procarbazine has been researched along with Abnormalities, Drug-Induced in 14 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The induction of dominant cataract mutations by procarbazine was studied concomitantly with the induction of specific-locus mutations in treated male mice." | 7.67 | Dominant cataract and recessive specific-locus mutations detected in offspring of procarbazine-treated male mice. ( Favor, J; Kratochvilova, J; Neuhäuser-Klaus, A, 1988) |
| "The study aimed at to induce cleft-lip-alveolus-palate (CLAP) applying procarbazine in rat fetuses at the 14(th) day of pregnancy, to supply thiocyanate and/or folic acid sufficient for preventive treatment and subsequently to investigate cleft extent in the palatal area as well as bone maturity." | 3.74 | Different bone sesitivity to malformations induced by procarbazine in fetal rats. ( Fanghanel, J; Gedrange, T; Gredes, T; Kubein-Meesenburg, D; Kundt, G; Proff, P; Weingartner, J, 2008) |
| "The induction of dominant cataract mutations by procarbazine was studied concomitantly with the induction of specific-locus mutations in treated male mice." | 3.67 | Dominant cataract and recessive specific-locus mutations detected in offspring of procarbazine-treated male mice. ( Favor, J; Kratochvilova, J; Neuhäuser-Klaus, A, 1988) |
| "A case of human fetal renal maldevelopment following the administration of nitrogen mustard, vincristine, procarbazine, and prednisone in early pregnancy for therapy of Hodgkin's disease is reported." | 3.65 | Fetal renal malformation following treatment of Hodgkin's disease during pregnancy. ( Mellman, WJ; Mennuti, MT; Shepard, TH, 1975) |
| "Because several previous authors have repeatedly described treatment with thiamine as one of the sufficient prophylactic measures in slowing the development of viscerocranial malformations, especially cleft alveolus and palate, it is of utmost importance that the timing of treatment and dosage of thiamine be taken into consideration not only in animal experiments but also when applying results to humans." | 1.30 | Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats. ( Bienengräber, V; Fanghänel, J; Kundt, G; Malek, FA, 1997) |
| "Procarbazine (PCZ) is an antineoplastic agent useful in the treatment of Hodgkin's disease, brain tumors, and chronic leukemia." | 1.29 | Profile of procarbazine-induced embryotoxicity in an embryo hepatocyte co-culture system and after in utero glutathione depletion. ( Andrews, JE; Ebron-McCoy, MT; Kavlock, RJ; Nichols, HP, 1995) |
| "Procarbazine and BCNU were given for 5 months before conception and throughout the first and second trimesters, and streptozotocin was given throughout the third trimester." | 1.27 | Successful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancy. ( Chudley, AE; Schapira, DV, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weingartner, J | 1 |
| Proff, P | 1 |
| Fanghanel, J | 3 |
| Kundt, G | 3 |
| Gedrange, T | 1 |
| Kubein-Meesenburg, D | 1 |
| Gredes, T | 1 |
| Schapira, DV | 1 |
| Chudley, AE | 1 |
| Johnson, JM | 1 |
| Thompson, DJ | 1 |
| Burek, JD | 1 |
| Haggerty, GC | 1 |
| Dyke, IL | 1 |
| Lower, CE | 1 |
| Solomon, JL | 1 |
| Ebron-McCoy, MT | 1 |
| Nichols, HP | 1 |
| Andrews, JE | 1 |
| Kavlock, RJ | 1 |
| Bienengräber, V | 2 |
| Malek, FA | 1 |
| Gundlach, KK | 1 |
| Malek, F | 1 |
| Mennuti, MT | 1 |
| Shepard, TH | 1 |
| Mellman, WJ | 1 |
| Avilés, A | 1 |
| Zepeda, G | 1 |
| Cruz, J | 1 |
| Nagao, T | 1 |
| Fujikawa, K | 1 |
| Wright, JA | 1 |
| Brickell, L | 1 |
| Foster, J | 1 |
| Kratochvilova, J | 1 |
| Favor, J | 1 |
| Neuhäuser-Klaus, A | 1 |
| Fishbein, L | 1 |
| Flamm, WG | 1 |
| Garrett, MJ | 1 |
1 review available for procarbazine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Potential environmental chemical hazards. I. Drugs.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Analgesics; Animals; Aspirin; Carcinogens; Drug-Rela | 1972 |
13 other studies available for procarbazine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Different bone sesitivity to malformations induced by procarbazine in fetal rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Cleft Palate; Drug Therapy, Combination; Femal | 2008 |
Successful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Fema | 1984 |
The neuroteratogenicity of procarbazine in the rat: behavioral, morphological, and neurochemical aspects.
Topics: Abnormalities, Drug-Induced; Animals; Avoidance Learning; Behavior, Animal; Brain; Choline; Choline | 1984 |
Profile of procarbazine-induced embryotoxicity in an embryo hepatocyte co-culture system and after in utero glutathione depletion.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Biotransformation; Buthionine Sulfoximine; Ce | 1995 |
Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats.
Topics: Abnormalities, Drug-Induced; Alveolar Process; Animals; Body Weight; Bone and Bones; Cleft Palate; C | 1997 |
Malformations of the temporo-mandibular joint in laboratory animals and in man.
Topics: Abnormalities, Drug-Induced; Animals; Cyclophosphamide; Female; Glycine; Humans; Hydroxamic Acids; I | 1999 |
Disturbances of palatogenesis and their prophylaxis in animal experiments.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Embryonic and Fetal Development; Female; Humans; | 1999 |
Fetal renal malformation following treatment of Hodgkin's disease during pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Adult; Autopsy; Female; Fetus; Hodgkin Disease; Huma | 1975 |
[Hodgkin's disease during pregnancy. Study of late effects in the newborn infants].
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chrom | 1991 |
Genotoxic potency in mouse spermatogonial stem cells of triethylenemelamine, mitomycin C, ethylnitrosourea, procarbazine, and propyl methanesulfonate as measured by F1 congenital defects.
Topics: Abnormalities, Drug-Induced; Animals; Ethylnitrosourea; Male; Mesylates; Mice; Mice, Inbred ICR; Mit | 1990 |
The neuroteratogenicity of procarbazine hydrochloride in the rat: histopathological and immunocytochemical aspects.
Topics: Abnormalities, Drug-Induced; Animals; Astrocytes; Cerebral Cortex; Female; Neurons; Oligodendroglia; | 1989 |
Dominant cataract and recessive specific-locus mutations detected in offspring of procarbazine-treated male mice.
Topics: Abnormalities, Drug-Induced; Animals; Cataract; Epistasis, Genetic; Fertility; Genes, Dominant; Gene | 1988 |
Letter: Teratogenic effects of combination chemotherapy.
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Agents; Drug Therapy, Combination; Female; Foot D | 1974 |