procarbazine has been researched along with Cell Transformation, Neoplastic in 5 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several hydrazine derivatives (HD) tested so far have pharmacological activities, but many also have toxic side effects, including carcinogenesis." | 1.30 | Contribution of hydrazines-derived alkyl radicals to cytotoxicity and transformation induced in normal c-myc-overexpressing mouse fibroblasts. ( Armelin, MC; Cidade, MR; Gamberini, M; Leite, LC; Valotta, LA, 1998) |
| "The chromosomes of the Ehrlich ascites tumor have been studied by means of both Q-banding and G-banding." | 1.26 | The effect of procarbazine on the chromosomes of normal and malignant mouse cells. ( Rapp, M; Therman, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaplan, HS | 1 |
| Gamberini, M | 1 |
| Cidade, MR | 1 |
| Valotta, LA | 1 |
| Armelin, MC | 1 |
| Leite, LC | 1 |
| Kirchner, EM | 1 |
| Ebsen, M | 1 |
| Kirchner, J | 1 |
| Theegarten, D | 1 |
| Voigtmann, R | 1 |
| Rapp, M | 1 |
| Therman, E | 1 |
| Audubert, F | 1 |
1 review available for procarbazine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Hodgkin's disease: biology, treatment, prognosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, Neoplastic; Giant Cell Tumors; | 1981 |
4 other studies available for procarbazine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Contribution of hydrazines-derived alkyl radicals to cytotoxicity and transformation induced in normal c-myc-overexpressing mouse fibroblasts.
Topics: 3T3 Cells; Animals; Cell Survival; Cell Transformation, Neoplastic; DNA Damage; DNA Replication; Ele | 1998 |
Transformation of Hodgkin's disease to high-grade B-cell lymphoma: remission after Rituximab monotherapy.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplasti | 2001 |
The effect of procarbazine on the chromosomes of normal and malignant mouse cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Transformation, Neoplastic; Chromosomes; Drug Evaluation, Pr | 1977 |
[The action of 1-methyl-2-(p-isopropyl-carbamoyl-benzyl)-hydrazine on DNA, in vitro and in vivo (cells in culture)].
Topics: Animals; Antineoplastic Agents; Benzoates; Cell Line; Cell Transformation, Neoplastic; Cells, Cultur | 1972 |