procarbazine has been researched along with Injuries, Radiation in 32 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Procarbazine was recognized as major gonadotoxic agent in boys and eliminated successively from the treatment regimens." | 2.53 | Late Effects Following Treatment of Hodgkin Lymphoma During Childhood and Adolescence. Results of the Hodgkin Lymphoma Late Effects Research Project. ( Brämswig, J; Dörffel, W; Lüders, H; Riepenhausen, M, 2016) |
| "Reporting the first case of localized Hodgkin lymphoma treated with protontherapy in France." | 1.51 | Protontherapy versus best photon for mediastinal Hodgkin lymphoma: Dosimetry comparison and treatment using ILROG guidelines. ( Abbassi, LM; Arsène-Henry, A; Dendale, R; Goudjil, F; Kirova, YM, 2019) |
| "Adaptation of patients with Hodgkin's lymphoma can take place only after successful treatment, the probability of relapse and fear of repeated courses strongly interfere with this process, especially in the first years after its closure." | 1.42 | [Hodgkin's lymphoma and radiotherapy]. ( Datsenko, PV; Panshin, GA, 2015) |
| "The majority of patients with Hodgkin's disease can be cured by combination of polychemotherapy and radiotherapy (RT) that can produce late toxic pulmonary and cardiac effects which often remain at a subclinical level." | 1.36 | Cardiopulmonary toxicity of different chemoradiotherapy combined regimens for Hodgkin's disease. ( Bonfante, V; Busia, A; Laffranchi, A; Villani, F; Viviani, S, 2010) |
| "Therefore, 126 patients suffering from Hodgkin's disease were investigated after a follow-up of at least 5 years from the completion of the combined treatment." | 1.35 | Cardiopulmonary response to exercise in patients with different degrees of lung toxicity after radio-chemotherapy for Hodgkin's disease. ( Bonfante, V; Busia, A; Laffranchi, A; Villani, F; Villani, M; Viviani, S, 2009) |
| "Epilepsy was the most important risk factor for disability." | 1.32 | Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap. ( Jereb, B; Macedoni-Luksic, M; Todorovski, L, 2003) |
| " There were three fatal toxic events, two due to viral infection and one to a second malignant tumor (NHL)." | 1.28 | Hodgkin's disease in children: treatment with MOPP and low-dose, extended field irradiation without laparotomy. Late results and toxicity. ( Berry, M; Blanchette, V; Chan, H; Doherty, M; Doyle, J; Freedman, M; Greenberg, M; Jenkin, D; Panzarella, T; Saunders, F, 1990) |
| "Radiation pericarditis was accompanied either by feebly marked signs or no signs at all." | 1.27 | [Radiation pericarditis following treatment of lymphogranulomatosis]. ( Baĭsogolov, GD; Shapiro, IB; Shishkin, IP, 1983) |
| "A 27 year old man with Hodgkin's disease experienced three separate episodes of chest pain, each occurring on the sixth day of a cycle of mustargen, oncovin, procarbazine, prednisone (MOPP) combination chermotherapy." | 1.26 | Unusual cardiac reaction to chemotherapy following mediastinal irradiation in a patient with Hodgkin's disease. ( Greenwald, ES; Grossman, J; Weinstein, P, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (37.50) | 18.7374 |
| 1990's | 8 (25.00) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abbassi, LM | 1 |
| Goudjil, F | 1 |
| Arsène-Henry, A | 1 |
| Dendale, R | 1 |
| Kirova, YM | 1 |
| Datsenko, PV | 1 |
| Panshin, GA | 1 |
| Dörffel, W | 1 |
| Riepenhausen, M | 1 |
| Lüders, H | 1 |
| Brämswig, J | 1 |
| Villani, F | 2 |
| Busia, A | 2 |
| Villani, M | 1 |
| Laffranchi, A | 2 |
| Viviani, S | 2 |
| Bonfante, V | 2 |
| Schlienger, M | 1 |
| Ferroir, JP | 1 |
| Huguet, F | 1 |
| Deluen, F | 1 |
| Pène, F | 1 |
| Marseguerra, R | 1 |
| Touboul, E | 1 |
| Macedoni-Luksic, M | 1 |
| Jereb, B | 1 |
| Todorovski, L | 1 |
| Lai, R | 1 |
| Abrey, LE | 2 |
| Rosenblum, MK | 1 |
| DeAngelis, LM | 2 |
| Eich, HT | 2 |
| Haverkamp, U | 1 |
| Engert, A | 2 |
| Kocher, M | 1 |
| Skripnitchenko, R | 1 |
| Brillant, C | 1 |
| Sehlen, S | 1 |
| Dühmke, E | 2 |
| Diehl, V | 2 |
| Müller, RP | 2 |
| Fisher, B | 1 |
| Seiferheld, W | 1 |
| Schultz, C | 1 |
| DeAngelis, L | 1 |
| Nelson, D | 1 |
| Schold, SC | 1 |
| Curran, W | 1 |
| Mehta, M | 1 |
| Klimm, B | 1 |
| Haverkamp, H | 1 |
| Lohri, A | 1 |
| Koch, P | 1 |
| Boissevain, F | 1 |
| Trenn, G | 1 |
| Worst, P | 1 |
| Müller-Hermelink, K | 1 |
| Pfistner, B | 1 |
| Collis, CH | 1 |
| Baĭsogolov, GD | 2 |
| Shishkin, IP | 1 |
| Shapiro, IB | 1 |
| Fuller, LM | 1 |
| Gamble, JF | 1 |
| Velazquez, WS | 1 |
| Rodgers, RW | 1 |
| Butler, JJ | 1 |
| North, LB | 1 |
| Martin, RG | 1 |
| Gehan, EA | 1 |
| Shullenberger, CC | 1 |
| Scholz, KH | 1 |
| Herrmann, C | 1 |
| Tebbe, U | 1 |
| Chemnitius, JM | 1 |
| Helmchen, U | 1 |
| Kreuzer, H | 1 |
| Ilveskoski, I | 1 |
| Saarinen, UM | 1 |
| Wiklund, T | 1 |
| Perkkiö, M | 1 |
| Salmi, TT | 1 |
| Lanning, M | 1 |
| Mäkipernaa, A | 1 |
| Pihko, H | 1 |
| Aisenberg, AC | 1 |
| Yahalom, J | 1 |
| Lange, B | 1 |
| Littman, P | 1 |
| Schnaufer, L | 1 |
| Evans, A | 1 |
| Young, RC | 1 |
| Johnson, RE | 1 |
| Canellos, GP | 2 |
| Chabner, BA | 1 |
| Brereton, HD | 1 |
| Berard, CW | 1 |
| DeVita, VT | 1 |
| Hellman, S | 2 |
| Mauch, P | 1 |
| Goodman, RL | 1 |
| Rosenthal, DS | 2 |
| Moloney, WC | 1 |
| Weinstein, P | 1 |
| Greenwald, ES | 1 |
| Grossman, J | 1 |
| Allavena, C | 1 |
| Conroy, T | 1 |
| Aletti, P | 1 |
| Bey, P | 1 |
| Lederlin, P | 1 |
| Belkov, SA | 1 |
| Andriukhin, VI | 1 |
| Korsakov, VB | 1 |
| Pugachev, VF | 1 |
| Riazantsev, EA | 1 |
| Morris, ID | 1 |
| Shalet, SM | 1 |
| Jenkin, D | 2 |
| Doyle, J | 2 |
| Berry, M | 1 |
| Blanchette, V | 1 |
| Chan, H | 1 |
| Doherty, M | 1 |
| Freedman, M | 1 |
| Greenberg, M | 1 |
| Panzarella, T | 1 |
| Saunders, F | 1 |
| Trovò, MG | 1 |
| Minatel, E | 1 |
| Veronesi, A | 1 |
| Roncadin, M | 1 |
| De Paoli, A | 1 |
| Franchin, G | 1 |
| Magri, DM | 1 |
| Tirelli, U | 1 |
| Carbone, A | 1 |
| Grigoletto, E | 1 |
| Mauch, PM | 1 |
| Rosenberg, SA | 1 |
| Kaplan, HS | 1 |
| Morgenstern, D | 1 |
| Fleischer, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Improving the Therapeutic Ratio by Using Proton Beam Radiation Therapy for Patients With Stage IA-IIIBX (Bulky/Non-bulky) Hodgkin Lymphoma Involving the Mediastinum Following Standard Chemotherapy[NCT00850200] | 20 participants (Actual) | Interventional | 2009-08-31 | Completed | |||
| Evaluation of Late Treatment Effects in Long-Term Survivors of Hodgkin's Disease Previously Treated at NIH: A Multi-Institutional Trial[NCT00924131] | 157 participants (Anticipated) | Observational | 2009-04-17 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00850200)
Timeframe: Immediately proceeding completion of each of the three treatment plans
| Intervention | percentage of body receiving 4 Gy (Median) |
|---|---|
| Proton Radiation Plan | 0.161 |
| Conventional Photon Radiation Plan | 0.291 |
| Intensity Modulated Radiation Plan | 0.355 |
Disease free survival as assessed with the Kaplan-Meier product limit method (NCT00850200)
Timeframe: 4 years after beginning of radiation therapy
| Intervention | percentage of participants (Number) |
|---|---|
| Treated Cohort | 93 |
Overall survival as assessed with the Kaplan-Meier product limit method. (NCT00850200)
Timeframe: 4 years after beginning of radiation therapy
| Intervention | percentage of participants (Number) |
|---|---|
| Treated Cohort | 92 |
7 reviews available for procarbazine and Injuries, Radiation
| Article | Year |
|---|---|
Late Effects Following Treatment of Hodgkin Lymphoma During Childhood and Adolescence. Results of the Hodgkin Lymphoma Late Effects Research Project.
Topics: Adolescent; Child; Combined Modality Therapy; Early Detection of Cancer; Heart; Hodgkin Disease; Hum | 2016 |
[Dropped Head Syndrome after whiplash injury in a patient treated for a Hodgkin's lymphoma by mantle field radiotherapy].
Topics: Accidents, Traffic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cervical Plexus; Cerv | 2013 |
Treatment-induced leukoencephalopathy in primary CNS lymphoma: a clinical and autopsy study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Cranial Irradia | 2004 |
Lung damage from cytotoxic drugs.
Topics: Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Carmustine; Chlorambucil; Cyclophosphamide | 1980 |
Myocardial infarction in young patients with Hodgkin's disease--potential pathogenic role of radiotherapy, chemotherapy, and splenectomy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Coronar | 1993 |
Problems in Hodgkin's disease management.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplant | 1999 |
Protection of gonadal function from cytotoxic chemotherapy and irradiation.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Dogs; Doxorubicin; Female; Humans; Male | 1990 |
8 trials available for procarbazine and Injuries, Radiation
| Article | Year |
|---|---|
Biophysical analysis of the acute toxicity of radiotherapy in Hodgkin's lymphoma--a comparison between extended field and involved field radiotherapy based on the data of the German Hodgkin Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dacarbazine; Doxorubici | 2005 |
Secondary analysis of Radiation Therapy Oncology Group study (RTOG) 9310: an intergroup phase II combined modality treatment of primary central nervous system lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Cognition; Combined Modality | 2005 |
Poorer outcome of elderly patients treated with extended-field radiotherapy compared with involved-field radiotherapy after chemotherapy for Hodgkin's lymphoma: an analysis from the German Hodgkin Study Group.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modalit | 2007 |
Ototoxicity in children with malignant brain tumors treated with the "8 in 1" chemotherapy protocol.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; | 1996 |
Treatment for primary CNS lymphoma: the next step.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous Syst | 2000 |
Advanced lymphocytic lymphoma: randomized comparisons of chemotherapy and radiotherapy, alone or in combination.
Topics: Adult; Aged; Blood Platelets; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; | 1977 |
Combined radiotherapy and chemotherapy versus radiotherapy alone in locally advanced epidermoid bronchogenic carcinoma. A randomized study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; C | 1990 |
The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin's disease: 1962-1984.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Combine | 1985 |
17 other studies available for procarbazine and Injuries, Radiation
| Article | Year |
|---|---|
Protontherapy versus best photon for mediastinal Hodgkin lymphoma: Dosimetry comparison and treatment using ILROG guidelines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxorubicin; Etoposide; | 2019 |
[Hodgkin's lymphoma and radiotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Chemotherapy, A | 2015 |
Cardiopulmonary response to exercise in patients with different degrees of lung toxicity after radio-chemotherapy for Hodgkin's disease.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cardiovascular Diseases; Com | 2009 |
Cardiopulmonary toxicity of different chemoradiotherapy combined regimens for Hodgkin's disease.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cardiovascular Diseases; Com | 2010 |
Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Brain; Brain Damage, Chronic; B | 2003 |
[Radiation pericarditis following treatment of lymphogranulomatosis].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclop | 1983 |
Evaluation of the significance of prognostic factors in stage III Hodgkin's disease treated with MOPP and radiotherapy.
Topics: Adult; Antineoplastic Agents; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Hepati | 1980 |
Treatment of advanced Hodgkin's disease in pediatric patients.
Topics: Adolescent; Amenorrhea; Antineoplastic Agents; Bone Marrow; Child; Cyclophosphamide; Female; Hodgkin | 1978 |
The place of radiation therapy in the treatment of Hodgkin's disease.
Topics: Adult; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Male; Mechlorethamine; Myocardial | 1978 |
Unusual cardiac reaction to chemotherapy following mediastinal irradiation in a patient with Hodgkin's disease.
Topics: Adult; Drug Therapy, Combination; Heart; Hodgkin Disease; Humans; Male; Mechlorethamine; Mediastinal | 1976 |
Late cardiopulmonary toxicity after treatment for Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Exerci | 1992 |
[Plasmapheresis in the treatment of cytostatic disease in patients with lymphogranulomatosis].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; | 1991 |
Hodgkin's disease in children: treatment with MOPP and low-dose, extended field irradiation without laparotomy. Late results and toxicity.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modali | 1990 |
Pediatric Hodgkin's disease. Later results and toxicity--the Toronto experience.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Follow | 1989 |
[Clinical studies of the diagnosis and treatment of Hodgkin's disease (1967-1986)].
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Female; | 1987 |
Reduction of fatal complications from combined modality therapy in Hodgkin's disease.
Topics: Actuarial Analysis; Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Pro | 1985 |
[Changes in the lung in lymphogranulomatosis and the results of cytostatic treatment].
Topics: Antibiotics, Antineoplastic; Cyclophosphamide; Diagnosis, Differential; Hodgkin Disease; Lung; Lymph | 1974 |