procarbazine has been researched along with Cleft Palate in 7 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sex-related differences in the frequency of cleft palates and microgenia in rat fetuses prenatally treated with procarbazine (200 mg/kg on day 14 of gestation (GD14), group 1), and the anti-teratogenic effect of prenatal folic acid supplementation (4 mg/kg on GD14 through GD17, group 2) were studied in LEW." | 7.72 | Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2003) |
| "We investigated the effects of prenatal folic acid supplementation on procarbazine (PCZ)-induced intra-uterine growth retardation (IUGR), cleft palates, and microgenia." | 7.72 | Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2004) |
| "In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals." | 7.71 | Is it possible to prevent cleft palate by prenatal administration of folic acid? An experimental study. ( Bienengräber, V; Fanghänel, J; Gundlach, KK; Malek, FA; Möritz, KU; Weingärtner, J, 2001) |
| "The study aimed at to induce cleft-lip-alveolus-palate (CLAP) applying procarbazine in rat fetuses at the 14(th) day of pregnancy, to supply thiocyanate and/or folic acid sufficient for preventive treatment and subsequently to investigate cleft extent in the palatal area as well as bone maturity." | 3.74 | Different bone sesitivity to malformations induced by procarbazine in fetal rats. ( Fanghanel, J; Gedrange, T; Gredes, T; Kubein-Meesenburg, D; Kundt, G; Proff, P; Weingartner, J, 2008) |
| "Sex-related differences in the frequency of cleft palates and microgenia in rat fetuses prenatally treated with procarbazine (200 mg/kg on day 14 of gestation (GD14), group 1), and the anti-teratogenic effect of prenatal folic acid supplementation (4 mg/kg on GD14 through GD17, group 2) were studied in LEW." | 3.72 | Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2003) |
| "We investigated the effects of prenatal folic acid supplementation on procarbazine (PCZ)-induced intra-uterine growth retardation (IUGR), cleft palates, and microgenia." | 3.72 | Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2004) |
| "In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals." | 3.71 | Is it possible to prevent cleft palate by prenatal administration of folic acid? An experimental study. ( Bienengräber, V; Fanghänel, J; Gundlach, KK; Malek, FA; Möritz, KU; Weingärtner, J, 2001) |
| "When thiocyanate was administered alone, an increased cleft rate was unexpectedly found for the secondary palate." | 1.32 | Do folic acid and thiocyanate have a preventive effect on exogenously induced disturbances of embryonic cranial development? ( Bienengräber, V; Fanghänel, J; Kundt, G; Martens, A; Weingärtner, J, 2004) |
| "Because several previous authors have repeatedly described treatment with thiamine as one of the sufficient prophylactic measures in slowing the development of viscerocranial malformations, especially cleft alveolus and palate, it is of utmost importance that the timing of treatment and dosage of thiamine be taken into consideration not only in animal experiments but also when applying results to humans." | 1.30 | Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats. ( Bienengräber, V; Fanghänel, J; Kundt, G; Malek, FA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weingartner, J | 3 |
| Proff, P | 1 |
| Fanghanel, J | 7 |
| Kundt, G | 4 |
| Gedrange, T | 1 |
| Kubein-Meesenburg, D | 1 |
| Gredes, T | 1 |
| Malek, FA | 4 |
| Möritz, KU | 3 |
| Bienengräber, V | 6 |
| Martens, A | 1 |
| Malek, F | 1 |
| Gundlach, KK | 1 |
7 other studies available for procarbazine and Cleft Palate
| Article | Year |
|---|---|
Different bone sesitivity to malformations induced by procarbazine in fetal rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Cleft Palate; Drug Therapy, Combination; Femal | 2008 |
Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats.
Topics: Animals; Cleft Palate; Congenital Abnormalities; Dietary Supplements; Female; Folic Acid; Male; Mand | 2003 |
Reduction of procarbazine-induced cleft palates by prenatal folic acid supplementation in rats.
Topics: Animals; Antineoplastic Agents; Cleft Palate; Dietary Supplements; Disease Models, Animal; Dose-Resp | 2004 |
Do folic acid and thiocyanate have a preventive effect on exogenously induced disturbances of embryonic cranial development?
Topics: Animals; Cleft Palate; Female; Folic Acid; Hematinics; Palate; Procarbazine; Rats; Rats, Inbred Lew; | 2004 |
Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats.
Topics: Abnormalities, Drug-Induced; Alveolar Process; Animals; Body Weight; Bone and Bones; Cleft Palate; C | 1997 |
Disturbances of palatogenesis and their prophylaxis in animal experiments.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Embryonic and Fetal Development; Female; Humans; | 1999 |
Is it possible to prevent cleft palate by prenatal administration of folic acid? An experimental study.
Topics: Animals; Chin; Cleft Palate; Female; Fetal Diseases; Folic Acid; Pilot Projects; Pregnancy; Procarba | 2001 |