procarbazine has been researched along with Experimental Neoplasms in 30 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A human medulloblastoma (BN-2) and a glioblastoma (BN-3) which were previously established in nude mice were used to determine the effect of combined modality therapy with gamma-radiation, and three chemotherapeutic agents, procarbazine, 1,4-cyclohexadiene-1,4-dicarbamic acid, 2,5-bis(1-aziridinyl)-3,6-dioxo diethylester (AZQ), and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)." | 3.66 | Combined modality treatment using radiation and/or chemotherapy in an athymic nude mouse-human medulloblastoma and glioblastoma xenograft model. ( Feola, J; Houchens, DP; Ovejera, AA; Slagel, DE, 1982) |
| "Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin." | 3.66 | In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity. ( Fodstad, O; Olsnes, S; Pihl, A; Tveit, KM, 1980) |
| "Intracerebral murine glioma 26 was used as a model system for evaluating two-drug combinations of antitumor agents, BCNU was combined with either procarbazine, dianhydrogalactitol, or ellipticine." | 3.66 | Correlations between experimental chemotherapy in the murine glioma and effectiveness of clinical therapy regimens. ( Levin, VA; Wilson, CB, 1978) |
| " Dose-response relationships of 3 triple-drug combinations and their component agents were explored, allowing the relative contributions of single agents in each combination to be assessed." | 1.26 | Experimental combination and single-agent chemotherapy in human lung-tumour xenografts. ( Jones, JM; Peckham, MJ; Shorthouse, AJ; Steel, GG, 1982) |
| "Seven human brain tumors were transplanted into the brains (6/7 takes) and subcutaneous tissues (7/7 takes) of athymic nude mice." | 1.26 | Human brain tumor transplantation into nude mice. ( Basler, GA; Chernik, NL; Posner, JB; Shapiro, WR, 1979) |
| "The chromosomes of the Ehrlich ascites tumor have been studied by means of both Q-banding and G-banding." | 1.26 | The effect of procarbazine on the chromosomes of normal and malignant mouse cells. ( Rapp, M; Therman, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (96.67) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schold, SC | 1 |
| Bigner, DD | 1 |
| Shorthouse, AJ | 1 |
| Jones, JM | 1 |
| Steel, GG | 1 |
| Peckham, MJ | 1 |
| Floersheim, GL | 1 |
| Slagel, DE | 1 |
| Feola, J | 1 |
| Houchens, DP | 1 |
| Ovejera, AA | 1 |
| Bacci, M | 1 |
| Cavaliere, A | 1 |
| Fratini, D | 1 |
| Bello, JL | 1 |
| Kariev, NI | 1 |
| Mainardi, JV | 1 |
| Betancourt, M | 1 |
| Lage, A | 1 |
| Barroso, MC | 1 |
| Alfonso, L | 1 |
| Senapati, N | 1 |
| Houchens, D | 1 |
| Ovejera, A | 1 |
| Beard, R | 1 |
| Nines, R | 1 |
| Tveit, KM | 1 |
| Fodstad, O | 3 |
| Olsnes, S | 1 |
| Pihl, A | 3 |
| Aass, N | 2 |
| Hoffmann, CC | 1 |
| Ehrke, MJ | 1 |
| Mihich, E | 1 |
| Lemon, HM | 1 |
| Volm, M | 2 |
| Faufmann, M | 1 |
| MAttern, J | 2 |
| Wayss, K | 2 |
| Weisburger, JH | 1 |
| Griswold, DP | 1 |
| Prejean, JD | 1 |
| Casey, AE | 1 |
| Wood, HB | 1 |
| Weisburger, EK | 1 |
| Sieber, SM | 1 |
| Adamson, RH | 1 |
| Shapiro, WR | 2 |
| Basler, GA | 1 |
| Chernik, NL | 1 |
| Posner, JB | 2 |
| Broder, LE | 1 |
| Weintraub, BD | 1 |
| Rosen, SW | 1 |
| Rapp, M | 1 |
| Therman, E | 1 |
| Hasegawa, H | 1 |
| Weinstock, LT | 1 |
| Cheng, CC | 1 |
| Levin, VA | 1 |
| Wilson, CB | 1 |
| Rogers, AE | 1 |
| Akhtar, R | 1 |
| Zeisel, SH | 1 |
| Nikonova, TV | 1 |
| Draudin-Krylenko, VA | 1 |
| Bukin, IuV | 1 |
| Turusov, VS | 1 |
| Kaufmann, M | 1 |
| Goerttler, K | 1 |
| Kline, I | 1 |
| Heinrich, M | 1 |
| Osswald, H | 1 |
| Vormittag, W | 1 |
| Zubrod, CG | 1 |
| Friedl, HP | 1 |
| Karrer, K | 1 |
| Kühböck, J | 1 |
1 review available for procarbazine and Experimental Neoplasms
| Article | Year |
|---|---|
Present status of cancer chemotherapy.
Topics: Alkylating Agents; Animals; Anti-Bacterial Agents; Antimetabolites; Carmustine; DNA, Neoplasm; Evalu | 1974 |
29 other studies available for procarbazine and Experimental Neoplasms
| Article | Year |
|---|---|
Treatment of five subcutaneous human glioma tumor lines in athymic mice with carmustine, procarbazine, and mithramycin.
Topics: Animals; Carmustine; Disease Models, Animal; Drug Therapy, Combination; Glioma; Humans; Mice; Mice, | 1983 |
Experimental combination and single-agent chemotherapy in human lung-tumour xenografts.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carc | 1982 |
Comparative growth of human tumors in pharmacologically immunosuppressed, immune-deprived, cyclosporin A-treated and nude mice.
Topics: Animals; Antilymphocyte Serum; Cyclophosphamide; Cyclosporins; Cytarabine; Humans; Male; Mice; Mice, | 1982 |
Procarbazine hydrochloride.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Female; Haplorhini; Humans; Male; Maternal-Feta | 1981 |
Combined modality treatment using radiation and/or chemotherapy in an athymic nude mouse-human medulloblastoma and glioblastoma xenograft model.
Topics: Animals; Aziridines; Benzoquinones; Brain Neoplasms; Carmustine; Cell Line; Glioma; Humans; Medullob | 1982 |
Lung carcinogenesis by procarbazine chlorate in BALB/c mice.
Topics: Animals; Female; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Procarbaz | 1982 |
Experimental approach for the search of effective drug combination in cancer chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Leukemi | 1982 |
Ultrasonic hyperthermia and drugs as therapy for human tumor xenografts.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Synergism; Female; Hot Temp | 1982 |
In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity.
Topics: Abrin; Animals; Antineoplastic Agents; Dacarbazine; Humans; Lomustine; Melanoma; Mice; Mice, Nude; N | 1980 |
Response to chemotherapy of human, malignant melanoma xenografts in athymic, nude mice.
Topics: Abrin; Animals; Antineoplastic Agents; Dacarbazine; Humans; Lomustine; Melanoma; Mice; Mice, Nude; N | 1980 |
An inverse relationship between the growth rate of human melanoma xenografts and their response to some cytostatic drugs.
Topics: Animals; Dacarbazine; Humans; Lomustine; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Neopl | 1980 |
Temporal specificity of procarbazine in the inhibition of mouse immune responses to allogeneic tumor.
Topics: Animals; Female; Immunization; Immunosuppressive Agents; Mast-Cell Sarcoma; Mice; Mice, Inbred C57BL | 1979 |
Estriol prevention of mammary carcinoma induced by 7,12-dimethylbenzanthracene and procarbazine.
Topics: Animals; Benz(a)Anthracenes; Carcinogens; Castration; Corticosterone; Dehydroepiandrosterone; Estrad | 1975 |
Sensitivity tests of tumors to cytostatic agents. I. Comparative investigations on transplanted tumors in vivo and in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Division; Cricetinae; Da | 1975 |
The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinogens; Chlorambucil; Cyclophosphamide; Dacarbazine; Dactinomyc | 1975 |
Discussion: some comments on the potential carcinogenicity of the clinically useful antitumor agents.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Haplorhi | 1977 |
Human brain tumor transplantation into nude mice.
Topics: Animals; Brain Neoplasms; Carmustine; Glioblastoma; Humans; Mice; Mice, Nude; Neoplasm Transplantati | 1979 |
Influence of chemotherapeutic agents on chorionic gonadotropin-alpha subunit secretion in a human lung cancer cell line (ChaGo): discordance of cytotoxic and secretory effects.
Topics: Antineoplastic Agents; Cell Division; Cell Line; Chorionic Gonadotropin; Dactinomycin; Hormones, Ect | 1978 |
The effect of procarbazine on the chromosomes of normal and malignant mouse cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Transformation, Neoplastic; Chromosomes; Drug Evaluation, Pr | 1977 |
Chemotherapy of experimental metastatic brain tumors in female Wistar rats.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Carotid Arteries; Cells, Cul | 1979 |
A structural modification study of procarbazine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; In Vitro Techniques; Leukemia L121 | 1979 |
Correlations between experimental chemotherapy in the murine glioma and effectiveness of clinical therapy regimens.
Topics: Animals; Carmustine; Dianhydrogalactitol; Drug Therapy, Combination; Ellipticines; Glioma; Lomustine | 1978 |
Procarbazine carcinogenicity in methotrexate-treated or lipotrope-deficient male rats.
Topics: Animals; Carcinogens; Choline Deficiency; Leukemia, Experimental; Lipid Metabolism; Liver; Male; Mam | 1990 |
[Protective action of nicotinamide and pyridoxine on the initiation stage of carcinogenesis induced in mice by procarbazine].
Topics: Animals; Drug Evaluation, Preclinical; Female; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neoplasms | 1988 |
[Selective tumour chemotherapy using oncobiograms (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cricetinae; Culture Techniques; Cytarabine; Dactinomycin; | 1974 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides | 1974 |
[Test of multi-step-therapy of cancer (combination of pretreatment with glucose with chemotherapy and whole body hyperthermia) in Walker- and DS-carcinosarcoma of rat (author's transl)].
Topics: Animals; Carcinoma 256, Walker; Carcinosarcoma; Cyclophosphamide; Female; Fever; Germ-Free Life; Glu | 1974 |
[Cytostatic immunosuppressive therapy, chromosomal aberrations and carcinogenic effect (author's transl)].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Chromosomes, Human, 1-3; C | 1974 |
The relation of tumour size to the results of chemotherapy in malignant tumours.
Topics: Amputation, Surgical; Animals; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Mercaptopurine | 1971 |