procarbazine has been researched along with Abnormalities, Congenital in 3 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sex-related differences in the frequency of cleft palates and microgenia in rat fetuses prenatally treated with procarbazine (200 mg/kg on day 14 of gestation (GD14), group 1), and the anti-teratogenic effect of prenatal folic acid supplementation (4 mg/kg on GD14 through GD17, group 2) were studied in LEW." | 7.72 | Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2003) |
| "Sex-related differences in the frequency of cleft palates and microgenia in rat fetuses prenatally treated with procarbazine (200 mg/kg on day 14 of gestation (GD14), group 1), and the anti-teratogenic effect of prenatal folic acid supplementation (4 mg/kg on GD14 through GD17, group 2) were studied in LEW." | 3.72 | Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats. ( Bienengräber, V; Fanghänel, J; Malek, FA; Möritz, KU, 2003) |
| "Twelve women (12%) experienced 13 miscarriages after a median of 50 months (range, 13-120) from the end of therapy." | 1.38 | Impact of different treatment approaches on pregnancy outcomes in 99 women treated for Hodgkin lymphoma. ( Alfò, M; Annechini, G; Cavalieri, E; De Sanctis, V; Enrici, RM; Filippone, FR; Minniti, G; Muni, R; Osti, MF; Pulsoni, A; Valeriani, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Sanctis, V | 1 |
| Filippone, FR | 1 |
| Alfò, M | 1 |
| Muni, R | 1 |
| Cavalieri, E | 1 |
| Pulsoni, A | 1 |
| Annechini, G | 1 |
| Valeriani, M | 1 |
| Osti, MF | 1 |
| Minniti, G | 1 |
| Enrici, RM | 1 |
| Malek, FA | 1 |
| Möritz, KU | 1 |
| Fanghänel, J | 1 |
| Bienengräber, V | 1 |
| Dein, RA | 1 |
| Mennuti, MT | 1 |
| Kovach, P | 1 |
| Gabbe, SG | 1 |
1 review available for procarbazine and Abnormalities, Congenital
| Article | Year |
|---|---|
The reproductive potential of young men and women with Hodgkin's disease.
Topics: Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Congenital Abnormalities; Female; | 1984 |
2 other studies available for procarbazine and Abnormalities, Congenital
| Article | Year |
|---|---|
Impact of different treatment approaches on pregnancy outcomes in 99 women treated for Hodgkin lymphoma.
Topics: Abortion, Spontaneous; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Congenital | 2012 |
Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats.
Topics: Animals; Cleft Palate; Congenital Abnormalities; Dietary Supplements; Female; Folic Acid; Male; Mand | 2003 |