procarbazine has been researched along with Disease Models, Animal in 16 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of prenatal folic acid supplementation on procarbazine (PCZ)-induced intra-uterine growth retardation (IUGR), cleft palates, and microgenia." | 7.72 | Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2004) |
| "We investigated the effects of prenatal folic acid supplementation on procarbazine (PCZ)-induced intra-uterine growth retardation (IUGR), cleft palates, and microgenia." | 3.72 | Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2004) |
| "Procarbazine (P) is an effective chemotherapeutic drug especially used in lymphoma treatment; however testicular toxicity is a limiting factor." | 1.40 | The effect of melatonin on procarbazine induced testicular toxicity on rats. ( Akgül, EÖ; Alp, BF; Babacan, O; Erdem, O; Gulgun, M; Kesik, V; Korkmazer, N; Malkoç, E; Poyrazoglu, Y; Saldır, M; Yiğit, N, 2014) |
| "Because several previous authors have repeatedly described treatment with thiamine as one of the sufficient prophylactic measures in slowing the development of viscerocranial malformations, especially cleft alveolus and palate, it is of utmost importance that the timing of treatment and dosage of thiamine be taken into consideration not only in animal experiments but also when applying results to humans." | 1.30 | Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats. ( Bienengräber, V; Fanghänel, J; Kundt, G; Malek, FA, 1997) |
| "Procarbazine was ineffective." | 1.28 | The chemotherapeutic response of a murine (VM) model of human glioma. ( Bradford, R; Darling, JL; Thomas, DG, 1990) |
| "The effects of chronic administration of cyclophosphamide and procarbazine on testicular function in the rat were examined." | 1.27 | A rat model for chemotherapy-induced male infertility. ( Glode, LM; Gould, SF; Nett, T; Powell, D, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Alp, BF | 1 |
| Kesik, V | 1 |
| Malkoç, E | 1 |
| Yiğit, N | 1 |
| Saldır, M | 1 |
| Babacan, O | 1 |
| Akgül, EÖ | 1 |
| Poyrazoglu, Y | 1 |
| Korkmazer, N | 1 |
| Gulgun, M | 1 |
| Erdem, O | 1 |
| Oskooii, AE | 1 |
| Gholizad, LM | 1 |
| Zare, S | 1 |
| Nejati, V | 1 |
| Malek, FA | 2 |
| Möritz, KU | 1 |
| Fanghänel, J | 2 |
| Bienengräber, V | 2 |
| Schold, SC | 1 |
| Bigner, DD | 1 |
| Gould, SF | 1 |
| Powell, D | 1 |
| Nett, T | 1 |
| Glode, LM | 1 |
| Morris, ID | 1 |
| Kundt, G | 1 |
| Walker, MD | 1 |
| Weiss, HD | 1 |
| DeVita, VT | 1 |
| Hasegawa, H | 1 |
| Shapiro, WR | 1 |
| Posner, JB | 1 |
| Volm, M | 1 |
| Kaufmann, M | 1 |
| Mattern, J | 1 |
| Wayss, K | 1 |
| Bradford, R | 2 |
| Darling, JL | 2 |
| Sier, N | 1 |
| Thomas, DG | 2 |
| Kline, I | 1 |
| Glucksberg, H | 1 |
| Fefer, A | 1 |
3 reviews available for procarbazine and Disease Models, Animal
| Article | Year |
|---|---|
Protection against cytotoxic-induced testis damage--experimental approaches.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Infertility, Male; Male; Procarbazin | 1993 |
Chemotherapy in the treatment of malignant brain tumors.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphami | 1975 |
Human models of human diseases; breast cancer and the lymphomas.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Disease Models, Animal; Drug Therapy, Combination; | 1979 |
13 other studies available for procarbazine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
The effect of melatonin on procarbazine induced testicular toxicity on rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cytoprotection; Disease Models, Animal; Follicle Stimu | 2014 |
A comparison of effects of ABVD and ChlVPP chemotherapeutic protocols for Hodgkin's disease on rats' epididiymal and testicular tissues.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Dacarbazine; Disea | 2010 |
Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats.
Topics: Animals; Antineoplastic Agents; Cleft Palate; Dietary Supplements; Disease Models, Animal; Dose-Resp | 2004 |
Treatment of five subcutaneous human glioma tumor lines in athymic mice with carmustine, procarbazine, and mithramycin.
Topics: Animals; Carmustine; Disease Models, Animal; Drug Therapy, Combination; Glioma; Humans; Mice; Mice, | 1983 |
A rat model for chemotherapy-induced male infertility.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Disease Models, Animal; Drug Therapy, Combination; | 1983 |
Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats.
Topics: Abnormalities, Drug-Induced; Alveolar Process; Animals; Body Weight; Bone and Bones; Cleft Palate; C | 1997 |
Chemotherapy of experimental metastatic brain tumors in female Wistar rats.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Carotid Arteries; Cells, Cul | 1979 |
[Possibilities and limits of pre-therapeutic neoplasm sensitivity cytostatics tests under short-term conditions].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Cyclophosphamide; Dactinomycin; D | 1975 |
The VM model of glioma: preparation of multicellular tumour spheroids (MTS) and their response to chemotherapy.
Topics: Animals; Carmustine; Cell Division; Disease Models, Animal; Drug Screening Assays, Antitumor; Glioma | 1990 |
The chemotherapeutic response of a murine (VM) model of human glioma.
Topics: Animals; Astrocytoma; Brain Neoplasms; Carmustine; Disease Models, Animal; Lomustine; Mice; Mice, In | 1990 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides | 1974 |
Chemotherapy of established graft-versus-host disease in mice.
Topics: Animals; Benzoates; Cyclophosphamide; Disease Models, Animal; Graft vs Host Disease; Immunosuppressi | 1972 |