; Glioma; Humans; Lomustine; Meth | 1978 |
Lomustine, vincristine, and procarbazine in the treatment of metastatic malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Hematologic Diseases; Humans; L | 1985 |
Combination chemotherapy in the treatment of advanced Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Benzoates; Female; Hodgkin Disease; Humans; Leukopen | 1973 |