procarbazine has been researched along with Anemia in 14 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether epoetin alfa reduces anemia-related fatigue, improves other aspects of health-related patient-recorded outcomes (PROs), reduces the number of RBC transfusions, and has an impact on freedom from treatment failure (FFTF) and overall survival (OS) in patients with advanced-stage Hodgkin's lymphoma (HL)." | 5.14 | Epoetin alfa in patients with advanced-stage Hodgkin's lymphoma: results of the randomized placebo-controlled GHSG HD15EPO trial. ( Borchmann, P; Diehl, V; Engert, A; Flechtner, HH; Fuchs, M; Haverkamp, H; Josting, A; Lohri, A; Nogova, L; Rank, A; Sökler, M; Sturm, I; Topp, MS; Villalobos, M; Vogelhuber, M; Zenz, T; Zijlstra, J, 2010) |
| "To improve survival of elderly patients with primary central nervous system lymphoma (PCNSL), we conducted a phase II study with high-dose methotrexate (MTX) combined with procarbazine and CCNU." | 2.74 | High-dose methotrexate combined with procarbazine and CCNU for primary CNS lymphoma in the elderly: results of a prospective pilot and phase II study. ( Deckert, M; Feuerhake, F; Finke, J; Ihorst, G; Illerhaus, G; Marks, R; Müller, F; Ostertag, C, 2009) |
| "However, leukocytopenia was observed in many patients despite combined use of G-CSF, suggesting the dose and administration method of THP should be studied further." | 2.68 | [Usefulness of THP-COPBLM therapy in elderly patients with non-Hodgkin's lymphoma]. ( Nakayama, M; Niitsu, N; Umeda, M, 1997) |
| " This side effect could be explained by a cycling of the hematopoietic stem-cells and call to some caution when androgens are used during cancer chemotherapy." | 2.64 | [Increased hematological toxicity of antineoplastic drugs with simultaneous androgenotherapy (author's transl)]. ( Barthélémy, M; Bilski-Pasquier, G; Blanc, CM; Bouchard, M; Bousser, J; Zittoun, R, 1977) |
| "Acquired ichthyosis is a rare condition that can reveal an unsuspected haematological malignancy, thus allowing early diagnosis and management." | 1.38 | [Acquired ichthyosis and haematological malignancies: five cases]. ( Baybay, H; Berrady, R; Bono, W; El Hatimi, A; Gallouj, S; Khammar, Z; Lahlou, M; Lamchachti, L; Mernissi, FZ, 2012) |
| "In three patients with advanced Hodgkin's disease treated with combination chemotherapy (MOPP) incorporating vincristine, and receiving at the same time a fixed daily dose of 8000 U of rHu-EPO subcutaneously for 10 to 15 days because of myelosuppressive anemia, myeloaspirates were performed one week before and 24 hours after the administration of vincristine." | 1.28 | Selective metaphasic arrest of erythroblasts by vincristine in patients receiving high doses of recombinant human erythropoietin for myelosuppressive anemia. ( Marmont, AM, 1992) |
| "Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Illerhaus, G | 1 |
| Marks, R | 1 |
| Müller, F | 1 |
| Ihorst, G | 1 |
| Feuerhake, F | 1 |
| Deckert, M | 1 |
| Ostertag, C | 1 |
| Finke, J | 1 |
| Engert, A | 3 |
| Josting, A | 2 |
| Haverkamp, H | 1 |
| Villalobos, M | 1 |
| Lohri, A | 1 |
| Sökler, M | 1 |
| Zijlstra, J | 1 |
| Sturm, I | 1 |
| Topp, MS | 1 |
| Rank, A | 1 |
| Zenz, T | 1 |
| Vogelhuber, M | 1 |
| Nogova, L | 1 |
| Borchmann, P | 1 |
| Fuchs, M | 1 |
| Flechtner, HH | 1 |
| Diehl, V | 2 |
| Bauer, K | 1 |
| Herbst, C | 1 |
| Brillant, C | 1 |
| Monsef, I | 1 |
| Kluge, S | 1 |
| Skoetz, N | 1 |
| Morabito, F | 1 |
| Hohaus, S | 1 |
| Mammi, C | 1 |
| Marcheselli, L | 1 |
| Gentile, M | 1 |
| Merli, F | 1 |
| Montanini, A | 1 |
| Stelitano, C | 1 |
| La Sala, A | 1 |
| Scalone, R | 1 |
| Voso, MT | 1 |
| Luminari, S | 1 |
| Iannitto, E | 1 |
| Gobbi, P | 1 |
| Federico, M | 1 |
| Berrady, R | 1 |
| Baybay, H | 1 |
| Khammar, Z | 1 |
| Lahlou, M | 1 |
| Lamchachti, L | 1 |
| Gallouj, S | 1 |
| El Hatimi, A | 1 |
| Mernissi, FZ | 1 |
| Bono, W | 1 |
| Sieber, M | 1 |
| Bredenfeld, H | 1 |
| Reineke, T | 1 |
| Rueffer, U | 1 |
| Koch, T | 1 |
| Naumann, R | 1 |
| Boissevain, F | 1 |
| Koch, P | 1 |
| Worst, P | 1 |
| Soekler, M | 1 |
| Eich, H | 1 |
| Müller-Hermelink, HK | 1 |
| Franklin, J | 1 |
| Paulus, U | 1 |
| Wolf, J | 1 |
| Niitsu, N | 1 |
| Nakayama, M | 1 |
| Umeda, M | 1 |
| Colombi, M | 1 |
| Guffanti, A | 1 |
| Alietti, A | 1 |
| Latargia, ML | 1 |
| Vener, C | 1 |
| Maiolo, AT | 1 |
| Baldini, L | 1 |
| Zittoun, R | 1 |
| Barthélémy, M | 1 |
| Bouchard, M | 1 |
| Blanc, CM | 1 |
| Bousser, J | 1 |
| Bilski-Pasquier, G | 1 |
| Thumb, N | 1 |
| Marmont, AM | 1 |
| Fairley, GH | 1 |
| Greenberg, LH | 1 |
| Wong, S | 1 |
| Richardson, AP | 1 |
| Dollinger, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Patients Over 65 Years With Primary CNS Lymphoma: High-dose Methotrexate Combined With Chemo-immunotherapy Followed by Maintenance Therapy[NCT00989352] | Phase 2 | 56 participants (Anticipated) | Interventional | 2009-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for procarbazine and Anemia
| Article | Year |
|---|---|
Targeted BEACOPP Variants in Patients With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma: Final Analysis of a Randomized Phase II Study.
Topics: Anemia; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosp | 2016 |
High-dose methotrexate combined with procarbazine and CCNU for primary CNS lymphoma in the elderly: results of a prospective pilot and phase II study.
Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Comb | 2009 |
Epoetin alfa in patients with advanced-stage Hodgkin's lymphoma: results of the randomized placebo-controlled GHSG HD15EPO trial.
Topics: Adolescent; Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphami | 2010 |
Role of glutathione-S-transferase (GST) polymorphisms in patients with advanced Hodgkin lymphoma: results from the HD2000 GISL trial.
Topics: Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Bleomycin; Carbopl | 2012 |
14-day variant of the bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone regimen in advanced-stage Hodgkin's lymphoma: results of a pilot study of the German Hodgkin's Lymphoma Study Group.
Topics: Adolescent; Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphami | 2003 |
[Usefulness of THP-COPBLM therapy in elderly patients with non-Hodgkin's lymphoma].
Topics: Aged; Aged, 80 and over; Anemia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclopho | 1997 |
OPP-EBV-CAD regimen as salvage treatment in advanced refractory or resistant multiple myeloma.
Topics: Adult; Aged; Agranulocytosis; Anemia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cau | 2000 |
[Increased hematological toxicity of antineoplastic drugs with simultaneous androgenotherapy (author's transl)].
Topics: Androgens; Anemia; Antineoplastic Agents; Drug Therapy, Combination; Humans; Lymphoma; Mechlorethami | 1977 |
6 other studies available for procarbazine and Anemia
| Article | Year |
|---|---|
Eleventh biannual report of the Cochrane Haematological Malignancies Group: Focus on Hodgkin lymphoma.
Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bendamustine Hydrochloride; Ble | 2010 |
[Acquired ichthyosis and haematological malignancies: five cases].
Topics: Adult; Aged; Allopurinol; Anemia; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Ant | 2012 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
Selective metaphasic arrest of erythroblasts by vincristine in patients receiving high doses of recombinant human erythropoietin for myelosuppressive anemia.
Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Erythroblasts; Erythropoietin; Hodgkin Disea | 1992 |
The use of different drugs and combinations in the treatment of Hodgkin's disease.
Topics: Administration, Oral; Anemia; Drug Evaluation; Drug Therapy, Combination; Hodgkin Disease; Humans; I | 1973 |
Combination chemotherapy of Hodgkin's disease in private practice.
Topics: Adolescent; Adult; Aged; Anemia; Biopsy; Female; Hodgkin Disease; Humans; Male; Mechlorethamine; Mid | 1972 |