Compounds > procaine
Page last updated: 2024-11-03

procaine and Myocardial Infarction

procaine has been researched along with Myocardial Infarction in 43 studies

Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

Research Excerpts

ExcerptRelevanceReference
"The effect of lidocaine (n = 6) and procainamide (n = 12) on electrogram characteristics from electrically normal right ventricular and electrically abnormal left ventricular endocardial sites was determined in 18 patients with prior myocardial infarction."3.67Effects of lidocaine and procainamide on normal and abnormal intraventricular electrograms during sinus rhythm. ( Buxton, AE; Josephson, ME; Kadish, AH; Marchlinski, FE; Miller, JM; Schmitt, CG, 1988)
"Cardiac arrest was induced either with HTK (n = 10), HTK-N (n = 10) or HTK-N + S-NO-HSA (n = 10)."1.42The nitric oxide donor, S-nitroso human serum albumin, as an adjunct to HTK-N cardioplegia improves protection during cardioplegic arrest after myocardial infarction in rats. ( Aumayr, K; Dzilic, E; Gasser, H; Hallström, S; Kerjaschki, D; Kreibich, M; Pelzmann, B; Podesser, BK; Trescher, K, 2015)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199038 (88.37)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (9.30)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Boening, A1
Hinke, M1
Heep, M1
Boengler, K1
Niemann, B1
Grieshaber, P1
Trescher, K1
Dzilic, E1
Kreibich, M1
Gasser, H1
Aumayr, K1
Kerjaschki, D1
Pelzmann, B1
Hallström, S1
Podesser, BK1
Braathen, B1
Jeppsson, A1
Scherstén, H1
Hagen, OM1
Vengen, Ø1
Rexius, H1
Lepore, V1
Tønnessen, T1
Wei, L2
Wu, RB2
Yang, CM2
Zheng, SY2
Yu, XY2
MCGARRY, JJ1
KREUZIGER, H1
ASTEROTH, H1
LAMMERS, L1
NICKAU, RH1
CORSE, HL1
IVEY, JF1
DE MATTEIS, F1
ALBANO, T1
OSTAPIUK, FE1
THEINL, K2
TIAVOKIN, VV1
LESIUIS, Ie1
GEINE, GA1
NAIK, BK1
RAO, UB1
SARMA, RN1
SABOO, RM1
WELFLING, J1
KOEHLER, U1
KOLESOV, VI1
PAVLOVA, RV1
SWAN, DM1
McGOWAN, JM1
BAUMANN, W1
FISH, CA1
GRANTHAM, EG1
HARRIS, AS1
ESTANDIA, A1
FORD, TJ1
SMITH, HT1
OLSEN, RW1
TILLOTSON, RF1
ABAZA, A1
LEPAGE, M1
SIEGEL, P1
SCHIFF, J1
Neĭmark, II1
Fornel', MB1
Cataldi, GM1
Vagner, EA1
Zaugo'lnikov, VS1
Tuev, AV1
Matveev, AT2
Agafonov, VA2
Zaĭtsev, OG1
Mar'ianovskiĭ, MG1
Selivestrov, GD1
Schmitt, CG1
Kadish, AH1
Marchlinski, FE1
Miller, JM1
Buxton, AE1
Josephson, ME1
Johansson, BW1
Chazov, EI1
Lukomskiĭ, PE1
Doshchitsin, VL1
van der Molen, HR1
Lukkes, J1
Ritter, K1
Redding, VJ1
Rees, JR1
Nordeck, H1
Eichler, K1
Mulch, R1
Völker, D1
Dixon, TC1
Neumark, II1
Barabash, FM1
Yüksel, Y1
Mnushkin, AS1
Bogdanova, LI1
Harris, A1
Bluestone, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095]Phase 2110 participants (Actual)Interventional2012-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All Cause Mortality

Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution20
Cold Blood Cardioplegia24

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution6.0
Cold Blood Cardioplegia7.8

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution1.9
Cold Blood Cardioplegia2.6

Cardiac Dysrhythmias

Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution24
Cold Blood Cardioplegia30

Cardiac Marker - Troponin-I

Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution5.7
Cold Blood Cardioplegia7.8

Cardiac Marker - Troponin-I

Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution3.0
Cold Blood Cardioplegia4.8

Cardiac Marker - Troponin-I

Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution.03
Cold Blood Cardioplegia.03

Cardiovascular Mortality

Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Change in Creatine Phosphokinase-MB Isoenzyme (CK-MB)

Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery

Interventionng/mL (Median)
Cardioplegia: Custodiol HTK Solution18.8
Cold Blood Cardioplegia22.2

Change in Troponin I

Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery

Interventionng/mL (Median)
Cardioplegia: Custodiol HTK Solution9.65
Cold Blood Cardioplegia10.15

Changes in Left Ventricular (LV) Ejection Fraction (EF) by Transthoracic Echocardiogram (TTE)

LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery

Intervention% LV volume (Mean)
Cardioplegia: Custodiol HTK Solution-0.06
Cold Blood Cardioplegia1.9

Duration of Vasopressor / Inotropic Agent

Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionminutes (Median)
Cardioplegia: Custodiol HTK Solution340
Cold Blood Cardioplegia582

Intensive Care Unit (ICU) Length of Stay

Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission

Interventiondays (Median)
Cardioplegia: Custodiol HTK Solution3
Cold Blood Cardioplegia3

Myocardial Infarction

Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Postoperative Inotropic Infusion >20 Minutes

Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution47
Cold Blood Cardioplegia43

Time on Mechanically Assisted Ventilation

time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionhours (Median)
Cardioplegia: Custodiol HTK Solution10.5
Cold Blood Cardioplegia11.4

Reviews

2 reviews available for procaine and Myocardial Infarction

ArticleYear
[Treatment of arrhythmia in myocardial infarct].
    Kardiologiia, 1968, Volume: 8, Issue:10

    Topics: Amides; Arrhythmias, Cardiac; Atrial Fibrillation; Atropine; Cardiac Complexes, Premature; Cardiac G

1968
[Complex intra-arterial, detoxicating, and dietetic treatment of intermittent claudication].
    Zentralblatt fur Phlebologie, 1968, Aug-15, Volume: 7, Issue:3

    Topics: Adult; Aged; Animals; Arteriosclerosis; Ascorbic Acid; Catecholamines; Diet Therapy; Dietary Fats; F

1968

Trials

1 trial available for procaine and Myocardial Infarction

ArticleYear
One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized study.
    The Journal of thoracic and cardiovascular surgery, 2011, Volume: 141, Issue:4

    Topics: Biomarkers; Cardiac Surgical Procedures; Cardioplegic Solutions; Chi-Square Distribution; Creatine K

2011

Other Studies

40 other studies available for procaine and Myocardial Infarction

ArticleYear
Cardiac surgery in acute myocardial infarction: crystalloid versus blood cardioplegia - an experimental study.
    Journal of cardiothoracic surgery, 2020, Jan-08, Volume: 15, Issue:1

    Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Crystalloid Solutions; Glucose; Heart Arrest,

2020
The nitric oxide donor, S-nitroso human serum albumin, as an adjunct to HTK-N cardioplegia improves protection during cardioplegic arrest after myocardial infarction in rats.
    Interactive cardiovascular and thoracic surgery, 2015, Volume: 20, Issue:3

    Topics: Animals; Cardiac Output; Cardioplegic Solutions; Disease Models, Animal; Glucose; Heart Arrest; Hear

2015
Postoperative myocardial infarction; intravenous injections of novocaine.
    Bulletin mensuel - Societe de medecine militaire francaise, 1948, Volume: 42, Issue:4

    Topics: Heart; Humans; Infarction; Myocardial Infarction; Procaine

1948
Polymerised placenta haemoglobin attenuates cold ischaemia/reperfusion injury in isolated rat heart.
    Microvascular research, 2011, Volume: 82, Issue:3

    Topics: Animals; Apoptosis; Cold Ischemia; Female; Glucose; Hemoglobins; Interleukin-1beta; Mannitol; Myocar

2011
Cardioprotective effect of a hemoglobin-based oxygen carrier on cold ischemia/reperfusion injury.
    Cardiology, 2011, Volume: 120, Issue:2

    Topics: Animals; Blood Substitutes; Cold Ischemia; Down-Regulation; Glucose; Hemoglobins; Interleukin-6; Man

2011
Chills and fever due to procaine amide hydrochloride therapy.
    The New England journal of medicine, 1952, Dec-25, Volume: 247, Issue:26

    Topics: Chills; Fever; Myocardial Infarction; Procainamide; Procaine

1952
[Effect of novacaine block of both carotid sinuses on reflector collapse (Bezold-Jarisch reflex after veratrine and cardiac infarct)].
    Zeitschrift fur die gesamte experimentelle Medizin, 1953, Volume: 120, Issue:6

    Topics: Blood Pressure; Blood Pressure Determination; Carotid Sinus; Myocardial Infarction; Procaine; Reflex

1953
The use of intravenous procaine in acute myocardial infarction.
    The Journal of the Florida Medical Association. Florida Medical Association, 1954, Volume: 40, Issue:10

    Topics: Acute Disease; Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Humans; Myocardial Infa

1954
[Rare case of myocardial infarct arising during novocaine infiltration of stellate ganglion].
    Minerva medica, 1954, Feb-24, Volume: 45, Issue:16

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Conduction; Humans; Myocardial Infarcti

1954
[Retrosternal novocaine anesthesia in the treatment of myocardial infarct in acute stages].
    Terapevticheskii arkhiv, 1959, Volume: 31, Issue:6

    Topics: Anesthesia; Anesthesia, Conduction; Myocardial Infarction; Procaine

1959
[Additional observations on the treatment of myocardial infarct in old age with Panthesin and Hydergin (PH 203)].
    Wiener klinische Wochenschrift, 1961, Feb-24, Volume: 73

    Topics: Aged; Aged, 80 and over; Dihydroergotoxine; Drug Combinations; Ergot Alkaloids; Leucine; Myocardial

1961
[Therapy of myocardial infarct in old age with panthesin and hydergine (PH 203)].
    Wiener medizinische Wochenschrift (1946), 1960, Mar-05, Volume: 110

    Topics: 4-Aminobenzoic Acid; Dihydroergotoxine; Drug Combinations; Ergoloid Mesylates; Ergot Alkaloids; Leuc

1960
[Use of cervical vago-sympathetic novocaine block in stenocardia and myocardial infarct].
    Terapevticheskii arkhiv, 1959, Volume: 31

    Topics: Anesthesia; Anesthesia, Conduction; Angina Pectoris; Heart Rate; Humans; Myocardial Infarction; Proc

1959
[Acute disorders of the ventricular rhythm of the heart as terminal disorders and some possibilities for their treatment].
    Terapevticheskii arkhiv, 1962, Volume: 34

    Topics: Arrhythmias, Cardiac; Brugada Syndrome; Camphor; Cardiac Conduction System Disease; Coronary Disease

1962
[The effect of bilateral cervical vagosympathetic novocaine block on morphological changes in the myocardium after high ligation of the left coronary artery].
    Zdravookhranenie Belorussii, 1963, Volume: 9

    Topics: Anesthesia; Anesthesia, Conduction; Coronary Vessels; Ligation; Myocardial Infarction; Myocardium; P

1963
CARDIAC ISCHAEMIA AND FATAL CARDIAC INFARCTION IN PENICILLIN SENSITIVITY.
    The Journal of the Association of Physicians of India, 1963, Volume: 11

    Topics: Coronary Disease; Electrocardiography; Heart Failure; Infarction; Lidocaine; Myocardial Infarction;

1963
[PERIARTHRITIS OF THE SHOULDER AND CARDIOVASCULAR DISEASES].
    Coeur et medecine interne, 1963, Volume: 58

    Topics: Adrenal Cortex Hormones; Cardiovascular Diseases; Coronary Disease; Diagnosis; Humans; Lidocaine; My

1963
[ARTERIOSCLEROSIS AND CALCIUM METABOLISM].
    Medizinische Klinik, 1964, Jul-10, Volume: 59

    Topics: Arteriosclerosis; Ascorbic Acid; Calcium; Calcium, Dietary; Drug Therapy; Folic Acid; Geriatrics; Hu

1964
[TREATMENT OF MYOCARDIAL INFARCTION BY LIGATION OF THE INTERNAL MAMMARY ARTERY ASSOCIATED WITH BLOCK OF THE PRE-AORTIC NERVE PLEXUS].
    Vestnik khirurgii imeni I. I. Grekova, 1965, Volume: 94

    Topics: Aorta; Autonomic Nerve Block; Drug Therapy; Humans; Ligation; Mammary Arteries; Myocardial Infarctio

1965
Shoulder-hand syndrome following myocardial infarction; treatment by procaine block of the stellate ganglion.
    Journal of the American Medical Association, 1951, Jun-30, Volume: 146, Issue:9

    Topics: Cardiovascular Diseases; Humans; Myocardial Infarction; Myocardium; Procaine; Reflex Sympathetic Dys

1951
[On the pathogenesis and therapy of myocardial infarct, with special reference to the author's experience with injections of impletol and strophanthin].
    Arztliche Wochenschrift, 1951, Oct-12, Volume: 6, Issue:41

    Topics: Caffeine; Coronary Disease; Drug Combinations; Humans; Myocardial Infarction; Procaine; Strophanthin

1951
Relief of pain in acute myocardial infarction by procaine block of the sympathetic nerve supply.
    Annals of internal medicine, 1952, Volume: 36, Issue:1

    Topics: Coronary Disease; Humans; Myocardial Infarction; Pain; Procaine

1952
The effects of intravenous procaine and procaine amide (pronestyl) upon ectopic ventricular tachycardia accompanying acute myocardial infarction.
    Circulation, 1952, Volume: 5, Issue:4

    Topics: Myocardial Infarction; Procainamide; Procaine; Tachycardia; Tachycardia, Ventricular; Ventricular Pr

1952
[Prognostic and diagnostic significance of hiccup during myocardial infarction; therapeutic effect of procaine amide].
    Clinique (Paris, France), 1952, Mar-15, Volume: 47, Issue:449

    Topics: Cardiovascular Diseases; Hiccup; Myocardial Infarction; Procainamide; Procaine; Prognosis

1952
Pronestyl by continuous intravenous drip for stubborn ventricular tachycardia complicating coronary occlusion.
    Northwest medicine, 1952, Volume: 51, Issue:5

    Topics: Cardiovascular Diseases; Coronary Occlusion; Infusions, Intravenous; Myocardial Infarction; Procaina

1952
[Treatment of coronary insufficiecy by applying retrosternal potentiated block].
    Sovetskaia meditsina, 1966, Volume: 29, Issue:11

    Topics: Adult; Aged; Alcohols; Angina Pectoris; Aniline Compounds; Autonomic Nerve Block; Bis-Trimethylammon

1966
[On artificial pneumopericardium].
    La Clinica terapeutica, 1975, May-15, Volume: 73, Issue:3

    Topics: Coronary Disease; Heart Diseases; Humans; Myocardial Infarction; Pericarditis; Pericarditis, Tubercu

1975
[Subpleural nerve block in stenocardia and myocardial infarction].
    Sovetskaia meditsina, 1989, Issue:4

    Topics: Adult; Aged; Angina Pectoris; Autonomic Nerve Block; Humans; Male; Middle Aged; Myocardial Infarctio

1989
[Subpleural blocking in the treatment of ischemic heart disease during the prehospital stage].
    Sovetskaia meditsina, 1989, Issue:7

    Topics: Angina Pectoris; Autonomic Nerve Block; Coronary Disease; Emergency Medical Services; Female; Humans

1989
Effects of lidocaine and procainamide on normal and abnormal intraventricular electrograms during sinus rhythm.
    Circulation, 1988, Volume: 77, Issue:5

    Topics: Cardiac Catheterization; Coronary Disease; Electrocardiography; Electrodes; Heart Rate; Heart Ventri

1988
Ventricular repolarization and fibrillation threshold in hibernating species.
    European heart journal, 1985, Volume: 6 Suppl D

    Topics: Aconitine; Adrenergic Fibers; Animals; Body Temperature Regulation; Bundle-Branch Block; Calcium Chl

1985
[Clinical significance and treatment of disorders of the cardiac rhythm in patients with myocardial infarct].
    Kardiologiia, 1969, Volume: 9, Issue:1

    Topics: Adult; Aged; Amides; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Cardiac Complexes, P

1969
Early changes in collateral flow following coronary artery ligation: the role of the sympathetic nervous system.
    Cardiovascular research, 1968, Volume: 2, Issue:3

    Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Flow Velocity; Collateral Circulation; Coronary

1968
[Collateral dilatation therapy in coronary and peripheral arterial occlusive diseases. Experimental and clinical experiences with 1-benzyl-3-ethyl-6,7-dimethoxyisoquinoline hydrochloride (BEN)].
    Munchener medizinische Wochenschrift (1950), 1971, Jul-02, Volume: 113, Issue:27

    Topics: Aged; Arteries; Arteriosclerosis Obliterans; Benzyl Compounds; Collateral Circulation; Coronary Dise

1971
Cardiac arrest: experience and results in emergency treatment outside the operating theatre.
    The Medical journal of Australia, 1970, Apr-11, Volume: 1, Issue:15

    Topics: Adolescent; Adult; Aged; Atropine; Bicarbonates; Coronary Care Units; Craniocerebral Trauma; Death;

1970
[Clinical experimental foundation of various methods of surgical treatment of stenocardia and acute myocardial infarct].
    Zentralblatt fur Chirurgie, 1967, Jan-07, Volume: 92, Issue:1

    Topics: Adult; Aged; Angina Pectoris; Animals; Arteries; Autonomic Nerve Block; Cardiac Surgical Procedures;

1967
[Treatment of acute coronary insufficiency with retrosternal novacaine blocks].
    Vrachebnoe delo, 1967, Volume: 6

    Topics: Adult; Aged; Coronary Disease; Female; Humans; Injections; Male; Methods; Middle Aged; Myocardial In

1967
[Results in spinal anesthesia with a 4 per cent novocaine-corbasil solution (report of 500 cases)].
    Turk Tip Cemiyeti mecmuasi, 1967, Volume: 33, Issue:10

    Topics: Adolescent; Adult; Aged; Anesthesia, Spinal; Child; Diabetes Mellitus; Ephedrine; Female; Humans; Ma

1967
[Reflex anuria during the acute period of myocardial infarction].
    Sovetskaia meditsina, 1968, Volume: 31, Issue:12

    Topics: Aminophylline; Anuria; Female; Humans; Hypertension; Male; Myocardial Infarction; Procaine

1968
Treatment of slow heart rates following acute myocardial infarction.
    British heart journal, 1966, Volume: 28, Issue:5

    Topics: Anticoagulants; Atropine; Bradycardia; Myocardial Infarction; Pacemaker, Artificial; Procaine; Sympa

1966