procarbazine has been researched along with Abnormalities, Autosome in 23 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between 1978 and 1988, 20 children with medulloblastoma (MB) of the brain were treated postoperatively with MOPP (nitrogen mustard, vincristine, prednisone, and procarbazine)." | 3.68 | Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy. ( Hayani, A; Mahoney, DH; Taylor, LD, 1992) |
| "The frequency of chromosome aberrations in the peripheral blood of patients successfully treated for Hodgkin's disease (HD) and non-Hodgkin's lymphoma is compared with that seen in age-matched haematologically normal subjects." | 1.28 | Chromosome aberrations following cytotoxic therapy in patients in complete remission from lymphoma. ( Clark, RE; Jacobs, A; Jones, BM; White, AD, 1992) |
| " Time-response and dose-response were studied for chromosomal aberrations induced by transplacental treatment of mouse embryos." | 1.27 | New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. II. Clastogenic effects determined in transplacentally treated mouse embryos. ( Adler, ID, 1983) |
| "Because nonrandom acquired clonal chromosome abnormalities are a consistent feature of malignancies, our data suggest that AILD may be a malignant disease despite its original description as a benign proliferative process." | 1.26 | Nonrandom chromosome abnormalities in angioimmunoblastic lymphadenopathy. ( Haren, JM; Kaneko, Y; Larson, RA; Rowley, JD; Variakojis, D, 1982) |
| "Stage II Hodgkin's disease probably should be divided into two substages requiring different treatment." | 1.26 | [The current state of curability of Hodgkin's disease]. ( Streuli, RA; Ultmann, JE, 1981) |
| "2." | 1.25 | [Induction of chromosome aberrations by antirheumatic therapy]. ( Vormittag, W, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (52.17) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abraham, SK | 1 |
| Khandelwal, N | 1 |
| Hintzsche, H | 1 |
| Stopper, H | 1 |
| Idbaih, A | 1 |
| Dalmasso, C | 1 |
| Kouwenhoven, M | 1 |
| Jeuken, J | 1 |
| Carpentier, C | 1 |
| Gorlia, T | 1 |
| Kros, JM | 2 |
| French, P | 1 |
| Teepen, J | 1 |
| Broët, P | 1 |
| Delattre, O | 1 |
| Mokhtari, K | 1 |
| Sanson, M | 1 |
| Delattre, JY | 1 |
| van den Bent, M | 1 |
| Hoang-Xuan, K | 1 |
| Salas, C | 1 |
| Niembro, A | 1 |
| Lozano, V | 1 |
| Gallardo, E | 1 |
| Molina, B | 1 |
| Sánchez, S | 1 |
| Ramos, S | 1 |
| Carnevale, A | 1 |
| Pérez-Vera, P | 1 |
| Rivera Luna, R | 1 |
| Frias, S | 1 |
| Buckner, JC | 1 |
| Gesme, D | 1 |
| O'Fallon, JR | 1 |
| Hammack, JE | 1 |
| Stafford, S | 1 |
| Brown, PD | 1 |
| Hawkins, R | 1 |
| Scheithauer, BW | 1 |
| Erickson, BJ | 1 |
| Levitt, R | 1 |
| Shaw, EG | 1 |
| Jenkins, R | 1 |
| van den Bent, MJ | 1 |
| Looijenga, LH | 1 |
| Langenberg, K | 1 |
| Dinjens, W | 1 |
| Graveland, W | 1 |
| Uytdewilligen, L | 1 |
| Sillevis Smitt, PA | 1 |
| Jenkins, RB | 1 |
| Kneller, A | 1 |
| Cohen, N | 1 |
| Berkowicz, M | 1 |
| Reichart, M | 1 |
| Rosner, E | 1 |
| Sokolovski, M | 1 |
| Nagler, A | 1 |
| Rechavi, G | 1 |
| Amariglio, N | 1 |
| Trakhtenbrot, L | 1 |
| Kaneko, Y | 1 |
| Larson, RA | 1 |
| Variakojis, D | 1 |
| Haren, JM | 1 |
| Rowley, JD | 1 |
| Adler, ID | 1 |
| Zimmering, S | 1 |
| Chryssanthou, CP | 1 |
| Wallach, RC | 1 |
| Atchison, M | 1 |
| Streuli, RA | 1 |
| Ultmann, JE | 1 |
| Brandriff, BF | 1 |
| Meistrich, ML | 1 |
| Gordon, LA | 1 |
| Carrano, AV | 1 |
| Liang, JC | 1 |
| Kaplan, SS | 1 |
| Rybka, WB | 1 |
| Blom, J | 1 |
| Shekhter-Levin, S | 1 |
| Garaventa, A | 1 |
| Haupt, R | 1 |
| Panarello, C | 1 |
| Dodero, P | 1 |
| Gambini, C | 1 |
| Gambaro, M | 1 |
| Sharma, RK | 1 |
| Roberts, GT | 1 |
| Johnson, FM | 1 |
| Malling, HV | 1 |
| Neistadt, EL | 1 |
| Gershanovich, ML | 1 |
| Kolygin, BA | 1 |
| Ogorodnikova, BN | 1 |
| Fedoreev, GA | 1 |
| Chekharina, EA | 1 |
| Filov, VA | 1 |
| Vormittag, W | 2 |
| Hayani, A | 1 |
| Mahoney, DH | 1 |
| Taylor, LD | 1 |
| White, AD | 1 |
| Jones, BM | 1 |
| Clark, RE | 1 |
| Jacobs, A | 1 |
| Iurlo, A | 1 |
| Mecucci, C | 1 |
| Van Orshoven, A | 1 |
| Michaux, JL | 1 |
| Boogaerts, M | 1 |
| Van den Berghe, H | 1 |
| Ashby, J | 1 |
| Mirkova, E | 1 |
| Pinedo, HM | 1 |
| Van Hemel, JO | 1 |
| Vrede, MA | 1 |
| Van der Sluys Veer, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE III STUDY OF ADJUVANT PROCARBAZINE, CCNU AND VINCRISTINE CHEMOTHERAPY IN PATIENTS WITH HIGHLY ANAPLASTIC OLIGODENDROGLIOMA[NCT00002840] | Phase 3 | 350 participants (Anticipated) | Interventional | 1996-08-31 | Completed | ||
| PHASE II STUDY OF PREIRRADIATION PCV CHEMOTHERAPY IN PATIENTS WITH SUPRATENTORIAL LOW-GRADE GLIOMAS[NCT00002806] | Phase 2 | 43 participants (Actual) | Interventional | 1996-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for procarbazine and Abnormalities, Autosome
| Article | Year |
|---|---|
Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Chr | 2011 |
Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chromosome Aber | 2003 |
21 other studies available for procarbazine and Abnormalities, Autosome
| Article | Year |
|---|---|
Antigenotoxic effects of resveratrol: assessment of in vitro and in vivo response.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antimutagenic Agents; Bone Marrow Cells; Chromosome Aberrations; | 2016 |
Persistent genomic instability in peripheral blood lymphocytes from Hodgkin lymphoma survivors.
Topics: Adult; Aneuploidy; Case-Control Studies; Chromosomal Instability; Chromosome Aberrations; Chromosome | 2012 |
Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chromosome Aberrations; Chromosomes | 2003 |
Acquisition of a Ph chromosome with minor BCR/ABL fusion in treatment-related myelodysplastic syndrome with chromosome 7 abnormalities in a patient treated for Hodgkin disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromosome Aberrations; Chromosome | 2005 |
Nonrandom chromosome abnormalities in angioimmunoblastic lymphadenopathy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromosome Aberrations; Cyclophosph | 1982 |
New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. II. Clastogenic effects determined in transplacentally treated mouse embryos.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Bleomycin; Chromosome Aberrations; Embryo, Mammalian; Female; | 1983 |
Review of the current status of the mei-9a test for chromosome loss in Drosophila melanogaster: an assay with radically improved detection capacity for chromosome lesions induced by methyl methanesulfonate (MMS), dimethylnitrosamine (DMN), and especially
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Diethylnitrosamine; Dimethylnitrosamine; Droso | 1981 |
Meiotic chromosomal changes and sterility produced by nitrogen mustard and procarbazine in mice.
Topics: Animals; Animals, Newborn; Chromosome Aberrations; Female; Infertility; Litter Size; Male; Meiosis; | 1983 |
[The current state of curability of Hodgkin's disease].
Topics: Chromosome Aberrations; Drug Therapy, Combination; Hodgkin Disease; Humans; Leukemia; Mechlorethamin | 1981 |
Chromosomal damage in sperm of patients surviving Hodgkin's disease following MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) therapy with and without radiotherapy.
Topics: Adolescent; Adult; Aneuploidy; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromosome A | 1994 |
Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma.
Topics: Acute Disease; Aged; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Chromosome Aberra | 1998 |
Early occurrence of a secondary thyroid carcinoma in a child treated for Hodgkin disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Papillary; Chemotherapy, Adjuvant; Child; | 2001 |
Translocation and sperm abnormality assays in mouse spermatogonia treated with procarbazine.
Topics: Animals; Chromosome Aberrations; Chromosomes; Male; Mice; Mice, Inbred DBA; Mutagens; Procarbazine; | 1979 |
Effect of chemotherapy on the lymph node and bone marrow cell chromosomes in patients with Hodgkin's disease.
Topics: Adolescent; Adult; Bone Marrow; Child; Child, Preschool; Chromosome Aberrations; Cyclophosphamide; H | 1978 |
[Induction of chromosome aberrations by antirheumatic therapy].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Cyclophosphamide; Gold; Hu | 1975 |
Therapy-related myelodysplastic syndrome in children with medulloblastoma following MOPP chemotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool | 1992 |
Chromosome aberrations following cytotoxic therapy in patients in complete remission from lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cells, Cultured; Chromosome Aberrations | 1992 |
The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Female; Hodgkin Disea | 1988 |
Re-evaluation of 1,2-dimethylhydrazine in the mouse bone marrow micronucleus assay: observation of a positive response.
Topics: 1,2-Dimethylhydrazine; Animals; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Dimethylhydrazine | 1987 |
Letter: Acute myelofibrosis and chromosome damage after procarbazine treatment.
Topics: Aged; Aging; Aneuploidy; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Humans; Male; Penil | 1974 |
[Cytostatic immunosuppressive therapy, chromosomal aberrations and carcinogenic effect (author's transl)].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Chromosomes, Human, 1-3; C | 1974 |