procarbazine has been researched along with Neoplasms in 74 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Breast cancer survivors, those treated with procarbazine or other alkylating agents and those with a higher age at diagnosis are at highest risk of diminished ovarian function." | 4.95 | Chemotherapy-related late adverse effects on ovarian function in female survivors of childhood and young adult cancer: A systematic review. ( Kaspers, GJ; Lambalk, CB; Overbeek, A; van den Berg, MH; van Dulmen-den Broeder, E; van Leeuwen, FE, 2017) |
| "The role of ROS in cancer treatments and in the development of resistance to chemotherapy is now better understood." | 2.42 | The emerging role of reactive oxygen species in cancer therapy. ( Renschler, MF, 2004) |
| "Peripheral neurotoxicity is a crucial side effect of chemotherapeutic agents." | 2.41 | [Peripheral nervous system neurotoxicity secondary to chemotherapy treatment] . ( Iñiguez, C; Larrodé, P; Mauri, JA; Mayordomo, JI; Morales, F; Trés, A, 2000) |
| "Although G-CSF is widely used to prevent or ameliorate leukopenia during cytotoxic chemotherapies, its optimal use is still under debate and depends on many therapy parameters such as dosing and timing of cytotoxic drugs and G-CSF, G-CSF pharmaceuticals used and individual risk factors of patients." | 1.48 | Model-based optimization of G-CSF treatment during cytotoxic chemotherapy. ( Engel, C; Loeffler, M; Loibl, S; Schirm, S; Scholz, M, 2018) |
| "National Cancer Institute, National Institutes of Health, and the American Lebanese-Syrian Associated Charities." | 1.43 | Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort. ( Armstrong, GT; Chow, EJ; Donaldson, SS; Ginsberg, JP; Green, DM; Kenney, LB; Leisenring, WM; Levine, JM; Oeffinger, KC; Robison, LL; Shnorhavorian, M; Sklar, CA; Stovall, M; Stratton, KL, 2016) |
| "Both anticancer chemotherapeutics and monoclonal antibodies have the potential for acute HSR." | 1.38 | Prevention and handling of acute allergic and infusion reactions in oncology. ( Joerger, M, 2012) |
| "Although it is accepted that pediatric cancer treatment harbors a risk of gonadal damage, large cohort studies using up-to-date fertility markers are lacking." | 1.35 | Effect of childhood cancer treatment on fertility markers in adult male long-term survivors. ( Dohle, GR; Hählen, K; Hakvoort-Cammel, FG; van Casteren, NJ; van den Heuvel-Eibrink, MM; van der Linden, GH, 2009) |
| " The dose-response of ethylnitrosourea-induced mutation was found to be very close to that previously established using a pedigree-based approach for ESTR mutation detection." | 1.35 | Single-molecule PCR analysis of germ line mutation induction by anticancer drugs in mice. ( Dubrova, YE; Glen, CD; Smith, AG, 2008) |
| "Barriers to using online cancer information are environmental (hardware, connection speeds, time), personal (poor computer literacy and lack of awareness of appropriate sites) and economic (costs of journal subscriptions)." | 1.33 | Information sources used by New South Wales cancer clinicians: a qualitative study. ( Lowinger, JS; Pearson, S-; Ringland, C; Stark, H; Tan, EL; Ward, R, 2006) |
| "The expanding use of cytotoxic drugs in cancer therapy has resulted in a confusing and increasingly frequent array of severe renal complications." | 1.27 | Renal complications of cytotoxic therapy. ( Clarkson, AR; Healy, HG, 1983) |
| "The example of Hodgkin's lymphoma staging and treatment selection is used." | 1.27 | A decision-analysis methodology for consideration of morbidity factors in clinical decision-making. ( Corder, MP; Ellwein, LB, 1984) |
| "Thirty-four subsequent second malignant neoplasms were observed in 33 patients among those treated for Hodgkin's disease." | 1.27 | Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience. ( DeVita, VT; Glatstein, E; Kelley, PA; Kinsella, TJ; Makuch, RW; Tester, WJ; Waller, B, 1984) |
| "Secondary tumors were noted in 8 out of 675 patients with Hodgkin's disease during remission following treatment." | 1.27 | [Secondary malignant tumors following treatment of Hodgkin's disease]. ( Shishkin, IP, 1984) |
| "Patients who had a relapse of Hodgkin's disease did not have an increased incidence of second malignancy." | 1.27 | Second malignancy complicating Hodgkin's disease. ( Mercier, JP; Tawil, E, 1983) |
| "Depressive symptoms associated with cancer range from normal sadness through acute stress response to major depression." | 1.27 | Diagnosis and treatment of depression in the cancer patient. ( Holland, JC; Massie, MJ, 1984) |
| " The elimination half-life (t1/2 less than 80 min) allows autologous bone marrow transplantation 24 h after the drug administration." | 1.27 | Pharmacokinetics of high-dose melphalan in children and adults. ( Gouyette, A; Hartmann, O; Pico, JL, 1986) |
| "Two osteosarcomas, an Ewing sarcoma, and a bronchogenic carcinoma were also studied and grew similarly." | 1.26 | Growth of human tumors in mice after short-term immunosuppression with procarbazine, cyclophosphamide, and antilymphocyte serum. ( Floersheim, GL; Nassenstein, D; Torhorst, J, 1980) |
| "Two patients showed secondary tumors after 9 or 11 years respectively." | 1.26 | [A contribution to the cytostatic long-term chemotherapy of polycythemia vera (author's transl)]. ( Fereberger, W; Robier, FP; Sailer, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (72.97) | 18.7374 |
| 1990's | 5 (6.76) | 18.2507 |
| 2000's | 8 (10.81) | 29.6817 |
| 2010's | 7 (9.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schirm, S | 1 |
| Engel, C | 1 |
| Loibl, S | 1 |
| Loeffler, M | 1 |
| Scholz, M | 1 |
| Ghoreishi, R | 1 |
| Kia, M | 1 |
| Chow, EJ | 1 |
| Stratton, KL | 1 |
| Leisenring, WM | 1 |
| Oeffinger, KC | 1 |
| Sklar, CA | 1 |
| Donaldson, SS | 1 |
| Ginsberg, JP | 1 |
| Kenney, LB | 1 |
| Levine, JM | 1 |
| Robison, LL | 1 |
| Shnorhavorian, M | 1 |
| Stovall, M | 1 |
| Armstrong, GT | 1 |
| Green, DM | 1 |
| Overbeek, A | 1 |
| van den Berg, MH | 1 |
| van Leeuwen, FE | 1 |
| Kaspers, GJ | 1 |
| Lambalk, CB | 1 |
| van Dulmen-den Broeder, E | 1 |
| van Casteren, NJ | 1 |
| van der Linden, GH | 1 |
| Hakvoort-Cammel, FG | 1 |
| Hählen, K | 1 |
| Dohle, GR | 1 |
| van den Heuvel-Eibrink, MM | 1 |
| Graber, JJ | 1 |
| Rosenblum, MK | 1 |
| DeAngelis, LM | 1 |
| Joerger, M | 1 |
| Baldwin, A | 1 |
| Huang, Z | 1 |
| Jounaidi, Y | 1 |
| Waxman, DJ | 1 |
| TODD, ID | 1 |
| Kenis, Y | 1 |
| De Smedt, J | 1 |
| Tagnon, HJ | 1 |
| Renschler, MF | 1 |
| Preiss, R | 1 |
| Baumann, F | 1 |
| Regenthal, R | 1 |
| Matthias, M | 1 |
| Tan, EL | 1 |
| Stark, H | 1 |
| Lowinger, JS | 1 |
| Ringland, C | 1 |
| Ward, R | 1 |
| Pearson, S- | 1 |
| Glen, CD | 1 |
| Smith, AG | 1 |
| Dubrova, YE | 1 |
| Moser, K | 1 |
| Pohl, A | 1 |
| Healy, HG | 1 |
| Clarkson, AR | 1 |
| Corder, MP | 1 |
| Ellwein, LB | 1 |
| Tester, WJ | 1 |
| Kinsella, TJ | 1 |
| Waller, B | 1 |
| Makuch, RW | 1 |
| Kelley, PA | 1 |
| Glatstein, E | 1 |
| DeVita, VT | 4 |
| Rosner, F | 1 |
| Shishkin, IP | 1 |
| Tawil, E | 1 |
| Mercier, JP | 1 |
| Massie, MJ | 1 |
| Holland, JC | 1 |
| Clare, MG | 1 |
| Blain, E | 1 |
| Taylor, JH | 1 |
| Maxwell, MB | 1 |
| Levitt, DZ | 1 |
| Floersheim, GL | 1 |
| Nassenstein, D | 1 |
| Torhorst, J | 1 |
| Sullivan, KM | 1 |
| Storb, R | 1 |
| Shulman, HM | 1 |
| Shaw, CM | 1 |
| Spence, A | 1 |
| Beckham, C | 1 |
| Clift, RA | 1 |
| Buckner, CD | 1 |
| Stewart, P | 1 |
| Thomas, ED | 1 |
| Shiba, DA | 1 |
| Weinkam, RJ | 1 |
| Mustonen, R | 2 |
| Försti, A | 2 |
| Hietanen, P | 2 |
| Hemminki, K | 2 |
| Kyrtopoulos, SA | 1 |
| Anderson, LM | 1 |
| Chhabra, SK | 1 |
| Souliotis, VL | 1 |
| Pletsa, V | 1 |
| Valavanis, C | 1 |
| Georgiadis, P | 1 |
| Iñiguez, C | 1 |
| Larrodé, P | 1 |
| Mayordomo, JI | 1 |
| Mauri, JA | 1 |
| Trés, A | 1 |
| Morales, F | 1 |
| Schein, PS | 1 |
| Winokur, SH | 1 |
| Chabner, BA | 1 |
| Myers, CE | 1 |
| Oliverio, VT | 1 |
| Mattern, J | 2 |
| Kaufmann, M | 2 |
| Hinderer, H | 1 |
| Wayss, K | 2 |
| Volm, M | 2 |
| Sutow, WW | 1 |
| Sullivan, MP | 1 |
| Einhorn, LH | 1 |
| Sieber, SM | 1 |
| Fereberger, W | 1 |
| Robier, FP | 1 |
| Sailer, S | 1 |
| Krauthammer, C | 1 |
| Klerman, GL | 1 |
| Baumgartner, G | 2 |
| Old, LJ | 1 |
| Krakoff, IH | 1 |
| Weiss, RB | 1 |
| Hancock, BW | 1 |
| Vaughan Hudson, G | 1 |
| Vaughan Hudson, B | 1 |
| Haybittle, JL | 1 |
| Bennett, MH | 1 |
| MacLennan, KA | 1 |
| Jelliffe, AM | 1 |
| Coldman, AJ | 1 |
| Goldie, JH | 1 |
| Coleman, M | 1 |
| Boyd, DB | 1 |
| Jenkin, D | 1 |
| Doyle, J | 1 |
| Wang, QL | 1 |
| Ersbøll, J | 1 |
| Bakchine, H | 1 |
| Brauner, R | 1 |
| Thibaud, E | 1 |
| Rappaport, R | 1 |
| Flamant, F | 1 |
| Griscelli, C | 1 |
| Lemerle, J | 1 |
| Schaison, G | 1 |
| Schweisguth, O | 1 |
| Zucker, JM | 1 |
| Baumgartner, M | 1 |
| Frei, E | 1 |
| Gouyette, A | 1 |
| Hartmann, O | 1 |
| Pico, JL | 1 |
| Bergevin, PR | 1 |
| Tormey, DC | 1 |
| Blom, J | 1 |
| Greenwald, ES | 1 |
| Goerttler, K | 1 |
| Zwaveling, A | 1 |
| Deckers, C | 1 |
| Deckers-Passau, L | 1 |
| Maisin, J | 1 |
| Gauthier, JM | 1 |
| Mace, F | 1 |
| Sponzo, RW | 2 |
| Arseneau, JC | 4 |
| Canellos, GP | 4 |
| Singer, Z | 1 |
| Bonadonna, G | 1 |
| De Lena, M | 1 |
| Banfi, A | 1 |
| Lattuada, A | 1 |
| Lawhorn, TI | 1 |
| Stone, HH | 1 |
| Martin, JD | 1 |
| Kühböck, J | 1 |
| Sherins, RJ | 2 |
| Zubrod, CG | 1 |
| Spivack, SD | 1 |
| Goldenson, Y | 1 |
| Lev, L | 1 |
| Robinson, E | 1 |
| Durant, JR | 1 |
| Lessner, HE | 1 |
| Young, RC | 2 |
| Jedrzejczak, W | 1 |
| Siekierzyński, M | 1 |
| Berndt, H | 1 |
| Rieche, K | 1 |
| Levin, DL | 1 |
| Schnipper, LE | 1 |
| Bonner, H | 1 |
| Johnson, RE | 1 |
| Stern, MH | 1 |
| Curtis, AB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| (PRO#11307) Phase III Randomized Study of Autologous Stem Cell Transplantation With High-dose Melphalan Versus High-dose Melphalan and Bortezomib in Patients With Multiple Myeloma 65 Year or Older[NCT01453088] | Phase 2 | 63 participants (Actual) | Interventional | 2010-06-24 | Terminated (stopped due to Lack of Accrual) | ||
| Tandem Autologous Hematopoietic Stem Cell Transplant With Melphalan Followed by Melphalan and Bortezomib in Patients With Multiple Myeloma[NCT01241708] | Phase 3 | 146 participants (Actual) | Interventional | 2010-04-08 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01453088)
Timeframe: 1 year
| Intervention | Participants (Count of Participants) |
|---|---|
| Auto Transplant High Dose Melphalan | 27 |
| Auto Transplant High Dose Melphalan+Bortezomib | 27 |
Progression free survival of elderly patients with multiple myeloma treated with either high-dose melphalan versus high-dose melphalan and bortezomib at 3 years (NCT01453088)
Timeframe: Participants will be followed post transplant for a minimum of 3 years, and after that may be monitored as part of the study indefinitely
| Intervention | Participants (Count of Participants) |
|---|---|
| Auto Transplant High Dose Melphalan | 13 |
| Auto Transplant High Dose Melphalan+Bortezomib | 11 |
16 reviews available for procarbazine and Neoplasms
| Article | Year |
|---|---|
Chemotherapy-related late adverse effects on ovarian function in female survivors of childhood and young adult cancer: A systematic review.
Topics: Age Factors; Amenorrhea; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Breast Neoplasms; | 2017 |
The emerging role of reactive oxygen species in cancer therapy.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Combined Modality Therapy; DNA; Humans; Metalloporphy | 2004 |
[Recent developments in chemotherapy of malignant diseases].
Topics: Anthraquinones; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy | 1982 |
DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinogens, Environmental; Dimethylnitrosamine; DNA Ad | 1997 |
[Peripheral nervous system neurotoxicity secondary to chemotherapy treatment] .
Topics: Anti-HIV Agents; Antineoplastic Agents; Cyclosporine; Depsipeptides; Docetaxel; Doxorubicin; Humans; | 2000 |
Immunosuppressive and cytotoxic chemotherapy: long-term complications.
Topics: Alkylating Agents; Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Carcinogens; Chemical a | 1975 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; | 1977 |
Hypersensitivity reactions.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Aziridines; Benzoquinones; Bleomyc | 1992 |
Guide to the use of cancer chemotherapeutic agents.
Topics: Alkylating Agents; Allopurinol; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; | 1972 |
Cancer chemotherapy. II.
Topics: Animals; Antineoplastic Agents; Asparaginase; Azathioprine; Bleomycin; Cytarabine; Dactinomycin; Dau | 1972 |
[Chemotherapy of solid tumors].
Topics: Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Antineoplastic Agents; Bone Marrow; Diges | 1973 |
Chemotherapy in solid tumors of childhood.
Topics: Abdominal Neoplasms; Adolescent; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Eye Neopla | 1972 |
Recently recognized complications of cancer chemotherapy.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cyclophosphamide; Death, Sudden; Drug Therapy, Combination; | 1974 |
Present status of cancer chemotherapy.
Topics: Alkylating Agents; Animals; Anti-Bacterial Agents; Antimetabolites; Carmustine; DNA, Neoplasm; Evalu | 1974 |
Drugs 5 years later: procarbazine.
Topics: Animals; Bone Neoplasms; Carcinogens; Carcinoma; Drug Evaluation; Hodgkin Disease; Humans; Lung Neop | 1974 |
[Combination chemotherapy in the treatment of cancer].
Topics: Administration, Oral; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Dacti | 1972 |
2 trials available for procarbazine and Neoplasms
| Article | Year |
|---|---|
British National Lymphoma Investigation randomised study of MOPP (mustine, Oncovin, procarbazine, prednisolone) against LOPP (Leukeran substituted for mustine) in advanced Hodgkin's disease--long term results.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Female; Follow-Up S | 1991 |
[Polychemotherapy of malignant neoplasms].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Cyclophosphamide; Female; | 1972 |
56 other studies available for procarbazine and Neoplasms
| Article | Year |
|---|---|
Model-based optimization of G-CSF treatment during cytotoxic chemotherapy.
Topics: Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxo | 2018 |
Chemical reactivity and adsorption properties of pro-carbazine anti-cancer drug on gallium-doped nanotubes: a quantum chemical study.
Topics: Adsorption; Algorithms; Antineoplastic Agents; Binding Sites; Computer Simulation; Drug Delivery Sys | 2019 |
Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort.
Topics: Adolescent; Adult; Canada; Child; Cyclophosphamide; Female; Fertility Preservation; Humans; Live Bir | 2016 |
Effect of childhood cancer treatment on fertility markers in adult male long-term survivors.
Topics: Biomarkers; Child, Preschool; Cyclophosphamide; Female; Fertility; Follicle Stimulating Hormone; Fol | 2009 |
Herpes simplex encephalitis in patients with cancer.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Crania | 2011 |
Procarbazine and its hydrochloride.
Topics: Animals; Antineoplastic Agents; Female; Humans; Hydrochloric Acid; Male; Mice; Neoplasms; Procarbazi | 2011 |
Prevention and handling of acute allergic and infusion reactions in oncology.
Topics: Anaphylaxis; Antibodies, Monoclonal; Asparaginase; Drug Hypersensitivity; Humans; Immunoglobulin E; | 2012 |
Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Antineoplastic Agents, Alk | 2003 |
NATULAN IN MANAGEMENT OF LATE HODGKIN'S DISEASE, OTHER LYMPHORETICULAR NEOPLASMS, AND MALIGNANT MELANOMA.
Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Humans; Hydrazines; Lymphoma; Lymphoma, Follic | 1965 |
[Action of Natulan in 94 solid tumours. 1966].
Topics: Antineoplastic Agents; History, 20th Century; Humans; Neoplasms; Procarbazine | 2004 |
Plasma kinetics of procarbazine and azo-procarbazine in humans.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Area Under Curve; Female; Half-Life; Human | 2006 |
Information sources used by New South Wales cancer clinicians: a qualitative study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxorubicin; Dru | 2006 |
Single-molecule PCR analysis of germ line mutation induction by anticancer drugs in mice.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; DNA Mutational Analysis; Dose-Response | 2008 |
Renal complications of cytotoxic therapy.
Topics: Animals; Antineoplastic Agents; Asparaginase; Cisplatin; Cyclophosphamide; Cytarabine; Dogs; Fluorou | 1983 |
A decision-analysis methodology for consideration of morbidity factors in clinical decision-making.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Decision Making; Hodgkin Disease; Huma | 1984 |
Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Combine | 1984 |
Cancer and secondary leukemia.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Child; Child, Preschool; Female; | 1983 |
[Secondary malignant tumors following treatment of Hodgkin's disease].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophospha | 1984 |
Second malignancy complicating Hodgkin's disease.
Topics: Acute Disease; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cycloph | 1983 |
Diagnosis and treatment of depression in the cancer patient.
Topics: Adjustment Disorders; Antidepressive Agents, Tricyclic; Asparaginase; Combined Modality Therapy; Dep | 1984 |
Sister chromatid exchanges in human lymphocytes treated with combinations of cytotoxic drugs.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Child | 1982 |
Reexamining the dietary restrictions with procarbazine (an MAOI).
Topics: Cheese; Diet; Food Analysis; Humans; Monoamine Oxidase Inhibitors; Neoplasms; Procarbazine; Tyramine | 1980 |
Cancer chemotherapy: those dreaded side effects and what to do about them. Part five.
Topics: Antineoplastic Agents; Asparaginase; Cisplatin; Dacarbazine; Humans; Hydroxyurea; Neoplasms; Procarb | 1981 |
Growth of human tumors in mice after short-term immunosuppression with procarbazine, cyclophosphamide, and antilymphocyte serum.
Topics: Adenocarcinoma; Adolescent; Adult; Animals; Antilymphocyte Serum; Bone Neoplasms; Carcinoma; Child; | 1980 |
Immediate and delayed neurotoxicity after mechlorethamine preparation for bone marrow transplantation.
Topics: Adolescent; Adult; Anemia, Aplastic; Bone Marrow Transplantation; Central Nervous System; Central Ne | 1982 |
Quantitative analysis of procarbazine, procarbazine metabolites and chemical degradation products with application to pharmacokinetic studies.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Liver | 1982 |
Development of a 32P-postlabeling assay for 7-methylguanines in human DNA.
Topics: Adult; Aged; Chromatography, Ion Exchange; Dacarbazine; DNA; Dose-Response Relationship, Drug; Guani | 1993 |
Clinical pharmacology of anticancer drugs.
Topics: Animals; Antineoplastic Agents; Azacitidine; Bleomycin; Cyclophosphamide; Cytarabine; Dacarbazine; D | 1977 |
Sensitivity tests of tumors to cytostatic agents. II. Investigation on human tumors.
Topics: Antineoplastic Agents; Autoradiography; Breast Neoplasms; Cell Count; Cell Division; Culture Techniq | 1975 |
Childhood cancer: the improving prognosis.
Topics: Asparaginase; Child; Cyclophosphamide; Cytosine; Daunorubicin; Doxorubicin; Drug Therapy, Combinatio | 1976 |
Cancer chemotherapy.
Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Leuk | 1977 |
[A contribution to the cytostatic long-term chemotherapy of polycythemia vera (author's transl)].
Topics: Female; Humans; Male; Middle Aged; Neoplasms; Polycythemia Vera; Procarbazine; Time Factors | 1979 |
Secondary mania: manic syndromes associated with antecedent physical illness or drugs.
Topics: Adrenal Cortex Hormones; Adult; Bipolar Disorder; Bromides; Epilepsy, Temporal Lobe; Humans; Isoniaz | 1978 |
[Cytostatic therapy of inoperable carcinomas].
Topics: Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin | 1976 |
Combination chemotherapy.
Topics: Adult; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Fluor | 1975 |
Measurement by 32P-postlabelling of 7-methylguanine levels in white blood cell DNA of healthy individuals and cancer patients treated with dacarbazine and procarbazine. Human data and method development for 7-alkylguanines.
Topics: Chromatography, Thin Layer; Dacarbazine; Deoxyguanine Nucleotides; DNA; DNA, Neoplasm; Guanine; Huma | 1991 |
Role of mathematical modeling in protocol formulation in cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazi | 1985 |
Infusions, age, and drug doses: redux.
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxorubici | 1988 |
Pediatric Hodgkin's disease. Later results and toxicity--the Toronto experience.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Follow | 1989 |
[Various doses cisplatin combined with multi-drug chemotherapy of malignant solid tumors].
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neop | 1989 |
[Remission with antineoplastic agents?].
Topics: Antineoplastic Combined Chemotherapy Protocols; Humans; Mechlorethamine; Neoplasms; Prednisone; Proc | 1989 |
[Chemotherapy and ovarian function. Retrospective analysis in 17 girls treated for malignant tumor or hematologic disease].
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Pre | 1986 |
[Results of a pilot study of hyaluronidase as an adjunct to cytostatic therapy in malignant diseases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Tolerance; Female; Humans; Hyaluro | 1985 |
Current status and new vistas in combination chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Hodgkin Disease; H | 1985 |
Pharmacokinetics of high-dose melphalan in children and adults.
Topics: Adolescent; Adult; Carmustine; Child; Child, Preschool; Diuresis; Dose-Response Relationship, Drug; | 1986 |
Pharmacokinetics of high-dose melphalan in children and adults.
Topics: Adolescent; Adult; Carmustine; Child; Child, Preschool; Diuresis; Dose-Response Relationship, Drug; | 1986 |
Pharmacokinetics of high-dose melphalan in children and adults.
Topics: Adolescent; Adult; Carmustine; Child; Child, Preschool; Diuresis; Dose-Response Relationship, Drug; | 1986 |
Pharmacokinetics of high-dose melphalan in children and adults.
Topics: Adolescent; Adult; Carmustine; Child; Child, Preschool; Diuresis; Dose-Response Relationship, Drug; | 1986 |
[Selective tumour chemotherapy using oncobiograms (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cricetinae; Culture Techniques; Cytarabine; Dactinomycin; | 1974 |
Carcinogenicity of procarbazine.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Ear Canal; Ear Neoplasms; | 1974 |
Procabazine induced oxidative haemolysis: relationship in vivo red cell survival.
Topics: Cell Survival; Chromium Radioisotopes; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glut | 1974 |
[Chemotherapy of malignant neoplasms in Internal Medicine Departments].
Topics: Antineoplastic Agents; Drug Therapy, Combination; Humans; Methods; Neoplasms; Prednisone; Procarbazi | 1974 |
Secondary neoplasms in malignant lymphomas after intensive therapy.
Topics: Adult; Antineoplastic Agents; Follow-Up Studies; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; | 1973 |
Development of four-drug BCNU combination chemotherapy regimens.
Topics: Carmustine; Cyclophosphamide; Evaluation Studies as Topic; Hematologic Diseases; Hodgkin Disease; Hu | 1973 |
Intensive chemotherapy for Hodgkin's disease: long-term complications.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; E | 1973 |
[Treatment of neoplasms with partial synchronization of cell proliferation].
Topics: Antineoplastic Agents; Drug Interactions; Hodgkin Disease; Humans; Methods; Mitosis; Neoplasms; Nitr | 1974 |
[Chemotherapy of cancer. Hints for continuing medical education].
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Cytarabine; Daunorubicin; Education | 1974 |
Nonlymphomatous malignant tumors complicating Hodgkin's disease. Possible association with intensive therapy.
Topics: Adolescent; Adult; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Drug-Related S | 1972 |
Bar-shaped nuclear bodies in oral epithelial cells of children receiving chemotherapy for cancer.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Chromatin; Cyclophosphamide; Daun | 1971 |