procarbazine has been researched along with Nervous System Disorders in 8 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The best treatment of follicular lymphoma remains to be determined because the long natural history of follicular lymphoma requires mature data for accurate analysis." | 2.70 | Chemotherapy plus interferon-alpha2b versus chemotherapy in the treatment of follicular lymphoma. ( Avilés, A; Cleto, S; Díaz, N; Díaz-Maqueo, JC; García, EL; Neri, N; Talavera, A, 2001) |
| " Prospective pharmacokinetic studies to devise a rational dosing strategy for vinblastine in patients receiving ritonavir/lopinavir are warranted." | 1.38 | Incidence, predictors and significance of severe toxicity in patients with human immunodeficiency virus-associated Hodgkin lymphoma. ( Boro, J; Cheung, MC; Ezzat, HM; Harris, M; Hicks, LK; Leitch, HA; Lima, VD; Montaner, JS, 2012) |
| " Although the neurotoxic effects produced by different cytostatics present a different appearance and are partly of only sporadic or slight clinical importance, there is hardly a cytostatic which does not exercise a side effect on the nervous system." | 1.26 | [Neurotoxic side effects of cytostatic therapy (author's transl)]. ( Maurach, R; Strian, F, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ezzat, HM | 1 |
| Cheung, MC | 1 |
| Hicks, LK | 1 |
| Boro, J | 1 |
| Montaner, JS | 1 |
| Lima, VD | 1 |
| Harris, M | 1 |
| Leitch, HA | 1 |
| Strian, F | 2 |
| Maurach, R | 2 |
| Niitsu, N | 1 |
| Umeda, M | 1 |
| Abrey, LE | 1 |
| Yahalom, J | 1 |
| DeAngelis, LM | 1 |
| Neri, N | 1 |
| Avilés, A | 1 |
| Cleto, S | 1 |
| Díaz, N | 1 |
| Talavera, A | 1 |
| García, EL | 1 |
| Díaz-Maqueo, JC | 1 |
| Desser, RK | 1 |
| Ultmann, JE | 1 |
| Weiss, HD | 1 |
| Walker, MD | 1 |
| Wiernik, PH | 1 |
3 reviews available for procarbazine and Nervous System Disorders
| Article | Year |
|---|---|
[Cytostatic therapy: neurologic and psychiatric syndromes].
Topics: Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Dacarbazine; Dactinomycin; Doxoru | 1980 |
The sensitivity of Hodgkin's disease to chemotherapeutic agents administered singly.
Topics: Adrenal Cortex Hormones; Alopecia; Antineoplastic Agents; Bleomycin; Blood Platelet Disorders; Carmu | 1973 |
Neurotoxicity of commonly used antineoplastic agents (second of two parts).
Topics: Achilles Tendon; Animals; Antineoplastic Agents; Autonomic Nervous System; Central Nervous System Di | 1974 |
2 trials available for procarbazine and Nervous System Disorders
| Article | Year |
|---|---|
Treatment for primary CNS lymphoma: the next step.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous Syst | 2000 |
Chemotherapy plus interferon-alpha2b versus chemotherapy in the treatment of follicular lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dr | 2001 |
3 other studies available for procarbazine and Nervous System Disorders
| Article | Year |
|---|---|
Incidence, predictors and significance of severe toxicity in patients with human immunodeficiency virus-associated Hodgkin lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Bleomy | 2012 |
[Neurotoxic side effects of cytostatic therapy (author's transl)].
Topics: Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Dacarbazine; Dactinomycin; Doxoru | 1981 |
[Assessment of cardiac toxicity by 123I-MIBG myocardial SPECT in elderly non-Hodgkin lymphoma patients treated with COP-BLAM and G-CSF].
Topics: 3-Iodobenzylguanidine; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophospha | 1995 |