procarbazine has been researched along with Adverse Drug Event in 12 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Following optimal local therapy, adjuvant Procarbazine, Lomustine and Vincristine (PCV) improves overall survival (OS) in low-grade glioma (LGG)." | 8.02 | One year of procarbazine lomustine and vincristine is poorly tolerated in low grade glioma: a real world experience in a national neuro-oncology centre. ( Aslam, R; Breathnach, OS; Coyne, Z; Grogan, L; Hennessy, BT; Hennessy, MA; Keogh, RJ; Morris, PG, 2021) |
| "Following optimal local therapy, adjuvant Procarbazine, Lomustine and Vincristine (PCV) improves overall survival (OS) in low-grade glioma (LGG)." | 4.02 | One year of procarbazine lomustine and vincristine is poorly tolerated in low grade glioma: a real world experience in a national neuro-oncology centre. ( Aslam, R; Breathnach, OS; Coyne, Z; Grogan, L; Hennessy, BT; Hennessy, MA; Keogh, RJ; Morris, PG, 2021) |
| "The causes of death were Hodgkin's lymphoma in 36 patients, second neoplasms in 12, cardiorespiratory diseases in 4, pulmonary diseases in 2, and unknown in 6." | 2.72 | MOPPEBVCAD chemotherapy with limited and conditioned radiotherapy in advanced Hodgkin's lymphoma: 10-year results, late toxicity, and second tumors. ( Broglia, C; Cavanna, L; Chisesi, T; Corazza, GR; Corbella, F; Federico, M; Gobbi, PG; Iannitto, E; La Sala, A; Levis, A; Molica, S; Pavone, V; Sacchi, S; Valentino, F, 2006) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| "The eight patients who reported pretreatment nausea had more extensive disease than the other patients and had received twice as much chemotherapy." | 1.26 | Pretreatment nausea in cancer chemotherapy: a conditioned response? ( Carli, T; Curtis, GC; Kleinman, PD; Nesse, RM, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Keogh, RJ | 1 |
| Aslam, R | 1 |
| Hennessy, MA | 1 |
| Coyne, Z | 1 |
| Hennessy, BT | 1 |
| Breathnach, OS | 1 |
| Grogan, L | 1 |
| Morris, PG | 1 |
| Halbsguth, TV | 1 |
| Nogová, L | 1 |
| Mueller, H | 1 |
| Sieniawski, M | 1 |
| Eichenauer, DA | 1 |
| Schober, T | 1 |
| Nisters-Backes, H | 1 |
| Borchmann, P | 1 |
| Diehl, V | 1 |
| Engert, A | 1 |
| Josting, A | 1 |
| Gobbi, PG | 1 |
| Broglia, C | 1 |
| Levis, A | 1 |
| La Sala, A | 1 |
| Valentino, F | 1 |
| Chisesi, T | 1 |
| Sacchi, S | 1 |
| Corbella, F | 1 |
| Cavanna, L | 1 |
| Iannitto, E | 1 |
| Pavone, V | 1 |
| Molica, S | 1 |
| Corazza, GR | 1 |
| Federico, M | 1 |
| Nesse, RM | 1 |
| Carli, T | 1 |
| Curtis, GC | 1 |
| Kleinman, PD | 1 |
| Vinokurova, NA | 1 |
| Fishbein, L | 1 |
| Flamm, WG | 1 |
| DeVita, VT | 2 |
| Arseneau, JC | 2 |
| Sherins, RJ | 1 |
| Canellos, GP | 2 |
| Young, RC | 2 |
| Grundmann, E | 1 |
| Fritzsche, R | 1 |
| Sponzo, RW | 1 |
| Levin, DL | 1 |
| Schnipper, LE | 1 |
| Bonner, H | 1 |
| Johnson, RE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00284271] | Phase 2 | 65 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| A Phase Ib/II Trial of Combined SGN-35 (BrentuximabVedotin) Therapy With Cyclophosphamide, Procarbazine, Prednisone, Etoposide and Mitoxantrone (BrEPEM) for Older Patients With Untreated Hodgkin Lymphoma (HL)[NCT03576378] | Phase 1/Phase 2 | 41 participants (Actual) | Interventional | 2018-08-08 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for procarbazine and Adverse Drug Event
| Article | Year |
|---|---|
Potential environmental chemical hazards. I. Drugs.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Analgesics; Animals; Aspirin; Carcinogens; Drug-Rela | 1972 |
2 trials available for procarbazine and Adverse Drug Event
9 other studies available for procarbazine and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
One year of procarbazine lomustine and vincristine is poorly tolerated in low grade glioma: a real world experience in a national neuro-oncology centre.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug-Related Side Effects an | 2021 |
Pretreatment nausea in cancer chemotherapy: a conditioned response?
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Conditioning, Psycholo | 1980 |
[Combined chemotherapy in generalized lymphogranulomatosis].
Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents; Drug Therapy, Combination; Drug-Related Side | 1975 |
Treatment of Hodgkin's disease.
Topics: Drug-Related Side Effects and Adverse Reactions; Female; Hodgkin Disease; Humans; Laparotomy; Male; | 1974 |
Intensive chemotherapy for Hodgkin's disease: long-term complications.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; E | 1973 |
[Pathology of treated Hodgkin's disease. A retrospective study (author's transl)].
Topics: Adolescent; Adult; Age Factors; Aged; Autopsy; Child; Child, Preschool; Drug Therapy, Combination; D | 1974 |
Nonlymphomatous malignant tumors complicating Hodgkin's disease. Possible association with intensive therapy.
Topics: Adolescent; Adult; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Drug-Related S | 1972 |