procaine has been researched along with Myocardial Infarction in 43 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Excerpt | Relevance | Reference |
---|---|---|
"The effect of lidocaine (n = 6) and procainamide (n = 12) on electrogram characteristics from electrically normal right ventricular and electrically abnormal left ventricular endocardial sites was determined in 18 patients with prior myocardial infarction." | 3.67 | Effects of lidocaine and procainamide on normal and abnormal intraventricular electrograms during sinus rhythm. ( Buxton, AE; Josephson, ME; Kadish, AH; Marchlinski, FE; Miller, JM; Schmitt, CG, 1988) |
"Cardiac arrest was induced either with HTK (n = 10), HTK-N (n = 10) or HTK-N + S-NO-HSA (n = 10)." | 1.42 | The nitric oxide donor, S-nitroso human serum albumin, as an adjunct to HTK-N cardioplegia improves protection during cardioplegic arrest after myocardial infarction in rats. ( Aumayr, K; Dzilic, E; Gasser, H; Hallström, S; Kerjaschki, D; Kreibich, M; Pelzmann, B; Podesser, BK; Trescher, K, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 38 (88.37) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 4 (9.30) | 24.3611 |
2020's | 1 (2.33) | 2.80 |
Authors | Studies |
---|---|
Boening, A | 1 |
Hinke, M | 1 |
Heep, M | 1 |
Boengler, K | 1 |
Niemann, B | 1 |
Grieshaber, P | 1 |
Trescher, K | 1 |
Dzilic, E | 1 |
Kreibich, M | 1 |
Gasser, H | 1 |
Aumayr, K | 1 |
Kerjaschki, D | 1 |
Pelzmann, B | 1 |
Hallström, S | 1 |
Podesser, BK | 1 |
Braathen, B | 1 |
Jeppsson, A | 1 |
Scherstén, H | 1 |
Hagen, OM | 1 |
Vengen, Ø | 1 |
Rexius, H | 1 |
Lepore, V | 1 |
Tønnessen, T | 1 |
Wei, L | 2 |
Wu, RB | 2 |
Yang, CM | 2 |
Zheng, SY | 2 |
Yu, XY | 2 |
MCGARRY, JJ | 1 |
KREUZIGER, H | 1 |
ASTEROTH, H | 1 |
LAMMERS, L | 1 |
NICKAU, RH | 1 |
CORSE, HL | 1 |
IVEY, JF | 1 |
DE MATTEIS, F | 1 |
ALBANO, T | 1 |
OSTAPIUK, FE | 1 |
THEINL, K | 2 |
TIAVOKIN, VV | 1 |
LESIUIS, Ie | 1 |
GEINE, GA | 1 |
NAIK, BK | 1 |
RAO, UB | 1 |
SARMA, RN | 1 |
SABOO, RM | 1 |
WELFLING, J | 1 |
KOEHLER, U | 1 |
KOLESOV, VI | 1 |
PAVLOVA, RV | 1 |
SWAN, DM | 1 |
McGOWAN, JM | 1 |
BAUMANN, W | 1 |
FISH, CA | 1 |
GRANTHAM, EG | 1 |
HARRIS, AS | 1 |
ESTANDIA, A | 1 |
FORD, TJ | 1 |
SMITH, HT | 1 |
OLSEN, RW | 1 |
TILLOTSON, RF | 1 |
ABAZA, A | 1 |
LEPAGE, M | 1 |
SIEGEL, P | 1 |
SCHIFF, J | 1 |
Neĭmark, II | 1 |
Fornel', MB | 1 |
Cataldi, GM | 1 |
Vagner, EA | 1 |
Zaugo'lnikov, VS | 1 |
Tuev, AV | 1 |
Matveev, AT | 2 |
Agafonov, VA | 2 |
Zaĭtsev, OG | 1 |
Mar'ianovskiĭ, MG | 1 |
Selivestrov, GD | 1 |
Schmitt, CG | 1 |
Kadish, AH | 1 |
Marchlinski, FE | 1 |
Miller, JM | 1 |
Buxton, AE | 1 |
Josephson, ME | 1 |
Johansson, BW | 1 |
Chazov, EI | 1 |
Lukomskiĭ, PE | 1 |
Doshchitsin, VL | 1 |
van der Molen, HR | 1 |
Lukkes, J | 1 |
Ritter, K | 1 |
Redding, VJ | 1 |
Rees, JR | 1 |
Nordeck, H | 1 |
Eichler, K | 1 |
Mulch, R | 1 |
Völker, D | 1 |
Dixon, TC | 1 |
Neumark, II | 1 |
Barabash, FM | 1 |
Yüksel, Y | 1 |
Mnushkin, AS | 1 |
Bogdanova, LI | 1 |
Harris, A | 1 |
Bluestone, R | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095] | Phase 2 | 110 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 0 |
Cold Blood Cardioplegia | 0 |
CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 20 |
Cold Blood Cardioplegia | 24 |
CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 6.0 |
Cold Blood Cardioplegia | 7.8 |
CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 1.9 |
Cold Blood Cardioplegia | 2.6 |
Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 24 |
Cold Blood Cardioplegia | 30 |
Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 5.7 |
Cold Blood Cardioplegia | 7.8 |
Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | 3.0 |
Cold Blood Cardioplegia | 4.8 |
Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively
Intervention | ng/mL (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | .03 |
Cold Blood Cardioplegia | .03 |
Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 0 |
Cold Blood Cardioplegia | 0 |
Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
Intervention | ng/mL (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 18.8 |
Cold Blood Cardioplegia | 22.2 |
Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
Intervention | ng/mL (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 9.65 |
Cold Blood Cardioplegia | 10.15 |
LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery
Intervention | % LV volume (Mean) |
---|---|
Cardioplegia: Custodiol HTK Solution | -0.06 |
Cold Blood Cardioplegia | 1.9 |
Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure
Intervention | minutes (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 340 |
Cold Blood Cardioplegia | 582 |
Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission
Intervention | days (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 3 |
Cold Blood Cardioplegia | 3 |
Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 0 |
Cold Blood Cardioplegia | 0 |
Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure
Intervention | participants (Number) |
---|---|
Cardioplegia: Custodiol HTK Solution | 47 |
Cold Blood Cardioplegia | 43 |
time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure
Intervention | hours (Median) |
---|---|
Cardioplegia: Custodiol HTK Solution | 10.5 |
Cold Blood Cardioplegia | 11.4 |
2 reviews available for procaine and Myocardial Infarction
Article | Year |
---|---|
[Treatment of arrhythmia in myocardial infarct].
Topics: Amides; Arrhythmias, Cardiac; Atrial Fibrillation; Atropine; Cardiac Complexes, Premature; Cardiac G | 1968 |
[Complex intra-arterial, detoxicating, and dietetic treatment of intermittent claudication].
Topics: Adult; Aged; Animals; Arteriosclerosis; Ascorbic Acid; Catecholamines; Diet Therapy; Dietary Fats; F | 1968 |
1 trial available for procaine and Myocardial Infarction
Article | Year |
---|---|
One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized study.
Topics: Biomarkers; Cardiac Surgical Procedures; Cardioplegic Solutions; Chi-Square Distribution; Creatine K | 2011 |
40 other studies available for procaine and Myocardial Infarction
Article | Year |
---|---|
Cardiac surgery in acute myocardial infarction: crystalloid versus blood cardioplegia - an experimental study.
Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Crystalloid Solutions; Glucose; Heart Arrest, | 2020 |
The nitric oxide donor, S-nitroso human serum albumin, as an adjunct to HTK-N cardioplegia improves protection during cardioplegic arrest after myocardial infarction in rats.
Topics: Animals; Cardiac Output; Cardioplegic Solutions; Disease Models, Animal; Glucose; Heart Arrest; Hear | 2015 |
Postoperative myocardial infarction; intravenous injections of novocaine.
Topics: Heart; Humans; Infarction; Myocardial Infarction; Procaine | 1948 |
Polymerised placenta haemoglobin attenuates cold ischaemia/reperfusion injury in isolated rat heart.
Topics: Animals; Apoptosis; Cold Ischemia; Female; Glucose; Hemoglobins; Interleukin-1beta; Mannitol; Myocar | 2011 |
Cardioprotective effect of a hemoglobin-based oxygen carrier on cold ischemia/reperfusion injury.
Topics: Animals; Blood Substitutes; Cold Ischemia; Down-Regulation; Glucose; Hemoglobins; Interleukin-6; Man | 2011 |
Chills and fever due to procaine amide hydrochloride therapy.
Topics: Chills; Fever; Myocardial Infarction; Procainamide; Procaine | 1952 |
[Effect of novacaine block of both carotid sinuses on reflector collapse (Bezold-Jarisch reflex after veratrine and cardiac infarct)].
Topics: Blood Pressure; Blood Pressure Determination; Carotid Sinus; Myocardial Infarction; Procaine; Reflex | 1953 |
The use of intravenous procaine in acute myocardial infarction.
Topics: Acute Disease; Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Humans; Myocardial Infa | 1954 |
[Rare case of myocardial infarct arising during novocaine infiltration of stellate ganglion].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Conduction; Humans; Myocardial Infarcti | 1954 |
[Retrosternal novocaine anesthesia in the treatment of myocardial infarct in acute stages].
Topics: Anesthesia; Anesthesia, Conduction; Myocardial Infarction; Procaine | 1959 |
[Additional observations on the treatment of myocardial infarct in old age with Panthesin and Hydergin (PH 203)].
Topics: Aged; Aged, 80 and over; Dihydroergotoxine; Drug Combinations; Ergot Alkaloids; Leucine; Myocardial | 1961 |
[Therapy of myocardial infarct in old age with panthesin and hydergine (PH 203)].
Topics: 4-Aminobenzoic Acid; Dihydroergotoxine; Drug Combinations; Ergoloid Mesylates; Ergot Alkaloids; Leuc | 1960 |
[Use of cervical vago-sympathetic novocaine block in stenocardia and myocardial infarct].
Topics: Anesthesia; Anesthesia, Conduction; Angina Pectoris; Heart Rate; Humans; Myocardial Infarction; Proc | 1959 |
[Acute disorders of the ventricular rhythm of the heart as terminal disorders and some possibilities for their treatment].
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Camphor; Cardiac Conduction System Disease; Coronary Disease | 1962 |
[The effect of bilateral cervical vagosympathetic novocaine block on morphological changes in the myocardium after high ligation of the left coronary artery].
Topics: Anesthesia; Anesthesia, Conduction; Coronary Vessels; Ligation; Myocardial Infarction; Myocardium; P | 1963 |
CARDIAC ISCHAEMIA AND FATAL CARDIAC INFARCTION IN PENICILLIN SENSITIVITY.
Topics: Coronary Disease; Electrocardiography; Heart Failure; Infarction; Lidocaine; Myocardial Infarction; | 1963 |
[PERIARTHRITIS OF THE SHOULDER AND CARDIOVASCULAR DISEASES].
Topics: Adrenal Cortex Hormones; Cardiovascular Diseases; Coronary Disease; Diagnosis; Humans; Lidocaine; My | 1963 |
[ARTERIOSCLEROSIS AND CALCIUM METABOLISM].
Topics: Arteriosclerosis; Ascorbic Acid; Calcium; Calcium, Dietary; Drug Therapy; Folic Acid; Geriatrics; Hu | 1964 |
[TREATMENT OF MYOCARDIAL INFARCTION BY LIGATION OF THE INTERNAL MAMMARY ARTERY ASSOCIATED WITH BLOCK OF THE PRE-AORTIC NERVE PLEXUS].
Topics: Aorta; Autonomic Nerve Block; Drug Therapy; Humans; Ligation; Mammary Arteries; Myocardial Infarctio | 1965 |
Shoulder-hand syndrome following myocardial infarction; treatment by procaine block of the stellate ganglion.
Topics: Cardiovascular Diseases; Humans; Myocardial Infarction; Myocardium; Procaine; Reflex Sympathetic Dys | 1951 |
[On the pathogenesis and therapy of myocardial infarct, with special reference to the author's experience with injections of impletol and strophanthin].
Topics: Caffeine; Coronary Disease; Drug Combinations; Humans; Myocardial Infarction; Procaine; Strophanthin | 1951 |
Relief of pain in acute myocardial infarction by procaine block of the sympathetic nerve supply.
Topics: Coronary Disease; Humans; Myocardial Infarction; Pain; Procaine | 1952 |
The effects of intravenous procaine and procaine amide (pronestyl) upon ectopic ventricular tachycardia accompanying acute myocardial infarction.
Topics: Myocardial Infarction; Procainamide; Procaine; Tachycardia; Tachycardia, Ventricular; Ventricular Pr | 1952 |
[Prognostic and diagnostic significance of hiccup during myocardial infarction; therapeutic effect of procaine amide].
Topics: Cardiovascular Diseases; Hiccup; Myocardial Infarction; Procainamide; Procaine; Prognosis | 1952 |
Pronestyl by continuous intravenous drip for stubborn ventricular tachycardia complicating coronary occlusion.
Topics: Cardiovascular Diseases; Coronary Occlusion; Infusions, Intravenous; Myocardial Infarction; Procaina | 1952 |
[Treatment of coronary insufficiecy by applying retrosternal potentiated block].
Topics: Adult; Aged; Alcohols; Angina Pectoris; Aniline Compounds; Autonomic Nerve Block; Bis-Trimethylammon | 1966 |
[On artificial pneumopericardium].
Topics: Coronary Disease; Heart Diseases; Humans; Myocardial Infarction; Pericarditis; Pericarditis, Tubercu | 1975 |
[Subpleural nerve block in stenocardia and myocardial infarction].
Topics: Adult; Aged; Angina Pectoris; Autonomic Nerve Block; Humans; Male; Middle Aged; Myocardial Infarctio | 1989 |
[Subpleural blocking in the treatment of ischemic heart disease during the prehospital stage].
Topics: Angina Pectoris; Autonomic Nerve Block; Coronary Disease; Emergency Medical Services; Female; Humans | 1989 |
Effects of lidocaine and procainamide on normal and abnormal intraventricular electrograms during sinus rhythm.
Topics: Cardiac Catheterization; Coronary Disease; Electrocardiography; Electrodes; Heart Rate; Heart Ventri | 1988 |
Ventricular repolarization and fibrillation threshold in hibernating species.
Topics: Aconitine; Adrenergic Fibers; Animals; Body Temperature Regulation; Bundle-Branch Block; Calcium Chl | 1985 |
[Clinical significance and treatment of disorders of the cardiac rhythm in patients with myocardial infarct].
Topics: Adult; Aged; Amides; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Cardiac Complexes, P | 1969 |
Early changes in collateral flow following coronary artery ligation: the role of the sympathetic nervous system.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Flow Velocity; Collateral Circulation; Coronary | 1968 |
[Collateral dilatation therapy in coronary and peripheral arterial occlusive diseases. Experimental and clinical experiences with 1-benzyl-3-ethyl-6,7-dimethoxyisoquinoline hydrochloride (BEN)].
Topics: Aged; Arteries; Arteriosclerosis Obliterans; Benzyl Compounds; Collateral Circulation; Coronary Dise | 1971 |
Cardiac arrest: experience and results in emergency treatment outside the operating theatre.
Topics: Adolescent; Adult; Aged; Atropine; Bicarbonates; Coronary Care Units; Craniocerebral Trauma; Death; | 1970 |
[Clinical experimental foundation of various methods of surgical treatment of stenocardia and acute myocardial infarct].
Topics: Adult; Aged; Angina Pectoris; Animals; Arteries; Autonomic Nerve Block; Cardiac Surgical Procedures; | 1967 |
[Treatment of acute coronary insufficiency with retrosternal novacaine blocks].
Topics: Adult; Aged; Coronary Disease; Female; Humans; Injections; Male; Methods; Middle Aged; Myocardial In | 1967 |
[Results in spinal anesthesia with a 4 per cent novocaine-corbasil solution (report of 500 cases)].
Topics: Adolescent; Adult; Aged; Anesthesia, Spinal; Child; Diabetes Mellitus; Ephedrine; Female; Humans; Ma | 1967 |
[Reflex anuria during the acute period of myocardial infarction].
Topics: Aminophylline; Anuria; Female; Humans; Hypertension; Male; Myocardial Infarction; Procaine | 1968 |
Treatment of slow heart rates following acute myocardial infarction.
Topics: Anticoagulants; Atropine; Bradycardia; Myocardial Infarction; Pacemaker, Artificial; Procaine; Sympa | 1966 |