procaine has been researched along with HbS Disease in 7 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Procaine was found to stimulate K+ release and to inhibit phosphate uptake." | 1.33 | An explanation for the efficacy of procaine in the treatment of sickle cell anaemia. ( Abu-Salah, KM; Gambo, AH, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abu-Salah, KM | 2 |
| Gambo, AH | 1 |
| Aluoch, JR | 1 |
| Baker, RF | 2 |
| Powars, D | 2 |
| Haywood, LJ | 2 |
| Premachandra, BR | 1 |
| Kalra, VK | 1 |
| Mackenzie, RD | 1 |
| Gleason, EM | 1 |
| Schatzman, GL | 1 |
| Cawein, MJ | 1 |
| Baker, R | 1 |
1 review available for procaine and HbS Disease
| Article | Year |
|---|---|
The treatment of sickle cell disease. A historical and chronological literature review of the therapies applied since 1910.
Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Clinical Trials as Topic; Cyanates; Deamino Argi | 1984 |
1 trial available for procaine and HbS Disease
| Article | Year |
|---|---|
The treatment of sickle cell disease. A historical and chronological literature review of the therapies applied since 1910.
Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Clinical Trials as Topic; Cyanates; Deamino Argi | 1984 |
6 other studies available for procaine and HbS Disease
| Article | Year |
|---|---|
An explanation for the efficacy of procaine in the treatment of sickle cell anaemia.
Topics: Anemia, Sickle Cell; Ca(2+) Mg(2+)-ATPase; Enzyme Activation; Erythrocyte Membrane; Humans; Procaine | 2005 |
Inhibition of erythrocyte membrane ATPases with antisickling and anaesthetic substances and ionophoric antibiotics.
Topics: Adenosine Triphosphatases; Alfaxalone Alfadolone Mixture; Amphotericin B; Anemia, Sickle Cell; Eryth | 1996 |
Restriction of calcium uptake in normal and sickle red cells by procaine hydrochloride and P-aminobenzoic acid.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Anemia, Sickle Cell; Biological Transport, Active; Calcium; Ery | 1977 |
Photoaffinity labeling of procaine-binding sites in normal and sickle cell membranes.
Topics: Affinity Labels; Anemia, Sickle Cell; Binding Sites; Erythrocyte Membrane; Erythrocytes; Erythrocyte | 1979 |
An in vitro method for screening compounds for the effect on the rate of sickling of erythrocytes.
Topics: 2-Hydroxyphenethylamine; Anemia, Sickle Cell; Aniline Compounds; Antisickling Agents; Calcium; Eryth | 1976 |
Restoration of the deformability of "irreversibly" sickled cells by procaine hydrochloride.
Topics: Anemia, Sickle Cell; Blood Protein Electrophoresis; Cellulose; Electrophoresis; Erythrocytes; Humans | 1974 |