procarbazine has been researched along with Infertility in 13 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Infertility: A reduced or absent capacity to reproduce.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Buserelin (d-Ser-[TBU]6 LHRH ethylamide) was prescribed in two different dosage schedules to twenty men, and in a single dosage schedule to eight women." | 2.66 | Failure to preserve fertility in patients with Hodgkin's disease. ( Ahmed, R; Besser, GM; Crowther, D; Gregory, W; Malpas, JS; Rees, LH; Shalet, S; Smith, D; Waxman, JH; Wrigley, PF, 1987) |
| "The majority of patients with advanced Hodgkin's lymphoma are cured with currently available therapy, such as ABVD (Adriamycin [doxorubicin], bleomycin, vinblastine, and dacarbazine)." | 2.44 | Is BEACOPP better than ABVD? ( Cheson, BD, 2007) |
| "Most patients with early-stage Hodgkin's disease can now be cured by one of several therapeutic approaches." | 2.37 | Early-stage Hodgkin's disease: current approaches to treatment. ( MacKenzie, R; Rusthoven, JJ, 1985) |
| "Although it is accepted that pediatric cancer treatment harbors a risk of gonadal damage, large cohort studies using up-to-date fertility markers are lacking." | 1.35 | Effect of childhood cancer treatment on fertility markers in adult male long-term survivors. ( Dohle, GR; Hählen, K; Hakvoort-Cammel, FG; van Casteren, NJ; van den Heuvel-Eibrink, MM; van der Linden, GH, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Casteren, NJ | 1 |
| van der Linden, GH | 1 |
| Hakvoort-Cammel, FG | 1 |
| Hählen, K | 1 |
| Dohle, GR | 1 |
| van den Heuvel-Eibrink, MM | 1 |
| Cheson, BD | 1 |
| Diehl, V | 2 |
| Fuchs, M | 1 |
| Mauch, PM | 1 |
| Weinstein, H | 1 |
| Botnick, L | 1 |
| Belli, J | 1 |
| Cassady, JR | 1 |
| Chryssanthou, CP | 1 |
| Wallach, RC | 1 |
| Atchison, M | 1 |
| Bokemeyer, C | 1 |
| Schmoll, HJ | 1 |
| van Rhee, J | 1 |
| Kuczyk, M | 1 |
| Schuppert, F | 1 |
| Poliwoda, H | 1 |
| Carde, P | 1 |
| Cavalli, F | 1 |
| Franklin, J | 1 |
| Stutzman, L | 1 |
| Longo, DL | 1 |
| Glatstein, E | 1 |
| Duffey, PL | 1 |
| Young, RC | 1 |
| Hubbard, SM | 1 |
| Urba, WJ | 1 |
| Wesley, MN | 1 |
| Raubitschek, A | 1 |
| Jaffe, ES | 1 |
| Wiernik, PH | 1 |
| Glode, LM | 1 |
| Shannon, JM | 1 |
| Malik, N | 1 |
| Nett, T | 1 |
| Waxman, JH | 1 |
| Ahmed, R | 1 |
| Smith, D | 1 |
| Wrigley, PF | 1 |
| Gregory, W | 1 |
| Shalet, S | 1 |
| Crowther, D | 1 |
| Rees, LH | 1 |
| Besser, GM | 1 |
| Malpas, JS | 1 |
| Rosenberg, SA | 1 |
| Kaplan, HS | 1 |
| Rusthoven, JJ | 1 |
| MacKenzie, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Optimization of the Primary Therapy for Patients With Hodgkin's Lymphoma and Evaluation of the Positron Emission Tomography (PET) as a Diagnostic Tool for Primary Staging and Assessment of the Effects of the Therapy[NCT00188149] | Phase 4 | 300 participants | Interventional | 2000-05-31 | Recruiting | ||
| Ovarian Tissue Freezing For Fertility Preservation In Women Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen: A Study By The National Physicians Cooperative of the Oncofertility Consortium At Northwestern University[NCT00902720] | Phase 4 | 25 participants (Anticipated) | Interventional | 2009-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for procarbazine and Infertility
| Article | Year |
|---|---|
Is BEACOPP better than ABVD?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Topic; Cyclophosphamid | 2007 |
Will BEACOPP be the standard for high risk Hodgkin lymphoma patients in advanced stages?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Topic; Cyclophosphamid | 2007 |
Is escalated BEACOPP a standard therapy for advanced Hodgkin's disease?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Clinical Trials, Phase III | 2000 |
Current status of treatment of lymphomas.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combin | 1975 |
Early-stage Hodgkin's disease: current approaches to treatment.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fem | 1985 |
3 trials available for procarbazine and Infertility
| Article | Year |
|---|---|
Radiation therapy versus combination chemotherapy in the treatment of early-stage Hodgkin's disease: seven-year results of a prospective randomized trial.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Follow-Up Studies; | 1991 |
Failure to preserve fertility in patients with Hodgkin's disease.
Topics: Amenorrhea; Animals; Antineoplastic Combined Chemotherapy Protocols; Buserelin; Dogs; Female; Follic | 1987 |
The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin's disease: 1962-1984.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Combine | 1985 |
5 other studies available for procarbazine and Infertility
| Article | Year |
|---|---|
Effect of childhood cancer treatment on fertility markers in adult male long-term survivors.
Topics: Biomarkers; Child, Preschool; Cyclophosphamide; Female; Fertility; Follicle Stimulating Hormone; Fol | 2009 |
An evaluation of long-term survival and treatment complications in children with Hodgkin's disease.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Drug Therapy, Combination; Evalua | 1983 |
Meiotic chromosomal changes and sterility produced by nitrogen mustard and procarbazine in mice.
Topics: Animals; Animals, Newborn; Chromosome Aberrations; Female; Infertility; Litter Size; Male; Meiosis; | 1983 |
Long-term gonadal toxicity after therapy for Hodgkin's and non-Hodgkin's lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclop | 1994 |
Protection of rat spermatogenic epithelium from damage induced by procarbazine chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Child; Danazol; Epithelium; Estradiol; Gona | 1990 |