procarbazine has been researched along with Agranulocytosis in 12 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-four patients with progressive symptomatic multiple myeloma were treated with a protocol combining cyclophosphamide (10 mg/kg weekly), procarbazine (2 mg/kg daily), prednisolone (20 mg daily), and either BCNU (1 mg/kg weekly) (BCPP protocol) or MCNU (0." | 7.67 | [Combination chemotherapy of multiple myeloma--BCNU.cyclophosphamide.procarbazine.prednisolone and MCNU.cyclophosphamide.procarbazine.prednisolone therapy]. ( Ito, T; Komatsu, M; Saito, Y; Takahashi, H; Uzuka, Y, 1989) |
| "Forty-four patients with progressive symptomatic multiple myeloma were treated with a protocol combining cyclophosphamide (10 mg/kg weekly), procarbazine (2 mg/kg daily), prednisolone (20 mg daily), and either BCNU (1 mg/kg weekly) (BCPP protocol) or MCNU (0." | 3.67 | [Combination chemotherapy of multiple myeloma--BCNU.cyclophosphamide.procarbazine.prednisolone and MCNU.cyclophosphamide.procarbazine.prednisolone therapy]. ( Ito, T; Komatsu, M; Saito, Y; Takahashi, H; Uzuka, Y, 1989) |
| "We evaluated the efficacy and adverse effects of biweekly COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin and procarbazine) therapy combined with granulocyte colony-stimulating factor (G-CSF) for treating non-Hodgkin's lymphoma (NHL)." | 2.68 | Biweekly COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin and procarbazine) regimen combined with granulocyte colony stimulating factor (G-CSF) for intermediate-grade non-Hodgkin's lymphoma. ( Niitsu, N; Umeda, M, 1996) |
| "Eighteen patients with advanced Hodgkin's disease, refractory to combination chemotherapy with nitrogen mustard, vincristine, prednisone, and procarbazine (MOPP), were treated with vinblastine, doxorubicin (Adriamycin), bleomycin, CCNU, and dacarbazine (DTIC) (VABCD)." | 2.65 | Treatment of MOPP-refractory Hodgkin's disease with vinblastine, doxorubicin, bleomycin, CCNU, and dacarbazine. ( Bond, WH; Chenoweth, L; Einhorn, LH; Stevens, EE; Williams, SD, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Einhorn, LH | 1 |
| Williams, SD | 1 |
| Stevens, EE | 1 |
| Bond, WH | 1 |
| Chenoweth, L | 1 |
| Weitberg, AB | 1 |
| Harmon, DC | 1 |
| Pflieger, H | 1 |
| Wiesneth, M | 1 |
| Arnold, R | 1 |
| Niethammer, D | 1 |
| Kleihauer, E | 1 |
| McLaughlin, P | 1 |
| Hagemeister, FB | 1 |
| Swan, F | 1 |
| Cabanillas, F | 1 |
| Romaguera, J | 1 |
| Rodriguez, MA | 1 |
| Lee, MS | 1 |
| Pate, O | 1 |
| Sarris, A | 1 |
| Younes, A | 1 |
| Niitsu, N | 1 |
| Umeda, M | 1 |
| Colombi, M | 1 |
| Guffanti, A | 1 |
| Alietti, A | 1 |
| Latargia, ML | 1 |
| Vener, C | 1 |
| Maiolo, AT | 1 |
| Baldini, L | 1 |
| Viollier, AF | 1 |
| Senn, HJ | 1 |
| de Kreek, EJ | 1 |
| Sybesma, HB | 1 |
| Uzuka, Y | 1 |
| Saito, Y | 1 |
| Takahashi, H | 1 |
| Komatsu, M | 1 |
| Ito, T | 1 |
| Fairley, GH | 1 |
| Düllmann, J | 1 |
| Wulfhekel, U | 1 |
| Drescher, S | 1 |
| Hausmann, K | 1 |
| Marsh, JC | 1 |
| Levitt, M | 1 |
4 trials available for procarbazine and Agranulocytosis
| Article | Year |
|---|---|
Treatment of MOPP-refractory Hodgkin's disease with vinblastine, doxorubicin, bleomycin, CCNU, and dacarbazine.
Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Prot | 1983 |
Intensive conventional-dose chemotherapy for stage IV low-grade lymphoma: high remission rates and reversion to negative of peripheral blood bcl-2 rearrangement.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Biomark | 1994 |
Biweekly COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin and procarbazine) regimen combined with granulocyte colony stimulating factor (G-CSF) for intermediate-grade non-Hodgkin's lymphoma.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow | 1996 |
OPP-EBV-CAD regimen as salvage treatment in advanced refractory or resistant multiple myeloma.
Topics: Adult; Aged; Agranulocytosis; Anemia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cau | 2000 |
8 other studies available for procarbazine and Agranulocytosis
| Article | Year |
|---|---|
Autoimmune neutropenia, hemolytic anemia, and reticulocytopenia in Hodgkin's disease.
Topics: Adult; Agranulocytosis; Anemia, Hemolytic, Autoimmune; Antineoplastic Combined Chemotherapy Protocol | 1984 |
Granulocyte transfusions in children.
Topics: Acute Disease; Agranulocytosis; Anemia, Aplastic; Antilymphocyte Serum; Blood Transfusion; Bone Marr | 1981 |
[Curative aspects of modern combination chemotherapy in generalized malignant lymphomas].
Topics: Agranulocytosis; Cyclophosphamide; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Life | 1976 |
[From tumors to scales].
Topics: Agranulocytosis; Humans; Immunologic Deficiency Syndromes; Leg Ulcer; Leukopenia; Male; Mechloretham | 1975 |
[Combination chemotherapy of multiple myeloma--BCNU.cyclophosphamide.procarbazine.prednisolone and MCNU.cyclophosphamide.procarbazine.prednisolone therapy].
Topics: Aged; Aged, 80 and over; Agranulocytosis; Antineoplastic Agents; Antineoplastic Combined Chemotherap | 1989 |
The treatment of Hodgkin's disease.
Topics: Agranulocytosis; Antineoplastic Agents; Bone Marrow Diseases; Chlorambucil; Drug Combinations; Hodgk | 1972 |
[Hairy cell leukaemia clinical, light- and electronmicroscopical findings (author's transl)].
Topics: Adult; Agranulocytosis; Anemia, Aplastic; Anemia, Pernicious; Antibody Formation; Blood Platelets; C | 1974 |
Neutrophilia-inducing activity in plasma of neutropenic human beings.
Topics: Adult; Aged; Agranulocytosis; Blood Cell Count; Blood Transfusion, Autologous; Endotoxins; Humans; M | 1971 |