procarbazine has been researched along with Hematologic Diseases in 14 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Hematologic Diseases: Disorders of the blood and blood forming tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty six (17 males) patients with glioblastoma (GBL), median age 55 years, median Karnofsky Index (KI) 70/100, and 11 patients (9 males) with anaplastic astrocytoma (AA), median age 56 years, median KI 70/100 were treated at recurrence with dibromodulcitol (DBD) 1400 mg/m2 on day 1, BCNU 150 mg/m2 on day 2, and procarbazine (PCZ) 150 mg/day on days 1 to 15." | 9.08 | Response of recurrent glioblastoma and anaplastic astrocytoma to dibromodulcitol, BCNU and procarbazine--a phase-II study. ( De Witte, O; Hildebrand, J; Sahmoud, T, 1998) |
| "Sixty-five previously untreated patients with metastatic malignant melanoma were treated with lomustine, vincristine, and procarbazine." | 7.67 | Lomustine, vincristine, and procarbazine in the treatment of metastatic malignant melanoma. ( Bodurtha, A; Iscoe, N; Paterson, A; Quirt, I; Russell, J; Shelley, W; Young, V, 1985) |
| "Twenty six (17 males) patients with glioblastoma (GBL), median age 55 years, median Karnofsky Index (KI) 70/100, and 11 patients (9 males) with anaplastic astrocytoma (AA), median age 56 years, median KI 70/100 were treated at recurrence with dibromodulcitol (DBD) 1400 mg/m2 on day 1, BCNU 150 mg/m2 on day 2, and procarbazine (PCZ) 150 mg/day on days 1 to 15." | 5.08 | Response of recurrent glioblastoma and anaplastic astrocytoma to dibromodulcitol, BCNU and procarbazine--a phase-II study. ( De Witte, O; Hildebrand, J; Sahmoud, T, 1998) |
| "Sixty-five previously untreated patients with metastatic malignant melanoma were treated with lomustine, vincristine, and procarbazine." | 3.67 | Lomustine, vincristine, and procarbazine in the treatment of metastatic malignant melanoma. ( Bodurtha, A; Iscoe, N; Paterson, A; Quirt, I; Russell, J; Shelley, W; Young, V, 1985) |
| "Because of the diffuse nature of gliomatosis cerebri (GC), surgery is not suitable, and large field radiotherapy carries the risk of severe toxicity." | 2.71 | Initial chemotherapy in gliomatosis cerebri. ( Carpentier, A; Cartalat-Carel, S; Chinot, O; Cougnard, J; Delattre, JY; Djafari, L; Duffau, H; Gervais, H; Hoang-Xuan, K; Honnorat, J; Laigle, F; Mokhtari, K; Napolitano, M; Sanson, M; Taillandier, L; Taillibert, S, 2004) |
| " Prospective pharmacokinetic studies to devise a rational dosing strategy for vinblastine in patients receiving ritonavir/lopinavir are warranted." | 1.38 | Incidence, predictors and significance of severe toxicity in patients with human immunodeficiency virus-associated Hodgkin lymphoma. ( Boro, J; Cheung, MC; Ezzat, HM; Harris, M; Hicks, LK; Leitch, HA; Lima, VD; Montaner, JS, 2012) |
| " This observation suggests a strategy of individualized dosing adapted to hematotoxicity." | 1.32 | Low acute hematological toxicity during chemotherapy predicts reduced disease control in advanced Hodgkin's disease. ( Brosteanu, O; Diehl, V; Hasenclever, D; Loeffler, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aoki, H | 1 |
| Ogura, R | 1 |
| Tsukamoto, Y | 1 |
| Okada, M | 1 |
| Natsumeda, M | 1 |
| Isogawa, M | 1 |
| Yoshida, S | 1 |
| Fujii, Y | 1 |
| Ezzat, HM | 1 |
| Cheung, MC | 1 |
| Hicks, LK | 1 |
| Boro, J | 1 |
| Montaner, JS | 1 |
| Lima, VD | 1 |
| Harris, M | 1 |
| Leitch, HA | 1 |
| Tsimberidou, AM | 1 |
| McLaughlin, P | 1 |
| Younes, A | 1 |
| Rodriguez, MA | 1 |
| Hagemeister, FB | 1 |
| Sarris, A | 1 |
| Romaguera, J | 1 |
| Hess, M | 1 |
| Smith, TL | 1 |
| Yang, Y | 1 |
| Ayala, A | 1 |
| Preti, A | 1 |
| Lee, MS | 1 |
| Cabanillas, F | 1 |
| Brosteanu, O | 1 |
| Hasenclever, D | 1 |
| Loeffler, M | 1 |
| Diehl, V | 2 |
| Martinelli, G | 1 |
| Cocorocchio, E | 1 |
| Peccatori, F | 1 |
| Zucca, E | 1 |
| Saletti, PC | 1 |
| Calabrese, L | 1 |
| Pastano, R | 1 |
| Pruneri, G | 1 |
| Mazzetta, C | 1 |
| Ghielmini, M | 1 |
| Cavalli, F | 2 |
| Sanson, M | 1 |
| Cartalat-Carel, S | 1 |
| Taillibert, S | 1 |
| Napolitano, M | 1 |
| Djafari, L | 1 |
| Cougnard, J | 1 |
| Gervais, H | 1 |
| Laigle, F | 1 |
| Carpentier, A | 1 |
| Mokhtari, K | 1 |
| Taillandier, L | 1 |
| Chinot, O | 1 |
| Duffau, H | 1 |
| Honnorat, J | 1 |
| Hoang-Xuan, K | 1 |
| Delattre, JY | 1 |
| Bakemeier, RF | 1 |
| Anderson, JR | 1 |
| Costello, W | 1 |
| Rosner, G | 1 |
| Horton, J | 1 |
| Glick, JH | 1 |
| Hines, JD | 1 |
| Berard, CW | 1 |
| DeVita, VT | 1 |
| Hildebrand, J | 1 |
| De Witte, O | 1 |
| Sahmoud, T | 1 |
| Jakacki, RI | 1 |
| Siffert, J | 1 |
| Jamison, C | 1 |
| Velasquez, L | 1 |
| Allen, JC | 1 |
| Carde, P | 1 |
| Franklin, J | 1 |
| Peiffert, D | 1 |
| Bey, P | 1 |
| Lederlin, P | 1 |
| Conroy, T | 1 |
| Witz, F | 1 |
| Shelley, W | 1 |
| Quirt, I | 1 |
| Bodurtha, A | 1 |
| Iscoe, N | 1 |
| Russell, J | 1 |
| Paterson, A | 1 |
| Young, V | 1 |
| Bakchine, H | 1 |
| Brauner, R | 1 |
| Thibaud, E | 1 |
| Rappaport, R | 1 |
| Flamant, F | 1 |
| Griscelli, C | 1 |
| Lemerle, J | 1 |
| Schaison, G | 1 |
| Schweisguth, O | 1 |
| Zucker, JM | 1 |
| Durant, JR | 1 |
| Lessner, HE | 1 |
2 reviews available for procarbazine and Hematologic Diseases
| Article | Year |
|---|---|
Is escalated BEACOPP a standard therapy for advanced Hodgkin's disease?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Clinical Trials, Phase III | 2000 |
[Immediate hematological toxicity during combination chemotherapy-radiotherapy of Hodgkin's disease].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Blood Cell Count | 1989 |
4 trials available for procarbazine and Hematologic Diseases
| Article | Year |
|---|---|
Fludarabine, mitoxantrone, dexamethasone (FND) compared with an alternating triple therapy (ATT) regimen in patients with stage IV indolent lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; beta 2-Microglobulin; Bleomycin; Cispla | 2002 |
Initial chemotherapy in gliomatosis cerebri.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin | 2004 |
BCVPP chemotherapy for advanced Hodgkin's disease: evidence for greater duration of complete remission, greater survival, and less toxicity than with a MOPP regimen. Results of the Eastern Cooperative Oncology Group study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Carmustine; Clinical Trials | 1984 |
Response of recurrent glioblastoma and anaplastic astrocytoma to dibromodulcitol, BCNU and procarbazine--a phase-II study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Female; Glioblastoma; H | 1998 |
8 other studies available for procarbazine and Hematologic Diseases
| Article | Year |
|---|---|
Advantages of dose-dense methotrexate protocol for primary central nervous system lymphoma: comparison of two different protocols at a single institution.
Topics: Academies and Institutes; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic C | 2013 |
Incidence, predictors and significance of severe toxicity in patients with human immunodeficiency virus-associated Hodgkin lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Bleomy | 2012 |
Low acute hematological toxicity during chemotherapy predicts reduced disease control in advanced Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow; Cohort Studies; Cyclophospha | 2004 |
ChlVPP/ABVVP, a first line 'hybrid' combination chemotherapy for advanced Hodgkin's lymphoma: a retrospective analysis.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Di | 2004 |
Dose-intensive, time-compressed procarbazine, CCNU, vincristine (PCV) with peripheral blood stem cell support and concurrent radiation in patients with newly diagnosed high-grade gliomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Res | 1999 |
Lomustine, vincristine, and procarbazine in the treatment of metastatic malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Hematologic Diseases; Humans; L | 1985 |
[Chemotherapy and ovarian function. Retrospective analysis in 17 girls treated for malignant tumor or hematologic disease].
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Pre | 1986 |
Development of four-drug BCNU combination chemotherapy regimens.
Topics: Carmustine; Cyclophosphamide; Evaluation Studies as Topic; Hematologic Diseases; Hodgkin Disease; Hu | 1973 |