procarbazine has been researched along with Multiple Primary Neoplasms in 43 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 53-year-old man with multiple myeloma and plasma cell luekemia developed severe, acute bilateral optic neuroretinitis 8 days after chemotherapy with BCNU, procarbazine, cyclophosphamide, and prednisolone." | 7.66 | Optic neuroretinitis in association with BCNU and procarbazine therapy. ( Lennan, RM; Taylor, HR, 1978) |
| " After a median follow-up of more than 6 years following MOPP (mechlorethamine/vincristine/procarbazine/prednisone) chemotherapy with or without radiotherapy, 5% of patients with Hodgkin's disease developed second primaries, 60% of which were leukemias." | 4.78 | Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects. ( Petru, E; Schmähl, D, 1991) |
| "A 53-year-old man with multiple myeloma and plasma cell luekemia developed severe, acute bilateral optic neuroretinitis 8 days after chemotherapy with BCNU, procarbazine, cyclophosphamide, and prednisolone." | 3.66 | Optic neuroretinitis in association with BCNU and procarbazine therapy. ( Lennan, RM; Taylor, HR, 1978) |
| "Relapses were most frequent in previously involved unirradiated areas." | 2.67 | Management of relapse and survival in advanced stage Hodgkin's disease: the EORTC experience. ( Breed, WP; Burgers, JM; Carde, P; de Pauw, BE; Hagenbeek, A; Henry-Amar, M; Monconduit, M; Somers, R; Tarayre, M; Thomas, J, 1991) |
| "Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm." | 2.65 | Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease. ( Bartolucci, AA; Durant, JR; Gams, RA; Liu, C, 1983) |
| "The outlook for patients with Hodgkin's disease has improved dramatically over the past 20 years." | 2.37 | Hodgkin's disease. ( Portlock, CS, 1984) |
| "The occurrence of HIV associated non-Hodgkin's lymphoma (NHL) is a well recognized event." | 1.29 | Hodgkin's disease and non-Hodgkin's lymphoma in an HIV positive patient. ( Brody, J; Goh, JC; Kaplan, MH; Koduru, P; Lichtman, SM; Susin, M, 1993) |
| "Three patients with Stage III or IVB Hodgkin's disease were cured with MOPP (regimen of nitrogen mustard, Oncovin, prednisone, and procarbazine) and/or B-DOPA (regimen of bleomycin, dacarbazine, Oncovin, prednisone, and Adriamycin)." | 1.28 | Secondary uncommon solid neoplasms in cured Hodgkin's disease and follow-up of the original B-DOPA chemotherapy patient group. ( Lokich, JJ, 1990) |
| " There were three fatal toxic events, two due to viral infection and one to a second malignant tumor (NHL)." | 1.28 | Hodgkin's disease in children: treatment with MOPP and low-dose, extended field irradiation without laparotomy. Late results and toxicity. ( Berry, M; Blanchette, V; Chan, H; Doherty, M; Doyle, J; Freedman, M; Greenberg, M; Jenkin, D; Panzarella, T; Saunders, F, 1990) |
| "Biopsy specimen revealed malignant lymphoma." | 1.28 | [Triple malignancy including bladder carcinoma, prostate carcinoma and malignant lymphoma: a case report]. ( Kobayashi, Y; Kuyama, J; Matsuda, M; Miyagawa, M; Ohnishi, S; Oritani, K; Tada, Y; Yasunaga, Y; Yoshioka, T, 1989) |
| "Hodgkin's disease is one of the most curable cancers thanks to progress in radiotherapy and multi-drug chemotherapy regimens such as mechloretamine-vincristine-procarbazine-prednisone, best known as MOPP." | 1.28 | Ten-year nodular sclerosis Hodgkin's disease and second malignancies. ( Mirimanoff, RO; Zulian, GB, 1989) |
| "Patients who had a relapse of Hodgkin's disease did not have an increased incidence of second malignancy." | 1.27 | Second malignancy complicating Hodgkin's disease. ( Mercier, JP; Tawil, E, 1983) |
| "A patient is described who developed Hodgkin's disease 16 years after treatment of Wilms' tumor with radiation and actinomycin D." | 1.27 | Hodgkin's disease following Wilms' tumor: a case report. ( Bell, BA; Esseltine, DW; Freeman, CR, 1987) |
| "A patient seen at presentation for Hodgkin's disease (HD) at stage IV B was successfully treated with MOPP." | 1.27 | Gastric non-Hodgkin's lymphoma after successful treatment of Hodgkin's disease. ( Eridani, S; Singh, AK, 1986) |
| "Despite the dramatic response of Hodgkin's disease to intensive chemotherapy, the skin lesion was rapidly transformed into squamous cell carcinoma in 10 weeks." | 1.26 | Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease? ( Poleksic, S; Yeung, KY, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (76.74) | 18.7374 |
| 1990's | 8 (18.60) | 18.2507 |
| 2000's | 2 (4.65) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uchida, T | 1 |
| Sugimoto, K | 1 |
| Koike, M | 1 |
| Au, WY | 1 |
| Ma, SK | 1 |
| Wan, TS | 1 |
| Wang, EP | 1 |
| Lau, TC | 1 |
| Kwong, YL | 1 |
| Portlock, CS | 1 |
| Jacquillat, C | 2 |
| Khayat, D | 1 |
| Desprez-Curely, JP | 1 |
| Weil, M | 2 |
| Brocheriou, C | 1 |
| Auclerc, G | 2 |
| Chamseddine, N | 1 |
| Bernard, J | 1 |
| Schmitt, K | 1 |
| Tulzer, W | 1 |
| Gassmann, W | 1 |
| Schmitz, N | 1 |
| Kayser, W | 1 |
| Löffler, H | 1 |
| Rosner, F | 1 |
| Bartolucci, AA | 1 |
| Liu, C | 1 |
| Durant, JR | 1 |
| Gams, RA | 1 |
| Auclerc, MF | 1 |
| Maral, J | 1 |
| Tawil, E | 1 |
| Mercier, JP | 1 |
| Lichtman, SM | 1 |
| Brody, J | 1 |
| Kaplan, MH | 1 |
| Susin, M | 1 |
| Koduru, P | 1 |
| Goh, JC | 1 |
| Varterasian, ML | 1 |
| Aref, A | 1 |
| Karanes, C | 1 |
| Young, RC | 3 |
| Anderson, T | 1 |
| DeVita, VT | 4 |
| Garrett, MJ | 1 |
| Das, S | 1 |
| Smith, JD | 1 |
| Freedman, LS | 1 |
| Shellabarger, CJ | 1 |
| Holtzman, S | 1 |
| Stone, JP | 1 |
| Sieber, SM | 1 |
| Adamson, RH | 1 |
| Nissen, NI | 1 |
| Pajak, TF | 1 |
| Glidewell, O | 1 |
| Pedersen-Bjergaard, J | 1 |
| Stutzman, L | 1 |
| Falkson, G | 1 |
| Cuttner, J | 1 |
| Blom, J | 1 |
| Leone, L | 1 |
| Sawitsky, A | 1 |
| Coleman, M | 1 |
| Haurani, F | 1 |
| Spurr, CL | 1 |
| Harley, JB | 1 |
| Seligman, B | 1 |
| Cornell, C | 1 |
| Henry, P | 1 |
| Senn, HJ | 1 |
| Brunner, K | 1 |
| Martz, G | 1 |
| Maurice, P | 1 |
| Bank, A | 1 |
| Shapiro, L | 1 |
| James, GW | 1 |
| Holland, JF | 1 |
| Lennan, RM | 1 |
| Taylor, HR | 1 |
| Poleksic, S | 1 |
| Yeung, KY | 1 |
| Crafts, DC | 1 |
| Townsend, J | 1 |
| Wilson, CB | 1 |
| Levin, VA | 1 |
| Lokich, JJ | 1 |
| Viviani, S | 1 |
| Bonadonna, G | 1 |
| Santoro, A | 1 |
| Zanini, M | 1 |
| Zucali, R | 1 |
| Negretti, E | 1 |
| Valagussa, P | 1 |
| Burgers, JM | 1 |
| Somers, R | 1 |
| Henry-Amar, M | 1 |
| Tarayre, M | 1 |
| Carde, P | 1 |
| Thomas, J | 1 |
| Hagenbeek, A | 1 |
| Monconduit, M | 1 |
| de Pauw, BE | 1 |
| Breed, WP | 1 |
| Petru, E | 1 |
| Schmähl, D | 1 |
| Anderson, H | 1 |
| Crowther, D | 1 |
| Deakin, DP | 1 |
| Ryder, WD | 1 |
| Radford, JA | 1 |
| Jenkin, D | 1 |
| Doyle, J | 1 |
| Berry, M | 1 |
| Blanchette, V | 1 |
| Chan, H | 1 |
| Doherty, M | 1 |
| Freedman, M | 1 |
| Greenberg, M | 1 |
| Panzarella, T | 1 |
| Saunders, F | 1 |
| Longo, DL | 2 |
| Glatstein, E | 1 |
| Ihde, DC | 1 |
| Jaffe, ES | 1 |
| Straus, DJ | 1 |
| Kobayashi, Y | 1 |
| Yasunaga, Y | 1 |
| Yoshioka, T | 1 |
| Matsuda, M | 1 |
| Oritani, K | 1 |
| Kuyama, J | 1 |
| Ohnishi, S | 1 |
| Tada, Y | 1 |
| Miyagawa, M | 1 |
| Zulian, GB | 1 |
| Mirimanoff, RO | 1 |
| Bell, BA | 1 |
| Esseltine, DW | 1 |
| Freeman, CR | 1 |
| Takaue, Y | 1 |
| Sullivan, MP | 1 |
| Ramirez, I | 1 |
| Cleary, KR | 1 |
| van Eys, J | 1 |
| Hancock, SL | 1 |
| Hoppe, RT | 1 |
| Horning, SJ | 1 |
| Rosenberg, SA | 1 |
| Zandecki, M | 1 |
| Dupriez, B | 1 |
| Laï, JL | 1 |
| Fenaux, P | 1 |
| Facon, T | 1 |
| Lepelley, P | 1 |
| Estienne, MH | 1 |
| Huart, JJ | 1 |
| Jouet, JP | 1 |
| España, P | 1 |
| Bonilla, F | 1 |
| Yebra, M | 1 |
| Diego, J | 1 |
| Alvarez de Mon, M | 1 |
| Marazuela, M | 1 |
| Durántez, A | 1 |
| Sans-Sabrafen, J | 1 |
| Pedro Olivé, C | 1 |
| Buxó Costa, J | 1 |
| Pardo Peret, P | 1 |
| Rodríguez Ferrera, JC | 1 |
| Woessner, S | 1 |
| Galofré, M | 1 |
| Rodríguez Méndez, F | 1 |
| Eridani, S | 1 |
| Singh, AK | 1 |
| Blayney, DW | 1 |
| Greene, MH | 1 |
| Hubbard, SM | 1 |
| Postal, MG | 1 |
| Duffey, PL | 1 |
| Perri, RT | 1 |
| Allen, JI | 1 |
| Oken, MM | 1 |
| Limas, C | 1 |
| Kay, NE | 1 |
| Musto, P | 1 |
| Lucchi, T | 1 |
| Barbieri, D | 1 |
| Ferraresi, P | 1 |
| Lanza, F | 1 |
| Sahakian, GJ | 1 |
| al-Mondhiry, H | 1 |
| Lacher, MJ | 1 |
| Connolly, CE | 1 |
| Mims, CH | 1 |
| Costanzi, JJ | 1 |
| Arseneau, JC | 1 |
| Canellos, GP | 1 |
| Sherins, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial of Combined Weekly Bortezomib and Tositumomab I-131 in Patients With Relapsed or Refractory Follicular Non-Hodg[NCT00479167] | Phase 2 | 1 participants (Actual) | Interventional | 2007-05-31 | Terminated (stopped due to Lack of accrual and interest in study) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for procarbazine and Multiple Primary Neoplasms
| Article | Year |
|---|---|
Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cobalt Radioisotopes; | 1984 |
Non-Hodgkin's lymphoma occurring after Hodgkin's disease. Four new cases and a review of the literature.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; | 1984 |
The treatment of Hodgkin's disease: emphasizing programs at the Clinic Center, National Institutes of Health.
Topics: Adult; Bleomycin; Bone Marrow; Child; Clinical Trials as Topic; Drug Therapy, Combination; Female; H | 1977 |
Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Hod | 1991 |
Treatment of advanced Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Top | 1989 |
[Acute lymphoblastic leukemia, Burkitt-cell type, after Hodgkin's disease. Study of 2 cases].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; H | 1987 |
Recently recognized complications of cancer chemotherapy.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cyclophosphamide; Death, Sudden; Drug Therapy, Combination; | 1974 |
9 trials available for procarbazine and Multiple Primary Neoplasms
| Article | Year |
|---|---|
Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Female; Hodgkin | 1983 |
The treatment of Hodgkin's disease: emphasizing programs at the Clinic Center, National Institutes of Health.
Topics: Adult; Bleomycin; Bone Marrow; Child; Clinical Trials as Topic; Drug Therapy, Combination; Female; H | 1977 |
A comparative study of a BCNU containing 4-drug program versus MOPP versus 3-drug combinations in advanced Hodgkin's disease: a cooperative study by the Cancer and Leukemia Group B.
Topics: Adult; Antineoplastic Agents; Carmustine; Clinical Trials as Topic; Drug Therapy, Combination; Femal | 1979 |
Alternating versus hybrid MOPP-ABVD in Hodgkin's disease: the Milan experience.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarba | 1991 |
Management of relapse and survival in advanced stage Hodgkin's disease: the EORTC experience.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cause of Death; | 1991 |
A randomised study of adjuvant MVPP chemotherapy after mantle radiotherapy in pathologically staged IA-IIB Hodgkin's disease: 10-year follow-up.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female | 1991 |
The treatment of indolent lymphomas: watchful waiting v aggressive combined modality treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Doxorub | 1988 |
Treatment of advanced Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Top | 1989 |
Intercurrent death after Hodgkin disease therapy in radiotherapy and adjuvant MOPP trials.
Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Cardiovascular Diseases; Clinica | 1988 |
29 other studies available for procarbazine and Multiple Primary Neoplasms
| Article | Year |
|---|---|
[Composite lymphoma consisting of Hodgkin lymphoma and follicular lymphoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Groin; Hodgkin Disease; Humans; Ly | 2009 |
Concurrent mediastinal B cell lymphoma and chronic myeloid leukemia with an unusually favorable response to chemotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Clone Cells; Combined Modal | 2003 |
[Second tumor following Hodgkin's disease].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Presc | 1984 |
Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Combined Modality Therapy; Drug Resistanc | 1984 |
Cancer and secondary leukemia.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Child; Child, Preschool; Female; | 1983 |
[Acute leukemias and solid tumors in the course of Hodgkin disease].
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoco | 1983 |
Second malignancy complicating Hodgkin's disease.
Topics: Acute Disease; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cycloph | 1983 |
Hodgkin's disease and non-Hodgkin's lymphoma in an HIV positive patient.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cyclophosphamide; Dexametha | 1993 |
A blood stem cell transplant in a person with concomitant Hodgkin disease and testicular carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Germinoma; Hematopoietic | 1997 |
Long term experience with combination chemotherapy in advanced Hodgkin's disease.
Topics: Adult; Antineoplastic Agents; Bleomycin; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; | 1977 |
Apparent rat strain-related sensitivity to phorbol promotion of mammary carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenofibroma; Animals; Drug Synergism; Female; Leu | 1979 |
Discussion: some comments on the potential carcinogenicity of the clinically useful antitumor agents.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Haplorhi | 1977 |
Optic neuroretinitis in association with BCNU and procarbazine therapy.
Topics: Carmustine; Drug Therapy, Combination; Humans; Leukemia, Plasma Cell; Male; Middle Aged; Multiple My | 1978 |
Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease?
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Therapy, Combination; Hodgkin Disease; Humans; | 1978 |
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Therapy, Combination; Female; Hodgkin Dise | 1978 |
Secondary uncommon solid neoplasms in cured Hodgkin's disease and follow-up of the original B-DOPA chemotherapy patient group.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Dacarbaz | 1990 |
Hodgkin's disease in children: treatment with MOPP and low-dose, extended field irradiation without laparotomy. Late results and toxicity.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modali | 1990 |
[Triple malignancy including bladder carcinoma, prostate carcinoma and malignant lymphoma: a case report].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; | 1989 |
Ten-year nodular sclerosis Hodgkin's disease and second malignancies.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hodgkin Di | 1989 |
Hodgkin's disease following Wilms' tumor: a case report.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hodgk | 1987 |
Second malignant neoplasm in treated Hodgkin's disease. Report of a patient and scope of the problem.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; G | 1986 |
[Second tumors in patients treated for Hodgkin's disease].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modali | 1988 |
[Hodgkin's disease. Study of 100 cases].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Th | 1987 |
Gastric non-Hodgkin's lymphoma after successful treatment of Hodgkin's disease.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Celiac Disease; Hodgkin Disease; Humans; Immun | 1986 |
Decreasing risk of leukemia with prolonged follow-up after chemotherapy and radiotherapy for Hodgkin's disease.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Combined Modality Therapy; | 1987 |
Simultaneous presentation of relapsing Hodgkin's disease and treatment-related non-Hodgkin's lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; Humans; | 1985 |
[Acute lymphoblastic leukemia L3 in Hodgkin's disease in remission: primary or secondary leukosis?].
Topics: Antineoplastic Combined Chemotherapy Protocols; Hodgkin Disease; Humans; Karyotyping; Leukemia, Lymp | 1985 |
Acute leukemia in Hodgkin's disease.
Topics: Adult; Bleomycin; Carmustine; Chlorambucil; Drug Therapy, Combination; Female; Hodgkin Disease; Huma | 1974 |
Conversion of Hodgkin's disease to lymphoblastic lymphosarcoma.
Topics: Aged; Cyclophosphamide; Doxorubicin; Female; Hodgkin Disease; Humans; Liver; Lymph Node Excision; Ly | 1974 |