procarbazine has been researched along with Allergy, Drug in 17 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma." | 8.78 | Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992) |
| "Hypersensitivity to procarbazine associated with urticaria, angioedema, and painful joint swelling was found in a 20-year-old student being treated for Hodgkin's disease." | 7.65 | Hypersensitivity to procarbazine associated with angioedema, urticaria, and low serum complement activity. ( Alenty, A; Braunwald, J; Glovsky, MM; Opelz, G, 1976) |
| "A total of 44 patients with Hodgkin's disease and 23 patients with non-Hodgkin malignant lymphoma were treated with MOPP-combination chemotherapy." | 5.26 | Procarbazine-induced skin reactions in Hodgkin's disease and other malignant lymphomas. ( Andersen, E; Videbaek, A, 1980) |
| "The authors report the clinical features of hypersensitivity reactions believed to result from procarbazine in eight patients treated with mechlorethamine, vincristine, and procarbazine (MOP) for high-grade glioma." | 4.78 | Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma. ( Bushunow, P; Coyle, T; Graziano, S; Winfield, J; Wright, J, 1992) |
| "Hypersensitivity to procarbazine associated with urticaria, angioedema, and painful joint swelling was found in a 20-year-old student being treated for Hodgkin's disease." | 3.65 | Hypersensitivity to procarbazine associated with angioedema, urticaria, and low serum complement activity. ( Alenty, A; Braunwald, J; Glovsky, MM; Opelz, G, 1976) |
| " The use of most cytotoxic agents is associated with potential hypersensitivity reactions, and the constant increase of their administration has caused an increase in incidence of these adverse effects, thus becoming a relevant problem for clinicians." | 2.46 | The complex clinical picture of presumably allergic side effects to cytostatic drugs: symptoms, pathomechanism, reexposure, and desensitization. ( Pagani, M, 2010) |
| "Both anticancer chemotherapeutics and monoclonal antibodies have the potential for acute HSR." | 1.38 | Prevention and handling of acute allergic and infusion reactions in oncology. ( Joerger, M, 2012) |
| "Previously, adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) database were reviewed to confirm platinum agent-associated hypersensitivity reactions." | 1.37 | Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS. ( Brown, JB; Kadoyama, K; Kuwahara, A; Okuno, Y; Sakaeda, T; Yamamori, M, 2011) |
| " In addition, there was a significant dose-response association between the development of procarbazine hypersensitivity and the presence of therapeutic anticonvulsant serum levels (p = 0." | 1.30 | Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors. ( Coyle, TE; Hurteau, TE; Lehmann, DF; Newman, N, 1997) |
| "A patient with advanced Hodgkin's disease being treated with MOPP chemotherapy presented with delayed life-threatening pulmonary toxicity secondary to procarbazine." | 1.28 | Delayed life-threatening pneumonitis secondary to procarbazine. ( Alvarez, S; Ancalmo, N; Brooks, BJ; Grinton, SF; Hendler, NB, 1990) |
| "A patient suffering from Hodgkin's disease exhibiting acute allergic reaction to vincristine sulfate with mild to moderate dermatologic and cardiovascular signs is described." | 1.27 | Acute allergic reaction due to vincristine sulfate. A case report. ( Gassel, WD; Gropp, C; Havemann, K, 1984) |
| "A total of 44 patients with Hodgkin's disease and 23 patients with non-Hodgkin malignant lymphoma were treated with MOPP-combination chemotherapy." | 1.26 | Procarbazine-induced skin reactions in Hodgkin's disease and other malignant lymphomas. ( Andersen, E; Videbaek, A, 1980) |
| "Procarbazine may have been the responsible agent." | 1.26 | Diffuse pulmonary disease after therapy with nitrogen mustard, vincristine, procarbazine, and prednisone. ( Armstrong, JD; Farney, RJ; Hammer, S; Morris, AH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Van der Valk, H | 1 |
| Dijkstra, H | 1 |
| Walenkamp, A | 1 |
| Schuttelaar, MLA | 1 |
| Oude Elberink, HNG | 1 |
| Van de Ven, AAJM | 1 |
| Lee, C | 1 |
| Gianos, M | 1 |
| Klaustermeyer, WB | 1 |
| Pagani, M | 1 |
| Kadoyama, K | 1 |
| Kuwahara, A | 1 |
| Yamamori, M | 1 |
| Brown, JB | 1 |
| Sakaeda, T | 1 |
| Okuno, Y | 1 |
| Joerger, M | 1 |
| Gassel, WD | 1 |
| Gropp, C | 1 |
| Havemann, K | 1 |
| Weiss, RB | 2 |
| Bruno, S | 1 |
| Andersen, E | 1 |
| Videbaek, A | 1 |
| Lehmann, DF | 1 |
| Hurteau, TE | 1 |
| Newman, N | 1 |
| Coyle, TE | 1 |
| Pavlov, VV | 1 |
| Isaev, IG | 1 |
| Farney, RJ | 1 |
| Morris, AH | 1 |
| Armstrong, JD | 1 |
| Hammer, S | 1 |
| Glovsky, MM | 1 |
| Braunwald, J | 1 |
| Opelz, G | 1 |
| Alenty, A | 1 |
| Coyle, T | 1 |
| Bushunow, P | 1 |
| Winfield, J | 1 |
| Wright, J | 1 |
| Graziano, S | 1 |
| Brooks, BJ | 1 |
| Hendler, NB | 1 |
| Alvarez, S | 1 |
| Ancalmo, N | 1 |
| Grinton, SF | 1 |
| Amiel, JL | 1 |
| Mathé, G | 1 |
| Jones, SE | 1 |
| Moore, M | 1 |
| Blank, N | 1 |
| Castellino, RA | 1 |
5 reviews available for procarbazine and Allergy, Drug
| Article | Year |
|---|---|
Diagnosis and management of hypersensitivity reactions related to common cancer chemotherapy agents.
Topics: Antineoplastic Agents; Asparaginase; Carboplatin; Drug Hypersensitivity; Humans; Organoplatinum Comp | 2009 |
The complex clinical picture of presumably allergic side effects to cytostatic drugs: symptoms, pathomechanism, reexposure, and desensitization.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Asparaginase; Carboplatin; Cisplatin; Cyto | 2010 |
Hypersensitivity reactions to cancer chemotherapeutic agents.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Cisplatin; Drug | 1981 |
Hypersensitivity reactions.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Aziridines; Benzoquinones; Bleomyc | 1992 |
Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Hypersensit | 1992 |
12 other studies available for procarbazine and Allergy, Drug
| Article | Year |
|---|---|
Successful oral desensitization and reintroduction in selected glioma patients with procarbazine-mediated hypersensitivity.
Topics: Desensitization, Immunologic; Drug Hypersensitivity; Glioma; Humans; Procarbazine | 2020 |
Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS.
Topics: Adverse Drug Reaction Reporting Systems; Antineoplastic Agents; Asparaginase; Bayes Theorem; Data Mi | 2011 |
Prevention and handling of acute allergic and infusion reactions in oncology.
Topics: Anaphylaxis; Antibodies, Monoclonal; Asparaginase; Drug Hypersensitivity; Humans; Immunoglobulin E; | 2012 |
Acute allergic reaction due to vincristine sulfate. A case report.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Hyperse | 1984 |
Procarbazine-induced skin reactions in Hodgkin's disease and other malignant lymphomas.
Topics: Drug Hypersensitivity; Hodgkin Disease; Humans; Lymphoma; Procarbazine; Urticaria | 1980 |
Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain | 1997 |
[Allergic reaction to the administration of natulan in a patient with Hodgkin's disease].
Topics: Drug Eruptions; Drug Hypersensitivity; Hodgkin Disease; Humans; Male; Middle Aged; Procarbazine | 1978 |
Diffuse pulmonary disease after therapy with nitrogen mustard, vincristine, procarbazine, and prednisone.
Topics: Adult; Biopsy; Drug Hypersensitivity; Female; Hodgkin Disease; Humans; Lung Diseases; Mechlorethamin | 1977 |
Hypersensitivity to procarbazine associated with angioedema, urticaria, and low serum complement activity.
Topics: Adult; Angioedema; Complement C1; Complement C2; Complement C4; Complement System Proteins; Drug Hyp | 1976 |
Delayed life-threatening pneumonitis secondary to procarbazine.
Topics: Adult; Alveolitis, Extrinsic Allergic; Antineoplastic Combined Chemotherapy Protocols; Diagnosis, Di | 1990 |
[Chemotherapy of Hodgkin's disease].
Topics: Antineoplastic Agents; Bleomycin; Drug Hypersensitivity; Drug Therapy, Combination; Hodgkin Disease; | 1974 |
Hypersensitivity to procarbazine (Matulane) manifested by fever and pleuropulmonary reaction.
Topics: Administration, Oral; Antineoplastic Agents; Benzoates; Diagnosis, Differential; Drug Combinations; | 1972 |