procaine has been researched along with Hypotension in 35 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia." | 7.81 | Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. ( Diao, M; Huang, Y; Li, H; Lin, X; Liu, H; Ma, Y; Zhou, J, 2015) |
| "The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia." | 3.81 | Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. ( Diao, M; Huang, Y; Li, H; Lin, X; Liu, H; Ma, Y; Zhou, J, 2015) |
| "The incidence and degree of hypotension, time to establish surgical analgesia, and several other maternal and fetal variables were studied when 2-chloroprocaine, 3 per cent, and bupivacaine, 0." | 3.66 | Chloroprocaine vs. bupivacaine for lumbar epidural analgesia for elective cesarean section. ( Dewan, DM; Floyd, HM; Grant, WM; James, FM; Rhyne, L; Westmoreland, RT; Wheeler, AS, 1980) |
| "Chloroprocaine was comparable with plain 0." | 2.79 | Intrathecal 1% 2-chloroprocaine vs. 0.5% bupivacaine in ambulatory surgery: a prospective, observer-blinded, randomised, controlled trial. ( Camponovo, C; Cristina, D; Fanelli, A; Fanelli, G; Ghisi, D; Leschka, K; Riva, T; Vassiliou, T; Wulf, H, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (77.14) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 4 (11.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Camponovo, C | 1 |
| Wulf, H | 1 |
| Ghisi, D | 1 |
| Fanelli, A | 1 |
| Riva, T | 1 |
| Cristina, D | 1 |
| Vassiliou, T | 1 |
| Leschka, K | 1 |
| Fanelli, G | 1 |
| Fukushima, A | 1 |
| Chazono, K | 1 |
| Hashimoto, Y | 1 |
| Iwajima, Y | 1 |
| Yamamoto, S | 1 |
| Maeda, Y | 1 |
| Ohsawa, M | 1 |
| Ono, H | 1 |
| Liu, H | 1 |
| Huang, Y | 1 |
| Diao, M | 1 |
| Li, H | 1 |
| Ma, Y | 1 |
| Lin, X | 1 |
| Zhou, J | 1 |
| Ghafaripour, S | 1 |
| Sahmeddini, MA | 1 |
| Lahsaee, SM | 1 |
| Khosravi, MB | 1 |
| Sattari, H | 1 |
| Nikeghbalian, S | 1 |
| Shokrizadeh, S | 1 |
| Malekhosseine, SA | 1 |
| MASON, AA | 1 |
| PELMORE, JF | 1 |
| ASERMAN, D | 1 |
| KERR, WJ | 1 |
| LAGEN, JB | 1 |
| DOCAL, JC | 1 |
| ARRIEN ECHEVARRI, A | 1 |
| LEWIS, JM | 1 |
| REES, GA | 1 |
| SLEIGHT, P | 1 |
| CAMPBELL, JR | 1 |
| LAWSON, DD | 1 |
| SANFORD, J | 1 |
| BERGMANN, KH | 1 |
| LITWIN, J | 1 |
| Lee, JS | 1 |
| Harding, RE | 1 |
| Bjørnestad, E | 1 |
| Iversen, OL | 1 |
| Raeder, J | 1 |
| Fu, RQ | 1 |
| Tian, YK | 1 |
| Fang, WR | 1 |
| Meĭerovich, SI | 1 |
| Begara Mesa, D | 1 |
| Vilar Rodriguez, MA | 1 |
| Anshelevich, IuV | 1 |
| Dumesh, SZ | 1 |
| Slaĭdyn', AK | 1 |
| Sporan, VG | 1 |
| Abboud, TK | 1 |
| Khoo, SS | 1 |
| Miller, F | 1 |
| Doan, T | 1 |
| Henriksen, EH | 1 |
| James, FM | 1 |
| Dewan, DM | 1 |
| Floyd, HM | 1 |
| Wheeler, AS | 1 |
| Grant, WM | 1 |
| Rhyne, L | 1 |
| Westmoreland, RT | 1 |
| Conklin, KA | 1 |
| van der Wal, C | 1 |
| Ku, YH | 1 |
| Zhang, T | 1 |
| McAllister, CJ | 1 |
| Petin, GI | 1 |
| Strelets, BM | 1 |
| Krasavin, VA | 1 |
| MacLachlan, D | 1 |
| Forrest, AL | 1 |
| Sehhati, G | 1 |
| Frey, R | 1 |
| Mildner, R | 1 |
| Ahlgren, P | 1 |
| Praestholm, J | 1 |
| Foussard-Blanpin, O | 1 |
| Bretaudeau, J | 1 |
| Rosner, S | 1 |
| Borodianskiĭ, VI | 1 |
| Fukunaga, AF | 1 |
| Epstein, RM | 1 |
| Shnider, SM | 1 |
| Bartelheimer, HK | 1 |
| Bauditz, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chloroprocaine Versus Bupivacaine Spinal Anesthesia for Cervical Cerclage[NCT02862912] | Phase 4 | 43 participants (Actual) | Interventional | 2016-11-08 | Completed | ||
| Low Epidural Anesthesia With Chloroprocaine Versus Lidocaine: a Prospective, Randomized, Double-blinded Multi-centre Clinical Trial in China[NCT02287870] | Phase 4 | 120 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time from spinal anesthesia placement to ability to ambulate. (NCT02862912)
Timeframe: 5 hours
| Intervention | minutes (Median) |
|---|---|
| Chloroprocaine (CP) | 158 |
| Bupivacaine (BUP) | 229 |
"The mean difference between groups in time between the end of spinal injection (t IT) to time for no motor block (t motor), i.e. tIT - T motor. Motor block will be assessed using the Bromage scale:~Bromage Scale I = free movement of the legs and feet = no block II = able to flex knees, with free movement of feet = partial (33%) block III = unable to flex knees, but with free movement of the feet = almost complete (66%) block IV = unable to move legs or feet = complete block (100%)" (NCT02862912)
Timeframe: 3 hours
| Intervention | minutes (Median) |
|---|---|
| Chloroprocaine (CP) | 109 |
| Bupivacaine (BUP) | 112 |
Time from spinal anesthesia injection to ability to void spontaneously. (NCT02862912)
Timeframe: 5 hours
| Intervention | minutes (Median) |
|---|---|
| Bupivacaine (BUP) | 229 |
| Chloroprocaine (CP) | 158 |
1 review available for procaine and Hypotension
| Article | Year |
|---|---|
[Extradural anesthesia in cesarean operations].
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine; Cesarean Section; Ep | 1982 |
4 trials available for procaine and Hypotension
| Article | Year |
|---|---|
Intrathecal 1% 2-chloroprocaine vs. 0.5% bupivacaine in ambulatory surgery: a prospective, observer-blinded, randomised, controlled trial.
Topics: Abdomen; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Spinal | 2014 |
Hypotension after reperfusion in liver transplantation: histidine-tryptophan-ketoglutarate versus University of Wisconsin solution.
Topics: Adenosine; Adult; Allopurinol; Blood Gas Analysis; Female; Glucose; Glutathione; Hemodynamics; Human | 2010 |
Similar onset time of 2-chloroprocaine and lidocaine + epinephrine for epidural anesthesia for elective Cesarean section.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Cesarean Section; Double-B | 2006 |
Combined spinal and epidural anaesthesia with chloroprocaine for hysterectomy.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Dose-Response Relationship, Dru | 2008 |
30 other studies available for procaine and Hypotension
| Article | Year |
|---|---|
Oseltamivir produces hypothermic and neuromuscular effects by inhibition of nicotinic acetylcholine receptor functions: comparison to procaine and bupropion.
Topics: Animals; Bradycardia; Bupropion; Drug Synergism; Fever; Hypotension; Male; Mice; Muscle Relaxation; | 2015 |
Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Apgar | 2015 |
Combined use of hexamethonium bromide and procaine amide in controlled hypotension; a preliminary report.
Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle Relaxants, Centra | 1953 |
Controlled hypotension in neurosurgery with hexamethonium and procaine amide.
Topics: Cardiovascular Agents; Hexamethonium; Hypotension; Hypotension, Controlled; Muscle Relaxants, Centra | 1953 |
Cardiovascular diseases.
Topics: Arrhythmias, Cardiac; Cardiovascular Diseases; Cardiovascular Surgical Procedures; Cardiovascular Sy | 1953 |
[Controlled hypotension with novocaine and pendiomide].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Autonomic Agents; Hypotension; Hypotension, Control | 1954 |
[Intravenous novocaine and induced arterial hypotension].
Topics: Hypotension; Hypotension, Controlled; Procaine | 1957 |
ELECTROCARDIOGRAPHY DURING POSTERIOR FOSSA OPERATIONS.
Topics: Arrhythmias, Cardiac; Electrocardiography; Embolism; Embolism, Air; Humans; Hypotension; Infant; Lid | 1964 |
A CARDIOVASCULAR DEPRESSOR REFLEX FROM THE EPICARDIUM OF THE LEFT VENTRICLE IN THE DOG.
Topics: Alkaloids; Atropine; Blood Pressure; Bradycardia; Cold Temperature; Coronary Vessels; Dogs; Heart; H | 1964 |
INVESTIGATION OF RESPIRATORY AND CIRCULATORY EFFECTS OF ETHAMIVAN IN THE DOG AND CAT.
Topics: Amines; Aorta; Apnea; Atropine; Benzamides; Blood Pressure; Bradycardia; Carotid Arteries; Cats; Cen | 1964 |
[ON THE QUESTION OF A BLOOD-SPARING OPERATION METHOD IN THE VAGINALPERINEAL AREA].
Topics: Anesthesia; Anesthesia, Local; Anesthesiology; Female; Humans; Hypotension; Hypotension, Controlled; | 1964 |
[Effect of adrenaline administered after adrenolytic drug on hypotensive action of autohemolysates in cats].
Topics: Adrenergic Antagonists; Animals; Blood Pressure; Blood Pressure Determination; Cats; Epinephrine; He | 1954 |
Spinal anesthesia in severe preeclampsia.
Topics: Anesthesia, Spinal; Female; Humans; Hypotension; Pre-Eclampsia; Pregnancy; Procaine | 2004 |
[Experience in the treatment of trigeminal neuralgia with aminazine].
Topics: Adult; Aged; Analgesics; Chlorpromazine; Female; Humans; Hypotension; Injections, Intramuscular; Mal | 1966 |
[Complications after intravenous administration of anti-arrhythmia agents].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Ad | 1982 |
Maternal, fetal, and neonatal responses after epidural anesthesia with bupivacaine, 2-chloroprocaine, or lidocaine.
Topics: Adolescent; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Behavior; Bupi | 1982 |
Chloroprocaine vs. bupivacaine for lumbar epidural analgesia for elective cesarean section.
Topics: Analgesia; Anesthesia, Epidural; Apgar Score; Blood Gas Analysis; Bupivacaine; Cesarean Section; Eph | 1980 |
Epidural anaesthesia with chloroprocaine. Delayed onset, extensive spread, and prolonged duration.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Female; Humans; Hypotension; Pregnancy; Procai | 1980 |
Brain atriopeptin mediates AV3V depressor response.
Topics: Animals; Atrial Natriuretic Factor; Atropine Derivatives; Blood Pressure; Cerebral Ventricles; Drug | 1994 |
Adverse reactions to commonly prescribed drugs in patients with renal insufficiency.
Topics: Analgesics; Anti-Bacterial Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Drug-Related Side | 1977 |
[Suppression of cardiac activity and respiration during conduction anesthesia].
Topics: Anesthesia, Conduction; Arteriosclerosis Obliterans; Humans; Hypotension; Leg; Lidocaine; Male; Midd | 1989 |
Letter: Procaine and malignant hyperthermia.
Topics: Dose-Response Relationship, Drug; Female; Humans; Hypotension; Injections, Intravenous; Malignant Hy | 1974 |
[Complications of regional anaesthesia and their treatment (author's transl)].
Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis | 1973 |
[Complications of myelography with methiodal].
Topics: Adult; Anesthesia, Spinal; Blood Pressure; Female; Headache; Humans; Hypotension; Male; Mesylates; M | 1969 |
[Study of the mechanism of hypotension induced in certain conditions by epsilon-aminocaproic acid].
Topics: Aminocaproates; Animals; Atropine; Dogs; Ethanolamines; Hypotension; Phenylbutazone; Procaine; Prome | 1966 |
The diagnosis and treatment of cerebral concussion.
Topics: Ascorbic Acid; Aspirin; Brain Concussion; Cerebral Ventriculography; Cortisone; Diphenhydramine; Ele | 1967 |
[The therapy and prevention of acute renal insufficiency in traumatic shock].
Topics: Acute Kidney Injury; Adult; Autonomic Nerve Block; Diuresis; Female; Histamine H1 Antagonists; Human | 1966 |
Effects of cyclopropane on the sympathetic nervous system and on neural regulation of circulation in the cat.
Topics: Action Potentials; Animals; Aorta; Arrhythmias, Cardiac; Blood; Blood Circulation; Blood Pressure; B | 1974 |
New and interesting aspects of obstetric conduction anesthesia. A. Placental transfer of local anesthetics.
Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Animals; Fe | 1966 |
[Treatment of imipramine poisoning at childhood].
Topics: Arrhythmias, Cardiac; Carbon; Child, Preschool; Chloral Hydrate; Coma; Gastric Lavage; Humans; Hypot | 1970 |