procarbazine has been researched along with Ependymoma in 16 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to examine the range of sensitivity of a panel of short-term cultures derived from different types of malignant childhood brain tumours including medulloblastoma, ependymoma and glioblastoma multiforme to three cytotoxic drugs, lomustine (CCNU), vincristine (VCR) and procarbazine (PCB)." | 3.70 | Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine. ( Darling, JL; Harding, B; Harkness, W; Hayward, R; Lewandowicz, GM; Thomas, DG, 2000) |
| "Sixty-five patients with malignant brain tumors were treated with a combination of BCNU (100 mg/m2 qd X 1) and procarbazine (100 mg/m2 qd X 14); the cycle was repeated in 1 month and then on a 6-week schedule with procarbazine being given for 21 days." | 2.64 | BCNU (NSC-409962) and procarbazine (NSC-77213) treatment for malignant brain tumors. ( Boldrey, EB; Crafts, DC; Elashoff, RM; Enot, KJ; Levin, VA; Pischer, TL; Schultz, MJ; Seager, M; Wilson, CB, 1976) |
| "Ependymomas represent 10% of pediatric brain tumors." | 1.43 | [Pediatric ependymomas: Current diagnosis and therapy]. ( Alapetite, C; Beuriat, PA; Faure-Conter, C; Frappaz, D; Grill, J; Szathmari, A; Vasiljevic, A, 2016) |
| "Infants and young children who have brain tumors have a poor rate of survival and high treatment associated morbidity." | 1.30 | MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. ( Ater, JL; Bruner, J; Copeland, DR; Moore, B; van Eys, J; Woo, SY, 1997) |
| "Five children with brain tumors, who had had no prior chemotherapy, were treated with combination chemotherapy including nitrogen mustard, vincristine sulfate, procarbazine, prednisolone (MOPP) and intrathecal methotrexate." | 1.27 | [Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors]. ( Akita, H; Hashimoto, T; Hirose, M; Matsumoto, K; Miki, Y; Miyao, M; Ninomiya, T; Saijo, T; Sato, J, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gramatzki, D | 1 |
| Roth, P | 1 |
| Felsberg, J | 1 |
| Hofer, S | 1 |
| Rushing, EJ | 1 |
| Hentschel, B | 1 |
| Westphal, M | 1 |
| Krex, D | 1 |
| Simon, M | 1 |
| Schnell, O | 1 |
| Wick, W | 1 |
| Reifenberger, G | 1 |
| Weller, M | 1 |
| Frappaz, D | 2 |
| Vasiljevic, A | 1 |
| Beuriat, PA | 1 |
| Alapetite, C | 1 |
| Grill, J | 2 |
| Szathmari, A | 1 |
| Faure-Conter, C | 1 |
| Vos, MJ | 1 |
| Uitdehaag, BM | 1 |
| Barkhof, F | 1 |
| Heimans, JJ | 1 |
| Baayen, HC | 1 |
| Boogerd, W | 1 |
| Castelijns, JA | 1 |
| Elkhuizen, PH | 1 |
| Postma, TJ | 1 |
| Morris, DM | 1 |
| Steinert, HR | 1 |
| Wiernik, PH | 1 |
| Röttinger, EM | 1 |
| Geyer, JR | 1 |
| Zeltzer, PM | 1 |
| Boyett, JM | 1 |
| Rorke, LB | 1 |
| Stanley, P | 1 |
| Albright, AL | 1 |
| Wisoff, JH | 1 |
| Milstein, JM | 1 |
| Allen, JC | 1 |
| Finlay, JL | 1 |
| Schuler, D | 1 |
| Somló, P | 1 |
| Koós, R | 1 |
| Kálmánchey, R | 1 |
| Paraicz, E | 1 |
| Ater, JL | 1 |
| van Eys, J | 1 |
| Woo, SY | 1 |
| Moore, B | 1 |
| Copeland, DR | 1 |
| Bruner, J | 1 |
| Lewandowicz, GM | 1 |
| Harding, B | 1 |
| Harkness, W | 1 |
| Hayward, R | 1 |
| Thomas, DG | 1 |
| Darling, JL | 1 |
| Le Deley, MC | 1 |
| Gambarelli, D | 1 |
| Raquin, MA | 1 |
| Couanet, D | 1 |
| Pierre-Kahn, A | 1 |
| Habrand, JL | 1 |
| Doz, F | 1 |
| Gentet, JC | 1 |
| Edan, C | 1 |
| Chastagner, P | 1 |
| Kalifa, C | 1 |
| Levin, VA | 2 |
| Crafts, DC | 1 |
| Wilson, CB | 2 |
| Schultz, MJ | 1 |
| Boldrey, EB | 2 |
| Enot, KJ | 2 |
| Pischer, TL | 1 |
| Seager, M | 1 |
| Elashoff, RM | 1 |
| Ertel, IJ | 1 |
| Boesel, C | 1 |
| Shapiro, WR | 1 |
| Boratyński, W | 1 |
| Sato, J | 1 |
| Ninomiya, T | 1 |
| Saijo, T | 1 |
| Akita, H | 1 |
| Miki, Y | 1 |
| Hirose, M | 1 |
| Hashimoto, T | 1 |
| Miyao, M | 1 |
| Matsumoto, K | 1 |
| Vasantha Kumar, AR | 1 |
| Renaudin, J | 1 |
2 trials available for procarbazine and Ependymoma
| Article | Year |
|---|---|
Postoperative chemotherapy without irradiation for ependymoma in children under 5 years of age: a multicenter trial of the French Society of Pediatric Oncology.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Chemotherapy, Adjuvant | 2001 |
BCNU (NSC-409962) and procarbazine (NSC-77213) treatment for malignant brain tumors.
Topics: Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, C | 1976 |
14 other studies available for procarbazine and Ependymoma
| Article | Year |
|---|---|
Chemotherapy for intracranial ependymoma in adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dis | 2016 |
[Pediatric ependymomas: Current diagnosis and therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Ependymoma; Humans; Infant; | 2016 |
Interobserver variability in the radiological assessment of response to chemotherapy in glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat | 2003 |
Ineffectiveness of chemotherapy in patients with metastatic ependymoma of the cauda equina.
Topics: Adolescent; Adult; Cauda Equina; Child; Cyclophosphamide; Dianhydrogalactitol; Ependymoma; Female; H | 1983 |
[Survival of children with primitive neuroectodermal tumors and malignant ependymomas of the central nervous system after treatment with 8 cytostatic agents in one day. A report of the Children's Cancer Group].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cytarabine; Ependymoma; | 1995 |
Survival of infants with primitive neuroectodermal tumors or malignant ependymomas of the CNS treated with eight drugs in 1 day: a report from the Childrens Cancer Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cisplatin; Cyclophospha | 1994 |
The treatment of malignant scala posterior tumors in children: II. Preliminary result of the pre- and postoperative adjuvant chemotherapy of scala posterior tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, A | 1993 |
MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Chemotherapy, | 1997 |
Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Child; Dose-Response Relationship, Drug; | 2000 |
Brain tumors in children.
Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Diagnosis, Differential; Ependymoma; Female; | 1978 |
Chemotherapy of primary malignant brain tumors in children.
Topics: Antineoplastic Agents; Brain Neoplasms; Brain Stem; Carmustine; Child; Ependymoma; Glioma; Humans; M | 1975 |
[Results of combined treatment of neoplasms of the posterior cranial fossa in children].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Cerebellar Neoplasms; Child | 1992 |
[Combination chemotherapy with MOPP and intrathecal methotrexate in children with brain tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Choroid Pl | 1986 |
Procarbazine hydrochloride in the treatment of brain tumors. Phase 2 study.
Topics: Adolescent; Adult; Anticonvulsants; Astrocytoma; Brain Neoplasms; Child; Electroencephalography; Epe | 1974 |