Page last updated: 2024-11-03

procarbazine and Astrocytoma

procarbazine has been researched along with Astrocytoma in 97 studies

Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.

Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Research Excerpts

ExcerptRelevanceReference
"Adding temozolomide (TMZ) to radiation for patients with newly-diagnosed anaplastic astrocytomas (AAs) is common clinical practice despite the lack of prospective studies demonstrating a survival advantage."9.22The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide. ( Abuali, I; Grossman, SA; Lu, Y; Strowd, RE; Ye, X, 2016)
"The authors investigated the results of PCV chemotherapy within a cohort of 24 patients treated within the EORTC study 26971 on temozolomide chemotherapy in recurrent oligodendroglioma."9.11Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas. ( Allgeier, A; Brandes, AA; Enting, RH; Frenay, M; Kros, JM; Menten, J; Stege, EB; Taphoorn, MJ; Tosoni, A; Triebels, VH; van den Bent, MJ; van Heuvel, I, 2004)
"Temozolomide (TMZ) is an oral alkylating agent with a good safety profile and proven efficacy in the treatment of malignant glioma."9.10Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas. ( Foster, T; Newlands, ES; Zaknoen, S, 2003)
"After surgery, patients aged < or = 70 years, with World Health Organization grade 3 or 4 astrocytoma, were randomized to radiotherapy alone (RT) or RT plus procarbazine, lomustine, and vincristine (PCV) chemotherapy (RT-PCV) given at 6-week intervals to a maximum of 12 courses (procarbazine 100 mg/m2 days 1 to 10, lomustine 100 mg/m2 day 1, and vincristine 1."9.09Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. ( , 2001)
"Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma."9.08Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998)
"This study is a combined modality Phase II therapeutic trial to determine the efficacy of the novel combination of VP-16, Vincristine and Procarbazine in addition to postoperative radiation therapy in patients with high grade intracranial gliomas."9.08A therapeutic trial of radiation therapy with Vincristine, etoposide, and Procarbazine (VVP) in high grade intracranial gliomas--an Eastern Cooperative Oncology Group Study (E2392). ( Adams, G; Flynn, P; Grunnet, M; Hellman, R; Karp, D; Neuberg, DS; Robins, HI; Wagner, H, 1998)
"The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma."8.78Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992)
"IDH-mutant anaplastic astrocytomas (AAs) are chemosensitive tumors for which the best choice of adjuvant chemotherapy between procarbazine, lomustine, and vincristine (PCV) or temozolomide (TMZ) after radiotherapy (RT) remains unclear."8.02Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort. ( Bronniman, C; Carpentier, C; Ciron, DL; Dehais, C; Ducray, F; Esteyrie, V; Figarella-Branger, D; Martin, E; Moyal, EC; Network, P; Pouessel, D; Uro-Coste, E, 2021)
"We compared survival in patients with anaplastic astrocytoma (AA) treated with adjuvant procarbazine, lomustine, and vincristine (PCV) with survival in patients treated with temozolomide."7.73Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma. ( Brandes, AA; Ermani, M; Gardiman, M; Ghimenton, C; Iuzzolino, P; Nicolardi, L; Reni, M; Rotilio, A; Sotti, G; Tosoni, A, 2006)
"We have reported that carmustine (BCNU) and cisplatin administered before, during, and after radiotherapy did not improve the survival of patients with high-grade astrocytomas and were associated with more serious toxicities than radiotherapy plus BCNU."7.73Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma. ( Jung, SM; Liau, CT; Tseng, CK; Wei, KC, 2005)
"To the authors' knowledge, there is a scarcity of accurate data regarding the feasibility of standard chemotherapy with procarbazine, lomustine, and vincristine (PCV) in a homogeneous series of patients with primary anaplastic oligodendroglioma (AO) and oligoastrocytoma (AOA) that was recurrent after surgery and standard radiotherapy."7.72Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. ( Brandes, AA; Coria, B; Danieli, D; Ermani, M; Gardiman, M; Iuzzolino, P; Pasetto, LM; Talacchi, A; Tosoni, A; Vastola, F, 2004)
"A case of successful combination chemotherapy using vincristine, procarbazine, VP-16 and prednisolone to treat an inoperable low grade astrocytoma is presented."7.70Successful combination chemotherapy (vincristine, procarbazine, etoposide, and prednisolone) in the treatment of inoperable, radioresistant low grade astrocytoma: a case report. ( Janjindamai SHirunpat, S; Maipang MVasiknanonte, P, 2000)
"To determine any differences in outcome for patients with anaplastic astrocytoma (AA) treated with adjuvant carmustine (BCNU) versus procarbazine, lomustine, and vincristine (PCV) chemotherapy."7.70Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: A retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy. ( Curran, WJ; Kramer, S; Leibel, S; Nelson, DF; Prados, MD; Scott, C, 1999)
"Twenty consecutive patients with supratentorial Grade III and IV astrocytomas were treated with postoperative radiotherapy, and a simultaneous induction chemotherapy with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), procarbazine, bleomycin, and maintenance chemotherapy with CCNU."7.66Radiotherapy combined with procarbazine, bleomycin, and CCNU in the treatment of high-grade supratentorial astrocytomas. ( Greiner, RH; Markwalder, H; Seiler, RW; Zimmerman, A, 1978)
"Adding temozolomide (TMZ) to radiation for patients with newly-diagnosed anaplastic astrocytomas (AAs) is common clinical practice despite the lack of prospective studies demonstrating a survival advantage."5.22The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide. ( Abuali, I; Grossman, SA; Lu, Y; Strowd, RE; Ye, X, 2016)
" The group is now preparing a multi-institutional randomized controlled phase II/III study of chemoradiotherapy using ACNU versus procarbazine and ACNU for astrocytoma grades 3 and 4."5.11Randomized controlled trial on malignant brain tumors--activities of the Japan Clinical Oncology Group-Brain Tumor Study Group. ( Shibui, S, 2004)
"The authors investigated the results of PCV chemotherapy within a cohort of 24 patients treated within the EORTC study 26971 on temozolomide chemotherapy in recurrent oligodendroglioma."5.11Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas. ( Allgeier, A; Brandes, AA; Enting, RH; Frenay, M; Kros, JM; Menten, J; Stege, EB; Taphoorn, MJ; Tosoni, A; Triebels, VH; van den Bent, MJ; van Heuvel, I, 2004)
"Temozolomide (TMZ) is an oral alkylating agent with a good safety profile and proven efficacy in the treatment of malignant glioma."5.10Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas. ( Foster, T; Newlands, ES; Zaknoen, S, 2003)
" Between May 1992 and January 1998, eight children with unresectable or recurrent intramedullary glioma were treated with the BB SFOP protocol (a 16-month chemotherapy regimen with carboplatin, procarbazine, vincristine, cyclophosphamide, etoposide and cisplatin)."5.09Chemotherapy for unresectable and recurrent intramedullary glial tumours in children. Brain Tumours Subcommittee of the French Society of Paediatric Oncology (SFOP). ( Chastagner, P; Chouffai, Z; Couanet, D; Doireau, V; Grignon, Y; Grill, J; Kalifa, C; Lellouch-Tubiana, A; Marchal, JC; Zerah, M, 1999)
"After surgery, patients aged < or = 70 years, with World Health Organization grade 3 or 4 astrocytoma, were randomized to radiotherapy alone (RT) or RT plus procarbazine, lomustine, and vincristine (PCV) chemotherapy (RT-PCV) given at 6-week intervals to a maximum of 12 courses (procarbazine 100 mg/m2 days 1 to 10, lomustine 100 mg/m2 day 1, and vincristine 1."5.09Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. ( , 2001)
"Previous investigators have reported responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and procarbazine (MOP) for recurrent glioma."5.08Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results. ( Buckner, JC; Burch, PA; Dinapoli, RP; Galanis, E; Mailliard, JA; Morton, RF; Novotny, PJ; Rowland, KM; Schaefer, PL; Scheithauer, BW; Vukov, AM, 1998)
"This study is a combined modality Phase II therapeutic trial to determine the efficacy of the novel combination of VP-16, Vincristine and Procarbazine in addition to postoperative radiation therapy in patients with high grade intracranial gliomas."5.08A therapeutic trial of radiation therapy with Vincristine, etoposide, and Procarbazine (VVP) in high grade intracranial gliomas--an Eastern Cooperative Oncology Group Study (E2392). ( Adams, G; Flynn, P; Grunnet, M; Hellman, R; Karp, D; Neuberg, DS; Robins, HI; Wagner, H, 1998)
"Seventy-five patients harboring astrocytomas received 4 cycles of infra-ophthalmic carotid injections of BCNU, combined with vincristine intravenously and procarbazine orally."5.07Combined intra-arterial chemotherapy followed by radiation in astrocytomas. ( Hager, B; Hannisdal, E; Heier, M; Hirschberg, H; Nome, O; Watne, K; Wester, K, 1992)
"The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma."4.78Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992)
"IDH-mutant anaplastic astrocytomas (AAs) are chemosensitive tumors for which the best choice of adjuvant chemotherapy between procarbazine, lomustine, and vincristine (PCV) or temozolomide (TMZ) after radiotherapy (RT) remains unclear."4.02Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort. ( Bronniman, C; Carpentier, C; Ciron, DL; Dehais, C; Ducray, F; Esteyrie, V; Figarella-Branger, D; Martin, E; Moyal, EC; Network, P; Pouessel, D; Uro-Coste, E, 2021)
" However, a randomized controlled study (RTOG 9802) showed that adding of procarbazine, CCNU, and vincristine (PCV) chemotherapy to fractionated radiotherapy (FRT) in patients with "high-risk" WHO grade II gliomas, including DA, has significant positive impact on both progression-free survival and overall survival."3.88Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults. ( Narita, Y, 2018)
"While procarbazine with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (PC) added to vincristine (PCV) was proven beneficial in the treatment of co-deleted anaplastic oligodendroglioma (AO), the question of whether PC alone is sufficient is important, as vincristine adds toxicity with uncertain benefit."3.81PC or PCV, That Is the Question: Primary Anaplastic Oligodendroglial Tumors Treated with Procarbazine and CCNU With and Without Vincristine. ( De Groot, J; Liu, D; Shonka, N; Smith, L; Webre, C, 2015)
"We compared survival in patients with anaplastic astrocytoma (AA) treated with adjuvant procarbazine, lomustine, and vincristine (PCV) with survival in patients treated with temozolomide."3.73Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma. ( Brandes, AA; Ermani, M; Gardiman, M; Ghimenton, C; Iuzzolino, P; Nicolardi, L; Reni, M; Rotilio, A; Sotti, G; Tosoni, A, 2006)
"We have reported that carmustine (BCNU) and cisplatin administered before, during, and after radiotherapy did not improve the survival of patients with high-grade astrocytomas and were associated with more serious toxicities than radiotherapy plus BCNU."3.73Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma. ( Jung, SM; Liau, CT; Tseng, CK; Wei, KC, 2005)
"We collected 6 case-reports of symptomatric non removable low grade fibrillary astrocytoma of adults treated with a procarbazine-CCNU-vincristine chemotherapy regimen."3.72[Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults]. ( Alchaar, H; Bleuse, A; Bondiau, PY; Bourg, V; Brunetto, JL; Chanalet, S; Chatel, M; Courdi, A; Darcourt, J; Fauchon, F; Fontaine, D; Frénay, M; Grellier, P; Guibert, F; Lanteri-Minet, M; Lebrun, C; Lonjon, M; Michiels, JF; Paquis, P; Paquis, V; Ramaioli, A; Rasendrarijao, D; Vandenbos, F, 2004)
"To the authors' knowledge, there is a scarcity of accurate data regarding the feasibility of standard chemotherapy with procarbazine, lomustine, and vincristine (PCV) in a homogeneous series of patients with primary anaplastic oligodendroglioma (AO) and oligoastrocytoma (AOA) that was recurrent after surgery and standard radiotherapy."3.72Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. ( Brandes, AA; Coria, B; Danieli, D; Ermani, M; Gardiman, M; Iuzzolino, P; Pasetto, LM; Talacchi, A; Tosoni, A; Vastola, F, 2004)
"The aim of this study was to examine the range of sensitivity of a panel of short-term cultures derived from different types of malignant childhood brain tumours including medulloblastoma, ependymoma and glioblastoma multiforme to three cytotoxic drugs, lomustine (CCNU), vincristine (VCR) and procarbazine (PCB)."3.70Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine. ( Darling, JL; Harding, B; Harkness, W; Hayward, R; Lewandowicz, GM; Thomas, DG, 2000)
"A case of successful combination chemotherapy using vincristine, procarbazine, VP-16 and prednisolone to treat an inoperable low grade astrocytoma is presented."3.70Successful combination chemotherapy (vincristine, procarbazine, etoposide, and prednisolone) in the treatment of inoperable, radioresistant low grade astrocytoma: a case report. ( Janjindamai SHirunpat, S; Maipang MVasiknanonte, P, 2000)
"We report a patient who developed aplastic anemia after three courses of cyclohexylchloroethylnitrousurea (CCNU), procarbazine and oncovine administered after craniotomy and irradiation for brain astrocytoma."3.69Aplastic anemia induced by cyclohexylchloroethylnitrousurea. ( Elis, A; Lishner, M; Ravid, M; Savin, H, 1994)
"Twenty consecutive patients with supratentorial Grade III and IV astrocytomas were treated with postoperative radiotherapy, and a simultaneous induction chemotherapy with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), procarbazine, bleomycin, and maintenance chemotherapy with CCNU."3.66Radiotherapy combined with procarbazine, bleomycin, and CCNU in the treatment of high-grade supratentorial astrocytomas. ( Greiner, RH; Markwalder, H; Seiler, RW; Zimmerman, A, 1978)
"The prognosis of patients with anaplastic oligodendrogliomas (AOD) and oligoastrocytomas (AOA) is variable."2.78New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brai ( Bernsen, HJ; Brandes, AA; Delattre, JY; Frénay, M; Gorlia, T; Kouwenhoven, MC; Kros, JM; Lacombe, D; Taphoorn, MJ; Tijssen, CC; van den Bent, MJ, 2013)
"AOA tumors with necrosis are to be considered WHO grade IV tumors (GBM)."2.74Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951. ( Allgeier, A; Brandes, AA; Bromberg, JE; Gorlia, T; Grisold, W; Ibdaih, A; Kouwenhoven, MC; Kros, JM; Lacombe, D; Mirimanoff, R; Mokhtari, K; Sipos, L; Teepen, JL; van den Bent, MJ; van Duinen, SG; Vandenbos, F; Vecht, CJ; Wesseling, P, 2009)
"Because of the diffuse nature of gliomatosis cerebri (GC), surgery is not suitable, and large field radiotherapy carries the risk of severe toxicity."2.71Initial chemotherapy in gliomatosis cerebri. ( Carpentier, A; Cartalat-Carel, S; Chinot, O; Cougnard, J; Delattre, JY; Djafari, L; Duffau, H; Gervais, H; Hoang-Xuan, K; Honnorat, J; Laigle, F; Mokhtari, K; Napolitano, M; Sanson, M; Taillandier, L; Taillibert, S, 2004)
"Histologically, 69 had anaplastic astrocytoma; 14, anaplastic oligoastrocytoma; and 7, anaplastic oligodendroglioma."2.70Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas. ( Bruner, J; Chang, E; Gleason, MJ; Hess, KR; Ictech, SA; Kyritsis, A; Leeds, N; Levin, VA; Maor, MH; Meyers, CA; Yung, WK, 2002)
" Parameters were evaluated by age at diagnosis, gender, ethnic origin, pre- and postsurgery Karnofsky Performance Status (KPS) score, limit and amount of surgical resection, histopathologic type, number of chemotherapy courses, time between surgery and radiotherapy, response to combined therapy, and dosage and type of radiotherapy."2.70Long-term follow-up in managing anaplastic astrocytoma by multimodality approach with surgery followed by postoperative radiotherapy and PCV-chemotherapy: phase II trial. ( Gal, O; Kovner, F; Ron, IG; Vishne, TH, 2002)
"Estimated 4-year survival for the anaplastic astrocytoma (AA) stratum (n = 116) is 46%."2.68Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas. ( Davis, RL; Gutin, PH; Lamborn, K; Levin, VA; Phillips, TL; Prados, MR; Wara, WM; Wilson, CB, 1995)
"Seventy-nine patients harboring recurrent brain tumors received four cycles of infraophthalmic carotid injections of 160 mg of carmustine."2.67Combined intra-arterial and systemic chemotherapy for recurrent malignant brain tumors. ( Hager, B; Hannisdal, E; Hirschberg, H; Nome, O; Watne, K, 1992)
"Sixty-five patients with malignant brain tumors were treated with a combination of BCNU (100 mg/m2 qd X 1) and procarbazine (100 mg/m2 qd X 14); the cycle was repeated in 1 month and then on a 6-week schedule with procarbazine being given for 21 days."2.64BCNU (NSC-409962) and procarbazine (NSC-77213) treatment for malignant brain tumors. ( Boldrey, EB; Crafts, DC; Elashoff, RM; Enot, KJ; Levin, VA; Pischer, TL; Schultz, MJ; Seager, M; Wilson, CB, 1976)
"Most malignant brain tumors are resistant to the chemotherapeutic agents because of the existence of several mechanisms or substances such as the blood-brain barrier, genes and proteins."2.43[Resent advances in chemotherapy for malignant brain tumors]. ( Shibui, S, 2005)
"In the present study, patients with anaplastic astrocytoma treated with chemotherapy protocols other than TMZ had the longest OS; however, in the glioblastoma group, OS was 32 months in those treated with standard TMZ and 12 months in those treated with other protocols (P = 0."1.43High-grade glioma in children and adolescents: a single-center experience. ( Akalan, N; Akyuz, C; Cengiz, M; Eren, G; Gurkaynak, M; Ozyigit, G; Varan, A; Yazici, G; Yüce, D; Zorlu, F, 2016)
"Patients with neurofibromatosis type 1 (NF1) often have gliomas as a complication, most of which are benign pilocytic astrocytomas which have arisen in optic pathways."1.31Neurofibromatosis type 1-associated unusual pleomorphic astrocytoma displaying continual malignant progression. ( Hirato, J; Kamiya, M; Kurachi, H; Nakazato, Y; Sasaki, A; Yokoo, H, 2001)
"Malignant oligodendrogliomas have been shown to be responsive to chemotherapy."1.28The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy. ( Glass, J; Gruber, ML; Hochberg, FH; Louis, DN; Rattner, B; Smith, D, 1992)
"Six patients (1 anaplastic astrocytoma) have developed progressive disease."1.28VP-16, vincristine and procarbazine with radiation therapy for treatment of malignant brain tumors. ( Calogero, JA; Hellman, RM; Kaplan, BM, 1990)
"Procarbazine was ineffective."1.28The chemotherapeutic response of a murine (VM) model of human glioma. ( Bradford, R; Darling, JL; Thomas, DG, 1990)
"Secondary acute leukemias are rare in the evolution of malignant gliomas and the usefulness of subsequent radiochemotherapy cannot be questioned at the present time."1.27Two cases of acute leukemia following treatment of malignant glioma. ( Audebert, AA; Canuel, C; Debray, J; Genot, JY; Krulik, M; Poisson, M; Renoux, M; Smadja, N; van Efferterre, R, 1983)
"12 patients with brain tumors were treated with a combination of procarbazine, CCNU (bis-2-chloroethyl-3-cyclohexyl-1-nitrosourea) and vincristine."1.27Procarbazine, CCNU and vincristine (PCV) combination chemotherapy for brain tumors. ( Biran, S; Brufman, G; Catane, R; Halpern, J; Sulkes, A, 1984)
"Four who had nonirradiated anaplastic astrocytomas all responded and survived for 38+ to 48."1.27Intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and systemic chemotherapy for malignant gliomas: a follow-up study. ( Avellanosa, AM; Barua, NR; Hong, CI; Patel, A; West, CR, 1983)

Research

Studies (97)

TimeframeStudies, this research(%)All Research%
pre-199023 (23.71)18.7374
1990's25 (25.77)18.2507
2000's35 (36.08)29.6817
2010's13 (13.40)24.3611
2020's1 (1.03)2.80

Authors

AuthorsStudies
Esteyrie, V1
Dehais, C1
Martin, E1
Carpentier, C1
Uro-Coste, E1
Figarella-Branger, D1
Bronniman, C1
Pouessel, D1
Ciron, DL1
Ducray, F2
Moyal, EC1
Network, P1
Narita, Y2
Gorlia, T4
Delattre, JY2
Brandes, AA7
Kros, JM6
Taphoorn, MJ3
Kouwenhoven, MC2
Bernsen, HJ1
Frénay, M4
Tijssen, CC1
Lacombe, D3
van den Bent, MJ7
Rakotonjanahary, J1
De Carli, E1
Delion, M1
Kalifa, C2
Grill, J2
Doz, F1
Leblond, P1
Bertozzi, AI1
Rialland, X1
Webre, C1
Shonka, N1
Smith, L1
Liu, D1
De Groot, J1
Yazici, G1
Zorlu, F1
Cengiz, M1
Ozyigit, G1
Eren, G1
Yüce, D1
Varan, A2
Akyuz, C2
Akalan, N2
Gurkaynak, M1
Strowd, RE1
Abuali, I1
Ye, X1
Lu, Y1
Grossman, SA1
Buckner, JC5
Shaw, EG2
Pugh, SL1
Chakravarti, A1
Gilbert, MR1
Barger, GR1
Coons, S1
Ricci, P1
Bullard, D1
Brown, PD2
Stelzer, K1
Brachman, D1
Suh, JH1
Schultz, CJ1
Bahary, JP1
Fisher, BJ1
Kim, H1
Murtha, AD1
Bell, EH1
Won, M1
Mehta, MP1
Curran, WJ4
Combs, SE1
Schmidt-Graf, F1
Meyer, B1
Ibdaih, A2
Bromberg, JE1
Mokhtari, K3
van Duinen, SG1
Teepen, JL1
Wesseling, P2
Vandenbos, F2
Grisold, W1
Sipos, L2
Mirimanoff, R1
Vecht, CJ1
Allgeier, A2
Dubbink, HJ1
Sanson, M3
van der Lee-Haarloo, CR1
Hegi, M1
Jeuken, JW1
Dinjens, WN1
Idbaih, A1
Taphoorn, M1
Hoang-Xuan, K2
Van den Bent, M1
Ogawa, K1
Ishiuchi, S1
Inoue, O1
Yoshii, Y1
Saito, A1
Watanabe, T1
Iraha, S1
Toita, T1
Kakinohana, Y1
Ariga, T1
Kasuya, G1
Murayama, S1
Shibui, S3
Mizusawa, J1
Beppu, T1
Ogasawara, K1
Sawamura, Y1
Kobayashi, H1
Nishikawa, R1
Mishima, K1
Muragaki, Y1
Maruyama, T1
Kuratsu, J1
Nakamura, H2
Kochi, M2
Minamida, Y1
Yamaki, T1
Kumabe, T1
Tominaga, T1
Kayama, T1
Sakurada, K1
Nagane, M1
Kobayashi, K1
Ito, T1
Yazaki, T1
Sasaki, H1
Tanaka, K1
Takahashi, H1
Asai, A1
Todo, T1
Wakabayashi, T2
Takahashi, J1
Takano, S1
Fujimaki, T1
Sumi, M1
Miyakita, Y1
Nakazato, Y2
Sato, A1
Fukuda, H1
Nomura, K1
Pizer, B1
Salehzadeh, A1
Brodbelt, A1
Mallucci, C1
Afra, D2
Vitanovics, D1
Murphy, C1
Pickles, T1
Knowling, M1
Thiesse, B1
Gesme, D1
O'Fallon, JR1
Hammack, JE1
Stafford, S1
Hawkins, R1
Scheithauer, BW2
Erickson, BJ1
Levitt, R1
Jenkins, R1
Vos, MJ1
Uitdehaag, BM1
Barkhof, F1
Heimans, JJ1
Baayen, HC1
Boogerd, W1
Castelijns, JA1
Elkhuizen, PH1
Postma, TJ1
Newlands, ES1
Foster, T1
Zaknoen, S1
Lichy, MP1
Bachert, P1
Henze, M1
Lichy, CM1
Debus, J1
Schlemmer, HP1
Prados, MD4
Seiferheld, W1
Sandler, HM1
Phillips, T2
Schultz, C2
Urtasun, R2
Davis, R2
Gutin, P3
Cascino, TL2
Greenberg, HS3
Lebrun, C1
Fontaine, D1
Chanalet, S1
Bourg, V1
Alchaar, H1
Bleuse, A1
Bondiau, PY1
Brunetto, JL1
Chatel, M1
Courdi, A1
Darcourt, J1
Fauchon, F1
Guibert, F1
Grellier, P1
Lanteri-Minet, M1
Lonjon, M1
Michiels, JF1
Paquis, P1
Paquis, V1
Ramaioli, A1
Rasendrarijao, D1
Chamberlain, MC2
Cartalat-Carel, S1
Taillibert, S1
Napolitano, M1
Djafari, L1
Cougnard, J1
Gervais, H1
Laigle, F1
Carpentier, A1
Taillandier, L1
Chinot, O1
Duffau, H1
Honnorat, J1
de Wit, MC1
de Bruin, HG2
Eijkenboom, W1
Sillevis Smitt, PA1
Triebels, VH1
Menten, J1
Tosoni, A3
Stege, EB1
Enting, RH2
van Heuvel, I2
Vastola, F1
Pasetto, LM1
Coria, B1
Danieli, D1
Iuzzolino, P2
Gardiman, M2
Talacchi, A1
Ermani, M3
Stege, EM1
Looijenga, LH1
van der Rijt, CD1
Smitt, PA1
Liau, CT1
Wei, KC1
Tseng, CK1
Jung, SM1
Nicolardi, L1
Ghimenton, C1
Reni, M1
Rotilio, A2
Sotti, G1
Atahan, L1
Söylemezoglu, F1
Selek, U1
Yalçin, B1
Kutluk, T1
Büyükpamukçu, M1
Mohile, NA1
Forsyth, P1
Stewart, D1
Raizer, JJ1
Paleologos, N1
Kewalramani, T1
Louis, DN4
Cairncross, JG1
Abrey, LE1
Seiler, RW2
Kelly, KA1
Kirkwood, JM1
Kapp, DS1
West, CR1
Avellanosa, AM1
Barua, NR1
Patel, A1
Hong, CI1
Brufman, G1
Halpern, J1
Sulkes, A1
Catane, R1
Biran, S1
Cangir, A3
Ragab, AH1
Steuber, P1
Land, VJ1
Berry, DH1
Krischer, JP1
Bradley, NJ1
Darling, JL3
Oktar, N1
Bloom, HJ1
Thomas, DG3
Davies, AJ1
Genot, JY1
Krulik, M1
Poisson, M1
van Efferterre, R1
Renoux, M1
Audebert, AA1
Canuel, C1
Smadja, N1
Debray, J1
Levin, VA8
Prados, MR1
Wara, WM1
Davis, RL1
Gutin, PH1
Phillips, TL1
Lamborn, K1
Wilson, CB6
Cole, SJ1
Fraser, DE1
Whittle, IR1
Elis, A1
Lishner, M1
Savin, H1
Ravid, M1
Schuler, D1
Somló, P1
Koós, R1
Kálmánchey, R1
Paraicz, E1
Kim, L1
Hochberg, FH2
Thornton, AF2
Harsh, GR1
Patel, H1
Finkelstein, D1
Hellman, R1
Neuberg, DS1
Wagner, H1
Grunnet, M1
Robins, HI1
Karp, D1
Flynn, P1
Adams, G1
Abele, M1
Leonhardt, M1
Dichgans, J1
Weller, M1
Galanis, E1
Burch, PA1
Schaefer, PL1
Dinapoli, RP1
Novotny, PJ1
Rowland, KM1
Vukov, AM1
Mailliard, JA1
Morton, RF1
Turazzi, S1
Scelzi, E1
Berti, F1
Amistà, P1
Licata, C1
Fiorentino, MV1
Scott, C2
Nelson, DF1
Leibel, S1
Kramer, S1
Doireau, V1
Zerah, M1
Lellouch-Tubiana, A1
Couanet, D1
Chastagner, P2
Marchal, JC1
Grignon, Y1
Chouffai, Z1
Yung, WK3
Sandler, H1
Henson, JW1
Källén, K1
Geijer, B1
Malmström, P2
Andersson, AM1
Holtås, S1
Ryding, E1
Rosén, I1
Lewandowicz, GM1
Harding, B1
Harkness, W1
Hayward, R1
Maipang MVasiknanonte, P1
Janjindamai SHirunpat, S1
Lesser, GJ1
Kajita, Y1
Mizuno, M1
Nagasaka, T1
Yoshida, J1
Yokoo, H1
Kamiya, M1
Sasaki, A1
Hirato, J1
Kurachi, H1
Hess, KR2
Wong, ET1
Jaeckle, KA2
Kyritsis, AP1
Bruner, J1
Kyritsis, A1
Leeds, N1
Gleason, MJ1
Meyers, CA1
Ictech, SA1
Chang, E1
Maor, MH1
Ron, IG1
Gal, O1
Vishne, TH1
Kovner, F1
Ushio, Y1
Greiner, RH1
Zimmerman, A1
Markwalder, H1
Crafts, DC2
Schultz, MJ1
Boldrey, EB4
Enot, KJ3
Pischer, TL2
Seager, M1
Elashoff, RM1
Drafts, D1
Ertel, IJ2
Boesel, C1
Hoffman, WF1
Seager, ML1
Townsend, J1
Watne, K2
Hannisdal, E2
Nome, O2
Hager, B2
Hirschberg, H2
Jeremic, B1
Jovanovic, D1
Djuric, LJ1
Jevremovic, S1
Mijatovic, LJ1
Boratyński, W1
Wester, K1
Heier, M1
Glass, J1
Gruber, ML1
Smith, D1
Rattner, B1
Coyle, T1
Bushunow, P1
Winfield, J1
Wright, J1
Graziano, S1
Ogilvy-Stuart, AL1
Shalet, SM1
Gattamaneni, HR1
Sandberg-Wollheim, M1
Strömblad, LG1
Anderson, H1
Borgström, S1
Brun, A1
Cronqvist, S1
Hougaard, K1
Salford, LG1
Hellman, RM1
Calogero, JA1
Kaplan, BM1
Newton, HB1
Junck, L1
Bromberg, J1
Page, MA1
Bradford, R1
Sposto, R1
Jenkin, RD1
Boesel, CP1
Venes, JL1
Ortega, JA1
Evans, AE1
Wara, W1
Hammond, D1
Friedman, HS1
Schold, SC1
Djang, WT1
Kurtzberg, J1
Longee, DC1
Halperin, EC1
Falletta, JM1
Coleman, RE1
Oakes, WJ1
Comella, G1
Scoppa, G1
De Marco, M1
Ianniello, GP1
Melillo, G1
Coucourde, F1
Zarrilli, D1
Pendergrass, TW1
Milstein, JM1
Geyer, JR1
Mulne, AF1
Kosnik, EJ1
Morris, JD1
Heideman, RL1
Ruymann, FB1
Stuntz, JT1
Bleyer, WA1
Stokes, DC1
Shenep, JL1
Horowitz, ME1
Hughes, WT1
Olive, D1
Philip, T1
Zucker, JM1
Czorny, A1
Lapras, C1
Brunat-Mentigny, M1
van Eys, J2
Baram, TZ1
Bruner, JM1
Martinez-Prieto, J1
Kocsis, B1
Kerpel-Fronius, S1
Eckhardt, S1
Coody, D1
Smith, B1
Vasantha Kumar, AR1
Renaudin, J1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Study of Observation in Favorable Low-Grade Glioma and a Phase II Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma[NCT00003375]Phase 2/Phase 3370 participants (Actual)Interventional1998-10-31Completed
PHASE III STUDY OF ADJUVANT PROCARBAZINE, CCNU AND VINCRISTINE CHEMOTHERAPY IN PATIENTS WITH HIGHLY ANAPLASTIC OLIGODENDROGLIOMA[NCT00002840]Phase 3350 participants (Anticipated)Interventional1996-08-31Completed
PHASE II STUDY OF PREIRRADIATION PCV CHEMOTHERAPY IN PATIENTS WITH SUPRATENTORIAL LOW-GRADE GLIOMAS[NCT00002806]Phase 243 participants (Actual)Interventional1996-07-31Completed
Does Varenicline Influence Alcohol Consumption in Alcohol Dependent Individuals?[NCT00846859]Phase 2162 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for procarbazine and Astrocytoma

ArticleYear
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms

2004
[Resent advances in chemotherapy for malignant brain tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brai

2005
Anaplastic oligodendroglioma and oligoastrocytoma.
    Neurologic clinics, 2007, Volume: 25, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brai

2007
Glioblastoma multiforme: pathology, natural history and treatment.
    Cancer treatment reviews, 1984, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Antigens, Neoplasm; Antigens, Surface; Astrocytoma; Brain Neoplasms; Carmus

1984
Chemotherapy of low-grade gliomas.
    Seminars in radiation oncology, 2001, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chi

2001
[Chemo-radiotherapy for malignant brain tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Central Nervous System

2002
Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma.
    Cancer, 1992, May-15, Volume: 69, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Hypersensit

1992

Trials

36 trials available for procarbazine and Astrocytoma

ArticleYear
New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brai
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:16

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biomarkers, Tu

2013
The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide.
    Journal of neuro-oncology, 2016, Volume: 127, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazin

2016
Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
    The New England journal of medicine, 2016, Apr-07, Volume: 374, Issue:14

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modali

2016
[Not Available].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2016, Volume: 192, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemoradiotherapy; Dis

2016
Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951.
    Neuro-oncology, 2009, Volume: 11, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cell Proliferation; Ch

2009
MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Dec-10, Volume: 27, Issue:35

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant

2009
Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951.
    Cancer, 2011, Jul-01, Volume: 117, Issue:13

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined

2011
Phase II trial of radiotherapy after hyperbaric oxygenation with multiagent chemotherapy (procarbazine, nimustine, and vincristine) for high-grade gliomas: long-term results.
    International journal of radiation oncology, biology, physics, 2012, Feb-01, Volume: 82, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain N

2012
Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305).
    Cancer chemotherapy and pharmacology, 2013, Volume: 71, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemoradi

2013
[Chemotherapy of recurrent supratentorial malignant gliomas (phase II study)].
    Ideggyogyaszati szemle, 2002, Jan-20, Volume: 55, Issue:1-2

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astr

2002
Concurrent modified PCV chemotherapy and radiotherapy in newly diagnosed grade IV astrocytoma.
    Journal of neuro-oncology, 2002, Volume: 57, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modali

2002
Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jan-15, Volume: 21, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chromosome Aber

2003
Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas.
    British journal of cancer, 2003, Jul-21, Volume: 89, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astro

2003
Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404.
    International journal of radiation oncology, biology, physics, 2004, Mar-15, Volume: 58, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Che

2004
Randomized controlled trial on malignant brain tumors--activities of the Japan Clinical Oncology Group-Brain Tumor Study Group.
    Neurologia medico-chirurgica, 2004, Volume: 44, Issue:4

    Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Glioblastoma; Humans

2004
Initial chemotherapy in gliomatosis cerebri.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin

2004
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms

2004
Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas.
    Neurology, 2004, Sep-14, Volume: 63, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytom

2004
A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis.
    Journal of neuro-oncology, 2008, Volume: 89, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Busulfan; Combi

2008
Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas.
    International journal of radiation oncology, biology, physics, 1995, Apr-30, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasm

1995
A therapeutic trial of radiation therapy with Vincristine, etoposide, and Procarbazine (VVP) in high grade intracranial gliomas--an Eastern Cooperative Oncology Group Study (E2392).
    Journal of neuro-oncology, 1998, Volume: 37, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Comb

1998
Phase II trial of nitrogen mustard, vincristine, and procarbazine in patients with recurrent glioma: North Central Cancer Treatment Group results.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Female; Glioma;

1998
Procarbazine and high-dose tamoxifen as a second-line regimen in recurrent high-grade gliomas: a phase II study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain; Brain N

1999
Chemotherapy for unresectable and recurrent intramedullary glial tumours in children. Brain Tumours Subcommittee of the French Society of Paediatric Oncology (SFOP).
    British journal of cancer, 1999, Volume: 81, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carboplatin; Chemotherapy, Adjuvant; Ch

1999
A phase 3 randomized study of radiotherapy plus procarbazine, CCNU, and vincristine (PCV) with or without BUdR for the treatment of anaplastic astrocytoma: a preliminary report of RTOG 9404.
    International journal of radiation oncology, biology, physics, 1999, Dec-01, Volume: 45, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Che

1999
Quantitative 201Tl SPET imaging in the follow-up of treatment for brain tumour: a sensitive tool for the early identification of response to chemotherapy?
    Nuclear medicine communications, 2000, Volume: 21, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Female; Follow-

2000
Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jan-15, Volume: 19, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Central Nervous System Neo

2001
Response and progression in recurrent malignant glioma.
    Neuro-oncology, 1999, Volume: 1, Issue:4

    Topics: Actuarial Analysis; Adolescent; Adult; Aged; Aged, 80 and over; Alitretinoin; Antineoplastic Combine

1999
Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas.
    International journal of radiation oncology, biology, physics, 2002, May-01, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasm

2002
Long-term follow-up in managing anaplastic astrocytoma by multimodality approach with surgery followed by postoperative radiotherapy and PCV-chemotherapy: phase II trial.
    American journal of clinical oncology, 2002, Volume: 25, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Central

2002
BCNU (NSC-409962) and procarbazine (NSC-77213) treatment for malignant brain tumors.
    Cancer treatment reports, 1976, Volume: 60, Issue:3

    Topics: Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, C

1976
Combined intra-arterial and systemic chemotherapy for recurrent malignant brain tumors.
    Neurosurgery, 1992, Volume: 30, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma

1992
Advantage of post-radiotherapy chemotherapy with CCNU, procarbazine, and vincristine (mPCV) over chemotherapy with VM-26 and CCNU for malignant gliomas.
    Journal of chemotherapy (Florence, Italy), 1992, Volume: 4, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined

1992
Combined intra-arterial chemotherapy followed by radiation in astrocytomas.
    Journal of neuro-oncology, 1992, Volume: 14, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astro

1992
A randomized study of chemotherapy with procarbazine, vincristine, and lomustine with and without radiation therapy for astrocytoma grades 3 and/or 4.
    Cancer, 1991, Jul-01, Volume: 68, Issue:1

    Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Combined Moda

1991
The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group.
    Journal of neuro-oncology, 1989, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chi

1989

Other Studies

55 other studies available for procarbazine and Astrocytoma

ArticleYear
Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort.
    The oncologist, 2021, Volume: 26, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Humans; Lomustine; Pro

2021
Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults.
    Progress in neurological surgery, 2018, Volume: 31

    Topics: Adult; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Procarbazi

2018
Mortality in Children with Optic Pathway Glioma Treated with Up-Front BB-SFOP Chemotherapy.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Antineoplastic Agents; Astrocytoma; Carboplatin; Child; Child, Preschool; Cisplatin; Cohort Studies;

2015
PC or PCV, That Is the Question: Primary Anaplastic Oligodendroglial Tumors Treated with Procarbazine and CCNU With and Without Vincristine.
    Anticancer research, 2015, Volume: 35, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astr

2015
High-grade glioma in children and adolescents: a single-center experience.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016, Volume: 32, Issue:2

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astro

2016
Singapore Cancer Network (SCAN) Guidelines for Systemic Therapy of High-Grade Glioma.
    Annals of the Academy of Medicine, Singapore, 2015, Volume: 44, Issue:10

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Beva

2015
Prolonged survival associated with the use of intraoperative carmustine (Gliadel) in a paediatric patient with recurrent grade III astrocytoma.
    British journal of neurosurgery, 2013, Volume: 27, Issue:4

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Carmustine; Combi

2013
Interobserver variability in the radiological assessment of response to chemotherapy in glioma.
    Neurology, 2003, Mar-11, Volume: 60, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat

2003
Monitoring individual response to brain-tumour chemotherapy: proton MR spectroscopy in a patient with recurrent glioma after stereotactic radiotherapy.
    Neuroradiology, 2004, Volume: 46, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Astrocytoma; Brain Neoplasms;

2004
[Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults].
    Revue neurologique, 2004, Volume: 160, Issue:5 Pt 1

    Topics: Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Astrocytom

2004
Gliomatosis cerebri: better definition, better treatment.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocyt

2004
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study.
    Cancer, 2004, Nov-01, Volume: 101, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Combined Modality Therapy;

2004
Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine.
    Cancer, 2005, Feb-15, Volume: 103, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neo

2005
Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma.
    Chang Gung medical journal, 2005, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasm

2005
Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma.
    Neuro-oncology, 2006, Volume: 8, Issue:3

    Topics: Adjuvants, Pharmaceutic; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; As

2006
Astrocytic tumors in children: treatment results from a single institution.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007, Volume: 23, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi

2007
Late results of multimodality therapy of high-grade supratentorial astrocytomas.
    Surgical neurology, 1981, Volume: 15, Issue:2

    Topics: Adult; Antineoplastic Agents; Astrocytoma; Bleomycin; Brain Neoplasms; Drug Therapy, Combination; Fe

1981
Intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and systemic chemotherapy for malignant gliomas: a follow-up study.
    Neurosurgery, 1983, Volume: 13, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

1983
Procarbazine, CCNU and vincristine (PCV) combination chemotherapy for brain tumors.
    Oncology, 1984, Volume: 41, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modali

1984
Combination chemotherapy with vincristine (NSC-67574), procarbazine (NSC-77213), prednisone (NSC-10023) with or without nitrogen mustard (NSC-762)(MOPP vs OPP) in children with recurrent brain tumors.
    Medical and pediatric oncology, 1984, Volume: 12, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Follow-Up

1984
The failure of human leukocyte interferon to influence the growth of human glioma cell populations: in vitro and in vivo studies.
    British journal of cancer, 1983, Volume: 48, Issue:6

    Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms;

1983
Two cases of acute leukemia following treatment of malignant glioma.
    Cancer, 1983, Jul-15, Volume: 52, Issue:2

    Topics: Acute Disease; Adult; Astrocytoma; Brain Neoplasms; Female; Glioma; Humans; Leukemia; Nitrosourea Co

1983
Rapid resolution following chemotherapy of Broca's dysphasia due to recurrent anaplastic astrocytoma.
    British journal of neurosurgery, 1994, Volume: 8, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aphasia, Broca; Astrocytoma; Fatal Outcome; Follow-U

1994
Aplastic anemia induced by cyclohexylchloroethylnitrousurea.
    Anti-cancer drugs, 1994, Volume: 5, Issue:1

    Topics: Adult; Anemia, Aplastic; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Blood Cell Cou

1994
The treatment of malignant scala posterior tumors in children: II. Preliminary result of the pre- and postoperative adjuvant chemotherapy of scala posterior tumors.
    Medical and pediatric oncology, 1993, Volume: 21, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, A

1993
Procarbazine, lomustine, and vincristine (PCV) chemotherapy for grade III and grade IV oligoastrocytomas.
    Journal of neurosurgery, 1996, Volume: 85, Issue:4

    Topics: Adult; Astrocytoma; Brain Neoplasms; Female; Humans; Lomustine; Male; Middle Aged; Procarbazine; Pro

1996
CCNU overdose during PCV chemotherapy for anaplastic astrocytoma.
    Journal of neurology, 1998, Volume: 245, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neo

1998
Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: A retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:11

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carm

1999
BUdR radiosensitization in anaplastic astrocytoma.
    International journal of radiation oncology, biology, physics, 1999, Dec-01, Volume: 45, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Che

1999
Spinal cord astrocytoma: response to PCV chemotherapy.
    Neurology, 2000, Jan-25, Volume: 54, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biopsy; Fatal Outcome; Humans; L

2000
Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:15

    Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Child; Dose-Response Relationship, Drug;

2000
Successful combination chemotherapy (vincristine, procarbazine, etoposide, and prednisolone) in the treatment of inoperable, radioresistant low grade astrocytoma: a case report.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2000, Volume: 83, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Etoposide; Fema

2000
Efficacy of adjuvant therapy with procarbazine, MCNU, and vincristine for oligodendroglial tumors.
    Neurologia medico-chirurgica, 2001, Volume: 41, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemotherapy, A

2001
Neurofibromatosis type 1-associated unusual pleomorphic astrocytoma displaying continual malignant progression.
    Pathology international, 2001, Volume: 51, Issue:7

    Topics: Adolescent; Antigens, Nuclear; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biomarke

2001
Medical Research Council adjuvant trial in high-grade gliomas.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Oct-01, Volume: 19, Issue:19

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant

2001
Radiotherapy combined with procarbazine, bleomycin, and CCNU in the treatment of high-grade supratentorial astrocytomas.
    Journal of neurosurgery, 1978, Volume: 48, Issue:6

    Topics: Adolescent; Adult; Aged; Astrocytoma; Bleomycin; Brain Neoplasms; Child; Drug Therapy, Combination;

1978
Single-agent chemotherapy of brain tumors. A five-year review.
    Archives of neurology, 1976, Volume: 33, Issue:11

    Topics: Astrocytoma; Bone Marrow Diseases; Brain Neoplasms; Carmustine; Glioma; Humans; Imidazoles; Lomustin

1976
Brain tumors in children.
    Pediatric annals, 1978, Volume: 7, Issue:8

    Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Diagnosis, Differential; Ependymoma; Female;

1978
BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors.
    Cancer treatment reports, 1978, Volume: 62, Issue:12

    Topics: Astrocytoma; Bone Marrow; Brain Neoplasms; Carmustine; Drug Therapy, Combination; Fluorouracil; Glio

1978
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma.
    Cancer treatment reports, 1978, Volume: 62, Issue:1

    Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Therapy, Combination; Female; Hodgkin Dise

1978
[Results of combined treatment of neoplasms of the posterior cranial fossa in children].
    Neurologia i neurochirurgia polska, 1992, Volume: Suppl 1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Cerebellar Neoplasms; Child

1992
The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy.
    Journal of neurosurgery, 1992, Volume: 76, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Admi

1992
Thyroid function after treatment of brain tumors in children.
    The Journal of pediatrics, 1991, Volume: 119, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine

1991
VP-16, vincristine and procarbazine with radiation therapy for treatment of malignant brain tumors.
    Journal of neuro-oncology, 1990, Volume: 8, Issue:2

    Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Etoposide; Female; Glioblastom

1990
Procarbazine chemotherapy in the treatment of recurrent malignant astrocytomas after radiation and nitrosourea failure.
    Neurology, 1990, Volume: 40, Issue:11

    Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Drug Eval

1990
The chemotherapeutic response of a murine (VM) model of human glioma.
    British journal of cancer, 1990, Volume: 61, Issue:1

    Topics: Animals; Astrocytoma; Brain Neoplasms; Carmustine; Disease Models, Animal; Lomustine; Mice; Mice, In

1990
Criteria for termination of phase II chemotherapy for patients with progressive or recurrent brain tumor.
    Neurology, 1989, Volume: 39, Issue:1

    Topics: Adolescent; Antineoplastic Agents; Astrocytoma; Aziridines; Benzoquinones; Brain Neoplasms; Cohort S

1989
Radiotherapy and combination chemotherapy with carmustine, vincristine, and procarbazine (BVP) in primary brain tumors.
    Journal of neuro-oncology, 1985, Volume: 3, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Combined M

1985
Eight drugs in one day chemotherapy for brain tumors: experience in 107 children and rationale for preradiation chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Cisplatin; Comb

1987
Presentation of Pneumocystis carinii pneumonia as unilateral hyperlucent lung.
    Chest, 1988, Volume: 94, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child, Preschool; Huma

1988
[Efficacy of the "8 drugs in a day" protocol in brain tumors in children].
    Archives francaises de pediatrie, 1988, Volume: 45, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cer

1988
Salvage chemotherapy for recurrent primary brain tumors in children.
    The Journal of pediatrics, 1988, Volume: 113, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi

1988
Dibromodulcitol-based combined postoperative chemotherapy of malignant astrocytomas and glioblastomas.
    Journal of neuro-oncology, 1986, Volume: 4, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined

1986
MOPP regimen as primary chemotherapy for brain tumors in infants.
    Journal of neuro-oncology, 1985, Volume: 3, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms;

1985
Procarbazine hydrochloride in the treatment of brain tumors. Phase 2 study.
    Journal of neurosurgery, 1974, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Astrocytoma; Brain Neoplasms; Child; Electroencephalography; Epe

1974