Page last updated: 2024-11-03

procarbazine and Atrophy

procarbazine has been researched along with Atrophy in 3 studies

Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research Excerpts

ExcerptRelevanceReference
"We examined the hypothesis that induction of reversible testicular atrophy, subsequent to withdrawal of gonadotrophin support, would alleviate the testicular toxicity of the anti-cancer drug procarbazine."3.68Prolonged suppression of spermatogenesis by oestrogen does not preserve the seminiferous epithelium in procarbazine-treated rats. ( Bardin, CW; Gunsalus, G; Morris, ID; Ward, JA, 1990)
"Epilepsy was the most important risk factor for disability."1.32Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap. ( Jereb, B; Macedoni-Luksic, M; Todorovski, L, 2003)
" LD50 at day 59 for procarbazine appears to be approximately 600 mg kg-1 body weight using this regimen."1.29Testicular cytotoxicity of intravenous procarbazine in rats. ( Doubek, WG; Janney, CG; Johnson, FE; Tolman, KC, 1993)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Macedoni-Luksic, M1
Jereb, B1
Todorovski, L1
Johnson, FE1
Doubek, WG1
Tolman, KC1
Janney, CG1
Morris, ID1
Bardin, CW1
Gunsalus, G1
Ward, JA1

Other Studies

3 other studies available for procarbazine and Atrophy

ArticleYear
Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap.
    Pediatric hematology and oncology, 2003, Volume: 20, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Brain; Brain Damage, Chronic; B

2003
Testicular cytotoxicity of intravenous procarbazine in rats.
    Surgical oncology, 1993, Volume: 2, Issue:1

    Topics: Animals; Atrophy; Injections, Intravenous; Male; Oligospermia; Organ Size; Procarbazine; Rats; Rats,

1993
Prolonged suppression of spermatogenesis by oestrogen does not preserve the seminiferous epithelium in procarbazine-treated rats.
    International journal of andrology, 1990, Volume: 13, Issue:3

    Topics: Analysis of Variance; Androgen-Binding Protein; Animals; Atrophy; Epithelium; Estradiol; Follicle St

1990