procarbazine has been researched along with Cancer of Prostate in 11 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The national Prostatic Cancer Project has evaluated single and combination chemotherapeutic agents for the treatment of patients with advanced prostatic cancer that has been unresponsive to hormonal therapy." | 3.75 | Chemotherapy of hormonally unresponsive prostatic carcinoma. ( deKernion, JB; Lindner, A, 1984) |
| "In the past 20 years, 3,500 prostate cancer patients have been recruited in 16 phase III trials in untreated and advanced disease and in seven phase II trials in hormone-refractory, metastatic disease." | 2.69 | European Organization for Research and Treatment of Cancer (EORTC) prostate cancer trials, 1976-1996. ( Denis, L, 1998) |
| " It has become evident that DES at a dosage of 3 mg/day carries a significantly higher risk of overall cardiovascular toxicity than does cyproterone acetate, but severe cardiovascular complications did not differ between treatment groups." | 2.65 | Treatment of prostatic cancer: the EORTC experience--preliminary results of prostatic carcinoma trials. ( Schroeder, FH, 1984) |
| "Procarbazine was associated with excessive toxicity, resulting in many patients (28%) discontinuing therapy within the first 3 weeks and closure of this particular arm of the study." | 2.65 | Comparison of procarbazine, imidazole-carboxamide and cyclophosphamide in relapsing patients with advanced carcinoma of the prostate. ( Chu, TM; Gaeta, JF; Gibbons, RP; Johnson, DE; Loening, SA; Murphy, GP; Prout, GR; Saroff, J; Schmidt, JD; Scott, WW; Slack, NH; Soloway, MS, 1979) |
| "Biopsy specimen revealed malignant lymphoma." | 1.28 | [Triple malignancy including bladder carcinoma, prostate carcinoma and malignant lymphoma: a case report]. ( Kobayashi, Y; Kuyama, J; Matsuda, M; Miyagawa, M; Ohnishi, S; Oritani, K; Tada, Y; Yasunaga, Y; Yoshioka, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schroeder, FH | 1 |
| deKernion, JB | 2 |
| Lindner, A | 1 |
| Schmidt, JD | 3 |
| Scott, WW | 3 |
| Gibbons, R | 1 |
| Johnson, DE | 3 |
| Prout, GR | 3 |
| Loening, S | 1 |
| Soloway, M | 1 |
| Pontes, JE | 1 |
| Slack, NH | 2 |
| Murphy, GP | 5 |
| Denis, L | 1 |
| Saroff, J | 2 |
| Joiner, JR | 1 |
| Gibbons, RP | 2 |
| Loening, SA | 1 |
| Soloway, MS | 1 |
| Chu, TM | 1 |
| Gaeta, JF | 1 |
| Kobayashi, Y | 1 |
| Yasunaga, Y | 1 |
| Yoshioka, T | 1 |
| Matsuda, M | 1 |
| Oritani, K | 1 |
| Kuyama, J | 1 |
| Ohnishi, S | 1 |
| Tada, Y | 1 |
| Miyagawa, M | 1 |
| Portnoĭ, AS | 1 |
| Shimada, Y | 1 |
| Nagai, M | 1 |
| Irino, S | 1 |
| Uda, H | 1 |
2 reviews available for procarbazine and Cancer of Prostate
| Article | Year |
|---|---|
Chemotherapy of hormonally unresponsive prostatic carcinoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carmustine; Cispla | 1984 |
[Chemotherapy of prostatic cancer].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; | 1985 |
5 trials available for procarbazine and Cancer of Prostate
| Article | Year |
|---|---|
Treatment of prostatic cancer: the EORTC experience--preliminary results of prostatic carcinoma trials.
Topics: Castration; Clinical Trials as Topic; Combined Modality Therapy; Cyproterone; Cyproterone Acetate; D | 1984 |
Chemotherapy of hormonally unresponsive prostatic carcinoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carmustine; Cispla | 1984 |
European Organization for Research and Treatment of Cancer (EORTC) prostate cancer trials, 1976-1996.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic | 1998 |
[Chemotherapy of advanced prostate cancer].
Topics: Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Dacarbazine; Diethylstilbestrol; Drug Eval | 1977 |
Comparison of procarbazine, imidazole-carboxamide and cyclophosphamide in relapsing patients with advanced carcinoma of the prostate.
Topics: Aged; Aminoimidazole Carboxamide; Castration; Clinical Trials as Topic; Cyclophosphamide; Drug Evalu | 1979 |
5 other studies available for procarbazine and Cancer of Prostate
| Article | Year |
|---|---|
Chemotherapy programs of the National Prostatic Cancer Project (NPCP).
Topics: Antineoplastic Agents; Cyclophosphamide; Dacarbazine; Diethylstilbestrol; Drug Evaluation; Drug Ther | 1980 |
Chemotherapy of advanced prostatic cancer by the National Prostatic Cancer Group.
Topics: Antineoplastic Agents; Cyclophosphamide; Dacarbazine; Fluorouracil; Humans; Male; Procarbazine; Pros | 1976 |
[Triple malignancy including bladder carcinoma, prostate carcinoma and malignant lymphoma: a case report].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; | 1989 |
[A case of primary malignant lymphoma of the prostate].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Humans; Lymphoma; Male; Middle Age | 1987 |
Proceedings: Cancer of the prostate.
Topics: Amides; Antineoplastic Agents; Arginase; Bleomycin; Busulfan; Carbamates; Chromomycins; Cyclic P-Oxi | 1973 |