procaine has been researched along with Disease Models, Animal in 46 studies
Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
procaine : A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since reepithelization of the cornea is a critical problem, we envisioned that the anticonvulsant phenytoin sodium can promote reepithelization of corneal ulcers as it was repurposed for skin wound healing." | 7.96 | Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers. ( Afifi, SA; El Sayed, NS; Mahmoud, DB, 2020) |
| "The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368." | 7.91 | Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019) |
| "Regional myocardial ischemia was induced by occlusion of a diagonal branch of left anterior descending coronary artery of anesthetized cats." | 5.35 | Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2? ( Fu, LW; Longhurst, JC; Phan, A, 2008) |
| " Since reepithelization of the cornea is a critical problem, we envisioned that the anticonvulsant phenytoin sodium can promote reepithelization of corneal ulcers as it was repurposed for skin wound healing." | 3.96 | Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers. ( Afifi, SA; El Sayed, NS; Mahmoud, DB, 2020) |
| "The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368." | 3.91 | Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368. ( Gao, H; Gao, J; Li, WC; Wang, ZJ, 2019) |
| "There were no significant differences in inflammation between procaine and saline groups at any of the time intervals." | 3.88 | Procaine and saline have similar effects on articular cartilage and synovium in rat knee. ( Akca, B; Ankay Yilbas, A; Bahador Zirh, E; Buyukakkus, B; Saricaoglu, F; Uzumcugil, F; Zeybek, D, 2018) |
| " This study compared the protective effects of two widely used preservation solutions, histidine-tryptophan-ketoglutarate (HTK) and Celsior (CEL; Sangstat Medical, Menlo Park, CA), for ischemia-reperfusion injury using a rat heterotopic heart transplantation model with older donors." | 3.77 | Histidine-tryptophan-ketoglutarate or celsior: which is more suitable for cold preservation for cardiac grafts from older donors? ( Billiar, TR; Huang, CS; Kawamura, T; Lee, S; Nakao, A; Shigemura, N; Toyoda, Y, 2011) |
| "We have proposed that the reflex increase in arginine vasopressin (AVP) secretion in response to hypovolemia is due to arterial baroreceptor unloading." | 3.70 | Systolic pressure predicts plasma vasopressin responses to hemorrhage and vena caval constriction in dogs. ( Keil, LC; Thrasher, TN, 2000) |
| "Administration of imipramine plus serotonin (5-HT) to rats has been proposed as an animal model of Duchenne muscular dystrophy." | 3.65 | Skeletal muscle necrosis following membrane-active drugs plus serotonin. ( Meltzer, HY, 1976) |
| "In an experimental model of hemorrhagic shock, TMZ, ALO, and HTK solution attenuated cell damage in multiple parenchyma and increased antioxidant defenses." | 1.72 | Bretschneider Solution and Two Antianginal Drugs Protect Peripheral Tissue in an Animal Model of Hemorrhagic Shock. ( Ambrosio, G; Azzato, F; Cao, G; Milei, J; Moriondo, M; Muller, A; Ortiz Fragola, JP; Sangiorgio, M; Tumarkin, M, 2022) |
| "Cardiac arrest was induced in female large white pigs by intravenous injection of potassium chloride." | 1.46 | An Oxygenated and Transportable Machine Perfusion System Fully Rescues Liver Grafts Exposed to Lethal Ischemic Damage in a Pig Model of DCD Liver Transplantation. ( Azoulay, D; Ben Mosbah, I; Calderaro, J; Cohen, JL; Compagnon, P; Corlu, A; Disabato, M; Feray, C; Hentati, H; Levesque, E, 2017) |
| "Cardiac arrest was induced either with HTK (n = 10), HTK-N (n = 10) or HTK-N + S-NO-HSA (n = 10)." | 1.42 | The nitric oxide donor, S-nitroso human serum albumin, as an adjunct to HTK-N cardioplegia improves protection during cardioplegic arrest after myocardial infarction in rats. ( Aumayr, K; Dzilic, E; Gasser, H; Hallström, S; Kerjaschki, D; Kreibich, M; Pelzmann, B; Podesser, BK; Trescher, K, 2015) |
| "In all livers, parameters of reperfusion injury remained unaffected by EPO." | 1.38 | Erythropoietin as additive of HTK preservation solution in cold ischemia/reperfusion injury of steatotic livers. ( Abshagen, K; Eipel, C; Hübschmann, U; Menger, MD; Vollmar, B; Wagner, KF, 2012) |
| "Regional myocardial ischemia was induced by occlusion of a diagonal branch of left anterior descending coronary artery of anesthetized cats." | 1.35 | Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2? ( Fu, LW; Longhurst, JC; Phan, A, 2008) |
| "(4) Reperfusion injury was analyzed in the isolated perfused liver by enzyme release and bile production." | 1.35 | Attenuated cold storage injury of rat livers using a modified HTK solution. ( Bahde, R; de Groot, H; Gemsa, O; Minin, E; Palmes, D; Rauen, U; Spiegel, HU; Stratmann, U, 2008) |
| "This situation may be similar to that in malignant hyperpyrexia (MH) occurring in mammals." | 1.26 | The chick as a model for malignant hyperpyrexia. ( Korczyn, AD; Shavit, S; Shlosberg, I, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (30.43) | 18.7374 |
| 1990's | 1 (2.17) | 18.2507 |
| 2000's | 7 (15.22) | 29.6817 |
| 2010's | 18 (39.13) | 24.3611 |
| 2020's | 6 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ortiz Fragola, JP | 1 |
| Cao, G | 1 |
| Tumarkin, M | 1 |
| Moriondo, M | 1 |
| Muller, A | 1 |
| Sangiorgio, M | 1 |
| Azzato, F | 1 |
| Ambrosio, G | 1 |
| Milei, J | 1 |
| Chen, Z | 1 |
| Kebschull, L | 1 |
| Föll, DA | 1 |
| Rauen, U | 3 |
| Hansen, U | 1 |
| Heitplatz, B | 1 |
| Hessler, M | 1 |
| Senninger, N | 1 |
| Vogel, T | 1 |
| Mohr, A | 1 |
| Becker, F | 1 |
| Oğuz, S | 1 |
| Aşgün, HF | 1 |
| Büyük, B | 1 |
| Mahmoud, DB | 1 |
| Afifi, SA | 1 |
| El Sayed, NS | 1 |
| Chernova, ON | 1 |
| Mavlikeev, MO | 1 |
| Kiyasov, AP | 1 |
| Bozo, IY | 1 |
| Deev, RV | 1 |
| Compagnon, P | 1 |
| Levesque, E | 1 |
| Hentati, H | 1 |
| Disabato, M | 1 |
| Calderaro, J | 1 |
| Feray, C | 1 |
| Corlu, A | 1 |
| Cohen, JL | 1 |
| Ben Mosbah, I | 1 |
| Azoulay, D | 1 |
| Özer, N | 1 |
| Bülbüloğlu, E | 1 |
| Yormaz, S | 1 |
| Ece, İ | 1 |
| Ankay Yilbas, A | 1 |
| Akca, B | 1 |
| Buyukakkus, B | 1 |
| Bahador Zirh, E | 1 |
| Zeybek, D | 1 |
| Uzumcugil, F | 1 |
| Saricaoglu, F | 1 |
| Lautenschläger, I | 1 |
| Pless-Petig, G | 1 |
| Middel, P | 1 |
| de Groot, H | 2 |
| Stojanovic, T | 1 |
| Wang, D | 1 |
| Zhang, X | 1 |
| Qu, D | 1 |
| Han, J | 1 |
| Meng, F | 1 |
| Xu, M | 1 |
| Zheng, Q | 1 |
| Li, WC | 1 |
| Gao, H | 1 |
| Gao, J | 1 |
| Wang, ZJ | 1 |
| Carnevale, ME | 1 |
| Lausada, N | 1 |
| Juan de Paz, L | 1 |
| Stringa, P | 1 |
| Machuca, M | 1 |
| Rumbo, M | 1 |
| Guibert, EE | 1 |
| Tiribelli, C | 1 |
| Gondolesi, GE | 1 |
| Rodriguez, JV | 1 |
| Chen, Y | 1 |
| Qin, C | 1 |
| Wang, G | 1 |
| Xiao, M | 1 |
| Xiao, G | 1 |
| Luan, Z | 1 |
| Du, C | 1 |
| Wang, J | 1 |
| Xu, X | 1 |
| Gok, E | 1 |
| Kubiak, CA | 1 |
| Guy, E | 1 |
| Ponder, M | 1 |
| Hoenerhoff, MJ | 1 |
| Rojas-Pena, A | 1 |
| Kemp, SWP | 1 |
| Bartlett, RH | 1 |
| Ozer, K | 1 |
| Trescher, K | 2 |
| Dzilic, E | 1 |
| Kreibich, M | 1 |
| Gasser, H | 1 |
| Aumayr, K | 1 |
| Kerjaschki, D | 1 |
| Pelzmann, B | 1 |
| Hallström, S | 2 |
| Podesser, BK | 2 |
| Golriz, M | 1 |
| Fonouni, H | 1 |
| Kuttymuratov, G | 1 |
| Esmaeilzadeh, M | 1 |
| Rad, MT | 1 |
| Jarahian, P | 1 |
| Longerich, T | 1 |
| Faridar, A | 1 |
| Abbasi, S | 1 |
| Mehrabi, A | 1 |
| Gebhard, MM | 1 |
| Fu, LW | 1 |
| Phan, A | 1 |
| Longhurst, JC | 1 |
| Aarsaether, E | 1 |
| Stenberg, TA | 1 |
| Jakobsen, Ø | 1 |
| Busund, R | 1 |
| Hosgood, SA | 1 |
| Yang, B | 1 |
| Bagul, A | 1 |
| Mohamed, IH | 1 |
| Nicholson, ML | 1 |
| Abbasova, KR | 1 |
| Chepurnov, SA | 1 |
| Chepurnova, NE | 1 |
| van Luijtelaar, G | 1 |
| Eipel, C | 1 |
| Hübschmann, U | 1 |
| Abshagen, K | 1 |
| Wagner, KF | 1 |
| Menger, MD | 1 |
| Vollmar, B | 1 |
| Lee, S | 1 |
| Huang, CS | 1 |
| Kawamura, T | 1 |
| Shigemura, N | 1 |
| Billiar, TR | 1 |
| Nakao, A | 1 |
| Toyoda, Y | 1 |
| Srinivasan, PK | 1 |
| Yagi, S | 1 |
| Doorschodt, B | 1 |
| Nagai, K | 1 |
| Afify, M | 1 |
| Uemoto, S | 1 |
| Tolba, R | 1 |
| Hasun, M | 1 |
| Baumgartner, A | 1 |
| Dietl, W | 1 |
| Wolfsberger, M | 1 |
| Bahde, R | 1 |
| Palmes, D | 1 |
| Gemsa, O | 1 |
| Minin, E | 1 |
| Stratmann, U | 1 |
| Spiegel, HU | 1 |
| Tapsoba, YA | 1 |
| Feuvray, D | 1 |
| de Leiris, J | 1 |
| Hall, GM | 1 |
| Lucke, JN | 1 |
| Lister, D | 1 |
| Korczyn, AD | 1 |
| Shavit, S | 1 |
| Shlosberg, I | 1 |
| Lassner, F | 1 |
| Becker, M | 1 |
| Fansa, H | 1 |
| Walter, GF | 1 |
| Berger, A | 1 |
| Thrasher, TN | 1 |
| Keil, LC | 1 |
| Keeling, IM | 1 |
| Obermayr, RP | 1 |
| Schneider, B | 1 |
| Spieckermann, PG | 1 |
| Kadar, T | 1 |
| Fishbeine, E | 1 |
| Meshulam, Y | 1 |
| Sahar, R | 1 |
| Chapman, S | 1 |
| Liani, H | 1 |
| Barness, I | 1 |
| Amir, A | 1 |
| Wood, CE | 1 |
| Meltzer, HY | 1 |
| Lumsden, CE | 1 |
| Howard, L | 1 |
| Aparicio, SR | 1 |
| Bradbury, M | 1 |
| Hearse, DJ | 1 |
| Stewart, DA | 1 |
| Green, DG | 1 |
| House, AK | 1 |
| Brooks, AJ | 1 |
| Woodman, K | 1 |
| Sheil, AG | 1 |
| Heffron, JJ | 1 |
| Mitchell, G | 1 |
| Katz, MA | 1 |
| Shear, L | 1 |
| Frolova, AI | 1 |
| Wang, GY | 1 |
| Zhong, SZ | 1 |
| Demetrescu, M | 1 |
| Julien, RM | 1 |
| Bull, AB | 1 |
| Harrison, GG | 1 |
| Hübner, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Custodiol-HTK Solution as a Cardioplegic Agent- A Prospective Non-Inferiority Randomized Clinical Trial[NCT01681095] | Phase 2 | 110 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants with all-cause mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
CK-MB measured 24 hours post-operatively (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 20 |
| Cold Blood Cardioplegia | 24 |
CK-MB measured 48 hours post-operatively (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 6.0 |
| Cold Blood Cardioplegia | 7.8 |
CK-MB measured pre-operatively (NCT01681095)
Timeframe: pre-operative
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 1.9 |
| Cold Blood Cardioplegia | 2.6 |
Number of participants with new or worsening of cardiac dysrhythmias (NCT01681095)
Timeframe: up to 36 hrs post surgery
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 24 |
| Cold Blood Cardioplegia | 30 |
Troponin-I measured 24 hours post-operative (NCT01681095)
Timeframe: 24 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 5.7 |
| Cold Blood Cardioplegia | 7.8 |
Troponin-I measured 48 hours post-operative (NCT01681095)
Timeframe: 48 hours post procedure
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3.0 |
| Cold Blood Cardioplegia | 4.8 |
Troponin-I measured pre-operatively (NCT01681095)
Timeframe: pre-operatively
| Intervention | ng/mL (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | .03 |
| Cold Blood Cardioplegia | .03 |
Number of participants with cardiovascular-related mortality AS reported in the Society of Thoracic Surgeons (STS) database after 30 days postoperative (NCT01681095)
Timeframe: 30 days post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Creatine phosphokinase MB isoenzyme (CK-MB) difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 18.8 |
| Cold Blood Cardioplegia | 22.2 |
Troponin I values, difference from baseline 7 hours post surgery (NCT01681095)
Timeframe: Baseline and 7 hours post surgery
| Intervention | ng/mL (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 9.65 |
| Cold Blood Cardioplegia | 10.15 |
LV ejection fraction by TTE, difference from baseline at 24 hours post surgery (NCT01681095)
Timeframe: Baseline and 24 hours post surgery
| Intervention | % LV volume (Mean) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | -0.06 |
| Cold Blood Cardioplegia | 1.9 |
Total time in minutes on any vasopressor or inotropic agent, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | minutes (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 340 |
| Cold Blood Cardioplegia | 582 |
Duration of stay in ICU, from ICU admission to ICU discharge (NCT01681095)
Timeframe: up to 100 days after admission
| Intervention | days (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 3 |
| Cold Blood Cardioplegia | 3 |
Number or participants fulfilling at least two of the following 3 criteria: (1) CK-MB of 100 ug/L or more and/or troponin-I of 3.0 ug/L or more, (2) appearance of new postoperative Q waves on the EKG of more than 0.03 seconds, and (3) a new hypokinetic or akinetic area in the left or right ventricle by echocardiography. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 0 |
| Cold Blood Cardioplegia | 0 |
Number of patients receiving vasopressor or inotropic infusion for greater than 20 minutes in the operating room, including norepinephrine, epinephrine, vasopressin, milrinone, dobutamine, dopamine and/or neo-synephrine. (NCT01681095)
Timeframe: during operative procedure
| Intervention | participants (Number) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 47 |
| Cold Blood Cardioplegia | 43 |
time in hours from intubation to extubation, with intervening transport to the cardiac critical care unit. (NCT01681095)
Timeframe: up to 36 hours post procedure
| Intervention | hours (Median) |
|---|---|
| Cardioplegia: Custodiol HTK Solution | 10.5 |
| Cold Blood Cardioplegia | 11.4 |
2 reviews available for procaine and Disease Models, Animal
| Article | Year |
|---|---|
Malignant hyperthermia--pearls out of swine?
Topics: Animals; Body Temperature; Dantrolene; Disease Models, Animal; Halothane; Magnesium Sulfate; Maligna | 1980 |
Electron microscopic investigation of cardioplegia. Electron microscopy of various forms of cardiac arrest in correlation with myocardial function.
Topics: Adenosine Triphosphate; Animals; Cell Nucleus; Citrates; Coronary Disease; Disease Models, Animal; D | 1971 |
44 other studies available for procaine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Bretschneider Solution and Two Antianginal Drugs Protect Peripheral Tissue in an Animal Model of Hemorrhagic Shock.
Topics: Allopurinol; Animals; Cardiovascular Agents; Disease Models, Animal; Glucose; Glutathione; Insulin; | 2022 |
A novel histidine-tryptophan-ketoglutarate formulation ameliorates intestinal injury in a cold storage and ex vivo warm oxygenated reperfusion model in rats.
Topics: Animals; Cold Ischemia; Disease Models, Animal; Glucose; Humans; Intestinal Mucosa; Intestine, Small | 2020 |
Effectiveness of Brain Protection With Histidine-Tryptophan-Ketoglutarate Solutions.
Topics: Animals; Biopsy; Brain; Brain Ischemia; Cardioplegic Solutions; Disease Models, Animal; Glucose; Mal | 2020 |
Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers.
Topics: Administration, Ophthalmic; Animals; Cornea; Corneal Ulcer; Crown Ethers; Disease Models, Animal; Dr | 2020 |
Reactive Changes in Elements of Stromal-Vascular Differons of Dysferlin-Deficient Skeletal Muscles after Procaine Injection.
Topics: Animals; Disease Models, Animal; Dysferlin; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Muscle, S | 2021 |
An Oxygenated and Transportable Machine Perfusion System Fully Rescues Liver Grafts Exposed to Lethal Ischemic Damage in a Pig Model of DCD Liver Transplantation.
Topics: Allografts; Animals; Biomarkers; Disease Models, Animal; Energy Metabolism; Equipment Design; Female | 2017 |
Evaluation of silybum marinaum efficacy on University of Wisconsin and histidine-tryptophan-ketoglutarate solutions latter the damage of the perfused liver.
Topics: Adenosine; Allopurinol; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Model | 2017 |
Procaine and saline have similar effects on articular cartilage and synovium in rat knee.
Topics: Anesthetics, Local; Animals; Cartilage, Articular; Disease Models, Animal; Hindlimb; Inflammation; M | 2018 |
Cold Storage Injury to Rat Small-bowel Transplants-Beneficial Effect of a Modified HTK Solution.
Topics: Alanine; Animals; Cell Hypoxia; Cold Ischemia; Disease Models, Animal; Glucose; Glycine; Humans; Int | 2018 |
Astragalin and dihydromyricetin as adjuncts to histidine‑tryptophan‑ketoglutarate cardioplegia enhances protection during cardioplegic arrest.
Topics: Animals; Apoptosis; Biomarkers; Cardioplegic Solutions; Cardiotonic Agents; Cytokines; Disease Model | 2018 |
Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Gap Junc | 2019 |
The Novel N,N-bis-2-Hydroxyethyl-2-Aminoethanesulfonic Acid-Gluconate-Polyethylene Glycol-Hypothermic Machine Perfusion Solution Improves Static Cold Storage and Reduces Ischemia/Reperfusion Injury in Rat Liver Transplant.
Topics: Alkanesulfonic Acids; Allografts; Animals; Cold Ischemia; Disease Models, Animal; Gluconates; Glucos | 2019 |
Contribution of heparin to recovery of incarcerated intestine in a rat incarcerated hernia model.
Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Heparin; Hernia, Abdominal; Intestinal Obstr | 2019 |
Long-term Effects of Hypothermic Ex Situ Perfusion on Skeletal Muscle Metabolism, Structure, and Force Generation After Transplantation.
Topics: Amputation, Traumatic; Animals; Cold Ischemia; Disease Models, Animal; Glucose; Hindlimb; Humans; Ma | 2019 |
The nitric oxide donor, S-nitroso human serum albumin, as an adjunct to HTK-N cardioplegia improves protection during cardioplegic arrest after myocardial infarction in rats.
Topics: Animals; Cardiac Output; Cardioplegic Solutions; Disease Models, Animal; Glucose; Heart Arrest; Hear | 2015 |
Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model.
Topics: Adenosine; Allopurinol; Animals; Biopsy, Needle; Disease Models, Animal; Female; Glucose; Glutathion | 2017 |
Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2?
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthetics, Local; Animals; Cat | 2008 |
Mechanoenergetic function and troponin T release following cardioplegic arrest induced by St Thomas' and histidine-tryptophan-ketoglutarate cardioplegia--an experimental comparative study in pigs.
Topics: Animals; Bicarbonates; Biomarkers; Calcium Chloride; Cardioplegic Solutions; Cardiopulmonary Bypass; | 2009 |
A comparison of hypothermic machine perfusion versus static cold storage in an experimental model of renal ischemia reperfusion injury.
Topics: Acid-Base Equilibrium; Adenosine; Allopurinol; Animals; Aspartate Aminotransferases; Biomarkers; Cit | 2010 |
The role of perioral afferentation in the occurrenceof spike-wave discharges in the WAG/Rij modelof absence epilepsy.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Electroencephalography; E | 2010 |
Erythropoietin as additive of HTK preservation solution in cold ischemia/reperfusion injury of steatotic livers.
Topics: Animals; Cold Temperature; Disease Models, Animal; Erythropoietin; Fatty Liver; Female; Glucose; Ion | 2012 |
Histidine-tryptophan-ketoglutarate or celsior: which is more suitable for cold preservation for cardiac grafts from older donors?
Topics: Animals; Cold Temperature; Disaccharides; Disease Models, Animal; Electrolytes; Glucose; Glutamates; | 2011 |
Impact of venous systemic oxygen persufflation supplemented with nitric oxide gas on cold-stored, warm ischemia-damaged experimental liver grafts.
Topics: Animals; Biomarkers; Cold Temperature; Disease Models, Animal; Gases; Glucose; Lipid Peroxidation; L | 2012 |
New HTK-N46B cardioplegia provides superior protection during ischemia/reperfusion in failing hearts.
Topics: Animals; Biomarkers; Cardiac Surgical Procedures; Cardioplegic Solutions; Disease Models, Animal; Gl | 2013 |
Attenuated cold storage injury of rat livers using a modified HTK solution.
Topics: Animals; Apoptosis; Bile; Blood Pressure; Cryopreservation; Disease Models, Animal; Glucose; Heart R | 2008 |
[Factors affecting the post-ischemic recuperation of isolated perfused rat heart].
Topics: Animals; Coronary Disease; Disease Models, Animal; Heart; Heart Arrest, Induced; In Vitro Techniques | 1980 |
The chick as a model for malignant hyperpyrexia.
Topics: Animals; Calcium; Chickens; Dantrolene; Disease Models, Animal; Drug Evaluation, Preclinical; Malign | 1980 |
Preservation of peripheral nerve grafts: a comparison of normal saline, HTK organ preservation solution, and DMEM Schwann cell culture medium.
Topics: Animals; Cardioplegic Solutions; Cell Division; Cell Survival; Cryopreservation; Culture Media; Dise | 1995 |
Systolic pressure predicts plasma vasopressin responses to hemorrhage and vena caval constriction in dogs.
Topics: Anesthetics, Local; Animals; Aorta, Thoracic; Arginine Vasopressin; Atrial Function; Baroreflex; Blo | 2000 |
Postischemic cardiac function recovery in the isolated rat heart: effects of adenosine deaminase and nucleoside transport inhibition.
Topics: Adenine; Adenosine Deaminase; Affinity Labels; Animals; Cardioplegic Solutions; Disease Models, Anim | 2000 |
Treatment of skin injuries induced by sulfur mustard with calmodulin antagonists, using the pig model.
Topics: Administration, Topical; Anesthetics, Local; Animals; Blister; Calmodulin; Dermatologic Agents; Dise | 2000 |
The ovine fetal endocrine reflex responses to haemorrhage are not mediated by cardiac nerves.
Topics: Adrenergic alpha-Agonists; Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Blood Pressur | 2002 |
Skeletal muscle necrosis following membrane-active drugs plus serotonin.
Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Drug Synergism; Histamine H1 Anta | 1976 |
Anti-synaptic antibody in allergic encephalomyelitis. II. The synapse-blocking effects in tissue culture of demyelinating sera from experimental allergic encephalomyelitis.
Topics: Animals; Cerebellum; Complement System Proteins; Culture Techniques; Disease Models, Animal; Electri | 1975 |
Myocardial susceptibility to ischemic damage: a comparative study of disease models in the rat.
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Cardiomegaly; Coronary Circulation; Coronary Diseas | 1978 |
A comparison of flushing fluids for initial perfusion of kidneys for transplantation.
Topics: Animals; Disease Models, Animal; Dogs; Enzymes; Erythrocytes; Glucose; Hypertonic Solutions; Kidney; | 1979 |
Letter: Procaine for malignant hyperthermia.
Topics: Animals; Calcium; Disease Models, Animal; Halothane; Humans; Malignant Hyperthermia; Procaine; Sarco | 1975 |
Effects of renal nerves on renal hemodynamics. II. Renal denervation models.
Topics: Animals; Denervation; Disease Models, Animal; Dogs; Ethanol; Female; Glomerular Filtration Rate; Hem | 1975 |
[Strangulated ileus with and without suprapleural novocaine blockade].
Topics: Animals; Autonomic Nerve Block; Disease Models, Animal; Dogs; Intestinal Obstruction; Procaine; Spla | 1976 |
Experimental study of lymphatic contractility in lymphedema and its clinical significance.
Topics: Animals; Dilatation, Pathologic; Disease Models, Animal; Epinephrine; Lymphatic System; Lymphedema; | 1985 |
Local anesthesia and experimental epilepsy.
Topics: Animals; Benzocaine; Cats; Disease Models, Animal; Female; Lidocaine; Male; Procaine; Seizures; Time | 1974 |
Recent advances in the understanding of anaesthetic-induced malignant hyperpyrexia.
Topics: Acidosis; Anesthetics; Animals; Anura; Bicarbonates; Caffeine; Calcium; Cold Temperature; Disease Mo | 1973 |