procarbazine has been researched along with Atrophy in 3 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the hypothesis that induction of reversible testicular atrophy, subsequent to withdrawal of gonadotrophin support, would alleviate the testicular toxicity of the anti-cancer drug procarbazine." | 3.68 | Prolonged suppression of spermatogenesis by oestrogen does not preserve the seminiferous epithelium in procarbazine-treated rats. ( Bardin, CW; Gunsalus, G; Morris, ID; Ward, JA, 1990) |
| "Epilepsy was the most important risk factor for disability." | 1.32 | Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap. ( Jereb, B; Macedoni-Luksic, M; Todorovski, L, 2003) |
| " LD50 at day 59 for procarbazine appears to be approximately 600 mg kg-1 body weight using this regimen." | 1.29 | Testicular cytotoxicity of intravenous procarbazine in rats. ( Doubek, WG; Janney, CG; Johnson, FE; Tolman, KC, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Macedoni-Luksic, M | 1 |
| Jereb, B | 1 |
| Todorovski, L | 1 |
| Johnson, FE | 1 |
| Doubek, WG | 1 |
| Tolman, KC | 1 |
| Janney, CG | 1 |
| Morris, ID | 1 |
| Bardin, CW | 1 |
| Gunsalus, G | 1 |
| Ward, JA | 1 |
3 other studies available for procarbazine and Atrophy
| Article | Year |
|---|---|
Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Brain; Brain Damage, Chronic; B | 2003 |
Testicular cytotoxicity of intravenous procarbazine in rats.
Topics: Animals; Atrophy; Injections, Intravenous; Male; Oligospermia; Organ Size; Procarbazine; Rats; Rats, | 1993 |
Prolonged suppression of spermatogenesis by oestrogen does not preserve the seminiferous epithelium in procarbazine-treated rats.
Topics: Analysis of Variance; Androgen-Binding Protein; Animals; Atrophy; Epithelium; Estradiol; Follicle St | 1990 |