procarbazine has been researched along with Cholestasis in 3 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cholestasis was observed in all cases; in most patients a moderate increase in the transaminase activity was also seen." | 1.29 | Hodgkin's disease presenting as a cholestatic febrile illness: incidence and main characteristics in a series of 421 patients. ( Briones, J; Bruguera, M; Cervantes, F; Font, C; Grau, JM; Montserrat, E; Rozman, C, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pass, AK | 1 |
| McLin, VA | 1 |
| Rushton, JR | 1 |
| Kearney, DL | 1 |
| Hastings, CA | 1 |
| Margolin, JF | 1 |
| Cervantes, F | 1 |
| Briones, J | 1 |
| Bruguera, M | 1 |
| Font, C | 1 |
| Grau, JM | 1 |
| Rozman, C | 1 |
| Montserrat, E | 1 |
| Kaaden, R | 1 |
| Zwack, K | 1 |
| Wienbeck, M | 1 |
| Klotz, E | 1 |
3 other studies available for procarbazine and Cholestasis
| Article | Year |
|---|---|
Vanishing bile duct syndrome and Hodgkin disease: a case series and review of the literature.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cholestasis; Combined Modality The | 2008 |
Hodgkin's disease presenting as a cholestatic febrile illness: incidence and main characteristics in a series of 421 patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cholestas | 1996 |
[Icteric cholestasis as an early symptom in Hodgkin's disease].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bleomycin; Cholestasis; Cyclophospham | 1990 |