procarbazine has been researched along with Neutropenia in 22 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the feasibility of 1-(4-amino- 2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) of pre-treated procarbazine for elderly patients with newly diagnosed glioblastomas." | 9.12 | Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma. ( Abe, T; Miyagi, N; Ogo, E; Shigemori, M; Terasaki, M, 2007) |
| "A prospective phase II study of paclitaxel was performed in adult patients with recurrent hemispheric oligodendrogliomas." | 9.08 | Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas. ( Chamberlain, MC; Kormanik, PA, 1997) |
| "40 patients with symptomatic metastatic melanoma were treated with procarbazine, vincristine and lomustine (POC)." | 9.07 | Phase II trial of procarbazine, vincristine and lomustine (POC) chemotherapy in metastatic cutaneous malignant melanoma. ( Evans, BD; Harvey, VJ; Mak, D; Melville, P; Mitchell, PL; Samuel, LM; Thompson, PI, 1994) |
| "To evaluate the feasibility of 1-(4-amino- 2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) of pre-treated procarbazine for elderly patients with newly diagnosed glioblastomas." | 5.12 | Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma. ( Abe, T; Miyagi, N; Ogo, E; Shigemori, M; Terasaki, M, 2007) |
| "Fifty-six patients with newly diagnosed Stage II-IV Hodgkin disease, ages 18-77 years, were randomized to receive GM-CSF (5 microg/kg subcutaneously) or placebo from Day 7 to Day 4 before each chemotherapy administration (6 cycles of a hybrid of mechlorethamine, vincristine, procarbazine, and prednisone with doxorubicin, bleomycin, vinblastine, and dacarbazine)." | 5.09 | Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease. ( Aglietta, M; Amadori, S; Botto, B; Cantonetti, M; Castoldi, GL; Dammacco, F; Fagioli, F; Ferrara, R; Levis, A; Montemurro, F; Racanelli, V; Teofili, L; Volta, C, 2000) |
| "A prospective phase II study of paclitaxel was performed in adult patients with recurrent hemispheric oligodendrogliomas." | 5.08 | Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas. ( Chamberlain, MC; Kormanik, PA, 1997) |
| "40 patients with symptomatic metastatic melanoma were treated with procarbazine, vincristine and lomustine (POC)." | 5.07 | Phase II trial of procarbazine, vincristine and lomustine (POC) chemotherapy in metastatic cutaneous malignant melanoma. ( Evans, BD; Harvey, VJ; Mak, D; Melville, P; Mitchell, PL; Samuel, LM; Thompson, PI, 1994) |
| "The best treatment of follicular lymphoma remains to be determined because the long natural history of follicular lymphoma requires mature data for accurate analysis." | 2.70 | Chemotherapy plus interferon-alpha2b versus chemotherapy in the treatment of follicular lymphoma. ( Avilés, A; Cleto, S; Díaz, N; Díaz-Maqueo, JC; García, EL; Neri, N; Talavera, A, 2001) |
| "The clinical efficacy of COP-BLAM chemotherapy combined with human recombinant granulocyte colony-stimulating factor (G-CSF) was evaluated in 104 previously untreated patients with non-Hodgkin's lymphoma (NHL)." | 2.68 | COP-BLAM regimen combined with granulocyte colony-stimulating factor and high-grade non-Hodgkin's lymphoma. ( Niitsu, N; Umeda, M, 1995) |
| "Of our 19 patients with Hodgkin's disease (age range, 6 to 20 years) treated with this regimen, 2 had clinical stage I disease, 10 had stage II, 6 had stage III, and 1 had stage IV." | 2.67 | Vancouver hybrid: preliminary experience in the treatment of Hodgkin's disease in childhood and adolescence. ( Arndt, CA; Chen, MG; Gilchrist, GS; Khan, SP; Matsumoto, JM; O'Fallon, WM; Schomberg, PJ; Smithson, WA, 1994) |
| "Temozolomide (TMZ) has established antineoplastic activity in the central nervous system in other disease states, with a favorable toxicity profile." | 1.51 | Temozolomide as a Single Agent Maintenance Therapy in Elderly Patients With Primary CNS Lymphoma. ( Brenner, A; Butler, MJ; Faivre, G; Le, I, 2019) |
| "Neutropenia was documented in 20 dogs (57%): 12 grade I to II, 8 grade III to IV." | 1.48 | Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas. ( Amores-Fuster, I; Blackwood, L; Finotello, R; Harper, A; Killick, DR; Maddox, TW; Mason, SL; Tanis, JB, 2018) |
| "As consequence of cardiac arrest and cardiopulmonary resuscitation the surgical procedure was limited to total gastrectomy, feeding jejustomy and esophageal drainage through nasoesophageal catherization." | 1.40 | [Necrotizing gastritis in a patient in severe neutropenia]. ( Dedecjus, M; Lech-Marańda, E; Pielaciński, K; Prochorec-Sobieszek, M; Szczepanik, AB; Warzocha, K, 2014) |
| "Sixteen patients with Hodgkin's disease were treated with MOPP/ABVD and filgrastim support between January 1992 and March 1994." | 1.30 | G-CSF (filgrastim) as an adjunct to MOPP/ABVD therapy in Hodgkin's disease. ( Gustavsson, A, 1997) |
| " The optimal dosing for MV26PD remains to be determined." | 1.27 | Treatment of refractory lymphoma with methotrexate, VM-26 (teniposide), procarbazine, and dexamethasone: Cancer and Leukemia Group B study 7902. ( Anderson, J; Bloomfield, CD; Cooper, MR; Ginsberg, SJ; Gottlieb, AJ; Hurd, DD; Lachant, NA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanis, JB | 1 |
| Mason, SL | 1 |
| Maddox, TW | 1 |
| Blackwood, L | 1 |
| Killick, DR | 1 |
| Amores-Fuster, I | 1 |
| Harper, A | 1 |
| Finotello, R | 1 |
| Faivre, G | 1 |
| Butler, MJ | 1 |
| Le, I | 1 |
| Brenner, A | 1 |
| Pielaciński, K | 1 |
| Lech-Marańda, E | 1 |
| Warzocha, K | 1 |
| Dedecjus, M | 1 |
| Prochorec-Sobieszek, M | 1 |
| Szczepanik, AB | 1 |
| Terasaki, M | 1 |
| Abe, T | 1 |
| Miyagi, N | 1 |
| Ogo, E | 1 |
| Shigemori, M | 1 |
| Weitberg, AB | 1 |
| Harmon, DC | 1 |
| Valdivieso, M | 1 |
| Bodey, GP | 1 |
| Benjamin, RS | 1 |
| Barkley, HT | 1 |
| Freeman, MB | 1 |
| Ertel, M | 1 |
| Smith, TL | 1 |
| Mountain, CF | 1 |
| Engelhard, M | 1 |
| Gerhartz, H | 1 |
| Brittinger, G | 1 |
| Engert, A | 1 |
| Fuchs, R | 1 |
| Geiseler, B | 1 |
| Gerhartz, D | 1 |
| Haunauske, AR | 1 |
| Hartlapp, HJ | 1 |
| Huhn, D | 1 |
| Khan, SP | 1 |
| Gilchrist, GS | 1 |
| Arndt, CA | 1 |
| Smithson, WA | 1 |
| Chen, MG | 1 |
| Schomberg, PJ | 1 |
| Matsumoto, JM | 1 |
| O'Fallon, WM | 1 |
| Niitsu, N | 2 |
| Umeda, M | 2 |
| Watkins, SM | 1 |
| Samuel, LM | 1 |
| Harvey, VJ | 1 |
| Mitchell, PL | 1 |
| Thompson, PI | 1 |
| Mak, D | 1 |
| Melville, P | 1 |
| Evans, BD | 1 |
| Gustavsson, A | 1 |
| Chamberlain, MC | 1 |
| Kormanik, PA | 1 |
| Abele, M | 1 |
| Leonhardt, M | 1 |
| Dichgans, J | 1 |
| Weller, M | 1 |
| Lishner, M | 1 |
| Manor, Y | 1 |
| Kitay-Cohen, Y | 1 |
| Avishay, AE | 1 |
| Aglietta, M | 1 |
| Montemurro, F | 1 |
| Fagioli, F | 1 |
| Volta, C | 1 |
| Botto, B | 1 |
| Cantonetti, M | 1 |
| Racanelli, V | 1 |
| Teofili, L | 1 |
| Ferrara, R | 1 |
| Amadori, S | 1 |
| Castoldi, GL | 1 |
| Dammacco, F | 1 |
| Levis, A | 1 |
| Hamilton, VM | 1 |
| Norris, C | 1 |
| Bunin, N | 1 |
| Goldwein, JW | 1 |
| Bunin, GR | 1 |
| Lange, B | 1 |
| Meadows, AT | 1 |
| Neri, N | 1 |
| Avilés, A | 1 |
| Cleto, S | 1 |
| Díaz, N | 1 |
| Talavera, A | 1 |
| García, EL | 1 |
| Díaz-Maqueo, JC | 1 |
| Druker, BJ | 1 |
| Rosenthal, DS | 1 |
| Canellos, GP | 1 |
| Lachant, NA | 1 |
| Anderson, J | 1 |
| Ginsberg, SJ | 1 |
| Cooper, MR | 1 |
| Hurd, DD | 1 |
| Bloomfield, CD | 1 |
| Gottlieb, AJ | 1 |
| Stuart, NS | 1 |
| Blackledge, GR | 1 |
| Child, JA | 1 |
| Fletcher, J | 1 |
| Perren, TJ | 1 |
| O'Brien, CJ | 1 |
| Jones, EL | 1 |
| Ellis, IO | 1 |
| Kavanagh, JA | 1 |
| Kelly, KA | 1 |
11 trials available for procarbazine and Neutropenia
| Article | Year |
|---|---|
Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma.
Topics: Aged; Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Benzylisoquinolines; Brain Neoplasm | 2007 |
Role of intravenous hyperalimentation as an adjunct to intensive chemotherapy for small cell bronchogenic carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Bon | 1981 |
Cytokine efficiency in the treatment of high-grade malignant non-Hodgkin's lymphomas: results of a randomized double-blind placebo-controlled study with intensified COP-BLAM +/- rhGM-CSF.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modalit | 1994 |
Vancouver hybrid: preliminary experience in the treatment of Hodgkin's disease in childhood and adolescence.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplant | 1994 |
COP-BLAM regimen combined with granulocyte colony-stimulating factor and high-grade non-Hodgkin's lymphoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomyci | 1995 |
[Usefulness of COP-BLAM therapy with concomitant G-CSF in elderly patients with non-Hodgkin's lymphoma in comparison with patients not given G-CSF].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxorubicin; Fema | 1995 |
Phase II trial of procarbazine, vincristine and lomustine (POC) chemotherapy in metastatic cutaneous malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Lomustine; Male; Melano | 1994 |
Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas.
Topics: Adult; Alopecia; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; | 1997 |
Short term treatment with Escherichia coli recombinant human granulocyte-macrophage-colony stimulating factor prior to chemotherapy for Hodgkin disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modalit | 2000 |
Cyclophosphamide-based, seven-drug hybrid and low-dose involved field radiation for the treatment of childhood and adolescent Hodgkin disease.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Combined Modality Ther | 2001 |
Chemotherapy plus interferon-alpha2b versus chemotherapy in the treatment of follicular lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dr | 2001 |
11 other studies available for procarbazine and Neutropenia
| Article | Year |
|---|---|
Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Female; Lomustine; Lymp | 2018 |
Temozolomide as a Single Agent Maintenance Therapy in Elderly Patients With Primary CNS Lymphoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Disea | 2019 |
[Necrotizing gastritis in a patient in severe neutropenia].
Topics: Abdominal Pain; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; | 2014 |
Autoimmune neutropenia, hemolytic anemia, and reticulocytopenia in Hodgkin's disease.
Topics: Adult; Agranulocytosis; Anemia, Hemolytic, Autoimmune; Antineoplastic Combined Chemotherapy Protocol | 1984 |
Predicting neutropenia after chemotherapy for lymphoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cy | 1993 |
G-CSF (filgrastim) as an adjunct to MOPP/ABVD therapy in Hodgkin's disease.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antine | 1997 |
CCNU overdose during PCV chemotherapy for anaplastic astrocytoma.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neo | 1998 |
Association between alopecia and response to aggressive chemotherapy in patients with Hodgkin's disease.
Topics: Adult; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Doxorubicin | 1999 |
Chlorambucil, vinblastine, procarbazine, and prednisone. An effective but less toxic regimen than MOPP for advanced-stage Hodgkin's disease.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Chlorambucil; Female; Hodg | 1989 |
Treatment of refractory lymphoma with methotrexate, VM-26 (teniposide), procarbazine, and dexamethasone: Cancer and Leukemia Group B study 7902.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexametha | 1988 |
A new approach to the treatment of advanced high-grade non-Hodgkin's lymphoma--intensive two-phase chemotherapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubic | 1988 |