Page last updated: 2024-11-03

procaine and Myocardial Ischemia

procaine has been researched along with Myocardial Ischemia in 19 studies

Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).

Research Excerpts

ExcerptRelevanceReference
"The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368."7.91Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019)
"Regional myocardial ischemia was induced by occlusion of a diagonal branch of left anterior descending coronary artery of anesthetized cats."5.35Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2? ( Fu, LW; Longhurst, JC; Phan, A, 2008)
"The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368."3.91Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019)
" In our study we compared myocardial protection in isolated coronary bypass with a short period of ischemia using low dosage HTK and cold crystalloid cardioplegia."2.71Low-dose histidine-tryptophan-ketoglutarate solution for myocardial protection. ( Akay, T; Arslan, A; Aslamaci, S; Gultekin, B; Ozkan, S; Sezgin, A; Tasdelen, A; Uguz, E, 2005)
"Regional myocardial ischemia was induced by occlusion of a diagonal branch of left anterior descending coronary artery of anesthetized cats."1.35Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2? ( Fu, LW; Longhurst, JC; Phan, A, 2008)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.53)18.7374
1990's4 (21.05)18.2507
2000's11 (57.89)29.6817
2010's1 (5.26)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Wu, J1
Liu, X1
Wang, M1
Wang, X1
Su, S1
Li, WC1
Gao, H1
Gao, J1
Wang, ZJ1
Fu, LW1
Phan, A1
Longhurst, JC1
Jacob, M1
Paul, O1
Mehringer, L1
Chappell, D1
Rehm, M1
Welsch, U1
Kaczmarek, I1
Conzen, P1
Becker, BF1
Ikizler, M1
Dernek, S1
Sevin, B1
Maxey, TS1
Kural, T1
Yotsumoto, G1
Jeschkeit-Schubbert, S1
Funcke, C1
Kuhn-Régnier, F1
Fischer, JH1
Harlan, BJ1
Ross, D1
Macmanus, Q1
Knight, R1
Luber, J1
Starr, A1
Keembiyage, RD1
Newland, HS1
Lai, C1
Wei, J1
Chang, CY1
Chuang, YC1
Su, SH1
Lee, KC1
Tung, DY1
Lee, SL1
Lee, WC1
Arslan, A1
Sezgin, A1
Gultekin, B1
Ozkan, S1
Akay, T1
Uguz, E1
Tasdelen, A1
Aslamaci, S1
Kossitsky, GI1
Kalmykov, VW1
Bolotova, MF1
Mühlfeld, C1
Urru, M1
Rümelin, R1
Mirzaie, M1
Schöndube, F1
Richter, J5
Dörge, H1
Kober, IM1
Obermayr, RP1
Spieckermann, PG1
Schmiedl, A4
Schnabel, PA3
Hachida, M1
Lu, H1
Ohkado, A1
Hoshi, H1
Gu, H1
Nakanishi, T1
Koyanagi, H1
Gerber, SH1
Heyer, C1
Krüger, C1
Hagl, S1
Kübler, W1
Haass, M1
Stoletzki, S1
Kausch Blecken von Schmeling, H1
Marten, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095]Phase 2110 participants (Actual)Interventional2012-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All Cause Mortality

Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution20
Cold Blood Cardioplegia24

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution6.0
Cold Blood Cardioplegia7.8

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution1.9
Cold Blood Cardioplegia2.6

Cardiac Dysrhythmias

Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution24
Cold Blood Cardioplegia30

Cardiac Marker - Troponin-I

Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution5.7
Cold Blood Cardioplegia7.8

Cardiac Marker - Troponin-I

Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution3.0
Cold Blood Cardioplegia4.8

Cardiac Marker - Troponin-I

Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution.03
Cold Blood Cardioplegia.03

Cardiovascular Mortality

Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Change in Creatine Phosphokinase-MB Isoenzyme (CK-MB)

Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery

Interventionng/mL (Median)
Cardioplegia: Custodiol HTK Solution18.8
Cold Blood Cardioplegia22.2

Change in Troponin I

Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery

Interventionng/mL (Median)
Cardioplegia: Custodiol HTK Solution9.65
Cold Blood Cardioplegia10.15

Changes in Left Ventricular (LV) Ejection Fraction (EF) by Transthoracic Echocardiogram (TTE)

LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery

Intervention% LV volume (Mean)
Cardioplegia: Custodiol HTK Solution-0.06
Cold Blood Cardioplegia1.9

Duration of Vasopressor / Inotropic Agent

Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionminutes (Median)
Cardioplegia: Custodiol HTK Solution340
Cold Blood Cardioplegia582

Intensive Care Unit (ICU) Length of Stay

Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission

Interventiondays (Median)
Cardioplegia: Custodiol HTK Solution3
Cold Blood Cardioplegia3

Myocardial Infarction

Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Postoperative Inotropic Infusion >20 Minutes

Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution47
Cold Blood Cardioplegia43

Time on Mechanically Assisted Ventilation

time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionhours (Median)
Cardioplegia: Custodiol HTK Solution10.5
Cold Blood Cardioplegia11.4

Trials

1 trial available for procaine and Myocardial Ischemia

ArticleYear
Low-dose histidine-tryptophan-ketoglutarate solution for myocardial protection.
    Transplantation proceedings, 2005, Volume: 37, Issue:7

    Topics: Adult; Aged; Cardioplegic Solutions; Coronary Artery Bypass; Coronary Disease; Creatine Kinase; Fema

2005

Other Studies

18 other studies available for procaine and Myocardial Ischemia

ArticleYear
Reduction of Cold Ischemic Injury with the Addition of Compound Glycyrrhizin in HTK Solution in a Mouse Heart Transplantation Model.
    International heart journal, 2020, May-30, Volume: 61, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Cold Ischemia; Drug Evaluation, Preclinical; Glucose; Glycyrrhizi

2020
Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368.
    BMC anesthesiology, 2019, 01-08, Volume: 19, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Gap Junc

2019
Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2?
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthetics, Local; Animals; Cat

2008
Albumin augmentation improves condition of guinea pig hearts after 4 hr of cold ischemia.
    Transplantation, 2009, Apr-15, Volume: 87, Issue:7

    Topics: Animals; Cardiac Output; Cell Adhesion; Coronary Vessels; Edema; Endothelium, Vascular; Glucose; Gui

2009
Improved myocardial function with the addition of pinacidil to custadiol.
    Transplantation, 2002, Dec-27, Volume: 74, Issue:12

    Topics: Animals; Blood Pressure; Coronary Circulation; Creatine Kinase; Glucose; Heart; Hypothermia, Induced

2002
Total recovery of heart grafts of non-heart-beating donors after 3 hours of hypothermic coronary oxygen persufflation preservation in an orthotopic pig transplantation model.
    Transplantation, 2003, Mar-27, Volume: 75, Issue:6

    Topics: Animals; Diacetyl; Glucose; Heart Arrest; Heart Transplantation; Heart-Lung Machine; Hypothermia, In

2003
Cardioplegic solutions for myocardial preservation: analysis of hypothermic arrest, potassium arrest, and procaine arrest.
    Circulation, 1978, Volume: 58, Issue:3 Pt 2

    Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Heart; Heart Arrest, Induced; Hypothermia, In

1978
Tachycardia and myocardial ischaemia following subconjunctival injection of mydricaine (number 02) for vitrectomy procedure.
    Clinical & experimental ophthalmology, 2005, Volume: 33, Issue:1

    Topics: Aged; Anesthetics, Local; Atropine; Conjunctiva; Drug Therapy, Combination; Electrocardiography; Epi

2005
Successful heart transplantation after 13 hours of donor heart ischemia with the use of HTK solution: a case report.
    Transplantation proceedings, 2005, Volume: 37, Issue:5

    Topics: Adolescent; Glucose; Heart; Heart Transplantation; Humans; Male; Mannitol; Myocardial Ischemia; Pota

2005
Changes in brain circulation in acute coronary insufficiency.
    Biochemistry and experimental biology, 1977, Volume: 13, Issue:3

    Topics: Animals; Cerebrovascular Circulation; Constriction, Pathologic; Coronary Disease; Coronary Vessels;

1977
Myocardial ischemia tolerance in the newborn rat involving opioid receptors and mitochondrial K+ channels.
    The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, 2006, Volume: 288, Issue:3

    Topics: Animals; Decanoic Acids; Glucose; Hydroxy Acids; Mannitol; Mitochondria; Myocardial Ischemia; Myocyt

2006
How beneficial is the reduction of edema formation by polyethylene glycol during cardioplegic arrest?
    Transplantation proceedings, 1996, Volume: 28, Issue:1

    Topics: Animals; Blood Pressure; Cardioplegic Solutions; Coronary Circulation; Edema; Glucose; Heart; Heart

1996
Cellular edema and alterations in metabolite content in the ischemic and reperfused canine heart following different forms of cardiac arrest.
    Pathology, research and practice, 1996, Volume: 192, Issue:11

    Topics: Animals; Aorta; Bicarbonates; Calcium Chloride; Cardiomyopathies; Cardioplegic Solutions; Constricti

1996
Effectiveness of ischemic preconditioning on long-term myocardial preservation.
    Transplantation, 1998, Apr-27, Volume: 65, Issue:8

    Topics: Animals; Calcium; Cardioplegic Solutions; Coronary Circulation; Creatine Kinase; Glucose; Heart; In

1998
Influence of Bretschneider's cardioplegia on norepinephrine release from isolated perfused guinea-pig hearts.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Desipramine; Dose-Response Relationship, Drug; Fev

1999
Intercalated clear cells or pale cells in the sinus node of canine hearts? An ultrastructural study.
    The Anatomical record, 2000, 09-01, Volume: 260, Issue:1

    Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Female; Glucose; Heart; Heart

2000
Swelling of capillary endothelial cells and cardiomyocytes in the ischaemic myocardium of artificially arrested canine hearts.
    Journal of electron microscopy, 2001, Volume: 50, Issue:4

    Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Capillaries; Cardioplegic Solutions

2001
Different preservation of myocardial capillary endothelial cells and cardiomyocytes during and after cardioplegic ischemia (25 degrees C) of canine hearts.
    Pathology, research and practice, 2002, Volume: 198, Issue:4

    Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dogs; Endothelium, Vascular; Female

2002