procaine has been researched along with Leukemia, Erythroblastic, Acute in 2 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Leukemia, Erythroblastic, Acute: A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Procaine pretreatment did not abolish the ability of MEL cells to complete the "latent period" and commit upon the removal of the block." | 1.26 | Procaine inhibits the erythroid differentiation of MEL cells by blocking commitment: possible involvement of calcium metabolism. ( Housman, DE; Mitrani, AA; Tsiftsoglou, AS, 1981) |
| "Friend murine erythroleukemia (MEL) cells can be induced to differentiate along the erythroid pathway by such dissimilar agents as dimethyl sulfoxide (DMSO), butyrate, inhibitors of DNA synthesis, and certain highly polar agents." | 1.26 | Evidence for multiple sites of regulation of heme synthesis in murine erythroleukemia cells. ( Bonkowsky, HL; Deisseroth, A; Ebert, PS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsiftsoglou, AS | 1 |
| Mitrani, AA | 1 |
| Housman, DE | 1 |
| Ebert, PS | 1 |
| Bonkowsky, HL | 1 |
| Deisseroth, A | 1 |
2 other studies available for procaine and Leukemia, Erythroblastic, Acute
| Article | Year |
|---|---|
Procaine inhibits the erythroid differentiation of MEL cells by blocking commitment: possible involvement of calcium metabolism.
Topics: Animals; Calcimycin; Calcium; Cell Differentiation; Cell Division; Cell Line; Dimethyl Sulfoxide; Do | 1981 |
Evidence for multiple sites of regulation of heme synthesis in murine erythroleukemia cells.
Topics: Animals; Butyrates; Cell Differentiation; Clone Cells; Dimethyl Sulfoxide; Heme; Hemoglobins; Leukem | 1979 |