procarbazine has been researched along with Acute Myelogenous Leukemia in 39 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm." | 2.65 | Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease. ( Bartolucci, AA; Durant, JR; Gams, RA; Liu, C, 1983) |
| "Ten patients developed SANLL between the 34th and 123rd month of CR." | 2.38 | Increased risk of secondary acute nonlymphocytic leukemia after extended-field radiation therapy combined with MOPP chemotherapy for Hodgkin's disease. ( Andrieu, JM; Coscas, Y; Fermanian, J; Flandrin, G; Ifrah, N; Payen, C, 1990) |
| "Therapy-related acute myeloid leukemia and myelodysplastic syndromes (t-AML/MDS) represent severe late effects in patients treated for Hodgkin lymphoma (HL)." | 1.40 | Therapy-related acute myeloid leukemia and myelodysplastic syndromes in patients with Hodgkin lymphoma: a report from the German Hodgkin Study Group. ( Behringer, K; Böll, B; Borchmann, P; Diehl, V; Eichenauer, DA; Engert, A; Franklin, J; Fuchs, M; Halbsguth, T; Haverkamp, H; Klimm, B; Rothe, A; Sasse, S; Thielen, I; von Tresckow, B, 2014) |
| "To assess therapy-related acute myeloid leukemia/myelodysplastic syndrome (t-AML/MDS) risk in patients treated for Hodgkin lymphoma (HL) on successive generations of Stanford clinical trials." | 1.39 | Risk of therapy-related secondary leukemia in Hodgkin lymphoma: the Stanford University experience over three generations of clinical trials. ( Advani, RH; Balise, R; Greenberg, PL; Hoppe, RT; Horning, SJ; Koontz, MZ; Rosenberg, SA, 2013) |
| " Primary therapies were divided into four groups: radiotherapy alone, moderately dosed COPP/ABVD-like chemotherapies for intermediate and advanced stages and BEACOPP escalated." | 1.37 | Impact of first- and second-line treatment for Hodgkin's lymphoma on the incidence of AML/MDS and NHL--experience of the German Hodgkin's Lymphoma Study Group analyzed by a parametric model of carcinogenesis. ( Diehl, V; Engert, A; Franklin, J; Hasenclever, D; Josting, A; Loeffler, M; Scholz, M, 2011) |
| "Although it is accepted that pediatric cancer treatment harbors a risk of gonadal damage, large cohort studies using up-to-date fertility markers are lacking." | 1.35 | Effect of childhood cancer treatment on fertility markers in adult male long-term survivors. ( Dohle, GR; Hählen, K; Hakvoort-Cammel, FG; van Casteren, NJ; van den Heuvel-Eibrink, MM; van der Linden, GH, 2009) |
| "Concerning ANLL, the MOPP regimen was significantly associated with a higher risk: 3." | 1.31 | Fifteen-year secondary leukaemia risk observed in 761 patients with Hodgkin's disease prospectively treated by MOPP or ABVD chemotherapy plus high-dose irradiation. ( Andrieu, JM; Colonna, P; Delwail, V; Jais, JP, 2002) |
| "We report a 54-year-old patient with Hodgkin's disease who achieved a complete remission after combined modality treatment." | 1.29 | Factor VIII inhibitor prior to and during secondary acute nonlymphocytic leukemia in a patient with cured Hodgkin's disease. ( Bendandi, M; Cantagalli, F; Macchi, S; Mancino, A; Simoncelli, F; Stefanati, V; Tura, S; Visani, G; Zaccaria, A; Zinzani, PL, 1995) |
| "A case of Hodgkin's disease with isolated cerebral relapse is reported here." | 1.29 | Meningioma-like cerebral relapse of Hodgkin's disease. ( Catarini, M; Discepoli, G; Leoni, P; Montillo, M; Rychlicki, F; Scarpelli, M, 1994) |
| "Following irradiation alone, secondary acute nonlymphocytic leukemia (ANLL) is uncommon; following chemotherapy alone, the risk is increased, but not as much as when combined modality treatments are used." | 1.29 | Splenectomy and the increasing risk of secondary acute leukemia in Hodgkin's disease. ( Brusamolino, E; Fiacchini, M; Gobbi, PG; Tura, S; Zinzani, PL, 1993) |
| "In 74% of the acute myeloid leukemia patients, the truncated inhibitor was detected." | 1.29 | Urinary excretion of proteolyzed alpha1-antitrypsin: specificity, quantitation, and relation to therapy response in patients with acute myeloid leukemia. ( Busch, R; Dengler, R; Eger, G; Emmerich, B; Münstermann, U; Plewan, A, 1995) |
| "20 untreated Hodgkin's disease patients and 1 patient relapsing after radiotherapy (17 stage IIB-IV and 4 stage I-IIA) were given doxorubicin, bleomycin, etoposide and prednisone on a 21-day cycle." | 1.28 | ABEP as primary chemotherapy for Hodgkin's disease. ( Alberto, P; Mermillod, B; Zulian, GB, 1992) |
| "In 1984, the complete remission of malignant lymphoma was observed after MOPP, COPP and VAPP chemotherapies." | 1.28 | [Secondary leukemia (AML) with TcR beta rearrangement]. ( Akiyoshi, T; Hisano, S; Ishibashi, M; Kawara, T; Kikuchi, M; Kimura, N; Kyoshoin, K; Morioka, E; Okumura, M, 1989) |
| "Secondary tumors were noted in 8 out of 675 patients with Hodgkin's disease during remission following treatment." | 1.27 | [Secondary malignant tumors following treatment of Hodgkin's disease]. ( Shishkin, IP, 1984) |
| "A case of Hodgkin's disease is reported in which acute promyelocytic leukaemia developed within 5 months of initiation of chemotherapy." | 1.26 | Hodgkin's disease and acute promyelocytic leukaemia. A case report. ( King, JB; Rosenstrauch, WJ; Steytler, JG; van der Merwe, AM; van Eeden, PJ, 1980) |
| " A number of the toxic effects of procarbazine seen in humans were also noted in this series of monkeys, including vomiting and myelosuppression." | 1.26 | Carcinogenic and other adverse effects of procarbazine in nonhuman primates. ( Adamson, RH; Correa, P; Dalgard, DW; Sieber, SM, 1978) |
| "Nine patients with aplastic anemia rejected their first graft." | 1.26 | Experience with second marrow transplants. ( Buckner, CD; Clift, RA; Fefer, A; Neiman, PE; Storb, R; Thomas, ED; Wright, SE, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (53.85) | 18.7374 |
| 1990's | 11 (28.21) | 18.2507 |
| 2000's | 3 (7.69) | 29.6817 |
| 2010's | 4 (10.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eichenauer, DA | 1 |
| Thielen, I | 1 |
| Haverkamp, H | 1 |
| Franklin, J | 2 |
| Behringer, K | 1 |
| Halbsguth, T | 1 |
| Klimm, B | 1 |
| Diehl, V | 2 |
| Sasse, S | 1 |
| Rothe, A | 1 |
| Fuchs, M | 1 |
| Böll, B | 1 |
| von Tresckow, B | 1 |
| Borchmann, P | 1 |
| Engert, A | 3 |
| van Casteren, NJ | 1 |
| van der Linden, GH | 1 |
| Hakvoort-Cammel, FG | 1 |
| Hählen, K | 1 |
| Dohle, GR | 1 |
| van den Heuvel-Eibrink, MM | 1 |
| Scholz, M | 1 |
| Josting, A | 1 |
| Hasenclever, D | 1 |
| Loeffler, M | 1 |
| Rancea, M | 1 |
| Skoetz, N | 1 |
| Monsef, I | 1 |
| Hübel, K | 1 |
| Bauer, K | 1 |
| Koontz, MZ | 1 |
| Horning, SJ | 1 |
| Balise, R | 1 |
| Greenberg, PL | 1 |
| Rosenberg, SA | 2 |
| Hoppe, RT | 1 |
| Advani, RH | 1 |
| Ogawa, M | 1 |
| Rosner, F | 1 |
| Bartolucci, AA | 1 |
| Liu, C | 1 |
| Durant, JR | 1 |
| Gams, RA | 1 |
| Shishkin, IP | 1 |
| Rosenstrauch, WJ | 1 |
| van der Merwe, AM | 1 |
| King, JB | 1 |
| van Eeden, PJ | 1 |
| Steytler, JG | 1 |
| Streuli, RA | 1 |
| Bendandi, M | 1 |
| Zaccaria, A | 1 |
| Zinzani, PL | 2 |
| Visani, G | 1 |
| Stefanati, V | 1 |
| Cantagalli, F | 1 |
| Mancino, A | 1 |
| Macchi, S | 1 |
| Simoncelli, F | 1 |
| Tura, S | 2 |
| Montillo, M | 1 |
| Scarpelli, M | 1 |
| Discepoli, G | 1 |
| Catarini, M | 1 |
| Rychlicki, F | 1 |
| Leoni, P | 1 |
| Fiacchini, M | 1 |
| Brusamolino, E | 1 |
| Gobbi, PG | 1 |
| Izumi, T | 1 |
| Ohtsuki, T | 1 |
| Ohya, K | 1 |
| Ogawa, Y | 1 |
| Yoshida, M | 1 |
| Muroi, K | 1 |
| Imagawa, S | 1 |
| Hatake, K | 1 |
| Kuriki, K | 1 |
| Saito, K | 1 |
| Miura, Y | 1 |
| Nishikawa, K | 1 |
| Dengler, R | 1 |
| Plewan, A | 1 |
| Münstermann, U | 1 |
| Busch, R | 1 |
| Eger, G | 1 |
| Emmerich, B | 1 |
| Valagussa, P | 1 |
| Bonadonna, G | 2 |
| Delwail, V | 1 |
| Jais, JP | 1 |
| Colonna, P | 1 |
| Andrieu, JM | 2 |
| Sutow, WW | 1 |
| Sullivan, MP | 1 |
| Trump, DL | 1 |
| Cowall, DE | 1 |
| Sieber, SM | 2 |
| Correa, P | 1 |
| Dalgard, DW | 1 |
| Adamson, RH | 1 |
| Wright, SE | 1 |
| Thomas, ED | 1 |
| Buckner, CD | 1 |
| Clift, RA | 1 |
| Fefer, A | 1 |
| Neiman, PE | 1 |
| Storb, R | 1 |
| Ramsay, NK | 1 |
| Coccia, PF | 1 |
| Krivit, W | 1 |
| Bloomfield, CD | 1 |
| Nesbit, ME | 1 |
| Zulian, GB | 1 |
| Mermillod, B | 1 |
| Alberto, P | 1 |
| Zurborn, KH | 1 |
| Gram, J | 1 |
| Glander, K | 1 |
| Delbrück, K | 1 |
| Pelzer, H | 1 |
| Löffler, H | 1 |
| Bruhn, HD | 1 |
| Ifrah, N | 1 |
| Payen, C | 1 |
| Fermanian, J | 1 |
| Coscas, Y | 1 |
| Flandrin, G | 1 |
| Lavey, RS | 1 |
| Akiyoshi, T | 1 |
| Kimura, N | 1 |
| Hisano, S | 1 |
| Kawara, T | 1 |
| Morioka, E | 1 |
| Ishibashi, M | 1 |
| Kyoshoin, K | 1 |
| Kikuchi, M | 1 |
| Okumura, M | 1 |
| Krischer, JP | 1 |
| Steuber, CP | 1 |
| Vietti, TJ | 1 |
| Culbert, SJ | 1 |
| Ragab, AH | 1 |
| Morgan, SK | 1 |
| Berry, DH | 1 |
| Hvizdala, E | 1 |
| Thomas, PJ | 1 |
| Land, VJ | 1 |
| Iurlo, A | 1 |
| Mecucci, C | 1 |
| Van Orshoven, A | 1 |
| Michaux, JL | 1 |
| Boogaerts, M | 1 |
| Van den Berghe, H | 1 |
| Kaplan, HS | 1 |
| Sahakian, GJ | 1 |
| al-Mondhiry, H | 1 |
| Lacher, MJ | 1 |
| Connolly, CE | 1 |
| Dubovsky, D | 1 |
| Jacobs, P | 1 |
| Schaefer, UW | 1 |
| Kanzler, G | 1 |
| Wakem, CJ | 1 |
| Bennett, JM | 1 |
| De Lena, M | 1 |
| Banfi, A | 1 |
| Lattuada, A | 1 |
| Fairley, GH | 1 |
7 reviews available for procarbazine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Fourteenth biannual report of the Cochrane Haematological Malignancies Group--focus on autologous stem cell transplantation in hematological malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Colony-Stimulating Factors; Cyclophospham | 2012 |
[Hematologic tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Dacarbazine | 2003 |
[Malignant lymphoma].
Topics: Adolescent; Adult; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Hodgkin Disea | 1981 |
[Chemotherapy of relapsed AML and ALL].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Etoposide; Granulocyte Col | 1996 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; | 1977 |
Increased risk of secondary acute nonlymphocytic leukemia after extended-field radiation therapy combined with MOPP chemotherapy for Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Th | 1990 |
Combination chemotherapy in malignant diseases.
Topics: Adult; Antineoplastic Agents; Asparaginase; Carmustine; Child; Cyclophosphamide; Cytarabine; Cytosin | 1971 |
3 trials available for procarbazine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Female; Hodgkin | 1983 |
Long-term results in the treatment of acute nonlymphocytic leukemia: a Pediatric Oncology Group Study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modali | 1989 |
The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin's disease: 1962-1984.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Combine | 1985 |
29 other studies available for procarbazine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Therapy-related acute myeloid leukemia and myelodysplastic syndromes in patients with Hodgkin lymphoma: a report from the German Hodgkin Study Group.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide | 2014 |
Effect of childhood cancer treatment on fertility markers in adult male long-term survivors.
Topics: Biomarkers; Child, Preschool; Cyclophosphamide; Female; Fertility; Follicle Stimulating Hormone; Fol | 2009 |
Impact of first- and second-line treatment for Hodgkin's lymphoma on the incidence of AML/MDS and NHL--experience of the German Hodgkin's Lymphoma Study Group analyzed by a parametric model of carcinogenesis.
Topics: Algorithms; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dacarbazine | 2011 |
Risk of therapy-related secondary leukemia in Hodgkin lymphoma: the Stanford University experience over three generations of clinical trials.
Topics: Academic Medical Centers; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Californ | 2013 |
Cancer and secondary leukemia.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Child; Child, Preschool; Female; | 1983 |
[Secondary malignant tumors following treatment of Hodgkin's disease].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophospha | 1984 |
Hodgkin's disease and acute promyelocytic leukaemia. A case report.
Topics: Adult; Drug Therapy, Combination; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Male; Mechloret | 1980 |
Factor VIII inhibitor prior to and during secondary acute nonlymphocytic leukemia in a patient with cured Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Blood Transfusion; Combined Modality | 1995 |
Meningioma-like cerebral relapse of Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fatal Outcome; Female; Ho | 1994 |
Splenectomy and the increasing risk of secondary acute leukemia in Hodgkin's disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hodgkin Di | 1993 |
Therapy-related leukemia with a novel 21q22 rearrangement.
Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromosomes, Human, Pair 21; | 1996 |
Urinary excretion of proteolyzed alpha1-antitrypsin: specificity, quantitation, and relation to therapy response in patients with acute myeloid leukemia.
Topics: Adult; Aged; alpha 1-Antitrypsin; Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; | 1995 |
Hodgkin's disease and the risk of acute leukemia in successfully treated patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarbazine; D | 1998 |
Fifteen-year secondary leukaemia risk observed in 761 patients with Hodgkin's disease prospectively treated by MOPP or ABVD chemotherapy plus high-dose irradiation.
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbaz | 2002 |
Childhood cancer: the improving prognosis.
Topics: Asparaginase; Child; Cyclophosphamide; Cytosine; Daunorubicin; Doxorubicin; Drug Therapy, Combinatio | 1976 |
Acute myelogenous leukemia as a late complication of the multimodality therapy for Hodgkin's disease.
Topics: Adult; Biopsy; Bone Marrow; Cytarabine; Daunorubicin; Hodgkin Disease; Humans; Leukemia, Myeloid, Ac | 1977 |
Carcinogenic and other adverse effects of procarbazine in nonhuman primates.
Topics: Animals; Bone Marrow; Carcinogens; Cercopithecus; Female; Haplorhini; Leukemia, Experimental; Leukem | 1978 |
Experience with second marrow transplants.
Topics: Anemia, Aplastic; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Graft Rejection; | 1976 |
Vinblastine, procarbazine, and cytosine arabinoside in combination for reinduction of childhood acute myelocytic leukemia.
Topics: Child; Child, Preschool; Cytarabine; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid, A | 1976 |
ABEP as primary chemotherapy for Hodgkin's disease.
Topics: Aclarubicin; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cytarabin | 1992 |
Influence of cytostatic treatment on the coagulation system and fibrinolysis in patients with non-Hodgkin's lymphomas and acute leukemias.
Topics: Acute Disease; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antithrombin I | 1991 |
Acute nonlymphocytic leukemia after radiation and MOPP chemotherapy for Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hodgkin Disease; Humans; | 1990 |
[Secondary leukemia (AML) with TcR beta rearrangement].
Topics: Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Cyclophosphamide; Female; Gene Rearra | 1989 |
The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Female; Hodgkin Disea | 1988 |
Acute leukemia in Hodgkin's disease.
Topics: Adult; Bleomycin; Carmustine; Chlorambucil; Drug Therapy, Combination; Female; Hodgkin Disease; Huma | 1974 |
Letter: Acute leukaemia and myeloma.
Topics: Aged; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid, Acute; Melphalan; Multiple Myelo | 1974 |
[Leukemia in Hodgkin's disease due to cancerostatic therapy?].
Topics: Adult; Chlorambucil; Cyclophosphamide; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Po | 1972 |
Hodgkin's disease terminating as acute leukaemia: case report and review of the literature.
Topics: Acute Disease; Adolescent; Adult; Bone Marrow; Female; Granuloma; Hodgkin Disease; Humans; Leukemia, | 1972 |
Secondary neoplasms in malignant lymphomas after intensive therapy.
Topics: Adult; Antineoplastic Agents; Follow-Up Studies; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; | 1973 |