procaine has been researched along with Seizures in 81 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The unilateral-onset psychomotor seizures were not identical to spontaneous psychomotor seizures, and the generalized seizures never occurred spontaneously in these monkeys." | 5.26 | Procaine-induced seizures in epileptic monkeys with bilateral hippocampal foci. ( Babb, TL; Crandall, PH; Finch, DM; Lieb, JP; Perryman, KM, 1979) |
| "Diazepam was found to block the generalized component of the cortico-generalized electrographic and motor seizure leaving the tonus only slightly suppressed." | 5.26 | The effect of procaine hydrochloride and diazepam, separately or in combination, on cortico-generalized kindled seizures. ( Burnham, WM; Livingston, K; Racine, R, 1979) |
| " Mice pretreated with procaine, lidocaine, and tetracaine had a lower incidence of seizures when convulsive doses of either nikethamide or doxapram hydrochloride were given intraperitoneally." | 3.65 | Interaction between local anesthetics and analeptic drugs. ( Aldrete, JA; Thompson, RG, 1975) |
| "Postoperative seizures were documented clinically and with electroencephalogram findings." | 1.62 | Scavenging right atrial Bretschneider histidine-tryptophan-ketoglutarate cardioplegia: Impact on hyponatremia and seizures in pediatric cardiac surgery patients. ( Bibevski, S; Niu, J; Ruzmetov, M; Scholl, FG; Turner, II, 2021) |
| "Chloroprocaine is a local ester anesthetic, producing excellent sensory block in clinical use." | 1.42 | Inhibition of Kv7/M Channel Currents by the Local Anesthetic Chloroprocaine. ( Cheng, Y; Jia, Q; Li, H; Zhang, F; Zhang, H; Zhao, S, 2015) |
| "Postoperative seizures were detected in 18 patients (2." | 1.37 | The effect of cardioplegic solution-induced sodium concentration fluctuation on postoperative seizure in pediatric cardiac patients. ( Byon, HJ; Chang, YE; Kim, CS; Kim, HS; Kim, JT; Kim, WH; Kim, YJ; Lee, JR; Lim, HG; Park, YH, 2011) |
| "When procaine was injected into the kindled AM, there was no paresis or EEG change." | 1.29 | Ipsilateral hemiconvulsive seizure after unilateral injection of procaine into the substantia innominata of amygdaloid-kindled rats. ( Ariga, K; Kumashiro, H; Mori, N; Wada, JA; Yokoyama, N, 1993) |
| "Although the toxic effect of local anaesthetics on the activity of cerebral cortex has been extensively studied, little is known about their toxic effect on brainstem." | 1.28 | Brainstem auditory evoked potentials during procaine toxicity in dogs. ( Ding, ZN; Hirota, K; Kobayashi, T; Murakami, S; Yamamoto, K; Yoshita, Y, 1992) |
| "However, lidocaine-induced convulsions were enhanced by AOAA." | 1.28 | Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord. ( Kawaguchi, M; Ouchi, K; Sato, T; Sawaki, K, 1991) |
| "The relationships between the convulsions induced by the local anesthetic procaine and monoamines in the spinal cord were investigated in rats." | 1.28 | Some correlations between procaine-induced convulsions and monoamines in the spinal cord of rats. ( Kawaguchi, M; Sawaki, K, 1989) |
| "In the maximal pentetrazol seizures test in rats denzimol showed a profile similar to that of phenytoin and carbamazepine, but different from that of barbiturates and benzodiazepines so that it is suggested that its clinical application would be that of "grand mal" and psychomotor type seizures therapy." | 1.27 | Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile. ( Barbadoro, E; Graziani, G; Testa, R; Tirone, F, 1983) |
| "Pretreatment with cimetidine resulted in a significant, dose-dependent decrease in the CD50 of lidocaine, whereas ranitidine pretreatment did not significantly alter the lidocaine CD50." | 1.27 | Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice. ( Kim, KC; Tasch, MD, 1986) |
| "Lidocaine and procaine seizure thresholds were studied." | 1.26 | Alteration of lidocaine- or procaine-induced convulsions by manipulation of brain amines. ( Ciarlone, AE, 1981) |
| "The unilateral-onset psychomotor seizures were not identical to spontaneous psychomotor seizures, and the generalized seizures never occurred spontaneously in these monkeys." | 1.26 | Procaine-induced seizures in epileptic monkeys with bilateral hippocampal foci. ( Babb, TL; Crandall, PH; Finch, DM; Lieb, JP; Perryman, KM, 1979) |
| "Diazepam was found to block the generalized component of the cortico-generalized electrographic and motor seizure leaving the tonus only slightly suppressed." | 1.26 | The effect of procaine hydrochloride and diazepam, separately or in combination, on cortico-generalized kindled seizures. ( Burnham, WM; Livingston, K; Racine, R, 1979) |
| "The conclusion of this study was that a respiratory acidosis increased the central nervous system toxicity of local anaesthetics and that the underlying metabolic conditions modified this increase." | 1.25 | Central nervous system effects of local anaesthetic agents. ( Englesson, S; Matousek, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (83.95) | 18.7374 |
| 1990's | 7 (8.64) | 18.2507 |
| 2000's | 2 (2.47) | 29.6817 |
| 2010's | 3 (3.70) | 24.3611 |
| 2020's | 1 (1.23) | 2.80 |
| Authors | Studies |
|---|---|
| Turner, II | 1 |
| Ruzmetov, M | 1 |
| Niu, J | 1 |
| Bibevski, S | 1 |
| Scholl, FG | 1 |
| Zhang, F | 1 |
| Cheng, Y | 1 |
| Li, H | 1 |
| Jia, Q | 1 |
| Zhang, H | 1 |
| Zhao, S | 1 |
| Hung, CH | 1 |
| Liu, KS | 1 |
| Shao, DZ | 1 |
| Cheng, KI | 1 |
| Chen, YC | 1 |
| Chen, YW | 1 |
| RICHARDS, RK | 3 |
| KUETER, KE | 1 |
| Kim, JT | 1 |
| Park, YH | 1 |
| Chang, YE | 1 |
| Byon, HJ | 1 |
| Kim, HS | 1 |
| Kim, CS | 1 |
| Lim, HG | 1 |
| Kim, WH | 1 |
| Lee, JR | 1 |
| Kim, YJ | 1 |
| BAHUET, R | 1 |
| PORTMANN, M | 1 |
| RABECHAULT, R | 1 |
| CANNAVA, A | 1 |
| ATZORI, AM | 1 |
| FRENCH, JD | 2 |
| KONIGSMARK, B | 2 |
| LIVINGSTON, RB | 2 |
| RICHLAND, KJ | 2 |
| LABORIT, H | 1 |
| BROUSSOLLE, B | 1 |
| PERRIMOND-TROUCHET, R | 1 |
| KEOHANE, J | 1 |
| BERGER, P | 1 |
| FAENZI, C | 1 |
| YERASIMIDES, TG | 1 |
| MARGOLIS, G | 1 |
| PONTON, HJ | 1 |
| FRANK, GB | 1 |
| SANDERS, HD | 3 |
| ORCUTT, JA | 1 |
| MICHAELSON, SM | 1 |
| PRYTHERCH, JP | 1 |
| JAMES, JA | 1 |
| FINK, CW | 1 |
| MARK, LC | 1 |
| BRAND, L | 1 |
| GOLDENSOHN, ES | 1 |
| NAKAJIMA, S | 1 |
| CAHILL, JF | 1 |
| ALDOUS, JG | 1 |
| WENNING, AS | 1 |
| SOLOV'EV, VN | 1 |
| OTTOSSON, JO | 1 |
| KAPILA, K | 1 |
| ARORA, RB | 1 |
| MERCIER, J | 1 |
| TOPCHIBASHEV, IM | 1 |
| ISAKHANOV, AG | 1 |
| DARO, AF | 1 |
| GOLLIN, HA | 1 |
| McDERMOTT, RA | 1 |
| MIGLIARESE, JF | 1 |
| BAUER, EC | 1 |
| RANDALL, LO | 1 |
| MORGAN, RE | 1 |
| BOWMAN, GW | 1 |
| Sasaki, M | 1 |
| Matsuda, T | 1 |
| Watanabe, M | 1 |
| Okuaki, A | 1 |
| Paton, WD | 1 |
| Abbadessa, S | 2 |
| Avellone, S | 2 |
| Di Gregorio, I | 2 |
| Natalè, E | 2 |
| Adamec, RE | 1 |
| Stark-Adamec, C | 1 |
| Burnham, WM | 2 |
| Bruun-Meyer, S | 1 |
| Perrin, R | 1 |
| Livingston, KE | 1 |
| Ciarlone, AE | 1 |
| Kawano, T | 1 |
| Graziani, G | 1 |
| Tirone, F | 1 |
| Barbadoro, E | 1 |
| Testa, R | 1 |
| Moore, DC | 1 |
| de Jong, RH | 3 |
| Bonin, JD | 3 |
| Kenepp, NB | 1 |
| Gutsche, BB | 1 |
| Brown, DL | 1 |
| Ransom, DM | 1 |
| Hall, JA | 1 |
| Leicht, CH | 1 |
| Schroeder, DR | 1 |
| Offord, KP | 1 |
| Mori, N | 1 |
| Wada, JA | 1 |
| Yokoyama, N | 1 |
| Ariga, K | 1 |
| Kumashiro, H | 1 |
| Abood, LG | 2 |
| Saraswati, M | 2 |
| Lerner-Marmarosh, N | 1 |
| Hashmi, M | 2 |
| Sawaki, K | 3 |
| Ohno, K | 1 |
| Miyamoto, K | 1 |
| Hirai, S | 1 |
| Yazaki, K | 1 |
| Kawaguchi, M | 3 |
| Kodama, M | 1 |
| Yamada, N | 1 |
| Sato, K | 1 |
| Sato, T | 2 |
| Morimoto, K | 1 |
| Kuroda, S | 1 |
| Chimote, KV | 1 |
| Moghe, PJ | 1 |
| Racine, R | 2 |
| Livingston, K | 2 |
| Joaquin, A | 1 |
| Babb, TL | 1 |
| Perryman, KM | 1 |
| Lieb, JP | 1 |
| Finch, DM | 1 |
| Crandall, PH | 1 |
| Thompson, RG | 1 |
| Aldrete, JA | 2 |
| Englesson, S | 1 |
| Matousek, M | 1 |
| Thompson, DS | 1 |
| Smith, RH | 1 |
| Lawson, NW | 1 |
| Hoffer, BJ | 1 |
| Seiger, A | 1 |
| Taylor, D | 1 |
| Olson, L | 1 |
| Freedman, R | 1 |
| Ding, ZN | 1 |
| Yoshita, Y | 1 |
| Hirota, K | 1 |
| Yamamoto, K | 1 |
| Kobayashi, T | 1 |
| Murakami, S | 1 |
| Ouchi, K | 1 |
| Shokeir, O | 1 |
| Code, WE | 1 |
| Hertz, L | 1 |
| Müller, M | 1 |
| Schramek, J | 1 |
| Kim, KC | 1 |
| Tasch, MD | 1 |
| Requin, J | 1 |
| Faure, E | 1 |
| Paillard, J | 1 |
| Müller, H | 1 |
| Demetrescu, M | 2 |
| Julien, RM | 2 |
| Ecobichon, DJ | 1 |
| Comeau, AM | 1 |
| Rudik, VP | 1 |
| Mercurio, JP | 1 |
| Gravlin, L | 1 |
| Kirchner, E | 1 |
| Bennett, CR | 1 |
| Monheim, LM | 1 |
| Ruskin, P | 1 |
| Sabelli, HC | 1 |
| Wikinski, JA | 1 |
| Usubiaga, JE | 1 |
| Wikinski, RW | 1 |
| Feinstein, MB | 1 |
| Lenard, W | 1 |
| Mathias, J | 1 |
| Bartelheimer, HK | 1 |
| Bauditz, W | 1 |
| Staniweski, JA | 1 |
| Phansalkar, AG | 1 |
| Kulkarni, SD | 1 |
| Balwani, JH | 1 |
| La Grutta, G | 1 |
| Montalbano, ME | 1 |
| Ortolani, EA | 1 |
| Zagami, MT | 1 |
| Francesconi, F | 1 |
| Dobbs, EC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks[NCT05816538] | 100 participants (Anticipated) | Interventional | 2023-04-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for procaine and Seizures
| Article | Year |
|---|---|
Local anesthetic drugs: tissue and systemic toxicity.
Topics: Anesthesia, Conduction; Anesthetics, Local; Animals; Apnea; Arrhythmias, Cardiac; Barbiturates; Cent | 1981 |
80 other studies available for procaine and Seizures
| Article | Year |
|---|---|
Scavenging right atrial Bretschneider histidine-tryptophan-ketoglutarate cardioplegia: Impact on hyponatremia and seizures in pediatric cardiac surgery patients.
Topics: Cardioplegic Solutions; Child, Preschool; Glucose; Heart Arrest, Induced; Humans; Hyponatremia; Infa | 2021 |
Inhibition of Kv7/M Channel Currents by the Local Anesthetic Chloroprocaine.
Topics: Anesthetics, Local; Animals; Carbamates; Dose-Response Relationship, Drug; Ganglia, Spinal; HEK293 C | 2015 |
The systemic toxicity of equipotent proxymetacaine, oxybuprocaine, and bupivacaine during continuous intravenous infusion in rats.
Topics: Analgesia; Anesthetics, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Hemodynamics; | 2010 |
Competitive inhibition of procaine convulsions in guinea pigs.
Topics: Animals; Guinea Pigs; Procaine; Seizures | 1946 |
Inhibition of procaine induced convulsions by its split products.
Topics: Procaine; Seizures; Therapeutics | 1946 |
The effect of cardioplegic solution-induced sodium concentration fluctuation on postoperative seizure in pediatric cardiac patients.
Topics: Adolescent; Cardiac Surgical Procedures; Cardioplegic Solutions; Cardiopulmonary Bypass; Child; Chil | 2011 |
[Very grave complications of local anesthesia cured by artificial hibernation].
Topics: Anesthesia, Local; Female; Hibernation; Pregnancy; Procaine; Seizures | 1953 |
[Pharmacology of procaine derivatives and their protective effect against procaine convulsions as a sample of competitive inhibition in central nervous system].
Topics: Central Nervous System; Humans; Procaine; Seizures | 1953 |
[Convulsive state and mechanism of action of luminal in procaine poisoning].
Topics: Barbiturates; Drug-Related Side Effects and Adverse Reactions; Procaine; Seizures | 1954 |
Experimental observations on the prevention of seizures by intravenous procaine injections.
Topics: Epilepsy; Humans; Injections, Intravenous; Procaine; Seizures | 1957 |
Experimental observations on the prevention of seizures by intravenous procaine injections.
Topics: Epilepsy; Humans; Injections, Intravenous; Procaine; Seizures | 1957 |
Experimental observations on the prevention of seizures by intravenous procaine injections.
Topics: Epilepsy; Humans; Injections, Intravenous; Procaine; Seizures | 1957 |
Experimental observations on the prevention of seizures by intravenous procaine injections.
Topics: Epilepsy; Humans; Injections, Intravenous; Procaine; Seizures | 1957 |
[Pharmacological trials concerning the mechanism of convulsions due to pure oxygen under pressure in mice].
Topics: Animals; Glutamates; Lysergic Acid Diethylamide; Mice; Oxygen; Pressure; Procaine; Seizures; Seroton | 1957 |
Procaine convulsions.
Topics: Humans; Procaine; Seizures | 1958 |
[Effects of chronic treatment with procaine and p-aminobenzoic acid on audiogenic crises in the white rat sensitized by nicotinoylhydrazide].
Topics: 4-Aminobenzoic Acid; Animals; Learning; Nervous System Physiological Phenomena; Niacin; Nicotinic Ac | 1961 |
[Effect of the inactivation of esterase on the neurotoxicity and DL-50 of procaine in mice].
Topics: Animals; Cholinesterase Inhibitors; Esterases; Mice; Nervous System; Neurotoxicity Syndromes; Procai | 1962 |
PROPHYLAXIS OF EXPERIMENTAL CONTRAST MEDIUM INJURY TO THE SPINAL CORD BY VASODEPRESSOR DRUGS.
Topics: Acetrizoic Acid; Angiography; Blood Circulation; Blood Pressure; Blood Pressure Determination; Contr | 1963 |
A PROPOSED COMMON MECHANISM OF ACTION FOR GENERAL AND LOCAL ANAESTHETICS IN THE CENTRAL NERVOUS SYSTEM.
Topics: Action Potentials; Anesthesia, Local; Anesthetics, Local; Animals; Cats; Central Nervous System; Cer | 1963 |
THE INHIBITION OF NICOTINE-INDUCED CONVULSIONS IN THE RAT.
Topics: Anesthetics; Anesthetics, Local; Anticonvulsants; Nicotine; Pharmacology; Phenobarbital; Procaine; R | 1963 |
ACUTE GLOMERULONEPHRITIS.
Topics: Blood Chemical Analysis; Child; Convalescence; Edema; Electrocardiography; Erythromycin; Glomerulone | 1964 |
RECOVERY AFTER PROCAINE-INDUCED SEIZURES IN DOGS.
Topics: Dogs; Electrocardiography; Electroencephalography; Paralysis; Pharmacology; Procaine; Research; Resp | 1964 |
EFFECTS OF CHEMICAL INJECTION INTO THE RETICULAR FORMATION OF RATS.
Topics: Chlorides; Citrates; Coma; Fear; Injections; Nikethamide; Pentobarbital; Potassium; Procaine; Rats; | 1964 |
THE RELATION BETWEEN ACUTE TOXICITY AND CRITICAL RATE OF DISPOSAL OF SEVERAL LOCAL ANESTHETICS.
Topics: Anesthetics; Anesthetics, Local; Blood; Lidocaine; Metabolism; Procaine; Propoxycaine; Rabbits; Rese | 1965 |
[Anticonvulsive action of novocaine].
Topics: Procaine; Seizures | 1954 |
Effect of lidocaine and procaine on the electroshock seizure threshold, with a comparison of the effects of phenytoin and phenobarbital.
Topics: Convulsive Therapy; Electroconvulsive Therapy; Electroshock; Humans; Hydantoins; Lidocaine; Phenobar | 1960 |
Anticonvulsant activity of procaine and its five congeners against experimentally induced convulsions.
Topics: Anticonvulsants; Procaine; Seizures | 1962 |
[Effect of cocaine, right pseudococaine and procaine on the audiogenic seizure of the white rat].
Topics: Animals; Cocaine; Epilepsy; Epilepsy, Reflex; Procaine; Rats; Seizures | 1950 |
[Control of convulsions in tetanus with analgesin].
Topics: Antipyrine; Drug Combinations; Ether; Humans; Plant Oils; Procaine; Seizures; Tetanus; Tetanus Toxoi | 1951 |
Procaine convulsions in obstetrics.
Topics: Female; Humans; Obstetric Labor Complications; Obstetrics; Pregnancy; Procaine; Seizures | 1952 |
Prevention of procaine convulsions by presidon and sodium pentobarbital.
Topics: Biomedical Research; Pentobarbital; Procaine; Seizures; Sodium | 1950 |
Procaine convulsions; report of a case.
Topics: Anesthetics, Local; Humans; Procaine; Seizures | 1949 |
[Effect of diazepam pretreatment on convulsions induced by procaine].
Topics: Animals; Diazepam; Injections, Intraperitoneal; Pentobarbital; Procaine; Rats; Seizures | 1966 |
Experiments on the convulsant and anaesthetic effects of oxygen.
Topics: Anesthesia, Inhalation; Animals; Anticonvulsants; Brain; Bromides; Chlorpromazine; Cobalt; Dimercapr | 1967 |
A comparison of the convulsant activity of procaine and pentylenetetrazol.
Topics: Animals; Anticonvulsants; Chlorpromazine; Dibenzylchlorethamine; Female; Hydroxybutyrates; Mice; Pen | 1967 |
[Action of radiations on the central nervous system. V. Changes in the convulsive threshold dose of some drugs].
Topics: Animals; Central Nervous System; Female; Male; Pentylenetetrazole; Procaine; Rabbits; Radiation Effe | 1967 |
Power spectral analysis of EEG drug response in the kindled rat brain.
Topics: Amygdala; Analysis of Variance; Animals; Electroencephalography; Hippocampus; Kindling, Neurologic; | 1981 |
Alteration of lidocaine- or procaine-induced convulsions by manipulation of brain amines.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Dopamine; Droxidopa; Fenclonin | 1981 |
[Relationship between procaine-induced convulsion and rat brain monoamine].
Topics: Amines; Animals; Procaine; Rats; Rats, Mutant Strains; Seizures | 1984 |
Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile.
Topics: Animals; Anticonvulsants; Electroencephalography; Electroshock; Female; Imidazoles; Male; Mice; Moto | 1983 |
Deaths from local anesthetic-induced convulsions in mice.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Female; Injections, Intr | 1980 |
Toxicity of local anesthetic mixtures.
Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Combinations; Female; Lethal Dose 50; Lidocaine; Mice | 1980 |
Inadvertent intravascular injections during lumbar epidural anesthesia.
Topics: Anesthesia, Epidural; Anesthesia, Local; Bupivacaine; Female; Humans; Injections, Intravenous; Medic | 1981 |
Mixtures of local anesthetics are no more toxic than the parent drugs.
Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Combinations; Female; Lethal Dose 50; Lidocaine; Mice | 1981 |
Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompanying cardiovascular changes.
Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Anesthetics; Anesthetics, Local; Blood Pressure; Br | 1995 |
Ipsilateral hemiconvulsive seizure after unilateral injection of procaine into the substantia innominata of amygdaloid-kindled rats.
Topics: Amygdala; Animals; Electroencephalography; Injections; Kindling, Neurologic; Male; Procaine; Rats; R | 1993 |
Affinity ligands and related agents for brain muscarinic and nicotinic cholinergic receptors.
Topics: Affinity Labels; Animals; Brain; Carbachol; Choline; Kinetics; Ligands; Mice; Naloxone; Nicotine; Ox | 1993 |
Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Brain; Drug Synergism; Lidocaine; Mal | 2000 |
The insular but not the perirhinal cortex is involved in the expression of fully-kindled amygdaloid seizures in rats.
Topics: Amygdala; Animals; Cerebral Cortex; Kindling, Neurologic; Male; Microinjections; Olfactory Pathways; | 2001 |
Putative neurotransmitters in CNS and chemoconvulsions.
Topics: Animals; Bemegride; Catecholamines; Central Nervous System; Female; Male; Mice; Neurotransmitter Age | 1977 |
Effects of procaine hydrochloride, diazepam, and diphenylhydantoin on seizure development in cortical and subcortical structures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Corpus Callosum; Diazepam; Electric Stimulation | 1975 |
Procaine-induced seizures in epileptic monkeys with bilateral hippocampal foci.
Topics: Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Efferent | 1979 |
The effect of procaine hydrochloride and diazepam, separately or in combination, on cortico-generalized kindled seizures.
Topics: Animals; Cerebral Cortex; Diazepam; Electrophysiology; Kindling, Neurologic; Male; Procaine; Rats; S | 1979 |
Interaction between local anesthetics and analeptic drugs.
Topics: Anesthetics, Local; Animals; Central Nervous System Stimulants; Doxapram; Drug Interactions; Lidocai | 1975 |
Central nervous system effects of local anaesthetic agents.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Allyl Compounds; Amines; Anesthetics, Local; Anilides; | 1975 |
Intravenous procaine for general anesthesia in dogs: a new look at an old technic.
Topics: Anesthesia, General; Anesthesia, Intravenous; Animals; Dogs; Hemodynamics; Preanesthetic Medication; | 1978 |
Seizures and related epileptiform activity in hippocampus transplanted to the anterior chamber of the eye I. Characterization of seizures, interictal spikes, and synchronous activity.
Topics: Animals; Anterior Chamber; Cerebellum; Cobalt; Diazepam; Electric Stimulation; Evoked Potentials; Fe | 1977 |
4-Bromoacetamidoprocaine: an affinity ligand for brain muscarinic and nicotinic cholinergic receptors.
Topics: Animals; Behavior, Animal; Brain; Carbachol; Chloromercuribenzoates; Hyperkinesis; Ligands; Mercapto | 1992 |
Brainstem auditory evoked potentials during procaine toxicity in dogs.
Topics: Animals; Awareness; Blood Pressure; Brain Stem; Dogs; Electroencephalography; Evoked Potentials, Aud | 1992 |
Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.
Topics: Aminooxyacetic Acid; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyr | 1991 |
Does inhibition of K+ transport in glial cells by local anaesthetics contribute to seizures?
Topics: Anesthetics, Local; Animals; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Globus P | 1990 |
Some correlations between procaine-induced convulsions and monoamines in the spinal cord of rats.
Topics: Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Male; Phenobarbital; Procaine; Rats; | 1989 |
Combined application of propranolol and local anesthetics: enhanced anticonvulsant action.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Lidocaine; | 1989 |
Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice.
Topics: Anesthetics, Local; Animals; Brain Diseases; Cimetidine; Dose-Response Relationship, Drug; Drug Inte | 1986 |
[Effects of unilateral procainization of the implantation zones of the vibrissae in the orientation of the initial motor syndrome of acoustic epilepsy in the mouse].
Topics: Animals; Injections; Mice; Procaine; Seizures | 1966 |
[A severe complication of stellatum blockade].
Topics: Autonomic Nerve Block; Ganglionic Blockers; Humans; Lidocaine; Male; Middle Aged; Procaine; Seizures | 1969 |
Local anesthesia and experimental epilepsy.
Topics: Animals; Benzocaine; Cats; Disease Models, Animal; Female; Lidocaine; Male; Procaine; Seizures; Time | 1974 |
A "neutral" local anesthetic for reasearch in experimental epilepsy.
Topics: Anesthetics, Local; Animals; Benzocaine; Cats; Cerebral Cortex; Electric Stimulation; Evoked Potenti | 1974 |
Genetic polymorphism of plasma carboxylesterases in the rabbit: correlation with pharmacologic and toxicologic effects.
Topics: Acetates; Animals; Atropine; Behavior, Animal; Benzoates; Choline; Cholinesterases; Electrophoresis; | 1974 |
[Paroxysmal musculo-tonic and diencephalo-epileptic symptoms of autonomic genesis].
Topics: Adult; Autonomic Nerve Block; Contracture; Diagnosis, Differential; Diencephalon; Epilepsy; Female; | 1972 |
Emergency submental injection.
Topics: Anesthesia, Dental; Emergencies; Epinephrine; Humans; Injections; Pentobarbital; Procaine; Seizures | 1967 |
Effects of antiepileptic drugs on electrically-induced responses of acutely and chronically isolated cerebral cortex of the cat.
Topics: Action Potentials; Animals; Anticonvulsants; Cats; Cerebral Cortex; Denervation; Depression, Chemica | 1968 |
[Incidents in dental local anesthesia].
Topics: Anesthesia, Dental; Anesthesia, Local; Epinephrine; Humans; Hypersensitivity, Delayed; Hypersensitiv | 1971 |
Effectiveness of various doses of premedicating drugs used for dental procedures in altering toxicity of procaine and lidocaine.
Topics: Dental Care; Drug Synergism; Lidocaine; Meperidine; Preanesthetic Medication; Procaine; Promethazine | 1971 |
CNS effects of local anesthetics only partially dependent on biogenic amine mechanisms.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Catecholamines; Central Nervous System; Chlorpromazin | 1969 |
Cardiovascular and neurological effects of 4,000 mg of procaine.
Topics: Adult; Aminobenzoates; Atropine; Bis-Trimethylammonium Compounds; Blood Pressure; Electrocardiograph | 1970 |
The antagonism of local anesthetic induced convulsions by the benzodiazepine derivative diazepam.
Topics: Animals; Cats; Diazepam; Drug Antagonism; Electroencephalography; Electromyography; Female; Lidocain | 1970 |
[Treatment of imipramine poisoning at childhood].
Topics: Arrhythmias, Cardiac; Carbon; Child, Preschool; Chloral Hydrate; Coma; Gastric Lavage; Humans; Hypot | 1970 |
The effects of inhalation anaesthetic agents on convulsant (LD-50) doses of local anaesthetics in the rat.
Topics: Anesthesia, Inhalation; Anesthetics, Local; Animals; Cardiovascular System; Drug Antagonism; Drug Sy | 1970 |
Influence of some antiarrhythmic agents on electrically induced convulsive seizures in rats.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Chloroquine; Electroshock; Female; Lidocaine; Male | 1970 |
[Action of ionizing radiations on some biochemical and bioelectrical activities of the central nervous system].
Topics: Aminobutyrates; Animals; Brain; Carboxy-Lyases; Central Nervous System; Cerebral Cortex; Cholinester | 1967 |
[Considerations on a case of convulsion caused by a local anesthetic].
Topics: Adolescent; Anesthetics, Local; Eyelids; Facial Injuries; Humans; Male; Procaine; Seizures | 1967 |
Convulsive properties of four local anesthetic preparations.
Topics: Aminobenzoates; Anesthetics, Local; Animals; Benzoates; Epinephrine; Female; Lidocaine; Male; Pentyl | 1966 |