procaine has been researched along with Melanoma in 5 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| " An established human melanoma cell line (SHG) derived from malignant ascites was used to evaluate the growth-inhibitory effects of local anesthetics (procaine and lidocaine) as well as of doxorubicin at incubation temperatures of 37." | 3.66 | Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line. ( Block, JB; Chlebowski, RT; Cundiff, D; Dietrich, MF, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Maksoud, MS | 1 |
| El-Gamal, MI | 1 |
| Lee, BS | 1 |
| Gamal El-Din, MM | 1 |
| Jeon, HR | 1 |
| Kwon, D | 1 |
| Ammar, UM | 1 |
| Mersal, KI | 1 |
| Ali, EMH | 1 |
| Lee, KT | 1 |
| Yoo, KH | 1 |
| Han, DK | 1 |
| Lee, JK | 1 |
| Kim, G | 1 |
| Choi, HS | 1 |
| Kwon, YJ | 1 |
| Lee, KH | 1 |
| Oh, CH | 1 |
| VENKEI, T | 1 |
| Chlebowski, RT | 1 |
| Block, JB | 1 |
| Cundiff, D | 1 |
| Dietrich, MF | 1 |
| Zhu, WG | 1 |
| Roberts, ZV | 1 |
| Dynlacht, JR | 1 |
| Borden, H | 1 |
| Hummer, GJ | 1 |
| Landon, CW | 1 |
| Paris, J | 1 |
5 other studies available for procaine and Melanoma
| Article | Year |
|---|---|
Discovery of New Imidazo[2,1-
Topics: Animals; Binding Sites; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Drug Scr | 2021 |
[Thermoelectrometric examinations in pathologic skin changes. II].
Topics: Autonomic Nerve Block; Body Temperature; Hemangiosarcoma; Histamine H1 Antagonists; Humans; Keratoac | 1963 |
Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line.
Topics: Cell Line; Cell Survival; Doxorubicin; Drug Synergism; Humans; Lidocaine; Melanoma; Procaine; Temper | 1982 |
Heat-induced modulation of lamin B content in two different cell lines.
Topics: Anesthetics, Local; Blotting, Western; Cell Survival; Glycerol; Heat-Shock Response; HeLa Cells; Hum | 1999 |
The use of procaine in acquired malignant hyperthermia in a patient with malignant melanoma metastatic to the parathyroid gland: a case report.
Topics: Humans; Male; Malignant Hyperthermia; Melanoma; Middle Aged; Neoplasm Metastasis; Parathyroid Glands | 1976 |