Compounds > procaine
Page last updated: 2024-11-03

procaine and Mitral Valve Insufficiency

procaine has been researched along with Mitral Valve Insufficiency in 3 studies

Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

Mitral Valve Insufficiency: Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Braathen, B1
Jeppsson, A1
Scherstén, H1
Hagen, OM1
Vengen, Ø1
Rexius, H1
Lepore, V1
Tønnessen, T1
KUCHERENKO, AE1
RATNER, GL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095]Phase 2110 participants (Actual)Interventional2012-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All Cause Mortality

Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution20
Cold Blood Cardioplegia24

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution6.0
Cold Blood Cardioplegia7.8

Biochemical Marker - Creatine Kinase MB Isoenzyme (CK-MB)

CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution1.9
Cold Blood Cardioplegia2.6

Cardiac Dysrhythmias

Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution24
Cold Blood Cardioplegia30

Cardiac Marker - Troponin-I

Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution5.7
Cold Blood Cardioplegia7.8

Cardiac Marker - Troponin-I

Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution3.0
Cold Blood Cardioplegia4.8

Cardiac Marker - Troponin-I

Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively

Interventionng/mL (Mean)
Cardioplegia: Custodiol HTK Solution.03
Cold Blood Cardioplegia.03

Cardiovascular Mortality

Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Change in Creatine Phosphokinase-MB Isoenzyme (CK-MB)

Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery

Interventionng/mL (Median)
Cardioplegia: Custodiol HTK Solution18.8
Cold Blood Cardioplegia22.2

Change in Troponin I

Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery

Interventionng/mL (Median)
Cardioplegia: Custodiol HTK Solution9.65
Cold Blood Cardioplegia10.15

Changes in Left Ventricular (LV) Ejection Fraction (EF) by Transthoracic Echocardiogram (TTE)

LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery

Intervention% LV volume (Mean)
Cardioplegia: Custodiol HTK Solution-0.06
Cold Blood Cardioplegia1.9

Duration of Vasopressor / Inotropic Agent

Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionminutes (Median)
Cardioplegia: Custodiol HTK Solution340
Cold Blood Cardioplegia582

Intensive Care Unit (ICU) Length of Stay

Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission

Interventiondays (Median)
Cardioplegia: Custodiol HTK Solution3
Cold Blood Cardioplegia3

Myocardial Infarction

Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution0
Cold Blood Cardioplegia0

Postoperative Inotropic Infusion >20 Minutes

Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure

Interventionparticipants (Number)
Cardioplegia: Custodiol HTK Solution47
Cold Blood Cardioplegia43

Time on Mechanically Assisted Ventilation

time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure

Interventionhours (Median)
Cardioplegia: Custodiol HTK Solution10.5
Cold Blood Cardioplegia11.4

Trials

1 trial available for procaine and Mitral Valve Insufficiency

ArticleYear
One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized study.
    The Journal of thoracic and cardiovascular surgery, 2011, Volume: 141, Issue:4

    Topics: Biomarkers; Cardiac Surgical Procedures; Cardioplegic Solutions; Chi-Square Distribution; Creatine K

2011

Other Studies

2 other studies available for procaine and Mitral Valve Insufficiency

ArticleYear
[ON THE DETERMINATION OF THE FUNCTIONAL STATUS OF THE CARDIOVASCULAR SYSTEM IN SURGICAL PATIENTS].
    Sovetskaia meditsina, 1963, Volume: 27

    Topics: Anesthesia; Anesthesia, Local; Appendectomy; Blood Flow Velocity; Blood Pressure Determination; Card

1963
[SURGICAL PROCEDURE IN ARTERIAL EMBOLISM].
    Vestnik khirurgii imeni I. I. Grekova, 1963, Volume: 91

    Topics: Anticoagulants; Cholecystectomy; Embolism; Femoral Artery; Humans; Iliac Artery; Intracranial Emboli

1963