procarbazine has been researched along with Lymph Node Metastasis in 26 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-one patients with metastatic melanoma were treated synchronously with procarbazine and radiotherapy." | 7.67 | Effective palliation of melanoma with procarbazine and radiotherapy given by a low-dose fractionation schedule. ( Abbott, RL; Ahmad, A; Gill, PG; Zeicmanis, J, 1986) |
| "Twenty-one patients with metastatic melanoma were treated synchronously with procarbazine and radiotherapy." | 3.67 | Effective palliation of melanoma with procarbazine and radiotherapy given by a low-dose fractionation schedule. ( Abbott, RL; Ahmad, A; Gill, PG; Zeicmanis, J, 1986) |
| "Sixty two patients with metastases of testicular teratoblastoma were subjected to combination chemotherapy." | 2.65 | [Combined chemotherapy of the metastases of testicular teratoblastomas]. ( Orel, NF, 1979) |
| "The treatment strategies of Hodgkin's lymphoma (HL) are different according to clinical stage and risk factors, yet the optimal treatment strategy remains unclear." | 1.34 | [Treatment results of stage IA Hodgkin lymphoma: a report of 97 cases]. ( Hu, DS; Hu, S; Song, QB; Tan, WY; Wei, L; Zeng, FY; Zhou, LQ, 2007) |
| "Of 6 patients who developed recurrence, 3 (7." | 1.33 | [Comparison of preliminary results of involved-field with extended field radiotherapy combined with chemotherapy for early stage Hodgkin's disease]. ( Han, JZ; Jin, J; Li, YX; Liu, XF; Liu, YP; Song, YW; Wang, SL; Wang, WH; Yu, ZH; Zhou, LQ, 2006) |
| "Treatment strategies in Hodgkin's disease have an impact on different risk factors." | 1.32 | Does bulky disease at diagnosis influence outcome in childhood Hodgkin's disease and require higher radiation doses? Results from the German-Austrian Pediatric Multicenter Trial DAL-HD-90. ( Dieckmann, K; Heinzl, H; Hofmann, J; Pötter, R; Schellong, G; Wagner, W, 2003) |
| "Seventeen patients with advanced stage Hodgkin's disease who relapsed or failed to respond to multiple regimens of combination chemotherapy (mostly Mechlorethamine, Vincristine, Procarbarzine, Prednisone and Adriamycin, Bleomycin, Vinblastine, Dacarbazine) were treated with accelerated hyperfractionated total lymphoid irradiation (TLI) and high-dose chemotherapy followed by autologous bone marrow transplantation (AuBMT)." | 1.28 | Total lymphoid irradiation, high-dose chemotherapy and autologous bone marrow transplantation for chemotherapy-resistant Hodgkin's disease. ( Clarkson, B; Fuks, Z; Gulati, S; Shank, B; Yahalom, J, 1989) |
| "The rate of recurrence formation was found to be in a significant correlation with general symptoms, age, size of the largest cluster of involved lymph nodes, combination of drugs and type of consolidating therapy." | 1.27 | [Peculiarities of the recurrence of lymphogranulomatosis in children following combined chemotherapy]. ( Kharatishvili, ZV; Kolygin, BA, 1983) |
| "Most of the children with Hodgkin's disease diagnosed before or during puberty can be cured with chemotherapy alone, and thus will not suffer from the damaging late effects of radiotherapy." | 1.27 | Treatment of Hodgkin's disease in children with or without radiotherapy. ( Behrendt, H; Van Bunningen, BN; Van Leeuwen, EF, 1987) |
| "Nineteen patients with Hodgkin's disease who relapsed primarily in nodal sites after intensive combination chemotherapy were retreated with wide-field radiation therapy alone or with additional chemotherapy between January 1971 and December 1984." | 1.27 | Wide-field radiation therapy alone or with chemotherapy for Hodgkin's disease in relapse from combination chemotherapy. ( Mauch, P; Rosenthal, D; Skarin, A; Tarbell, N; Weinstein, H, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (61.54) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gallamini, A | 1 |
| Tarella, C | 1 |
| Viviani, S | 2 |
| Rossi, A | 1 |
| Patti, C | 1 |
| Mulé, A | 1 |
| Picardi, M | 1 |
| Romano, A | 1 |
| Cantonetti, M | 1 |
| La Nasa, G | 1 |
| Trentin, L | 1 |
| Bolis, S | 1 |
| Rapezzi, D | 1 |
| Battistini, R | 1 |
| Gottardi, D | 1 |
| Gavarotti, P | 1 |
| Corradini, P | 1 |
| Cimminiello, M | 1 |
| Schiavotto, C | 1 |
| Parvis, G | 1 |
| Zanotti, R | 1 |
| Gini, G | 1 |
| Ferreri, AJM | 1 |
| Viero, P | 1 |
| Miglino, M | 1 |
| Billio, A | 1 |
| Avigdor, A | 1 |
| Biggi, A | 1 |
| Fallanca, F | 1 |
| Ficola, U | 1 |
| Gregianin, M | 1 |
| Chiaravalloti, A | 1 |
| Prosperini, G | 1 |
| Bergesio, F | 1 |
| Chauvie, S | 1 |
| Pavoni, C | 1 |
| Gianni, AM | 1 |
| Rambaldi, A | 1 |
| Sasse, S | 1 |
| Goergen, H | 1 |
| Plütschow, A | 1 |
| Böll, B | 1 |
| Eichenauer, DA | 1 |
| Fuchs, M | 1 |
| Behringer, K | 1 |
| Zijlstra, JM | 1 |
| Greil, R | 1 |
| Markova, J | 1 |
| Topp, MS | 1 |
| Meissner, J | 1 |
| Neubauer, A | 1 |
| Baues, C | 1 |
| Engert, A | 1 |
| Borchmann, P | 1 |
| von Tresckow, B | 1 |
| Dieckmann, K | 1 |
| Pötter, R | 1 |
| Hofmann, J | 1 |
| Heinzl, H | 1 |
| Wagner, W | 1 |
| Schellong, G | 2 |
| Cakar, M | 1 |
| Aksoy, S | 1 |
| Kilickap, S | 1 |
| Harputluoglu, H | 1 |
| Erman, M | 1 |
| Wang, WH | 1 |
| Li, YX | 1 |
| Song, YW | 1 |
| Jin, J | 1 |
| Liu, YP | 1 |
| Wang, SL | 1 |
| Zhou, LQ | 2 |
| Liu, XF | 1 |
| Yu, ZH | 1 |
| Han, JZ | 1 |
| Tan, WY | 1 |
| Hu, DS | 1 |
| Zeng, FY | 1 |
| Song, QB | 1 |
| Hu, S | 1 |
| Wei, L | 1 |
| Perevodchikova, NI | 1 |
| Bychkov, MB | 1 |
| Ausekar, BV | 1 |
| Kolygin, BA | 1 |
| Kharatishvili, ZV | 1 |
| Chisesi, T | 1 |
| Ricciardi, O | 1 |
| Dal Fior, S | 1 |
| Cappellari, F | 1 |
| Pozza, F | 1 |
| Dini, E | 1 |
| Schoengen, A | 1 |
| Orel, NF | 1 |
| Desforges, JF | 1 |
| Rutherford, CJ | 1 |
| Straus, DJ | 1 |
| Gaynor, JJ | 1 |
| Myers, J | 1 |
| Merke, DP | 1 |
| Caravelli, J | 1 |
| Chapman, D | 1 |
| Yahalom, J | 2 |
| Clarkson, BD | 1 |
| Solidoro, A | 1 |
| Payet, C | 1 |
| Sanchez-Lihon, J | 1 |
| Montalbetti, JA | 1 |
| Kaaden, R | 1 |
| Zwack, K | 1 |
| Wienbeck, M | 1 |
| Klotz, E | 1 |
| Bonadonna, G | 1 |
| Santoro, A | 1 |
| Zanini, M | 1 |
| Zucali, R | 1 |
| Negretti, E | 1 |
| Valagussa, P | 1 |
| Gill, PG | 1 |
| Abbott, RL | 1 |
| Ahmad, A | 1 |
| Zeicmanis, J | 1 |
| Behrendt, H | 1 |
| Van Bunningen, BN | 1 |
| Van Leeuwen, EF | 1 |
| Lawlor, E | 1 |
| O'Briain, DS | 1 |
| Finn, T | 1 |
| Ward, R | 1 |
| Rogers, FM | 1 |
| O'Brien, AA | 1 |
| Daly, PA | 1 |
| Gulati, S | 1 |
| Shank, B | 1 |
| Clarkson, B | 1 |
| Fuks, Z | 1 |
| Kanda, H | 1 |
| Hachisuka, K | 1 |
| Yamaguchi, A | 1 |
| Isogai, M | 1 |
| Kato, J | 1 |
| Matsushita, M | 1 |
| Oda, T | 1 |
| Harakawa, I | 1 |
| Kuze, S | 1 |
| Mayumi, T | 1 |
| Brämswig, JH | 1 |
| Schwarze, EW | 1 |
| Wannenmacher, M | 1 |
| Mauch, P | 1 |
| Tarbell, N | 1 |
| Skarin, A | 1 |
| Rosenthal, D | 1 |
| Weinstein, H | 1 |
| Lokich, JJ | 1 |
| Pinkus, GS | 1 |
| Moloney, WC | 1 |
| Gershanovich, ML | 1 |
| Semenov, II | 1 |
| Gutterman, JU | 1 |
| Mavligit, G | 1 |
| Gottlieb, JA | 1 |
| Burgess, MA | 1 |
| McBride, CE | 1 |
| Einhorn, L | 1 |
| Freireich, EJ | 1 |
| Hersh, EM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Clinical Study With Early Treatment Intensification In Patients With High- Risk Hodgkin Lymphoma, Identified As FDG-PET Scan Positive After 2 Conventional ABVD Courses[NCT00795613] | Phase 2 | 450 participants (Anticipated) | Interventional | 2008-06-30 | Active, not recruiting | ||
| [NCT00265018] | Phase 3 | 1,370 participants (Actual) | Interventional | 1998-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for procarbazine and Lymph Node Metastasis
| Article | Year |
|---|---|
Early Chemotherapy Intensification With Escalated BEACOPP in Patients With Advanced-Stage Hodgkin Lymphoma With a Positive Interim Positron Emission Tomography/Computed Tomography Scan After Two ABVD Cycles: Long-Term Results of the GITIL/FIL HD 0607 Tria
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Daca | 2018 |
Outcome of Patients With Early-Stage Infradiaphragmatic Hodgkin Lymphoma: A Comprehensive Analysis From the German Hodgkin Study Group.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemoradiotherap | 2018 |
[Combined chemotherapy of the metastases of testicular teratoblastomas].
Topics: Adolescent; Adult; Aged; Bleomycin; Choriocarcinoma; Cisplatin; Clinical Trials as Topic; Cyclophosp | 1979 |
Prognostic factors among 185 adults with newly diagnosed advanced Hodgkin's disease treated with alternating potentially noncross-resistant chemotherapy and intermediate-dose radiation therapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Doxorubicin; Female; | 1990 |
Alternating versus hybrid MOPP-ABVD in Hodgkin's disease: the Milan experience.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarba | 1991 |
An approach to reduce treatment and invasive staging in childhood Hodgkin's disease: the sequence of the German DAL multicenter studies.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials | 1988 |
20 other studies available for procarbazine and Lymph Node Metastasis
| Article | Year |
|---|---|
Does bulky disease at diagnosis influence outcome in childhood Hodgkin's disease and require higher radiation doses? Results from the German-Austrian Pediatric Multicenter Trial DAL-HD-90.
Topics: Adolescent; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Pres | 2003 |
Procarbazine, lomustine, vincristine combination may be effective in adult medulloblastoma patients with systemic metastases.
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; | 2005 |
[Comparison of preliminary results of involved-field with extended field radiotherapy combined with chemotherapy for early stage Hodgkin's disease].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modalit | 2006 |
[Treatment results of stage IA Hodgkin lymphoma: a report of 97 cases].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Co | 2007 |
[Adriamycin in the combined chemotherapy of small-cell lung cancer].
Topics: Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Lomustine; | 1983 |
[Peculiarities of the recurrence of lymphogranulomatosis in children following combined chemotherapy].
Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophos | 1983 |
Treatment of early stage Hodgkin's disease with radiation therapy plus short-cycle (3 MOPP) adjuvant chemotherapy.
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Evaluation S | 1983 |
[Chemotherapy of non-Hodgkin lymphomas].
Topics: Adult; Burkitt Lymphoma; Child; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Hairy | 1980 |
Management of Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Agents; Drug Therapy, Combination; Hodgkin Disease; Humans; Lympha | 1979 |
Gastric lymphomas: chemotherapy as a primary treatment.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomyci | 1990 |
[Icteric cholestasis as an early symptom in Hodgkin's disease].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bleomycin; Cholestasis; Cyclophospham | 1990 |
Effective palliation of melanoma with procarbazine and radiotherapy given by a low-dose fractionation schedule.
Topics: Brain Neoplasms; Combined Modality Therapy; Humans; Lymphatic Metastasis; Male; Melanoma; Palliative | 1986 |
Treatment of Hodgkin's disease in children with or without radiotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Child, Preschool; Daca | 1987 |
The simultaneous presentation of peripheral T-cell lymphoma and hairy cell leukemia.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Antineoplastic C | 1987 |
Total lymphoid irradiation, high-dose chemotherapy and autologous bone marrow transplantation for chemotherapy-resistant Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Combi | 1989 |
[Treatment of primary gastric lymphoma and factors that influence the prognosis].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophospha | 1988 |
Wide-field radiation therapy alone or with chemotherapy for Hodgkin's disease in relapse from combination chemotherapy.
Topics: Actuarial Analysis; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child, Presch | 1987 |
Hodgkin's disease in the elderly.
Topics: Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Liver Neoplasms | 1974 |
[Rational schemes of chemotherapy in different pulmonary forms of lymphogranulomatosis].
Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Cyclophosphamide; Drug | 1973 |
Chemoimmunotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and bacillus calmette--guérin.
Topics: Adult; Aged; Amides; Antibody Formation; Antineoplastic Agents; BCG Vaccine; Carmustine; Drug Therap | 1974 |