procaine has been researched along with Sjogren's Syndrome in 4 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " While corneal complications following long-term use or misuse of local anaesthetic solutions have been described, toxic epitheliopathy after a single application of six drops of preservative free oxybuprocaine is rare." | 5.39 | Toxic epitheliopathy from a single application of preservative free oxybuprocaine (0.4%) in a patient with Sjogren's syndrome. ( Ansari, H; Spencer, N; Weinberg, L, 2013) |
| " While corneal complications following long-term use or misuse of local anaesthetic solutions have been described, toxic epitheliopathy after a single application of six drops of preservative free oxybuprocaine is rare." | 1.39 | Toxic epitheliopathy from a single application of preservative free oxybuprocaine (0.4%) in a patient with Sjogren's syndrome. ( Ansari, H; Spencer, N; Weinberg, L, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, F | 1 |
| Wang, J | 1 |
| Sun, J | 1 |
| Shen, L | 1 |
| Liu, M | 1 |
| Zhao, E | 1 |
| Ansari, H | 1 |
| Weinberg, L | 1 |
| Spencer, N | 1 |
| LIPNITSKII, IF | 1 |
| Varshavskiĭ, AI | 1 |
| Guberskaia, TA | 1 |
4 other studies available for procaine and Sjogren's Syndrome
| Article | Year |
|---|---|
Procaine stimulates aquaporin‑5 expression in human salivary gland ductal cells via the suppression of DNA methyltransferase‑1.
Topics: Aquaporin 5; Cell Line; Cell Proliferation; CpG Islands; DNA (Cytosine-5-)-Methyltransferase 1; DNA | 2018 |
Toxic epitheliopathy from a single application of preservative free oxybuprocaine (0.4%) in a patient with Sjogren's syndrome.
Topics: Administration, Ophthalmic; Aged; Anesthetics, Local; Cataract Extraction; Corneal Diseases; Epithel | 2013 |
[Treatment of dry seborrhea (seborrhaea sicca) by intramuscular administration of novocaine].
Topics: Dermatitis; Dermatitis, Seborrheic; Injections, Intramuscular; Procaine; Sebaceous Gland Diseases; S | 1962 |
[The effect of drugs that correct regional blood circulation on the function of the parotid salivary glands in the combined treatment of patients with Sjögren's disease].
Topics: Adult; Aged; Combined Modality Therapy; Dental Care; Dimethyl Sulfoxide; Drug Evaluation; Drug Thera | 1991 |