Page last updated: 2024-11-03

procaine and Melanoma

procaine has been researched along with Melanoma in 5 studies

Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
" An established human melanoma cell line (SHG) derived from malignant ascites was used to evaluate the growth-inhibitory effects of local anesthetics (procaine and lidocaine) as well as of doxorubicin at incubation temperatures of 37."3.66Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line. ( Block, JB; Chlebowski, RT; Cundiff, D; Dietrich, MF, 1982)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Abdel-Maksoud, MS1
El-Gamal, MI1
Lee, BS1
Gamal El-Din, MM1
Jeon, HR1
Kwon, D1
Ammar, UM1
Mersal, KI1
Ali, EMH1
Lee, KT1
Yoo, KH1
Han, DK1
Lee, JK1
Kim, G1
Choi, HS1
Kwon, YJ1
Lee, KH1
Oh, CH1
VENKEI, T1
Chlebowski, RT1
Block, JB1
Cundiff, D1
Dietrich, MF1
Zhu, WG1
Roberts, ZV1
Dynlacht, JR1
Borden, H1
Hummer, GJ1
Landon, CW1
Paris, J1

Other Studies

5 other studies available for procaine and Melanoma

ArticleYear
Discovery of New Imidazo[2,1-
    Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10

    Topics: Animals; Binding Sites; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Drug Scr

2021
[Thermoelectrometric examinations in pathologic skin changes. II].
    Magyar onkologia, 1963, Volume: 7

    Topics: Autonomic Nerve Block; Body Temperature; Hemangiosarcoma; Histamine H1 Antagonists; Humans; Keratoac

1963
Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line.
    Cancer treatment reports, 1982, Volume: 66, Issue:1

    Topics: Cell Line; Cell Survival; Doxorubicin; Drug Synergism; Humans; Lidocaine; Melanoma; Procaine; Temper

1982
Heat-induced modulation of lamin B content in two different cell lines.
    Journal of cellular biochemistry, 1999, Dec-15, Volume: 75, Issue:4

    Topics: Anesthetics, Local; Blotting, Western; Cell Survival; Glycerol; Heat-Shock Response; HeLa Cells; Hum

1999
The use of procaine in acquired malignant hyperthermia in a patient with malignant melanoma metastatic to the parathyroid gland: a case report.
    Canadian Anaesthetists' Society journal, 1976, Volume: 23, Issue:6

    Topics: Humans; Male; Malignant Hyperthermia; Melanoma; Middle Aged; Neoplasm Metastasis; Parathyroid Glands

1976