procarbazine has been researched along with Osteonecrosis in 8 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The development of osteonecrosis is strictly related to the chemotherapy protocol adopted and the number of cycles received, with a strong correlation between the dose of corticosteroids included in the BEACOPP scheme and this complication." | 1.46 | Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP. ( Albano, D; Brancatelli, G; Galia, M; Grassedonio, E; La Grutta, L; Lagalla, R; Midiri, M; Mulè, A; Patti, C, 2017) |
| "We document a high incidence of aseptic bone necrosis, possibly related to prednisolone." | 1.38 | Two escalated followed by six standard BEACOPP in advanced-stage high-risk classical Hodgkin lymphoma: high cure rates but increased risk of aseptic osteonecrosis. ( Aurlien, E; Blystad, AK; Fiskvik, IH; Fosså, A; Hole, KH; Holte, H; Ikonomou, IM; Kolstad, A; Lauritzsen, GF, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Sugiyama, M | 1 |
| Terashita, Y | 1 |
| Cho, Y | 1 |
| Iguchi, A | 1 |
| Arai, R | 1 |
| Takakuwa, E | 1 |
| Honda, S | 1 |
| Manabe, A | 1 |
| Basic-Kinda, S | 1 |
| Karlak, I | 1 |
| Durakovic, N | 1 |
| Lubina, ZI | 1 |
| Livaja Radman, I | 1 |
| Dotlic, S | 1 |
| Peric, Z | 1 |
| Hude, I | 1 |
| Aurer, I | 1 |
| Albano, D | 2 |
| Patti, C | 2 |
| Midiri, M | 2 |
| Galia, M | 2 |
| La Grutta, L | 1 |
| Grassedonio, E | 1 |
| Mulè, A | 1 |
| Brancatelli, G | 1 |
| Lagalla, R | 1 |
| Fosså, A | 1 |
| Fiskvik, IH | 1 |
| Kolstad, A | 1 |
| Lauritzsen, GF | 1 |
| Aurlien, E | 1 |
| Blystad, AK | 1 |
| Hole, KH | 1 |
| Ikonomou, IM | 1 |
| Holte, H | 1 |
| Prosnitz, LR | 1 |
| Lawson, JP | 1 |
| Friedlaender, GE | 1 |
| Farber, LR | 1 |
| Pezzimenti, JF | 1 |
| Virgolini, L | 1 |
| De Maglio, A | 1 |
| Blijham, GH | 1 |
| Vermeulen, A | 1 |
| Mendes de Leon, DE | 1 |
8 other studies available for procarbazine and Osteonecrosis
| Article | Year |
|---|---|
Successful treatment of dumbbell-shaped Hodgkin lymphoma with massive sacral bone destruction.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Female; Hodgkin Disease; Hu | 2020 |
High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cross-Sectional Studies; Cyclophos | 2018 |
Osteonecrosis in Hodgkin lymphoma treated by BEACOPP.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxorubicin; Etoposide; | 2018 |
Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dose | 2017 |
Two escalated followed by six standard BEACOPP in advanced-stage high-risk classical Hodgkin lymphoma: high cure rates but increased risk of aseptic osteonecrosis.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemotherapy, Adjuvant | 2012 |
Avascular necrosis of bone in Hodgkin's disease patients treated with combined modality therapy.
Topics: Adult; Antineoplastic Agents; Drug Therapy, Combination; Female; Femur Head Necrosis; Hodgkin Diseas | 1981 |
Bilateral aseptic necrosis of the humeral head following combined therapy for Hodgkin's lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hodgkin Di | 1992 |
Osteonecrosis of sternum and rib in a patient treated for Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; H | 1985 |